what hormone is responsible for increasing blood calcium levels and decreasing blood phosphate ion levels

Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx

Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx

Ngày tải lên : 16/03/2014, 04:20
... referred to as CPT1A, CPT1B, and CPT1C. Whereas CPT1A is widely expressed in most tissues, CPT1B is only expressed in muscle, adipose tissue, heart, and testis [1], and CPT1C expression seems to be restricted ... occurring variation, Glu17, is responsible for both the low malonyl- CoA sensitivity and high carnitine affinity characteristics of the pig enzyme. This is the first demonstration that a single ... part, for the high degree of inhibition of the human enzyme. Experimental procedures Construction of deletions D18PigCPT1B and D28PigCPT1B for CPT1B expression in P. pastoris The deletions D18PigCPT1B...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc

Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc

Ngày tải lên : 23/03/2014, 07:20
... site and a sub- strate-binding site for factor IX. Blood 74, 244–251. 10 Bouma BN & Griffin JH (1977) Human blood coagula- tion factor XI. Purification, properties, and mechanism of activation ... AA, Gilchrist GS & Owen WG (1996) Genetic analysis and functional characterization of pro- thrombins Corpus Christi (Arg382–Cys), Dhahran (Arg271–His), and hypoprothrombinemia. Blood 88, 2611–2618. 30 ... FXI levels and hemorrhagic episodes are usu- ally associated with injury or surgery, but may be so severe as to demand replacement therapy [16]. The genetic basis of this rare coagulation disorder...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx

Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx

Ngày tải lên : 23/03/2014, 10:20
... the transcriptional factor that favors lysogeny and is responsible for primary control of the lambda develop- mental decision for lysis or lysogeny [4,7–9]. In the absence of CIII, CII is rapidly ... a lack of interaction between r 32 and CIII (Fig. 4). As for CII, competition between r 32 and CIII for binding to HflB would also decide the extent and efficiency of protection of r 32 by CIII, ... affinity for r 32 –HflB interaction and CIII–HflB interaction would play an important role in the inhibition of proteolysis of r 32 by HflB. Interestingly, both CII and r 32 are cytosolic sub- strates for...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf

Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf

Ngày tải lên : 29/03/2014, 22:21
... synthesis, it might be involved in the stearic acid incorporation after the de novo synthesis of this lipid (i.e. the second hypothesis). According to this hypothesis, previously raised for mammals ... t-test. Acknowledgements We thank Stephen Manon and Nadine Camougrand (IBGC, Universite ´ de Bordeaux ⁄ CNRS) for helpful discussions. This work was supported by the CNRS and the Conseil Re ´ gional Aquitaine. Work at ... of sn-2-acyl-1-lysoPI and 1 nmol of [ 14 C]stearoyl-CoA. Incu- bations were performed at 30 °C for 10 min. Reactions were stopped by the addition of 2 mL of chloroform ⁄ meth- anol (2 : 1, v ⁄ v) and 500 lL...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc

Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc

Ngày tải lên : 31/03/2014, 09:20
... site for the hydroxylation reaction to occur. The same seems to hold for the derivatives of mandelic acid: 3,4-dihydroxymandelic acid is oxidized by tyrosinase, whereas 4-hydroxymandelic acid is ... should be poor substrates for tyrosinase. On the other hand, 3,4- dihydroxybenzoic acid inhibited the dopachrome forma- tion, although the exact mechanism of this reaction has not been investigated ... reaction was assayed spectrophotometrically [13]. However, we have now shown that it does not result from its interaction with the enzyme but from chemical reactions in solution. What distinguishes...
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Báo cáo khoa học: Knock-out of the chloroplast-encoded PSI-J subunit of photosystem I in Nicotiana tabacum PSI-J is required for efficient electron transfer and stable accumulation of photosystem I pot

Báo cáo khoa học: Knock-out of the chloroplast-encoded PSI-J subunit of photosystem I in Nicotiana tabacum PSI-J is required for efficient electron transfer and stable accumulation of photosystem I pot

Ngày tải lên : 16/03/2014, 11:20
... procedure. Acknowledgements We wish to thank Ingrid Duschanek and Elli Gerick for excellent technical assistance, and Steen Malmmose for assistance with growing plants. The Danish National Research Foundation, the Danish ... containing 2% sucrose, and grown in 12 h dark ⁄ light cycles at 25 °C and 20 l mol photonsÆm )2 Æs )1 and, under selective condi- tions, 500 lgÆmL )1 spectinomycin. For thylakoid isolation and physiological ... nm caused by photo-oxidation of P700 to P700 + , followed by a slower absorption decrease due to reduction of P700 + by Pc. The reaction between Pc and P700 is a multistep reaction, which can be divided...
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Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx

Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx

Ngày tải lên : 23/03/2014, 06:20
... side-chain mediating cyclization [18]. Substitution of this position with l-Cys1 (TL6) abol- ished ligation and subsequent cyclization resulting in complete hydrolysis. This observation indicates that only ... the C-terminal amino acid is essential for recogni- tion of the substrate and subsequent ligation and macrocyclization. In addition, we speculated that S-methyl-l-Cys4 is incorporated into the ... activity. N-methylation induces conformational changes and elevates rotational barriers [41]. This rigidification of molecular dynamics gives rise to a preferential prefold of the oligopeptide. The substitution...
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Selling Financial Products - A proven methodology for increasing sales of banking and financial services doc

Selling Financial Products - A proven methodology for increasing sales of banking and financial services doc

Ngày tải lên : 23/03/2014, 11:20
... positioning of our client vis-à-vis competitors Preparation of course materials: Submission of course materials to client for approval Psychometric Questionnaire: Using Thomas International ... Capital Markets and Risk ■ Risks in derivatives ■ Fixed income and swaps ■ Treasury risk management ■ Asset and liability management ■ Credit derivatives ■ Asset securitisation and CDOs ■ Commodity ... Training Credit Analysis ■ Accounting concepts and developments ■ Corporate credit analysis ■ Credit portfolio risk management ■ Bank and country risk analysis ■ Analysis of non-bank financials ■...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

Ngày tải lên : 18/02/2014, 18:20
... post-hydrolysis. Therefore, the dissoci- ation of phosphate and ⁄ or ADP is likely to be responsible for resetting of the transporter. The data indicate that, like ABCB1 and ABCC1, the ‘power stroke’ for ... a conformation that contains a low-affinity binding site for [ 3 H]daunomycin imme- diately post-nucleotide hydrolysis. Discussion A precise molecular mechanism for substrate translo- cation by ... high-affinity conformation for the transporter, which is supported by the restoration of high-affinity binding in the ADP- bound conformation. That this step of the catalytic cycle is associated...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

Ngày tải lên : 22/02/2014, 04:20
... mentioned b efore except for the primer c oncentration (50 pmolÆ50 lL )1 reac- tion mix) and the concentration of the agarose slab gel used to visualize the PCR products was 4% (2% Gibco-BRL and 2% ... 5¢ and 3¢ flanking regions of each exon allowed us to identify 23 single nuc- leotide polymorphisms and two i nsertion/deletion events in the coding as well as the noncoding regions. A comparison ... 265/266-bp fragment is split into two fragments (240 and 26 bp) for each allele e xcept the M and F alleles, for wh ich no TaqIsite has been created (Fig. 8, Step IB), because of mutations (deletion o r...
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Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf

Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf

Ngày tải lên : 23/03/2014, 10:21
... wavelengths. (A, excitation and emission at 340 nm when Fura-2 is bound to calcium; B, excitation and emis- sion at 380 nm when Fura-2 is free). Intracellular calcium levels can then be calculated ... antibodies to SEP53 and the human SEP53 gene was cloned into a bacterial and insect cell-expres- sion system for the purification and acquisition of full-length protein for immunization, and to develop ... is that there is a relatively high degree of cell and tissue specificity in HSP and related stress-acti- vated transcription factor induction [39–44]. Consistent with this, our initial analysis...
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