what is the history of the mcintosh apple the fruit not the computer
Báo cáo khoa học: Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain doc
Ngày tải lên :
07/03/2014, 12:20
... [16]. The
active site is at the narrower end of the barrel as
mapped by the presence of ligands (Tris in Glu1.1 or
acarbose in the Glu-A structure).
Accuracy of models
As expected, the accuracy of ... confirms that the
deviation of torsion angles from ideal geometry of
these two residues is an intrinsic feature of the struc-
ture. In Glu1.1 there is another residue, Ser305 in the
generously ... and discussion
Description of the structures
There is one molecule in the asymmetric unit of both
structures composed of a single domain consisting of
14 helices, 12 of them forming an (a ⁄ a
6
)...
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routledge history of philosophy vol v british philosophy and the age of enlightenment - stuart brown
Ngày tải lên :
05/06/2014, 11:30
... developed is the main concern of this History.
In speaking of what is now regarded as philosophy’, we may have given the
impression that there now exists a single view of what philosophy is. This is ... Context (1994). He is the author of numerous articles on the history o
f
seventeenth century philosophy.
M.A.Stewart
is Professor of the History of Philosophy at the University of Lancaster. He
has ...
The history of philosophy, as its name implies, represents a union of two very different
disciplines, each of which imposes severe constraints upon the other. As an exercise in
the history of...
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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"
Ngày tải lên :
25/10/2012, 11:15
...
below the 0.70 for Bc1 in all groups. The relevance of
this finding is that it was the result of the first sub-
group analysis for these biomarkers. Bc1 should
therefore be studied in terms of ... subjects, the comparison of the
benign and control groups did not yield a statistically
significant difference. None of the proteomics reach
reasonable AUC values for the discrimination of the
BC. ...
products. These approaches, however, have poor
sensitivities and specificities since none of them alone
is useful for the majority of the BC and none of them is
specific for cancer or breast tissues....
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A STUDY ON THE USE OF PEER TEACHING IN ESP CLASSES AT THE COLLEGE OF SCIENCE, VIETNAM NATIONAL UNIVERSITY HANOI
Ngày tải lên :
29/01/2014, 10:49
... translate the materials in their specific fields written in
English. The biggest difficulty for the teachers of ESP here is that they do not have enough
knowledge of the specific field that they ... review of higher education research on teaching and learning: The
best answer to the question of what is the most effective method of teaching is that it depends
on the goal, the student, the ... design of the study.
The second part, the main part, of the study is divided into three chapters. Chapter 1
deals with the review of the literature relevant to the study. Chapter 2 covers the...
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Tài liệu Guidelines for the appointment of General Practitioners with Special Interests in the Delivery of Clinical Services pdf
Ngày tải lên :
14/02/2014, 21:20
... supervisor/s to confirm the satisfactory
fulfilment of the required training experience and the acquisition of the
competencies enumerated in this document and others thought necessary by the
employing ... level 1 services. Therefore an initial role of a GPwSI service may
be to support this further.
Further activities of the GPwSI service depend on the needs of the Primary Care
Organisation (PCO) and ... The number of sessions should be sufficient to ensure that
the GPwSI is able to meet the competencies of the service requirements, the skill
being assessed and the level of expertise required....
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
Ngày tải lên :
19/02/2014, 16:20
... sensitivity analysis of the
chicken Ig-b locus has not been finished because of the
technical difficulty of this type of assay, there may be
no difference in the range and extent of general sensi-
tivity ... acetylation of H3 and H4
histones, and the remaining DHSs in the deleted cells
were examined to determine the roles of these DHSs
on the transcription of Ig-b gene and on the mainten-
ance of the active ... the
Na channel gene and in the first intron of the Ig-b
gene. Furthermore, the acetylation status of H3 and
H4 histones was examined [15]. In the present study,
10 DT40-specific DHSs found in the...
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Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc
Ngày tải lên :
07/03/2014, 12:20
... concentration
of the inhibitor, A is locked to 0%, B to 100%, C is the
IC
50
value and D is the slope of the curve. The IC
50
value
is the concentration x, where y ẳ 50%.
K
m
was measured using the HPLC ... aggregation of
the protein. This is further confirmed by the existence
of a natural variant of CPU, where T347 is subsituted
by an I. Although accentuating the hydrophobic
character of the protein ... WT CPU and
thereby decreasing the observed K
m
in comparison to
WT CPU. This hypothesis is supported by the use of
a newly developed continuous coupled enzyme assay
instead of the discontinuous...
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Báo cáo khoa học: The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides pot
Ngày tải lên :
08/03/2014, 10:20
... hese gels, as the ODN h ybridizes to the
center of the input target RNA. The asterisk indicates the input target
RNA; the arrow indicates the digested product bands. The amount of
digested product ... investigate the nature of the differences in
response t o a ntisense ODNs we analyzed the RNase H levels
in the cell lines, as RNase H is claimed to be a key
component in the mechanism of inhibition of ... expression is presumed to result in
degradation of the target mRNA via RNase H activity. The
efđcacy of a particular ODN can therefore b est be a ddressed
by Northern blot analysis of the target...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
Ngày tải lên :
15/03/2014, 10:20
... loan is decided on the
basis of the borrower’s investment need
and their ability to repay. The amount of
the first loan does not exceed US$ 750
and the borrowers can apply for a second
loan of ... analysis of the
creditworthiness and the repayment capacity
of their clients, a domain where they have a
high level of expertise, while savings banks
could make use of their front and back of ce ... physical banking
infrastructure is essential to collect the often
small amounts of savings, and maintain them
at the disposal of the client on a permanent
basis. It requires skilled staff,...
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Surfing the waves of globalization - Asia and financial lobalization in the context of the trilemma
Ngày tải lên :
15/03/2014, 11:21
...
TIỂU LUẬN TÀI CHÍNH QUỐC TẾ
ĐỀ TÀI:
SURFING THE WAVES OF GLOBALIZATION: ASIA
AND FINANCIAL LOBALIZATION IN THE CONTEXT
OF THE TRILEMMA
+ GVHD : Ts Nguyễn Khắc Quốc Bảo
+ Nhóm ... cho nền kinh tế đóng theo đuổi chính sách tỷ giá cố định. Vì vậy, đối
với các nước có nền kinh tế đóng có mức độ nắm giữ IR cao ( cao hơn ngưỡng 15-16% GDP),
tốt cho việc theo đuổi chính sách ... trung vào việc theo đuổi tỷ giá hoái đoái
cố định. Đối với nền kinh tế này thì biên động đầu tư ít quan trọng nhưng nó làm quan trọng
hơn mức độ nắm giữ IR cao. Thật là quan trong khi theo đuổi...
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Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
Ngày tải lên :
23/03/2014, 12:20
... form.
These d ata suggest that chaperone a ctivity is not a
prerequisite for protection of t ranslation by small hsps after
heat shock [35].
The ubiquitin-proteasome pathway is a nother mech-
anism ... investigation into the regulation of
protein synthesis in mammalian cells, we have investigated
the e ffects of inhibition of the p roteasome o n the localiza-
tion and integrity of eIF4G in C2C12 ... [50,51].
Results
The proteasome inhibitor, MG132, promotes
an inhibition of protein synthesis without the cleavage
of eIF4GI or eIF4GII
In a number of different cell types, inhibition of the 26S
proteasome...
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Báo cáo khoa học: Analysis of the effect of potato carboxypeptidase inhibitor pro-sequence on the folding of the mature protein pot
Ngày tải lên :
23/03/2014, 21:20
... large dispersion of resonances at
the low or high fields. In the 0–1 p.p.m. region there are not
a significant number of potential shifted methyl protons,
and the dispersion of resonances is also ... by the presence of external thiols in the folding
mixture [18]. While the addition of Cys accelerates the
second stage of disulfide reshuffling of scrambled forms to
native PCI, the addition of ... Similarly, the pro-region of the guanylyl
cyclase activating peptide (GCAPII) contributes signifi-
cantly to the correct disulfide-coupled folding of the mature
protein and the dimerization of the molecule...
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Báo cáo Y học: The presence of phosphate at a catalytic site suppresses the formation of the MgADP-inhibited form of F1-ATPase potx
Ngày tải lên :
24/03/2014, 00:21
... course of
the ¯uorescence quenching on addition of MgATP in the
presence of various concentrations of P
i
is shown in Fig. 3B.
Although the ®nal magnitude of the ¯uorescence quenching
by the addition ... P
i
[18]. Here we
examined the effects of P
i
on the formation of the MgADP-
inhibited f orm o f the a
(W463F)3
b
(Y341W)3
c subcomplex. The
extent of ADP inhibition of the a
(W463F)3
b
(Y341W)3
c ... is at the c phosphate
of ATP, and does not interfere with ADP binding. The other
is that P
i
binds to a site o ther than any of the catalytic sites.
In the ®rst case, it is possible that P
i
binding...
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the neuroscience of social interaction decoding imitating and influencing the actions of others mar 2004
Ngày tải lên :
11/06/2014, 09:43
... reaching when there is no reason to
believe an object is hidden from sight fails to activate the F5 cells. Thus F5
and STS cells code the sight of actions on the basis of what is currently vis-
ible ... it. This leads to a fundamental problem. What we see is a series of
configurations of the person in space, but what we have to do is to issue a
series of motor commands. How can we translate what ... into what we
need to do? The discovery of mirror neurons demonstrated that a mechanism
for translation is present in the primate brain and is automatically elicited
when viewing the actions of others....
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báo cáo hóa học:" The influence of the level of physical activity and human development in the quality of life in survivors of stroke" potx
Ngày tải lên :
20/06/2014, 15:20
... smaller is the
numerator and therefore the worse the situation o f
development. Conversely, the closer the observed value
is to the maximum value, the better the situation in
terms of development.
The ... Brazil, and
that the HDI Table is based on the territorial division in
2000, year of completion of the last census, with 5,507
cities. The periods of interest for this study, on the
other hand, correspond ... defined
through the observation of t he world tendencies in
terms of i ndicators for the long term, allowing periodic
comparisons of the indexes obtained.
It is noteworthy that there are 27 states...
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