recent progress in the development of recombinant human hemoglobin rhbl 1 as an oxygen therapeutic

bài giảng chapter 1 overview of financial management and the financial environment

Ngày tải lên : 30/10/2014, 08:23

... provider of cash (i.e., capital) and a user of cash 1 - 19 What are some financial instruments? Instrument Rate (April 2003) U.S T-bills 1. 14% Banker’s acceptances 1. 22 Commercial paper 1. 21 Negotiable ... 1 - 41 Assume the MRP is zero for Year and increases by 0 .1% each year Step 2: Find MRP based on this equation: MRPt = 0 .1% (t - 1) MRP1 = 0 .1% x = 0.0% MRP10 = 0 .1% x = 0.9% MRP20 = 0 .1% x 19 ... funds - 24 The Top Banking Companies in the World, 12 /20 01 Bank Name Country Citigroup U.S Deutsche Bank AG Germany Credit Suisse Switzerland BNP Paribas France Bank of America U.S 1 - 25 What...

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Tài liệu overview of data modeling and database design pptx

Ngày tải lên : 10/12/2013, 17:15

... ID 10 0 10 1 10 2 10 3 PRODUCT_ID 10 011 10 013 304 21 410 10 2 018 0 DATE_ORDERED 31- AUG-92 31- AUG-92 01- SEP-92 02-SEP-92 S_ORD Table Technical Note: Foreign keys are not the same as the pointer-based ... contain a null value because no part of a PK can be NULL Example In the S_ITEM table, the ORD_ID cannot contain a null value because it is part of the PK Foreign Key ORD_ID 10 0 10 0 10 1 10 1 10 2 ... line Degree element indicating “one and only one.” Class Management Note: Note for page 8 -18 Question: Name some examples of these types of relationships in the top slide Answer: 1: 1 Husband and...

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Tài liệu overview of data modeling and database design pdf

Ngày tải lên : 21/12/2013, 06:17

... ORD_ID 10 0 10 0 10 1 10 1 10 2 Primary Key ID 10 0 10 1 10 2 10 3 Primary Key ITEM_ID PRODUCT_ID 10 011 10 013 304 21 410 10 2 018 0 S_ITEM Table CUSTOMER_ID 204 205 206 208 DATE_ORDERED 31- AUG-92 31- AUG-92 01- SEP-92 ... Values in the column must match the defined datatype User-defined Values must comply with the business rules Examples of UserĆDefined Data Integrity Constraints D An employee in the finance department ... operational database Stages of Development Strategy and Analysis D Study and analyze the business requirements Interview users and managers to identify the information requirements Incorporate the enterprise...

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Tài liệu An overview of customer satisfaction and loyalty doc

Ngày tải lên : 18/01/2014, 15:20

... meet them However, the overall process can be divided into six interactive phases Customer Satisfaction Measurement Process Phase 1: Mobilization Phase 4: Action Planning Define Business and Information ... Customers/Employees Phase 5: Implementation Implement Plans Phase 6: Tracking Phase 3: Needs and Performance Evaluation Provide Quantitative Measures of: • Importance of Key Attributes • Company Performance on ... Competitive Performance • Expectations of Specific Levels of Performance Determine Areas of Greatest Impact Provide Ongoing Quantitative Assessment of Performance Deliver Easy-toUnderstand Reports to...

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Tài liệu Database Encryption – An Overview of Contemporary Challenges and Design Considerations pdf

Ngày tải lên : 19/02/2014, 12:20

... [15 ] 3.5 Indexing Encrypted Data The indexing scheme proposed in [16 ] suggests encrypting the whole database row and assigning a set identifier to each value in this row The indexing scheme in ... scheme in [17 ] suggests building a B-Tree index over the table plaintext values and then encrypting the table at the row level and the B-Tree at the node level The indexing scheme in [18 ] is based ... constructing the index on the plaintext values and encrypting each page of the index separately Since the uniform encryption of all pages is likely to provide many cipher breaking clues, the indexing...

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Tài liệu Báo cáo Y học: The glucose-speciﬁc carrier of the Escherichia coli phosphotransferase system Synthesis of selective inhibitors and inactivation studies pptx

Ngày tải lên : 21/02/2014, 01:21

... obtained from the best ﬁt are: with 1d (A) KS1 ¼ lM, k1 ¼ 23 min )1, KI1 ¼ 19 lM, KS2 ¼ 19 0 lM, k2 ¼ 39 min )1, KI2 ¼ lM; with 3a (B) KS1 ¼ lM, k1 ¼ 16 min )1, KI1 ¼ lM, KS2 ¼ 14 0 lM, k2 ¼ 32 min )1, KI2 ... < 0.0 01 0.4 ± 0 .1 < 0.0 01 – – – – 0.0 01 0.0 01 0.0 01 0.0 01 0.0 01 Incubation in the simultaneous presence of 10 mM Glc b Incubation in the presence of 1. 5 mM phosphoenolpyruvate, 0.5 lM E1, 0.5 ... transporter The reactive analogues and [14 C]aMG or [14 C]2dGlc were added in molar ratio of 10 : and the uptake of [14 C]aMGlc via EIIGlc or of [14 C]2dGlc via EIIMan was measured (Fig 4) The C-1...

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An Overview of Consumer Data and Credit Reporting ppt

Ngày tải lên : 22/03/2014, 18:20

... Active accounts: 1- 2 2-4 More than 16 .5 13 .1 17.9 14 .1 12.6 14 .3 21. 3 21. 6 22.6 48 .1 52.7 45.2 10 0.0 10 0.0 10 0.0 21. 9 13 .5 21. 7 18 .3 13 .1 15.5 21. 8 18 .5 30.7 38.0 54.9 32.2 10 0.0 10 0.0 10 0.0 or less ... 18 .4 3 .1 5 .1 9.2 18 .9 45.4 15 .8 18 .5 17 .6 15 .1 29.7 11 .3 13 .8 12 .2 16 .8 17 .9 19 .2 14 .0 4.7 12 .0 13 .6 19 .4 16 .4 13 .7 15 .6 5.3 14 .0 17 .1 19.4 22.3 14 .2 14 .8 10 .8 19 .3 32.3 21. 7 Judgment: 22.4 Judgment: ... 1. 8 1. 1 1. 7 1. 2 1. 0 6.0 4.2 6.3 10 0.0 10 0.0 10 0.0 92.5 94.9 91. 9 3 .1 2.5 3.3 1. 2 1. 4 6 1. 9 1. 4 2 .1 100.0 10 0.0 10 0.0 86.5 84.7 83.4 5.5 5.0 4.6 1. 8 2.0 1. 7 1. 0 1. 4 1. 4 1. 4 3.9 5.9 8.0 10 0.0 10 0.0...

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An overview of research, policy and practice in teacher supply and demand, 1994–2008 docx

Ngày tải lên : 22/03/2014, 19:20

... Studies on the supply and demand of teachers have been conducted in an ongoing manner since at least 19 94 Underlying the language of ‘supply and demand’ is the concept of the market The market analogy ... (19 96) has pointed out, developing countries faced with financial constraints in the 19 80s and 19 90s tended to trade off PTRs against salaries The lower the PTRs and the smaller the classes, the ... known as the ‘Post-Washington Consensus’ of the ‘Washington Consensus’ of the 19 80s and 19 90s The Washington Consensus was characterised by the perception of clear boundaries between states and...

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Overview of Tax Legislation and Rates doc

Ngày tải lên : 29/03/2014, 19:20

... of gross assets before the investment; • an increase in the annual amount that can be invested though both EIS and VCTs in an individual company to 10 million; and • an increase in the annual amount ... December 2 010 alongside the draft legislation for Finance Bill 2 011 The Government announced on February 2 011 an increase in the effective rate of the Levy for the year 2 011 The rates were increased ... 2 011 will not be affected Summary of impacts Exchequer impact (£m) 2 011 -12 2 012 -13 -10 5 2 013 -14 -11 5 2 014 -15 -11 0 2 015 -16 -12 0 Economic impact Smaller companies tend to face barriers in raising...

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Structure, Properties, and Preparation Of Boronic Acid Derivatives Overview of Their Reactions and Applications

Ngày tải lên : 02/07/2014, 12:53

... 1. 588 1. 573 1. 573 1. 560 1. 494 1. 613 1. 613 1. 378 – 1. 365 1. 363 1. 362 1. 316 1. 408 1. 474 1. 438 1. 362 – 1. 346 1. 357 1. 352 1. 314 1. 372 1. 460 1. 4 31 – – – – – – – 1. 666 1. 6 41 10 11 12 13 13 17 18 19 23 ... structures of trityloxymethyl pinacolate boronic esters (e.g., in Figure 1. 2) are in the range 1. 31 1. 35 Å (Table 1. 1), and the dioxaborolane unit of these derivatives is nearly planar [17 ] The X-ray ... crystalline, with sharp melting points, and can thus be used for purifying and characterizing boronic acids The concept of internal coordination in diethanolamine esters has been exploited in the development...

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Báo cáo y học: "Developments in the scientific and clinical understanding of the spondyloarthritides" pptx

Ngày tải lên : 09/08/2014, 01:22

... [20], and partial remission [19 ] (the ASAS20, ASAS40, and ASAS partial remission criteria, respectively) of clinical symptoms Andrei Calin, of Bath, UK, had started this kind of work in the early ... early 90s with the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [ 21] , the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis ... for one of the defined diseases [2] The leading clinical symptoms for all subsets of SpA are inflammatory back pain and/or an asymmetrical arthritis predominantly of the lower limbs These criteria...

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Báo cáo y học: "Developments in the scientific and clinical understanding of autoinflammatory disorders" doc

Ngày tải lên : 09/08/2014, 01:22

... pyrin variant, E148Q encoded in exon 2, has allele frequencies of 10 % to 20% in Asian populations and up to 1% to 2% in Caucasians Whilst pyrin E148Q can cause FMF when coupled with an exon 10 ... interactions [13 ] Proteins with PYDs play important roles in the regulation of caspase -1 and thus modulate production of interleukin -1 (IL -1) In this regard, pyrin is thought to interact with another ... cysteine-rich domains, a transmembrane domain, and an intracellular death domain Binding of soluble circulating TNF causes trimerization of the receptor and activation of NF-κB, with downstream induction...

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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 06:22

... contained antibodies against some of these other proteins [ 81] Taken together, these findings indicate that antibodies against G6PI are not diagnostic markers for RA An interesting further twist in the ... arthritis has been supported by the DFG (SFB 4 21 TPC2), the BMBF (Kompetenznetz Rheuma) and the IZKF Jena 25 References 10 11 12 13 14 15 16 17 18 26 Zvaifler NJ: The immunopathology of joint inflammation ... following one single immunization with recombinant human or murine G6PI in adjuvant [93] (Fig 1) The incidence of arthritis upon immunization is in excess of 90%, and the time course is uniform and...

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Báo cáo y học: " Maintenance treatment with esomeprazole following initial relief of non-steroidal anti-inflammatory drug-associated upper gastrointestinal symptoms: the NASA2 and SPACE2 studies'''' doc

Ngày tải lên : 09/08/2014, 10:20

... abdominal pain and mean of diary cards for the last days were also assessed in terms of baseline values, last values, and change from baseline Each study was planned to include 300 patients in ... to assess GI symptom severity Mean change from baseline in the three QOLRAD dimensions of emotional distress, sleep disturbance, and food/drink problems was assessed, as was mean change from baseline ... Neither of the two deaths (both due to pancreatic carcinoma, one in the placebo arm and one in the esomeprazole 40 mg arm) in the study was assessed as related to the study drug Discussion In the...

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Báo cáo y học: "Developments in the scientific and clinical understanding of inflammatory myopathies" pps

Ngày tải lên : 09/08/2014, 13:21

... [34] The role of IL -1 in the pathogenesis in myositis is still uncertain In one case with an antisynthetase syndrome, treatment with anakinra was successful, supporting a role of IL -1 in some cases ... develop a striking combination of muscle and lung inflammation that replicates features of the human antisynthetase syndrome [ 51] An increased autoantigen expression in muscle tissue has been found ... in larger studies [35] Interestingly, the combination of IL -1 and IL -17 has been shown to induce IL-6 and CCL20 production by myoblasts in an in vitro system, but whether this is also true in...

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Báo cáo y học: "Developments in the scientific and clinical understanding of gout" docx

Ngày tải lên : 09/08/2014, 13:22

... domain-containing-3) inflammasome and lead to caspase -1 processing of pro-IL -1 Activation of the endothelium by IL -1 increases trafficking of neutrophils to the inflammatory site ASC, apoptosis-associated ... ancient and still common disease Competing interests The author declares that he has no competing interests References 10 11 12 13 14 15 16 The Scientific Basis of Rheumatology: A Decade of Progress ... regulated and requires the formation of homodimeric complexes of pro-caspase -1 in the presence of the cytoplasmic protein ASC (apoptosis-associated specklike protein containing a caspase-associated...

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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot

Ngày tải lên : 09/08/2014, 14:20

... http://arthritis-research.com/content /11 /3/230 Figure IL-1RAcP is the common co-receptor Several members of the IL -1 family of cytokines, including IL -1 (IL-1F1 and IL-1F2), IL-1F6, IL-1F8, IL-1F9, and IL-33 (IL-1F 11) , bind to their ... Murine Th17 differentiation requires the combination of TGF-β and IL-6 [11 0 ,11 1] The addition of IL -1 and TNF-α can further enhance the Th17 differentiation but cannot replace TGF-β or IL-6 [11 2] ... at the ACR Annual Scientific Meeting 2008) The results of other ongoing clinical trials targeting IL -17 will certainly increase our understanding of the role of this cytokine in human diseases...

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Báo cáo y học: "Developments in the scientific and clinical understanding of fibromyalgia" pdf

Ngày tải lên : 09/08/2014, 14:21

... (pregabalin) and the serotonin and noradrenalin reuptake inhibitors (duloxetine and milnacipran) As our understanding of the biological basis in general – and the genetic underpinning, in particular – of ... reuptake inhibition Milnacipran Antidepressant Balanced norepinephrine and serotonin reuptake inhibition Pregabalin Anticonvulsant α2δ ligand; affects calcium influx and release of excitatory amino ... to the ACR criteria requiring 11 out of 18 tender points – this finding occurs 11 times more commonly in women than in men [11 ] Wolfe developed an instrument that he designated a regional pain...

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Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx

Ngày tải lên : 12/08/2014, 19:22

... cmH2O above the lower inflection point was more effective in maintaining gas exchange and minimizing inflammation and lung injury than was PEEP set at the maximum curvature of the deflation pressure–volume ... and lung mechanics in a severely hypoxemic ARDS patient Competing interests 10 11 12 13 14 15 16 17 18 None declared Acknowledgements 12 0 Supported by grants from FIS G03/063 Red-Gira; Josefina ... posture, Cakar and coworkers [19 ] showed better oxygenation after RMs in the prone than in the supine position, and importantly the benefit was sustained at lower PEEP In other studies other adjuncts...

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Báo cáo y học: "Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis" pptx

Ngày tải lên : 13/08/2014, 11:22

... (95% CI) 279 31. 5% 280 28.6% 0. 91 (0. 71, 1. 17) 0.99 (0.69, 1. 40) 17 9 29.6% 18 3 24.4% 0. 81 (0.58, 1. 14) 16 .2% 0.82 (0.49, 1. 37) 12 8 25.8% 12 1 20.7% 0.80 (0. 51, 1. 26) 14 .8% 0.69 (0.42, 1. 14) 254 33.5% ... and stockholders of Eli Lilly and Company Authors' contributions P-FL and EA participated in the conception and design of the study, in the development and conduct of analyses, and in the clinical ... prospectively defined analyses were included in the ADDRESS statistical analysis plan to assess the influence of any learning curve on the observed outcomes We report the results of these analyses and additional...

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