... cost-effective way of as-sessing health risks; the identification of all risk points along the chain of events from the origin ofthe wastewater to the consumption ofthe produce (e.g. the farm-to-fork ... Ho-epner,2008). There is scope to improve the sustainability of the desalination process. The process results inthe discharge of a concentrated brine into the receiving waters. Temperature and salinity ... approach ofthe HAPPC meth-od in food safety); the design of a combination of health risk management mea-sures, to be applied along the same chain of events, with the aim of ensuring health...
... Secondly, Linh Dam New Town (located inthe south-west of Hanoi) deserves one ofthe new urban models, dealing with the high-density development inthe south-west of Hanoi. By learning from the ... landscape inthe south gateway ofthe capital city (HUD). 3.2.2. Uses and Activities Linh Dam project is one ofthe successful models ofthedevelopmentof high-rise apartment buildings. Thedevelopment ... quarters, the last one is the central area for the purpose of resettlement. Generally, getting along with the rapid expansion, the east bank ofthe Red River exhibited the beginnings of urbanization....
... jobs as family care, selling goods inthe streets or in- waiting labor markets. Although working time is rather long (11-13 hours/day) and continuously, their montly income average only ranges ... labors selling goods inthe streets and in- waiting labor market have to work in unsafe environments; their daily life are rather poor. 22.86% female freelane labors live in boarding houses characterized ... factors (living and working environments in cities, home-town customs, working conditions and relating policies) were identified as the determinants affecting to jobs and daily life of female...
... under the framework of financial globalization.II. Review of Institution Building inthe Financial SectorA. Main driving forces of institution buildingA review ofthe developments of China’s financial ... source of financing for enterprises, if their owncapital is excluded. In summary, the deepening process ofthe financial markets has rendered the dominance ofthe banking sector inthe financial ... forceful in improving microeconomic performance.2. Roleofthe central bank The central bank has played a roleof policy designing and implementation in the process of institution building inthe financial...
... (39 ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration ofthe wide range of vaccine efficacies deter-mined by clinical trials ... toexplore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site and the data ... <5 mm indurationafter skin testing with 5 TU of PPD tuberculin. The Tice strain of BCG is administeredpercutaneously; 0.3 mL ofthe reconstituted vaccine is usually placed on the skin in the lower...
... an important roleinthe financial system of the U.S. economy. They complement theroleof large banks by special-izing in relationship banking and providing credit to smallbusinesses—a sector ... “Small Business Lending and the Changing Structure ofthe Banking Industry,” Journal of Banking andFinance, August.Sullivan, Richard J. 2000. “How Has the Adoption of Internet Banking AffectedPerformance ... understanding issues facing community banks. I. THE CURRENT ROLEOF COMMUNITY BANKS The banking system inthe United States has always been unique in the sense of containing large numbers of small...
... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati,OH, USA) constantly maintained at 1% O2. Culturemedium ... lgÆmL)1insulin, 1 lm dexamethasone, and0.5 mm IDM). Cells were then maintained in DMEM con-taining 10% fetal bovine serum and 1 lgÆmL)1insulin. The medium was replaced every other day. ... cultured in DMEM containing 10% fetal bovineserum. OP9 cells were grown in aMEM containing 20%fetal bovine serum. C2C12 cells were maintained in DMEMcontaining 10% fetal bovine serum.Adipogenic...
... detected at the dimerinterface ofthe models or inthe surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure ... at the dimer interface ofthe models or inthe surroundings of the hinge loop residues. Likewise, the models of nonex-changing and exchanging HHP-RNase were prepared start-ing from 1Z7X. The ... through the exchange between subunits of either their N-ter-minal, or their C-terminal ends [33–35]. We foundthat the behavior with the model membrane of the dimer in which the C-terminal ends...
... N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleof the terminal ... results in reduction of the stability of GAT1 In order to study thein uence ofthe N-glycosylationand N-linked oligosaccharides on protein stability, the intracellular decay time ofthe GAT1, ... for the stability of this protein,but the terminal structure ofthe N-glycans is not.Defective N-glycosylation reduces the trafficking of GAT1 to the plasma membrane In order to study thein uence...
... thusblocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumouraction of BS-RNase is based on the ability ofthe proteinto resist the neutralizing ... plateau.These data indicate that the cell sulfhydryls responsiblefor the exchange with the protein disulfides are located in the plasma membrane. Furthermore, they show that, asproposed inthe hypothesis ... hypothesize that the cytotoxicactivity ofthe latter monomers was due to the presence in these proteins of disulfide bonds, with their potentialchemical instability. It is well known that in the...
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues inthe sameenzyme.To obtain an insight into ... by the surrounding residues. The results so far indicate thatlarger parts ofthe polar core ofthe catalytic TIM barrel of family 18 chitinases play a role during catalysis. It will thusbe interesting ... conformations. The Asp142 equiv-alent inthe family 18 chitinase from Coccidioides immitiswas found to be inthe ÔdownÕ position inthe apoenzymeand inthe ÔupÕ position inthe complex with allosamidin...
... a donor of propylaminegroups inthe metabolism of spermidine and spermine [2]and an intermediary inthe trans-sulfuration pathway tocysteine, one ofthe three amino acids involved in glutathi-one ... todetermine the functional roleofthe amino acid residuesinvolved in each. The present report describes the cloningand subsequent functional refolding, using a bacterialexpression system, ofthe ... domain of eachsubunit, inthe interface between the two dimers compri-sing the tetrameric structure [29]. This domain containsfive cysteine residues, two of them (Cys35 and Cys61)forming a...
... is the shift ofthe pH optimumfrom near neutral inthe wild-type to pH 9.2 inthe R389Amutant, which is in accord with an increase inthe pK of Y229 if the stabilizing R389 residue is lacking. ... coordination to the otherligands ofthe binding site (center I), but the bindingbecomes much weaker as emphasized by the dramaticincrease ofthe Na+ion concentration required to saturate the enzyme. ... carboxybiotin, or slow Na+move-ment through the channel to its binding site.Following the decarboxylation of carboxybiotin in the reaction cycle (Fig. 4B,C), the biotin prosthetic group leavesthe...