the role of newton in the development of calculus

... results in trimming the dry branches off the bush. And this is what the semantic type in (16) captures. 3.3 Impingement Predicates In order to capture the semantic properties of the arguments of the ... ( SOA [ch -of- loc-rel FIG El That is, as (16) above captures, in German trim- ming necessarily results in trimming something off something else; in the case of example (9) above trimming the bush ... representative verb of the impingement predicates class in German, the verb schlagen (hit) in examples (10)-(12) above, we propose the semantic types in (17) and (18), which are in the spirit of the MRS-based...

Ngày tải lên: 17/03/2014, 22:20

Ngày tải lên: 23/03/2014, 01:20

Ngày tải lên: 31/03/2014, 05:21

Ngày tải lên: 18/06/2014, 17:20

... specific to the use of ICTs in the health sector in developing countries. A summary of these key lessons as they relate to intermediaries and beneficiaries, to improving the functioning of health ... • the use of telemedicine to improve diagnosis and enhance patient care • improvements in the continuing professional development of health workers and better sharing of research findings ... understanding and the evidence base about the use of ICTs in the health sector are: • How to evaluate the impact of the use of ICTs on health? • What can be done to strengthen the role of and...

Ngày tải lên: 14/02/2014, 09:20

... ( 39 ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration of the wide range of vaccine efficacies deter- mined by clinical trials ... to explore the sources of the heterogeneity in the efficacy of the BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site and the data ... <5 mm induration after skin testing with 5 TU of PPD tuberculin. The Tice strain of BCG is administered percutaneously; 0.3 mL of the reconstituted vaccine is usually placed on the skin in the lower...

Ngày tải lên: 15/02/2014, 13:20

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs, thereby releasing the nucleocapsid into the lumen of these vesi- cles. Then, the capsid uses these intra-endosomal ... and mild developmental delay. The protein defective in this disorder is also a NHEJ protein. The distinct clinical features of the patients will be discussed in the context of the protein function. 3.4 ... Mutations in the ERCC1 gene induce a distinct set of accelerated ageing features, with a rate of onset depending on the severity of the mutation. The correlation between repair defect severity and clinical...

Ngày tải lên: 19/02/2014, 07:20

... which appear to be involved in the final resorption of the parental macronucleus during PND in T. thermophila, and suggested the involvement of mitochondria in this process [19]. In mammalian apop- tosis, ... key role in PND in Tetrahymena. Unfortunately, the involvement of mito- chondria in PND has not been clarified fully. To eluci- date the role of the mitochondrion as a key effector we studied the ... directly show the localization of mitochondria in the autophag- osome, as the red fluorescence corresponding to intact mitochondria was not observed in the area. Therefore, to confirm further the localization,...

Ngày tải lên: 20/02/2014, 03:20

... go in the same direction. The inverse is thecasefortheattractioninthecaseofAnabaena. Also, if the structure of the final complex in which electron transfer takes place remained unaltered with increasing ... character- ization of the plastocyanins has been described [1]. Representations of the electrostatic surfaces showing the changes introduced by the mutations are displayed in Fig. 1. The decay of the flash-induced ... interaction. Electron-transfer chains like that of oxygenic photosyn- thesis impose special restraints on the proteins involved. Reactions must be fast to allow rapid turnover of the chain. Binding between the reaction...

Ngày tải lên: 21/02/2014, 01:21

... 'all the present of earth vanished into the future of Heaven, and the Kingdom of the Infinite arose upon the ruins of the finite.' The beauty of earth was looked upon as an enchantment of the ... thorn. Delight in summer, complaint of winter this is the fundamental chord struck again and again; there is scarcely any trace of blending the feelings of the lover with those of Nature. It is ... and the howling of wind, the rustle of leaves, the soughing in the tree tops, were sounds of their presence. The worship of woods lasted far into Christian times, especially among the Saxons and...

Ngày tải lên: 21/02/2014, 20:20

... imaging of the brain was also performed in a subset of patients in this study. 36 It was found that use of corticosteroids possibly reduced the risk of developing hydrocephalus and vasculitic infarcts; ... of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. ... Vietnam. Following the publication of this trial, Prasad and Singh 12 updated their Cochrane systematic review on the efficacy of corticosteroids in TBM. 12 The combined mortality in the control...

Ngày tải lên: 06/03/2014, 04:20

... by the amount of internalized agonist [20]. As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Role of helix 8 and C-termini in bradykinin ... com- prising putative helix 8, may be involved in the inter- action of GPCRs with cognate G proteins. Synthetic peptides from the C-terminus of the G a subunit G t and of the Gc subunit of transducin ... addition of scintillation fluid. Nonspecific binding was determined in the presence of 5 lm unlabeled agonist and subtracted from the total binding to calculate the spe- cific binding. Internalization of...

Ngày tải lên: 07/03/2014, 16:20

... stomach, the presence of bile acids in the intestines, and the competition against other micro-organisms in the gastro-intestinal tract [91,92]. The tentative ways for selection of probiotics ... cytokines, such as IL-4 and IL-10, are induced by lactobacilli [84-85,88]. The outcome of the production of Th2 cytokines is the development of B cells and the immunoglobulin isotype switching ... colonizing the intestine may secrete the enzyme, thus increasing the intestinal amylase activity [82,83]. It is well established that probiotics alter gastrointestinal pH and flora to favor an increased...

Ngày tải lên: 08/03/2014, 09:20

... by Austin et al. [22]. In their study, the N-terminal domain of AnfA was truncated to prevent the intrinsic aggrega- tion of the intact form during purification. The obtained variant retained transcriptional ... potential ligands of the Fe-S cluster. Consequently, the binding of the ATP analog and the subsequent rearrangement of the inter- domain interaction affects the electronic condition of the Fe-S cluster ... may reside in the GAF domain and the environmental factors affecting AnfA activity remain unknown because of the absence of the N-terminal domain in this variant. Because sensing is a principal...

Ngày tải lên: 15/03/2014, 09:20

... distribution of BsArb43B in the proximity of the active site. Arabinotriose in the binding cleft is represented using sticks. (B) Detailed view of the binding cleft with arabinotri- ose. (C) Details of the ... with arabinohexose [15], this loop makes the reducing end of the carbohydrate chain bend towards the solvent, probably optimizing binding of the carbohydrate chain in the cleft, and resulting in trioses ... for the optimal activity of BsArb43B. Furthermore, to determine whether the role of the calcium is structural, thermal shift assays were per- formed to determine the T m of the protein in the...

Ngày tải lên: 15/03/2014, 23:20

... contrast, part of the incorporated CFMYP is not processed to EGMYP, enabling it to retain zinc. Indeed, 33% of the total zinc in the ovary at stage 1 and 13% of the total zinc in the testis at ... determined by ICP-AES. To investigate the accumulation of zinc in the gonads during gameto- genesis, increases in the size of the gonads during this period were taken into consideration. Thus, zinc ... of the zinc peaks was coincident with the MYP peak in both the ovary and the testis, indicating that part of the zinc in the immature gonads is bound to MYP. The elution patterns of zinc were...

Ngày tải lên: 16/03/2014, 05:20

... FEBS 3325 Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium ... thrombin cleavage site was engineered in the pET28a vector immediately after the N-terminal His-tag. The N-terminus His-tag of ACP was cleaved by the addition of 1 U of thrombin from bovine plasma ... obtain DG H2O , the free energy of unfolding in water at temperature T. In the first method, a single guanidine hydrochloride- induced denaturation, where the observed CD signal at each point in the...

Ngày tải lên: 16/03/2014, 10:20

... formation of MRN foci [19–21]. The Mre11-binding domain of human Nbs1 has been localized to amino acids 682–693 in the COOH- terminal region of the protein. Deletion of this region of Nbs1 results in ... damage, thereby promoting ATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with ... an NH 2 -terminally truncated Nbs1 protein that contains an intact Mre11-binding domain. Differences in the nature of the Nbs1 muta- tion, as well as in the dose of radiation administered to...

Ngày tải lên: 16/03/2014, 13:20

Ngày tải lên: 17/03/2014, 23:20

Ngày tải lên: 21/03/2014, 22:01