... to
neurogenesis. The list of these genes is reported in addi-
tional file 2. These results support the hypothesis of a
possible role of E6 and E7 inthe induction of neuroen-
docrine differentiation of SCLC. ... The
mean incidence of HPVs in lung cancer considering all
reviewed articles is 24.5%. While in Europe and in the
USA the average reported incidences is 17% and 15%,
respectively, the mean incidence of ... definitive
proof of direct connection between HPV infection and
SCLC development, our results support the hyp othesis
of HPV as a risk factor and/or cofactor inthe SCLC
development. Furthermore, the study...
... onto the witness stand to
testify against themselves. Between the time of its ratification and the onset
of the project of legibility, there was a dr
ˆ
ole de guerre concerning the meaning
of the ... narratives ofthe path of constitutional development spotlight
both the achievement ofthe collective rights of labor inthe 1930s and, at the
same time, the launching of an upward progression toward the ... though, owing in part to its deeper roots inthe English com-
mon law tradition, there was somewhat more flesh on the bones ofthe self-
incrimination privilege in advance ofthe statebuilding era...
... Also, in 1654 Pascal gave a lucid exposition of
Sources intheDevelopmentof Mathematics
The discovery ofin nite products by Wallis and in nite series by Newton marked the
beginning ofthe modern ... Contents
4 The Binomial Theorem 51
4.1 Preliminary Remarks 51
4.2 Landen’s Derivation ofthe Binomial Theorem 57
4.3 Euler’s Proof for Rational Indices 58
4.4 Cauchy: Proof ofthe Binomial Theorem ... Sums of Powers
Faulhaber published his Academia Algebrae in 1631. In spite ofthe Latin title, the text
is in German and in it he discussed the sums of powers of integers. He wished to study
the...
... results in trimming the
dry branches off the bush. And this is what the
semantic type in (16) captures.
3.3 Impingement Predicates
In order to capture the semantic properties of the
arguments ofthe ... (
SOA
[ch -of- loc-rel
FIG
El
That is, as (16) above captures, in German trim-
ming necessarily results in trimming something
off something else; inthe case of example (9)
above trimming the bush ... representative verb of the
impingement predicates
class in German, the verb
schlagen
(hit) in examples (10)-(12) above, we
propose the semantic types in (17) and (18), which
are inthe spirit ofthe MRS-based...
... method of localizing biologically active molecules in
defined area on the electrodes. Also the use of conducting poly-
mers inthe area of bioanalytical sciences is of great interest since
their ... polymer.
Whenever, there is a contact of these doped nanowires with the
analyte, there are changes inthe electrical characteristics. The use
of nanomaterials of CP could greatly improve diffusion since they
have ... early stage inthe electrochemical deposition; and (d) formation of a highly porous PANI nanofibre film
after the PANI overgrowth and intertwining.
counter ions for doping ofthe synthesized PANI....
... president ofthe National Academy
of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences
to secure the services of eminent members of appropriate professions ... that the FDA has agreed to include information
about the lack of activity of anti-EGFR antibodies inthe setting of KRAS
mutations inthe labels (i.e., while the indication remains broad, the ... Academy of Engineering in providing services to the government, the public,
and the scientific and engineering communities. The Council is administered jointly by
both Academies and the Institute of...
... president ofthe National Academy
of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences
to secure the services of eminent members of appropriate professions ... that the FDA has agreed to include information
about the lack of activity of anti-EGFR antibodies inthe setting of KRAS
mutations inthe labels (i.e., while the indication remains broad, the ... Academy of Engineering in providing services to the government, the public,
and the scientific and engineering communities. The Council is administered jointly by
both Academies and the Institute of...
... Although in-
corporation of this information reduced the num-
ber of possible parses, the processing time in-
creased because ofthe addition ofthe link nodes
in the grammar.
2 Constraint
Grammar ... the system
assigns all ofthe possible
roles
the words can
have by applying the lexical constraints (which
specify legal word categories) and allowing the
word to modify all the remaining ... words inthe
sentence or no words at all. Each ofthe arcs
in the network has associated with it a matrix
whose row and column indices are the roles that
the words can play inthe sentence. Initially,...
... deposition
of excess fatty acids into fat cellsinthe form of triglycerides, leads to the
developmentof obesity. Despite the pivotal role of obesity and dyslipide-
mia inthedevelopmentofthe metabolic ... obesit
y
b) Insulin resistance
c) Glucose intolerance
12
3
Fat cells
4
ApoE
Lipid-rich
meal
Intestine
Fig. 2. Model for the role of ApoE inthedevelopmentof diet-induced obesity in mice. Dietary ... brain apoE expression
reduces food intake in rats. Specifically, the intrecere-
broventricular injection of ApoE in rats decreased
their food intake, whereas intrecerebroventricular infu-
sion of...
... wealth of information regarding the clinical effects of gene
modification ofthe antitumor response.
DNA CANCERVACCINES
The generation of a vaccine for cancer is a concept based on three principles: ... cancers. Other functions for the cyclins exist as well. The
cyclin A gene is the site of integration ofthe hepatitis B virus (Chapter 6), thereby
promoting hepatitis virus integration into the ... express the
cytokine of interest. These cells then can be co-injected with irradiated wild-type or
modified tumor cells to boost the immune response at the site of injection. Like-
wise, the administration...
... ofthe beliefs are at work in their perceptions? These types of ques-
tions are considered inthe hopes of bringing into the public domain, the
personal commitments and beliefs held by some of ... do
they ascribe to their work inthe evolution of humanity within the evolu
-
32 INTRODUCTION
9
As stated by the chair ofthe ASME Nanotechnology Institute Advisory Board, in his welcoming
to the ... it is the
conversations themselves which determined much ofthe content of the
book. In other words, it is the author’s interpretation and analysis of the
conversations that determined the book’s...
... Most likely the observed
effect depends on the nature ofthecancer cells, the
characteristics ofthe used MSC, on the integrity of the
immune system and on the timing and site of injection.
Two ... 2),
such as the site of administration (i.e. the local environ-
ment ofthe stem cell inthe recipient) and the need for
in vitro culturing. The manipulation ofthecells may
also contribute to the tumourigenic ... inthe aetiology of
cancer where these cells may become tumourigenic [43].
According to this cancer stem cell theory, only small
fraction ofcells within a tumour, the so-called cancer
stem cells, ...
... out of six ofthe children defined "go out"
as going outside to do something or to play
outside. This resulted in some ofthe children
factoring the weather into the state of their ... Another kid interpreted "go out" as
going to dinner or doing anything else outside
of the house. The interpretation was not
consistent and if factoring in weather, the
degree of ... week
the child had coughing, wheezing, or shortness of breath,
the number of times inthe previous week the child used
rescue medication, and the types of medications the child
was taking. These...
... without colliding with an
obstacle.
The limiting factors in this prototype ofthe WCS were the
limited field of view ofthe camera, lack of degrees of free-
dom inthe camera mounting, and the low ... purposes)
mined the distance between the wheelchairs based on the
number of rotations ofthe spool holding the string, and
determined the angle between the leading wheelchair and
trailing wheelchair ... tests in an office
building on the University of Pittsburgh campus. The
wheelchair tracked a moving target (one ofthe investiga-
tors wearing a green shirt) around the course shown in
Figure 3. The...