role and function of dehydrogenases in cns and blood brain barrier pathophysiology

báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx

Ngày tải lên : 19/06/2014, 22:20

... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and Its ... IL-6 and GM-CSF into both the luminal and abluminal chambers [34] To determine whether IL-6 and GM-CSF secreted by BMECs into the abluminal chamber are also involved in the LPS-induced increase in ... HIV-1 activates proinflammatory and interferon-inducible genes in human brain microvascular endothelial cells: putative mechanisms of blood- brain barrier dysfunction J Cereb Blood Flow Metab 2007,...

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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt

Ngày tải lên : 12/08/2014, 20:20

... mechanism of brain injury in sepsis Studies have suggested that septic encephalopathy might involve a disturbance of plasma and brain neutral amino acid transport across the blood brain barrier ... Effects of magnesium administration on brain edema and blood brain barrier breakdown after experimental traumatic brain injury in rats J Neurosurg Anesthesiol 2003, 15:119-125 Heath DL, Vink R: ... the formation of brain edema in septic rats Magnesium administration attenuated the increased BBB permeability and caused a reduction in brain edema formation in our rat model of intraperitoneal...

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Chapter 2Communicating Over the Network Quangkien@gmail.com.OverviewDescribe the structure of a network, including the devices and media that are necessary for successful communications. Explain the function of protocols in network communications. Ex potx

Ngày tải lên : 01/04/2014, 12:20

... structure of a network, including the devices and media that are necessary for successful communications Explain the function of protocols in network communications Explain the advantages of using ... protocols Now – Industry standards Institute of Electrical and Electronics Engineers (IEEE) Examples: 802.3 (Ethernet), 802.11 (WLAN) Internet Engineering Task Force (IETF) Internet standards RFCs ... addresses, Original source address of host Final destination address of host Used by routers in selecting the best path 35 Interaction of Protocols frame Network access protocols (Data link and Physical...

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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf

Ngày tải lên : 19/06/2014, 22:20

... immunohistochemistry, in the brains of sham animals in both type of mice, Cnr1+/+ or Cnr1-/- The intracranial injection of TMEV induced the expression of VCAM-1 in the ipsilateral cerebral cortex surrounding blood ... side of injection, immunostained for VCAM-1 Arrows indicate VCAM-1 immunostaining Scale bar is 50 μm (B, D) Quantification of intensity of VCAM-1 staining as described in Material and methods in ... [13,18,49,50] the role of endocannabinoids in MS remains uncertain While most of studies on ECS and MS focused on established disease, understanding the role of endocannabinoids during the induction phase...

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Báo cáo y học: "Effects of PM10 in human peripheral blood monocytes and J774 macrophages" doc

Ngày tải lên : 12/08/2014, 18:21

... cortical staining In accord with the role of calcium and ROS in the induction of IL-1 expression, both of these factors appeared to play an important role in modulating the F-actin cytoskeleton ... Immunol 1989, 142(12):4339-4345 Dinarello CA: Interleukin-1 and Interleukin-1 antagonism Blood 1991, 77(8):1627-1652 Dinarello CA, Wolff SM: The role of interleukin-1 in disease New Engl J Med 1993, ... result in a diminished cellular killing and clearance of particles and pathogens from the lung The pro-inflammatory cytokine interleukin (IL-1) is not normally produced by the cells of healthy individuals,...

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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt

Ngày tải lên : 13/08/2014, 15:21

... with surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental ... anaphylatoxin C5a has been characterised as a mediator of BBB dysfunction in a variety of central nervous system (CNS) disorders, including traumatic brain injury and bacterial meningitis [30-32] In ... tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic substances During sepsis, however, blood- borne proinflammatory mediators...

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Function of BPGAPI in RAS mediated neuronal differentiation

Ngày tải lên : 11/09/2015, 10:02

... the position of glutamine 61 of Ras, which in turn coordinates the attacking water In addition, an arginine, called the arginine finger, is positioned into the phosphate-binding site and stabilizes ... diverse combinatorial arrangement of functional domains, highlights the complexity of their regulation This regulation includes proteinprotein or protein-lipid interactions, binding of second messengers, ... nucleotide to the G protein (I R Vetter and A Wittinghofer, 2001) GEF binding induces conformational changes in the switch regions and the P loop, while leaving the remainder of the structure largely...

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The function of DTRAF1 in drosophila neuroblast asymmetric cell division

Ngày tải lên : 15/09/2015, 17:11

... formation of cortical domains, which consist of PAR proteins: an anterior domain defined by the presence of a complex of PAR-3, PAR-6, and an atypical protein kinase C, and a posterior domain defined ... localization and function of cell-fate determinants The invariability of the lineage of neurons and glia that each NB produces could be a function of either invariant extrinsic cues each NB and its ... DmRIC-8 binds to GDP–Gαi in vitro and forms a complex with Gαi and Pins in vivo In DmRIC-8 mutants, Gαi, Pins and Gβ13F are mislocalized and spindle orientation is randomized All these data indicate...

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Assessment of neuropsychological function of attention in drop out students returning for diploma completion

Ngày tải lên : 30/09/2015, 13:42

... play a special role in recruiting other brain areas in a series of distributed networks that handle different components of executive functions, depending on the processing demands of the specific ... revision of the WAIS-R (Wechsler, 1981), and is widely standardized as a choice instrument for assessing intellectual functioning Among the construct definitions of intellectual functioning are working ... memory Working memory can be viewed as an active form of attentiveness, in which the process of attention is necessary in encoding and maintaining information in such an active state Accordingly,...

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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain

Ngày tải lên : 26/11/2015, 22:48

... growing in the brain [94] There are two basic kinds of brain tumors: primary brain tumors and metastatic brain tumors [95] Primary brain tumors start, and tend to stay, in the brain metastatic brain ... Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES TO CROSS THE BLOOD BRAIN BARRIER 10 ... transport proteins in the luminal and abluminal membranes of the brain capillary endothelial cell Fig The BBB as a selective sieve With these two functions of the blood brain barrier, the brain capillaries...

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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot

Ngày tải lên : 19/06/2014, 22:20

... spectrum of diseases that present with skin allergies and diarrhea, also complain of learning disabilities, hyperactivity and difficulty focusing ( brain fog”), reminiscent of ASD [36,37] In fact, ... Theoharides, T C and Konstantinidou, A.: Corticotropin-releasing hormone and the bloodbrain -barrier Front Biosci 2007, 12:1615-1628 52 Rehni, A K., Singh, T G., Singh, N., and Arora, S.: Tramadol-induced ... disruption of the blood- brain barrier and neuro-inflammation, thus contributing to the development of seizures Treating neuro-inflammation may be useful when antiseizure medications are ineffective...

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Application of biologically active micelles in drug delivery across the blood brain barrier

Ngày tải lên : 11/09/2015, 09:10

... challenging task in treatment of various diseases or injuries in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving into the brain parenchyma The blood brain barrier ... the meninges surrounding the brain and the spinal cord is called meningitis The infection of the brain tissue is called encephalitis If both brain and meninges are affected, the term meningo-encephalitis ... the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited penetration of drugs through the BBB into the brain...

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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Ngày tải lên : 14/02/2014, 19:20

... and functional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding core module in MAP2) across a range of ... v-KIND derivatives: v-KIND, full-length v-KIND; DKIND1, deletion of KIND1; DKIND2, deletion of KIND2; DKIND1 + 2, deletion of both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of ... in the KIND2 domain of v-KIND contain the core MAP2 binding module To identify the core MAP2-binding site within the KIND2 domain (amino acids 456–620), we analyzed ﬁve EGFP-fused KIND2 domain...

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Báo cáo khoa học: Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagicEscherichia coli: role of EspL2 in adherence and an alternative pathway for modulating cytoskeleton through Annexin A2 function pot

Ngày tải lên : 29/03/2014, 09:20

... An in vitro assay for the actin bundling activity of Annexin A2 clearly indicated enhancement of Annexin A2 activity in the presence of EspL2 protein [8] Furthermore, depletion of Annexin A2 in ... mixture of the two in vivo supported the interaction of both proteins and, furthermore, indicated a direct interaction between EspL2 and Annexin A2 [8] Annexin A2 binds to the cytosolic surface of ... is independent of actin pedestal formation, indicating that actin reorganization induced by the Tir–intimin interaction is not necessary for Annexin A2 accumulation Also, accumulation of Annexin...

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Báo cáo y học: " The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations" doc

Ngày tải lên : 12/08/2014, 16:20

... tobacco smoke (in utero and at time of survey) A Botto Khoury approach summarizing the data in a × table allowed for the evaluation of the independent and combined roles of genotype and exposure ... baseline spirometry using increasing concentrations of histamine (usually from 0.5 mg/ml to 8.0 mg/ml) according to standard procedures The 90th percentile of the distribution of PC20FEV1 in a ... because of different techniques of BHR assessment in the case-control study and in the cohort study analysis in the cohort study because of low number of cases while FEV1 was increased in carriers of...

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Circuit theory of finance and the role of incentives in financial sector reform

Ngày tải lên : 24/10/2012, 09:33

... concepts of financing and funding as, respectively, initial financing and s final financing (See Graziani, 1984) Monetary circuit theory, in particular, stresses the role of banks in sustaining the ... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing ... feed into payments for inputs as income of input suppliers, and only profits could in fact be saved However, since the income of input suppliers would have the same destination and use of corporate...

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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"

Ngày tải lên : 31/10/2012, 15:28

... 1.68 Function Gene ID NM_015456 NM_000213 NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ... and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced ... ANK3 Gene title cofactor of BRCA1 integrin, beta staufen, RNA binding protein, homolog (Drosophila) high mobility group nucleosomal binding domain ankyrin 3, node of Ranvier (ankyrin G) Signal Log...

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The role of language in adult education and poverty reduction in Botswan

Ngày tải lên : 05/11/2012, 16:27

... enables it to disseminate information, encourage participation in the education and economy of the communities To achieve its goal of disseminating useful information and eradicating poverty the ... Planning language, planning inequality: language policy in the community, London, Longman Rachal J R (1989), ‘The social context of adult and continuing education,’ in Merriam S B and Cunningham ... out In an education system where English dominates the majority of learners get little benefit from schooling, either in terms of acquiring the necessary language proficiency or in terms of content...

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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Ngày tải lên : 14/02/2014, 18:20

... protein kinase B (PKB)] In AKT, a cysteine substitution of the corresponding R25 in the pleckstrin homology (PH) domain also results in loss of function [16,17], thereby demonstrating related functions ... Holland J, Davies A, Flinter F, Hammarstrom L, Kinnon C, Levinsky R, Bobrow M et al (1993) The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases ... proline residues are over-represented, presumably secondary to the strong in uence of prolines on peptide folding [21] Thus, proline is a rigid amino acid creating a ﬁxed kink in a protein chain...

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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx

Ngày tải lên : 15/02/2014, 13:20

... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving ... of skin testing is the Mantoux tuberculin skin test using 0.1 mL of tuberculin units (TU) of purified protein derivative (PPD) (1 ) BCG vaccination contributes to the prevention and control of ... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered...

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