managing r amp d uncertainty and maximizing the commercial potential of pharmaceutical compounds using the dynamic modeling framework

Craniomaxillofacial Reconstructive and Corrective Bone Surgery: Principles of Internal Fixation Using the AO/ASIF Technique docx

Ngày tải lên : 29/06/2014, 11:20

... Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, NL-1105 A2 Amsterdam, The Netherlands Frederick J Kummer, PhD Associate Director and Research Professor, ... supraorbital nerve It extends across the roof of the orbit and the frontal bone The midportion of the bony orbital rim and the adjacent orbital roof and frontal bone are cleaved A fronto-orbital ... superolateral orbital cranial cleft traversing the lateral third of the upper eyelid and superolat- C .R Dufresne eral angle of the orbit It is the first of the “northbound” cranial counterparts of...

808
1K
3

the environmental photochemistry of pharmaceutical compounds in aqueous solution and on a clay surface

Ngày tải lên : 13/11/2014, 10:10

133
260
0

Uncertainty and imprecision in safety assessment of offshore structures

Ngày tải lên : 10/09/2015, 08:39

... approach) can be described with the aid of random variables, random processes or random ﬁelds using the probability theory and statistical methods Generally, randomness arises in an underlying random ... obtained for the uncertain variables by modeling the distribution parameters with the aid of fuzzy sets This modeling corresponds to the theory of fuzzy random variables and to fuzzy probability theory ... parameter θ Based on the posterior distribution, the updated estimate of the parameter θ cab be derived For instance, 1.2 Modeling of Uncertainty and Imprecision ˆ the expected value of Θ given the data...

247
382
0

Improving the properties of pharmaceutical powders using supercritical anti solvent processing

Ngày tải lên : 09/09/2015, 10:08

... Prof John Dodds, Dr Jerry Heng, Dr Gerry Steele and Dr Simon Black for giving me very useful advice in my research work I wish to thank Dr Elisabeth Rodier and Ms Sylvie for their advice and ... active pharmaceutical ingredient (API) are normally the most preferred state Moreover, about two thirds of the drug products used in the pharmaceutical industry are in the form of particulate solids ... research work are given in Chapter Chapter 2 Literature Review 2.1 Drug Development and Delivery One of the current challenges in drug development and delivery are the discoveries of new drug...

151
1.4K
0

RECOMMENDATIONS FOR BUILDING, MANAGING AND PROTECTING THE BRAND EQUITY IN VIASIA JOINT STOCK COMPANY

Ngày tải lên : 24/07/2013, 15:00

... criteria for the given products which meet the customers demands In the chapter three, the researcher supplied the customers evaluation criteria which are arranged in the order of their demands ... context The brand generates real value for the consumer when the brand is perceived in a differentiable, special and attractive manner from other rival brands When brand value is generated for the ... in the marketplace Some brands are largely unknown to most buyers Other brands have a high degree of consumer brand awareness Still others enjoy brand preference- buyers select them over the others...

46
424
1

Tài liệu Maximizing the Testing and Debugging Process pptx

Ngày tải lên : 24/12/2013, 07:17

... nagging problem is to recharge your batteries Okay, so you've approached your project with a well-defined plan, used comments and a standard naming convention, and double-checked all your code—but ... all your code—but you still have a project that's just not working properly What can you do? The remainder of this lesson will deal with that question < Day Day Up > ...

2
342
0

Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc

Ngày tải lên : 19/02/2014, 06:20

... that reason, we amplified the open reading frame from cDNA For the second of the two potential glycerol dehydrogenases, we predicted no introns and therefore amplified the open reading frame from the ... cerevisiae, and the enzymes were purified and characterized We show that one enzyme catalyses the reduction of d- glyceraldehyde and l-glyceraldehyde to 4230 glycerol, whereas the other reduces DHA ... start and the stop codons and to design primers to amplify the open reading frames using PCR For the first potential glycerol dehydrogenase gene, we predicted introns in the genomic DNA For that...

7
510
0

Báo cáo Y học: Monitoring the structural consequences of Phe12 ﬁ D-Phe and Leu15 ﬁ Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf

Ngày tải lên : 17/03/2014, 10:20

... structure possess a residue in disallowed regions of Ramachandran plot (Table and Fig S2) According to the PROCHECK-NMR [37] program, the average of the 40 models and the mean minimized structure ... ) and b-strand (m) conﬁgurations (D) Number of meaningful NOE constraints per residue for [D- Phe12, Aib15]CRH used in the structural calculations White, grey, and dark grey bars represent, respectively, ... molecule and the differences between the CRH analogue and the native structure [15] are also discussed The major goal of our study is the solution structure determination of a CRH analogue devoid of...

11
515
0

Forecast uncertainty and the Bank of England interest rate decisions ppt

Ngày tải lên : 22/03/2014, 23:20

... England inflation risk forecasts I recognize that the indicator variables are measures for the direction of risk that separate somewhat roughly into "upward risk and rest" and "downward risk and rest", ... nowcasts for the inflation gap, demeaned output growth and corresponding demeaned standard deviations with the corresponding forecasts for h = k = With increasing horizon, the forecast standard deviations ... is larger [smaller] than the mode forecast In that case, the Bank of England speaks of an upward [downward] risk The reported measure of skew, i.e the difference between the mean and mode forecast,...

56
359
0

Báo cáo khoa học: On the thermodynamic equilibrium between (R)-2-hydroxyacyl-CoA and 2-enoyl-CoAOn the thermodynamic equilibrium between (R)-2-hydroxyacyl-CoA and 2-enoyl-CoA doc

Ngày tải lên : 29/03/2014, 08:20

... All operations during the puriﬁcations were performed in this box Buffers and solutions were degassed under reduced pressure, purged with nitrogen, and prereduced with mm dithiothreitol Protein ... chloride was removed by evaporation under reduced pressure Then, a three-fold excess of the acid chloride was dissolved in dry acetonitrile and reacted with CoASH in 0.5 m NaHCO3 at room temperature, ... removed with a rotary evaporator to yield oil, which was treated with diethyl ether and dried under vacuum Butyryl-CoA, propionyl-CoA and acetyl-CoA were synthesized from their anhydrides [25] To...

9
400
0

Ph.D. Program in “Economics and Management” Accounting and governace The role of Corporate Disclosure docx

Ngày tải lên : 29/03/2014, 14:20

... the paper to the literature needs to be discussed and how the study could be improved and extended The presenter is also expected to provide examples from the practice regarding the type of disclosures ... to the disclosure literature? How is the research question being addressed? What are the key findings and implications of the study? How could the study be improved and extended? Part of the grading ... be presented and discussed during the course Term paper Each student is expected to write a term paper on a topic relating to the course The topic will be decided together by the student and the...

5
378
0

Báo cáo khoa học: "A Logical Basis for the D Combinator and Normal Form in CCG" pptx

Ngày tải lên : 31/03/2014, 00:20

... Hockenmaier and Steedman, 2002) and Eisner’s normal-form constraints (Bozsahin, 1998; Clark and Curran, 2007) Eisner’s normal form, referred to here as Eisner NF and paraphrased in (30), has the advantage ... (Borsley and Börjars, To Appear) Martin Pickering and Guy Barry 1993 Dependency Categorial Grammar and Coordination Linguistics, 31:855–902 David Reitter, Julia Hockenmaier, and Frank Keller 2006 ... Benthem and Alice ter Meulen, editors, Handbook of Logic and Language, pages 93–177 North Holland, Amsterdam Richard T Oehrle To Appear Multi-Modal Type Logical Grammar In Boersley and Börjars...

9
360
0

amit d.j. field theory, the renormalization group, and critical phenomena

Ngày tải lên : 08/05/2014, 12:54

404
172
0

báo cáo hóa học:" Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis" pot

Ngày tải lên : 18/06/2014, 15:20

... analysis, and writing of the manuscript HMB, GM and TRZ: contributed to study design and concept and writing and editing of the manuscript VT: contributed to the study design and concept, writing and ... involved in drafting the manuscript TZ provided samples, supervised in study design, and was involved in drafting the manuscript VT carried out the initial conception and design of the study, supervised ... biotechnology, Uden, The Netherlands) Protocols for each assay were per the manufacturer's product manuals Samples for 25(OH )D and DBP were tested in duplicates and LL-37 in single measurements The intra-assay...

9
404
0

d. Hadn''''t it been b 41. The talks in the classroom, in the corridor and in the schoolyard do not pdf

Ngày tải lên : 18/06/2014, 17:20

... miss the flight! a would b had c should d did >b 30 By the end of last year he four Shakespeare plays a read b had read c has read d was reading b 31 What bird is the symbol of the United States? ... summer in Japan a higher than b similar to c lower than d as high as c 36 "He didn't understand it." " " a So did I b I did too c I did either d Neither did I d 37 Do you know one of the largest ... transfer b 31 There are three kinds of solar eclipses: one is total, another is annular, and a the another is partial b the partial is other c other is partial d the other is partial > d 32 I think...

43
491
0

Strategic Information Management Third Edition Challenges and Strategies in Managing Information Systems by ROBERT D GALLIERS and Dorothy E Leidner_1 pot

Ngày tải lên : 21/06/2014, 13:20

... (which they regularly), the end users typically lay the blame at the feet of the DP Department and demand that they (the DP Department) fix and maintain the system Staff Not only does the DP Department ... Department retain (and increase) the previous complement of staff (programmers, analysts, designers), but it grows further, with the addition of Information System Planners, and Database and Data Administration ... The dialectic ensures that proper understanding and cooperation are developed and maintained between IT staff and the rest of the organization The dialectic can result in some constructive confrontation...

43
410
0

Strategic Information Management Third Edition Challenges and Strategies in Managing Information Systems by ROBERT D GALLIERS and Dorothy E Leidner_2 pot

Ngày tải lên : 21/06/2014, 13:20

... market in the branded packaged goods industry, Singapore requires improved coordination and control of trade documentation in order to compete more effectively in the cross-industry trade environment ... rules and regulations, major computers and communications vendors, and/ or cooperative arrangements within an industry Regardless of how the standards are set, they are critical to the operations of ... problems, and facilitating transborder data flow Therefore, decisions about the components of network architectures and standards require a move toward centralized, corporate management coordination...

43
264
0