Ngày tải lên :
07/03/2014, 21:20
... ± 241 , 1073 ± 186 , 9 78 ± 169, 1037 ± 233, 12 14 ± 206, 10 08 ± 185 , 1163 ± 202 and 1236 ± 242 d.p.m for wildtype V1aR, R46H, R46Q, R46N, R46P, R46V, R46F, R46Y, R46A, R46K, R46C, R46S, R46M, R46G, ... stabilize the G-protein interaction of the active receptor [ 28] In summary, Arg46 of the V1aR is required for high affinity agonist binding and signalling It is one of the constraining residues ... off-state The unique ability of arginyl to fulfil this constraining function in the N-terminus of the V1aR is similar to the unique constraining role of alanyl previously reported for Ala293 in the...