in this series of four minireviews the field of scaffold proteins and proteins of similar molecular⁄cellular functions is overviewed by binding and bringing into proximity two or more signaling proteins

Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc

Ngày tải lên : 16/03/2014, 11:20

... Therefore, binding of the iron regulator DmdR1 will interfere with RNA polymerase interac- tion and expression of the desferrioxamine cluster. Indeed, binding of the pure DmdR1 protein to the S. ... arrow). The1 9-bp palindromic region, which contains the repressor -binding site, is boxed, and the ribosome -binding site is underlined. The ATG is shown in bold letters. The reported tran- scription ... desferrioxamine biosynthesis from l-lysine and reported that desD is essential for desferrioxamine formation (Fig. 1) [15]. The ﬁrst step in the desferrioxamine pathway is the conversion of l-lysine into...

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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Ngày tải lên : 23/03/2014, 06:20

... with or without the pan- kinase inhibitor staurosporine at the concentrations indicated, and treated with 0.5 M sorbitol for 60 min, and then incubated for 3 h in sorbitol-free medium (in the ... cytoskeletal protein GKAP, therefore releasing it from the cytoskeleton into the cytoplasm [3]. Our aim in this study was to gain a better understanding of the role of hDlg phosphorylation by p38c when ... kinase inhibitors, at the concentrations indicated. Cells were exposed to 0.5 M sorbitol for 60 min, and then incubated for 9 h in sorbitol-free medium (in the continued absence or presence of inhibitor)....

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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf

Ngày tải lên : 21/02/2014, 01:21

... consisting of two, presumably distinct, stages. First, selectivity in vivo of the proteins for their metal cofactor is a prerequisite, as the proteins must fold de novo about their corresponding metal ion. ... hydrogen-bonding network involving various residues as well as the coordinated solvent. Q146 is of interest as it represents one of two residues originally identiﬁed to distinguish between FeSOD and MnSOD ... ratio of correct to incorrect metal in the active site of the enzyme is greatly increasedbymorethantwofoldtogreaterthan50times when the active-site glutamine residue is removed (Fe[Q69G] and Mn[Q146A],...

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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx

Ngày tải lên : 23/03/2014, 06:20

... EcoRI-StuI fragment containing K173R or K213R into the EcoRI ⁄ StuI site of single mutant K289R. Myc-tagged wild-type or mutant LRH-1 was generated by inserting the corresponding fragments into pcDNA-Tag3A ... localization of LRH-1 was suppressed by forskolin and cholera toxin. Forskolin treatment obviously in uences the expression of members involved in the SUMO pathway. The results obtained in the present ... that the effect of cAMP signaling on SUMO pathway is complex and cell type dependent. Notwithstanding, the up regulation of E1, the down regulation of E2 or E3 and the increased expression of SENP2...

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Báo cáo khoa học: A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents pdf

Ngày tải lên : 30/03/2014, 16:20

... insulin activation of GS was in the normal range, indicating that the PP1-G M is not required for the insulin activation of GS [25]. These workers postulated the existence of a novel insulin-activated ... glycogen-targeting subunits of PP1. Identiﬁcation of the PP1 -binding motif was des- cribed in Egloff et al. [43], the glycogen -binding domain in [15,31,44] and the substrate binding domain in [23,45]. ... respectively. Treatment of animals Diabetes was induced with either intravenous or intraperi- toneal injection of streptozotocin into male Wistar rats and insulin was subsequently administered intravenously into...

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Báo cáo Y học: High afﬁnity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-ﬁnger like sequences doc

Ngày tải lên : 08/03/2014, 23:20

... an adhesin [6]. However, neither the mode of binding nor the possible factors cooperating in binding protein are under- stood in any d etail. Laminin is a glycoprotein consisting of three chains ... enhancing laminin– enactin and laminin–collagen type I V binding. Previously, the enactin binding site was mapped to one of the zinc-ﬁnger containing repeats on t he laminin A chain [9]. More recently, ... binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-ﬁnger like sequences Keya Bandyopadhyay, Sudipan Karmakar, Abhijit Ghosh and...

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Tài liệu The Applicability of Remote Sensing in the Field of Air Pollution docx

Ngày tải lên : 17/02/2014, 10:20

... This report prepared by KNMI and JRC is the final result of a study on the applicability of remote sensing in the field of air pollution requested by the DG Environment. The objectives of this ... proxy for total aerosol mass. The single scattering albedo is a measure for the absorption and is an indicator for the aerosol composition or type. The Ångström parameter is an indicator for the ... from the single scattering albedo and/ or aerosol size information. For example, the Absorbing Aerosol Index [Torres et al., 1998] provides information on the presence of elevated absorbing aerosol...

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Credit appraisal for projects in the field of Petroleum in Vietnam Joint stock commercial bank for Industry and Trade - Hanoi branch

Ngày tải lên : 07/03/2014, 15:45

... commercial bank for Industry and Trade - Hanoi branch 2013 the project and minimize the risk for the loan. On the basis of the evaluation results and the level of risk, expertise can make decisions on the ... for the investor to get the investment license and the bank loan. - Market impact of the project Market appraisal helps the investor determine the most potential product for his project, and the ... leading to bad lending decisions for the bank. CHAPTER 2: ACTUAL SITUATION OF CREDIT APPRAISAL FOR PROJECTS IN THE FIELD OF PETROLEUM IN VIETINBANK 24 Credit appraisal for projects in the field of...

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POSITIONING OF MEDIA ECONOMIC FRAMEWORK IN THE FIELD OF PROJECT BUSINESS FOR NOVEL MEDIA docx

Ngày tải lên : 17/03/2014, 20:20

... dollars, and finally Facebook received 240 million US dollars in 2008 POSITIONING OF MEDIA ECONOMIC FRAMEWORK IN THE FIELD OF PROJECT BUSINESS FOR NOVEL MEDIA Nafis Iskander PhD ... different viewpoints of Framework  Project Business Analysis CONCLUSION  Future research will envision delving further into these novel criteria for social media. This delving will encompass ... QUESTIONS  What is output from investment of social media companies?  Which business models are working and might emerge in the future for social media?  What is the relevance of media economic...

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Continuing Education Programmes for Health Care Providers in the Field of Prevention of Chronic Diseases pdf

Ngày tải lên : 22/03/2014, 15:20

... variety of media. It is multiprofessional, interprofessional and intersectoral*, and includes networking*. It includes an evaluation* of the learning process* and its effects. It is provided ... education* an introductory course is recommended to motivate interested prospec- tive candidates and inform them about the nature and significance of the subject. Two levels of training in therapeutic ... revise/complete these lists of professional competencies by use of a table of specification, in order to determine whether they mention all the competencies to be expected of patients. This...

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ICT enabled independent living for elderly: A status-quo analysis on products and the research landscape in the field of Ambient Assisted Living (AAL) in EU-27 doc

Ngày tải lên : 28/03/2014, 16:20

... comprised the search for information – mainly web research – and the analysis of this information for the context of ICT-enabled independent living. To a major extent, the required information ... the number of mixed organisations (5) is quite negligible. This means that there are more private organisations working in the field of AAL (i.e. as partners in research consortia or in the ... is mainly organised and supported by the Bulgarian State Agency for Information Technologies and Communications (SAITC), the Bulgarian Ministry of Education and Science and the Ministry of...

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báo cáo sinh học:" Understanding the ‘four directions of travel’: qualitative research into the factors affecting recruitment and retention of doctors in rural Vietnam" doc

Ngày tải lên : 18/06/2014, 17:20

... housing is very scattered in the highland areas. On this basis, being provided with housing could be an important factor in the motivation of doctors working at the lower levels in the highland ... the findings of the first stage - the qualitative research which fed into the design of the questionnaire and contingent valuation. The focus of the study in Vietnam was doctors, as this is the ... stakeholders; the motivation for joining the profession by doctors; their views on the different factors affecting their willingness to work in rural areas (including different income streams, working...

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– QUESTIONS – Set 32 (Answers begin on page 136.) Each of the questions in this set contains doc

Ngày tải lên : 18/06/2014, 17:20

... number 21 is interpolated every other number into an otherwise simple addition series that increases by 2, beginning with the number 9. 13. b. In this series, each number is repeated, then 13 issubtracted ... a café or they may gather in suburban coffee shops to support one another in knitting and other aspects of life. They could be college roommates knitting in their dorm room or two senior citi- zens ... multiplication series; each number is 3 times the previous number. 70. a. In this series, the letters progress by 1; the numbers decrease by 3. 71. b. In this series, the letters progress by 2, and the...

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báo cáo hóa học: "Effects of intensive arm training with the rehabilitation robot ARMin II in chronic stroke patients: four single-cases" potx

Ngày tải lên : 19/06/2014, 08:20

... variety of training modes with complex exercises and the possibility of per- forming motivating games. The goal of this study was to investigate the effects of ARMin II training on motor function, ... right Diagnosis of stroke ischemic media insult right, bleeding into Ncl. Lentiformis ischemic media insult right, in the temporal dorsal brain ischemic insult in the right PCA* ischemic media insult right Months ... EU [1,2] and more than 0.7 million in the U.S. each year [3]. The major symptom of stroke is severe sensory and motor hemiparesis of the contralesional side of the body [4]. The degree of recovery...