from functional genomics to clinical relevancešgetting the phenotype right

Báo cáo khoa học: From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 (Heidelberg, Germany) Sergii Ivakhno pot

Ngày tải lên : 30/03/2014, 09:20

... antibodies and the difﬁculty in scaling up the ﬂow cytometry for simultaneous analysis of multiple kinases C Boone from The University of Toronto, Canada described two recent extensions to the synthetic ... genes and their regulatory elements The development of techniques to detect longdistance interactions was the topic of J Dekker’s talk from the University of Massachusetts Medical School (Boston, ... which the regulatory elements occur upstream of the genes that they regulate, in the human genome they are widely dispersed and occur between and within intones, making them very hard to map...

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Progestins and the Mammary Gland From Basic Science to Clinical Applications pdf

Ngày tải lên : 15/03/2014, 09:20

... been shown to exert their effects through ligand-activated steroid receptors in the mammary epithelium Approximately 10%–15% of the cells within the epithelium coexpress oestrogen receptor alpha ... cells from this subpopulation had the ability to produce the normal heterogeneous structure of the gland, suggesting that these cell markers are not sufﬁcient to completely mark the SC (Shackleton ... Consequently, the CSCs survive and are likely to be responsible for recurrence of the carcinomas It is therefore essential to develop therapies that target the CSC itself To aid the development...

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Báo cáo hóa học: " Application of functional genomics to the chimeric mouse model of HCV infection: optimization of microarray protocols and genomics analysis" potx

Ngày tải lên : 20/06/2014, 01:20

... However, the focus of the majority of these studies was to take advantage of the cross-species hybridization for the reasons outlined above The focus of the present study was to determine the feasibility ... hybridization of ML-RNA on the human arrays were chosen to determine whether the gene expression changes measured on the arrays was originating from the human tissue or the mouse tissue The species specificity ... shown) These probes were then used to determine the expression levels of these genes in HCV-infected chimeric samples relative to donor-matched uninfected samples and the results compared to the...

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Tài liệu Therapist''''s Guide to Clinical Intervention The 1-2-3''''s of Treatment Planning pdf

Ngày tải lên : 15/02/2014, 02:20

... edition, like the first, is intended to serve as a comprehensive resource tool Because of the positive response to the organization of the original text, the format has remained the same The Therapist's ... necessary to amass a commensurate amount of information To review the format for those familiar with the first edition and introduce this format to those who are new to the Therapist's Guide to Clinical ... and realistic weight These professionals will have to monitor the medical side of the disorder For the therapist to become involved, serious complications must arise in the therapeutic relationship...

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TEXTBOOK OF Hepatology From Basic Science to Clinical Practice doc

Ngày tải lên : 06/03/2014, 09:21

... lobes These landmarks together are customarily considered to form the letter H, and the parts of the liver between the uprights of the letter are the quadrate and caudate (spigelian) lobe The fossa ... anterior to the inferior vena cava It enters the right border of the lesser omentum and ascends anterior to the epiploic foramen to reach the right end of the porta hepatis In the hepatoduodenal ... anterior to the inferior vena cava and posterior to the neck of the pancreas It runs obliquely to the right and ascends behind the rst part of the duodenum, the common bile duct and the gastroduodenal...

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From Patient Data to Medical Knowledge The Principles and Practice of Health Informatics ppt

Ngày tải lên : 15/03/2014, 12:20

... calculations and how to present the results They were prepared to the best they could and then to expose the results to empirical tests, to use the system in practice and see if it worked The clinical evidence ... symptoms into the computer They had to be collected in a standard format, to match the data stored in the computer In order to manage the process efficiently, a form was designed that took the ... able to listen more constructively to their patients’ stories if they tried to understand them as stories, rather than attempting to express them in the structured and standardised format of the...

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An Introduction to Vascular Biology From basic science to clinical practice SECOND EDITION pdf

Ngày tải lên : 22/03/2014, 20:21

... regulator of the linkage between the cytoskeleton and the contractile machinery The cytoskeleton also attaches to the cell membrane and makes connection with the extracellular matrix or other ... connects the motor domain to the thick filament Rotation of the lever arm slides the actin filament to the left, relative to the thick filament position (b) The regulatory domain, called the lever ... vicinity of the cell membrane spreading to the contractile machinery located nearer the cell interior The permeability of the store therefore modulates the extent to which Ca2+ entering the cell...

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MICROPROCESSORS FROM ASSEMBLY LANGUAGE TO C USING THE PIC18FXX2 docx

Ngày tải lên : 23/03/2014, 00:20

... “0”, the upper switch (the P transistor) is closed, while the lower switch (the N transistor) is open This connects the output to Vdd, forcing the output to a “1” When the input value is “1”, the ... a “0” value for the bit shifted into the MSb, the binary value 0b1100 (12) shifted to the right by one position is 0b0110 (6) If this value is shifted to the right once more, the new value is ... because the carry ripples 18 Microprocessors from the rightmost bit to the leftmost bit There are many other ways to build an adder; this is the simplest form of a binary adder A3 I0 I1 B3 Y Y3 2 -to- 1...

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Tissue Regeneration – From Basic Biology to Clinical Application Edited by Jamie Davies doc

Ngày tải lên : 30/03/2014, 22:20

... changes in the balance of forces that are transmitted across transmembrane adhesion receptors that link the cytoskeleton to the ECM and to other cells These changes, in turn, alter the ECM mechanics, ... science to the regeneration of tissues (or to their de novo generation) Third, there is the construction of engineered scaffolds to guide normal healing processes and the behaviour of stem cells either ... growth is from the cells that were already there rather than being from the stem cells The dual mode of stem cell action, which places different emphasis on each mode according to the precise...

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TISSUE REGENERATION – FROM BASIC BIOLOGY TO CLINICAL APPLICATION ppt

Ngày tải lên : 27/06/2014, 09:20

... changes in the balance of forces that are transmitted across transmembrane adhesion receptors that link the cytoskeleton to the ECM and to other cells These changes, in turn, alter the ECM mechanics, ... science to the regeneration of tissues (or to their de novo generation) Third, there is the construction of engineered scaffolds to guide normal healing processes and the behaviour of stem cells either ... growth is from the cells that were already there rather than being from the stem cells The dual mode of stem cell action, which places different emphasis on each mode according to the precise...

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PULMONARY HYPERTENSION – FROM BENCH RESEARCH TO CLINICAL CHALLENGES pot

Ngày tải lên : 27/06/2014, 17:20

... whether the state of native EC is important in selecting EPC transduced with the desired gene or the vector-driven gene therapy, or 2) these results are simply related to the efficacy of the ... the right ventricle, and right ventricular hypertrophy to maintain an adequate flow Subsequently, right ventricular dilatation ensues the signs and symptoms of right heart failure occurence Therefore, ... – From Bench Research to Clinical Challenges caveolin-1 dysfunctional Statins therapy has shown to protect eNOS function in hypoxiainduced PH The major effect of statins is reported to be the...

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PROGRESS IN HEMODIALYSIS – FROM EMERGENT BIOTECHNOLOGY TO CLINICAL PRACTICE potx

Ngày tải lên : 28/06/2014, 03:20

... throughout the HD session (i.e., the numerator), the variation of its concentration is necessarily due to the change in the blood volume (i.e., the denominator) The various devices available vary in the ... action to bring it back towards the aimed values is immediately and automatically undertaken through the effectors, in a closed-loop that insures the stability of the monitored parameter The theoretical ... modulates the UF rate according to the relation of the actual BV to the cRBV The algorithm is designed to allow the maximal UF rate at the beginning of the session, where the plasma refilling capacity...

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Báo cáo y học: "omparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi" pps

Ngày tải lên : 09/08/2014, 22:23

... according to the manufacturer’s protocols (Evrogen) and 1,411 ABI dye terminator sequences were obtained mainly from the 5’ end The sequences were matched to the assembled genomic sequences to determine ... rather large in the fungal kingdom, ranging from approximately 90 in Ustilago maydis to approximately 350 in Gibberella zeae (according to the MEROPS database [24]) Dermatophytes belong to the ... whether only the NRPS or the entire associated gene cluster is absent from T verrucosum, we examined the conservation of the other constituents of the ARB_02149 gene cluster and observed that the...

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báo cáo khoa học: "From basic research to clinical development of MEK1/2 inhibitors for cancer therapy" pot

Ngày tải lên : 10/08/2014, 22:20

... activated in response to virtually all mitogenic factors Second, several studies have reported that the mitogenic response to growth factors is correlated with their ability to induce sustained ... and c-Kit receptors To what extent the inhibition of Raf signaling contributes to the clinical activity of the drug is not clear Future clinical trials of more selective Raf inhibitors will help ... Page of 11 whether blocking the pathway at the level of Raf is a clinically viable approach Inhibitors of MEK1/2 are highly selective for their targets However, results from the first clinical trials...

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From avant garde to tradition on the transformation of yu huas novels

Ngày tải lên : 06/10/2015, 21:22

... ——论余华小说创作的转型（1987－1995） FROM AVANT-GARDE TO TRADITION ——ON THE TRANSFORMATION OF YU HUA’S NOVELS （1987－1995） BY 刘艳平 LIU YAN PING 新加坡国立大学中文系硕士学位论文 A THESIS SUBMITTED FOR THE DEGREE OF MASTER ... through the dissertation process, never accepting less than my best efforts As my teacher and mentor, he has taught me more than I could ever give him credit for here Thanks go to the other faculty ... Hua’s novels, this thesis will analyze the characteristics and differences of his writings before and after the critical transformation in his career By taking into consideration the writer’s own...

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improving quality and performance by transfroming from functional structure to process based structure at serenco company

Ngày tải lên : 25/11/2016, 09:50

... organization from functional structure to process-based structure is not easy The company has to choice the right approach and methodology to make the transitioning success In the case of sTech, we use the ... services The main market of Serenco is local banking industry From the year of 2014, to adapt to the tough market, the company top management had reorganized company structure and products The company ... management to help the company to faster react to the rapidly changing in the market - Improve supply chain management to help the company become more competitive advantages 5 - Improving the company...

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The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application potx

Ngày tải lên : 22/03/2014, 21:20

... upon two factors The ﬁrst is the nucleophilicity of the amino acid residue and the second is the accessibility of the functional group to the chemical reagent The nucleophilicity of a functional ... assigns mass -to- charge ratios to ions based on their momentum, cyclotron frequency, time-of-ﬂight or other parameters The total metabolites produced by the products of the genome The study of the metabolome ... The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application...

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báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx

Ngày tải lên : 11/08/2014, 12:20

... the combined inhibition of the Ras pathway and of mTOR to overcome resistance to mTOR inhibitors alone Despite the discovery of these feedback and parallel pathways, their potential role in clinical ... resistance to rapalog mTOR inhibitors have been documented in laboratory model systems These include a negative feedback loop from S6K to the insulin receptor substrates (IRS) and Inhibition of mTORC1 ... targets in RCC Predictors of response to inhibitors of the VEGFR-mTOR-HIF signaling axis are likely to be relevant to other tumor types in which these agents are active or in which mTOR/HIF signaling...

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Báo cáo khoa học: "Evidence-based medicine: Classifying the evidence from clinical trials – the need to consider other dimension" pot

Ngày tải lên : 13/08/2014, 03:20

... subject to other considerations, such as the cost of the intervention being tested, the size of the population likely to benefit, the relevance of the clinical outcome being assessed, the future ... trial to decrease the probability of a beta error (for example, increase the power) from 0.20 to 0.10, the result would be greater recruitment, an increase in the number of patients exposed to placebo ... confidence interval 0.29 to 0.77, p = 0.003) [23] Yet the data safety and monitoring committee continued the trial because these initial findings were considered too large to be clinically possible...

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Báo cáo y học: "Bench-to-bedside review: Mobilizing patients in the intensive care unit – from pathophysiology to clinical trials" pot

Ngày tải lên : 13/08/2014, 16:20

... [61,62] Furthermore, both the IL-1 receptor antagonist and soluble TNF-α receptor, inhibitors of pro-inflammatory cytokines, are also elevated during exercise, without concomitant increases in the proPage ... protection Physical therapy in the intensive care unit Physical therapy practices vary greatly across ICUs, ranging from passive range of motion to transferring patients from the bed to a chair In ... http://ccforum.com/content/13/4/216 and automated orders for physical therapy, more patients received physical therapy during their ICU stay (73% in the protocol versus 6% in the usual care group), with a trend toward decreased...

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