drug discovery and development

DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE pptx

Ngày tải lên : 27/06/2014, 17:20

... process excellence handcuff drug development? Drug Discov Today 16: 377-381 Drug Discovery and Development – Present and Future [11] Kola I (2008) The State of Innovation in Drug Development Clin ... drug discovery and development Drug Discovery Today 11: 806-811 [14] Lowe JA, Jones P, Wilson DM (2010) Network biology as a new approach to drug discovery Current Opinion in Drug Discovery and ... These and many other such studies describe the way of incorporation of safety aspect in drug discovery process for Ayurvedic drugs Concept of Drug rediscovery” Contemporary Drug discovery and development...

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Antibiotic Discovery and Development pptx

Ngày tải lên : 14/03/2014, 10:20

... 679 Mycobacteria Drug Resistant and Persistent Tuberculosis: Mechanisms and Drug Development Ying Zhang 719 VOLUME II Part VII 23 24 Antibiotic Discovery Resistance Trends and Susceptibility ... intention is to attempt to capture the antibiotic discovery and development process and provide the reader with a sense of how it is done and where things stand in 2011 The book begins with a solid historical ... Antibiotic Discovery and Development Thomas J Dougherty ● Michael J Pucci Editors Antibiotic Discovery and Development Editors Thomas J Dougherty Senior Principal...

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fragment based drug discovery and x-ray crystallography

Ngày tải lên : 29/05/2014, 23:54

... (2009) Ligand efﬁciency and fragment-based drug discovery Drug Discov Today 14:278–283 83 Orita M, Ohno K, Niimi T (2009) Two ‘golden ratio’ indices in fragment-based drug discovery Drug Discov ... Fragment and Virtual Screening 61 Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey, and Roderick E Hubbard Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery ... approach to drug lead discovery: overview and advances in various techniques Drugs R D 9:217–227 92 Congreve M, Chessari G, Tisi D et al (2008) Recent developments in fragment-based drug discovery...

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Provision, discovery and development of ubiquitous services and applications

Ngày tải lên : 10/09/2015, 08:36

... “Service Discovery for Mobile Computing: Classiﬁcations, Considerations and Challenges” In Handbook of Mobile Systems Applications and Services (Editors: Anup Kumar and Bin Xie), CRC Press, Taylor and ... Provision and Discovery While there are scalable solutions (as will be surveyed in Section 2.1) that utilize P2P techniques such as Chord [24] and CAN [25] to handle the provision and discovery ... provision, discovery and development of ubiquitous services and applications The whole thesis consists of three parts First, a three-tier architecture (LASPD) is designed for scalable and effective...

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Development of database and computational methods for disease detection and drug discovery

Ngày tải lên : 10/09/2015, 09:04

... Bioinformatics and cheminformatics in drug discovery The combination of random screening and rational drug design have played an important role in drug discovery [44] The traditional drug discovery ... targets and drug of the approved, clinical trial, and experimental drugs These database lead to a better understanding of the disease and benefit for drug discovery Src promotes tumour invasion and ... Bioinformatics and cheminformatics in drug discovery 1.3 Introduction of bioinformatics and cheminformatics database development 11 1.4 Overview of virtual screening in drug discovery ...

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Knowledge discovery in biomedical research and drug design the development and application of biological databases

Ngày tải lên : 17/09/2015, 17:19

... Facilitating Drug Discovery 1.4.1 Overview of emerging technologies of drug discovery 1.4.2 The need of drug target databases for drug discovery 1.4.3 Adverse drug reaction (ADR) target database for drug ... in drug discovery have become supported by QSAR databases [Hansch, 1995; http://mmlin1.pha.unc.edu/~jin/QSAR/] 1.4.2 The need of drug target databases for drug discovery Drug discovery and development ... broad, both in the academia and industries This thesis reports our research on the development of biological databases and their applications in drug discovery and knowledge discovery in specific areas...

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Development and interpretation of machine learning models for drug discovery

Ngày tải lên : 26/11/2015, 09:59

... both precisely and intuitively This work is concerned with the development and interpretation of machine learning models for drug discovery To this end, it describes the design and application ... potency values, and the profiling of ligands against a panel of related targets Aside from the development of LBVS methods, understanding the resulting models is a key aspect in drug discovery Beneath ... understanding of computational models for drug discovery, and introduces chemically intuitive interpretations Thereby, we hope to contribute to further enhanced communication in interdisciplinary drug...

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Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc

Ngày tải lên : 10/08/2014, 05:21

... out molecular work and sequence analysis and prepared the manuscript SL and CV assisted in designing the study and drafting the manuscript KD and JR performed viral loads and genotyping KM supervised ... parameters and CD4 count only, is limited Virologic treatment failure and accompanying resistance are of concern with regard to the risk of disease progression and potential transmission of drug resistant ... start or switch treatment is based on clinical and immunological parameters [2,3] Information on the rate of treatment failure and the development of drug resistance in public hospitals in RLS,...

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báo cáo khoa học: " The first set of EST resource for gene discovery and marker development in pigeonpea (Cajanus cajan L.)" ppsx

Ngày tải lên : 12/08/2014, 03:21

... large-scale single pass sequencing of randomly picked cDNA clones, have been cost - effective and valuable resource for efficient and rapid identification of novel genes and development of molecular markers ... FW- and SMD- responsive ESTs, (ii) functional annotation of assembled unigenes, (iii) in silico identification of putative FW- and SMD- responsive genes, and (iv) development of novel SSR and ... pair-wise comparisons, the Audic and Claverie test, Fisher exact test and chisquare tests (Χ2) were used and in multiple comparisons R- statistics test, Greller and Tobin test and chi-square tests (Χ2)...

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báo cáo khoa học: " ESTs from a wild Arachis species for gene discovery and marker development" pdf

Ngày tải lên : 12/08/2014, 05:20

... transport and metabolism F Nucleotide transport and metabolism G Carbohydrate transport and metabolism H Coenzyme transport and metabolism I Lipid transport and metabolism P Inorganic ion transport and ... the partial sequences, database comparisons and functional categorization of 8,785 randomly collected cDNA clones of A stenosperma and their use for the development of 107 microsatellite markers ... information storage and processing, including various protein kinases (29.3%), and metabolism and energy conversion and sugar, water and ion transporters (21.5%) One drawback of functional classification...

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Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc

Ngày tải lên : 14/08/2014, 08:20

... bio-ligands Ligands and theand2 of bio-ligands and binding ATP, ligands Additionalfor file 1ownerships of metabolism-relevantADP and block numbers of for proteins folds that bindligands ligands them ... ACD-SC-derived ordinary molecules; Ligands, sc-PDB-derived ligands; Ligands (≤ 3), ligands covering ≤ folds; Ligands (4-9), ligands covering 4-9 folds; Ligands (≥ 10), ligands covering ≥ 10 folds Implications ... increasingly shared notion in drug development that the most fruitful basis for the discovery of a new drug is to start with an old drug [83-85] Another feature of the recent drug discovery paradigm shift...

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Drug discovery metformin and the control of diabetes

Ngày tải lên : 12/07/2015, 15:49

... hypoglycaemic drugs The symptoms of both forms of diabetes are similar (and include tiredness, extreme thirst and related copious urine production) The onset of type is more insidious, and patients ... antipsychotic drugs, which can increase both glucose and lipid levels and often increase weight It may also have a role in treating polycystic ovarian syndrome which can cause obesity and infertility ... used drug to treat type diabetes, and is one of only two oral antidiabetic drugs on the World Health Organization (WHO) list of essential medicines However, we still not completely understand...

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In silico methodologies for selection and prioritization of compounds in drug discovery

Ngày tải lên : 08/09/2015, 22:12

... the next step, the candidate drug enters the development process (clinical trials) in which it will be tested in humans for its efficacy and safety Novel drug discovery and development is known ... CHAPTER CHAPTER 1.1 INTRODUCTION TO COMPUTATIONAL METHODS IN DRUG DISCOVERY INTRODUCTION Figure 1.1 Stages of drug discovery and development Before work is started to discover any potential new ... SRC validation and test sets selected by the scoring scheme Dashed lines and circles denote aromatic bonds and atoms respectively Continuous lines and circles denote aliphatic bonds and atoms respectively...

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Chemical and pharmacological studies of ardisia elliptica antiplatelet, anticoagulant activities and multivariate data analysis for drug discovery

Ngày tải lên : 10/09/2015, 08:25

... Linearity, LOD and LOQ data of α-amyrin and β-amyrin standard calibration curves 162 Table 5.3 163 Table 5.4 Absolute and analytical recovery of α-amyrin and βamyrin Stability of α-amyrin and β-amyrin ... amyrin standard and (C) β- amyrin standard 65 Figure 3.2 Gas chromatograms of (A) 70% methanol extract of A elliptica, (B) hexane fraction, (C) α-amyrin standard and (D) β-amyrin standard 67 ... chromatograms of (A) isolated and purified β-amyrin and (B) β-amyrin standard 70 Figure 3.7 Gas chromatograms of (A) isolated and purified β-amyrin and (B) β-amyrin standard 71 Figure 3.8 Scanning...

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Development and application of computational methods and tools for adverse drug reaction and toxicity prediction

Ngày tải lên : 10/09/2015, 09:02

... In the end, 255 ST+ drugs and 239 ST- drugs, 103 TdP+ drugs and 157 TdP- drugs were retained For study of serious psychiatric ADRs, 321 and 169 drugs were identified PADR- and PADR- respectively ... desirable to facilitate drug development and safety assessment 1.2 QSAR studies for ADR and toxicity prediction To deliver promising drug candidates to reach the late stage of drug development with ... astemizole, grepafloxicin and cisapride [64] Therefore, to minimize the risk of patients exposed to a harmful drug and the time and money spent on the development of such drugs, a fast and accurate assessment...

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Biointormatics of targeted therapeutics and applications in drug discovery

Ngày tải lên : 12/09/2015, 09:10

... phase of drug discovery From hit to lead to clinical trial drugs and to approved drugs, the drug discovery process is still time and money consuming (48) and methods to identify drug candidates ... Therapeutics and Applications in Drug Discovery x Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery List of Tables Chapter Table Statistics of the drug targets, drugs and their ... years and the total discovery and development cost of a new drug is estimated to be as enormous as one billion US dollars.(2) Around half of the drug Chapter 1: Introduction development time and...

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Pharmacokinetics pharmacodynamics driven approach for lead optimization in anti mycobacterial and anti malarial drug discovery

Ngày tải lên : 22/09/2015, 15:17

... Pharmacokinetics and pharmacodynamics of anti-infective drugs: approaches and challenges in drug discovery and development International conference on Pharmacology and Drug Development, 9th – ... 1.2.2 Ideal drug candidates An ideal drug combination should consist of at least three drugs that are active against drug susceptible and drug resistant (MDR and XDR) tuberculosis and produce ... criteria are important early in drug discovery and development (Alanine et al., 2003) to select and progress the most promising candidates Figure Drug development process and time involvement Reprinted...

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Human embryonic stem cells as a cellular model for osteogenesis in implant testing and drug discovery

Ngày tải lên : 16/10/2015, 15:38

... the implant, but also helps us to understand development of osteoblast cells that constitute the bone and their function In sum, either as a model for drug discovery or implant testing, hESCs are ... implant testing and drug discovery along its differentiation process toward osteogenic lineage Most of the current implant testing relies on adult stem cell (Mesenchymal stem cells, etc.) and primary ... enables us to explore the specific drugs for human development and diseases 1.2 Stem cells: Often, the tissue involved in replacement not only requires the mechanical and structural support from implants,...

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EMBEDDED LINUX SYSTEM DESIGN AND DEVELOPMENT.pdf

Ngày tải lên : 04/08/2012, 14:23

... Ⅲ Understand the embedded Linux development environment Ⅲ Understand and create Linux BSP for a hardware platform Ⅲ Understand the Linux model for embedded storage and write drivers and applications ... memory leaks and memory corruption in applications and drivers Ⅲ Learn methods to proﬁle applications and the kernel Ⅲ Understand uCLinux architecture and its programming model Ⅲ Understand the embedded ... Ltd Ⅲ Windows, WinCE and Microsoft are registered trademarks and MS-DOS and DirectX are trademarks of Microsoft Corporation Ⅲ Solaris and Java are registered trademarks and ChorusOS is a trademark...

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