usa the link between smoking and lung cancer was confirmed a landmark article tobacco smoking as a possible etiologic factor in bronchogenic carcinoma by e l wynder and evarts graham was published in the journal of the american medical association
... factors, decreased plasma TT levels and endothelial dysfunction Obesity is associated with decreased TT, BAT and FT levels, as well as elevated E2 levels Such a decrease in TT levels is not associated ... TNFa, leptin, IL-6 and angiotensinogen, as well as reduced adiponectin levels This imbalance in such cytokines and adipokines results in increased nuclear factor kB It also results ina decrease in ... arterioles, as well asthe endothelium lining the lacunar spaces ofthe corpus cavernsoum; and (c) the endocrine milieu that regulates the fibroelastic properties ofthe penis via tissue maintenance...
... score on the elements ofa subindex, divide bythe number of elements, and multiply this ratio by 20 Thus, each subindex has a value betweenand 20 We define the overall standardized score asthe ... financial firms as they have different financial reporting formats and many ofthe key variables needed in our study are not available in COMPUSTAT database For each ofthe remaining industrial and ... than times inthe year? Did the audit committee meet more than times inthe year? Wasthe attendance at AC meetings more than 60%? Wasthe attendance at AC meetings more than 80%? Wasthe attendance...
... wages and salaries that is slightly smaller than the increase that we assumed for the baseline simulation, plus a small increase inthe direct taxation in 2013 An increase of real government ... balances in this baseline case—that is, the negative ofthe private sector balance, the government deficit, andthe current account balance—are illustrated in Figure These three balances are ... oftheAmerican Taxpayer Relief Act of 2013, the law that averted or delayed most tax increases and spending cuts contained inthe so-called “fiscal cliff.” This lastminute agreement allowed taxes...
... from the passage, while-listening which challenges and guides them to handle the information and messages inthe passage, and follow-up getting reflection on the language ofthe passage such as ... than sheer speed Nevertheless, learners will eventually need to be able to comprehend language delivered at varying rates of speech and delivered with few pauses In listening, the hearer may ... that generally learners have little awareness of their needs and are usually unable to express the needs they recognise except in very vague terms It is of importance in general language courses...
... reviewed original articles and reviews for relevance and included all pertinent studies inthe preparation ofthe manuscript We have also considered the bibliographies ofthe selected articles ... [52], the risk of colorectal cancerwas almost halved in women receiving HRT Similarly, theassociationbetween HRT and risks of oesophageal and gastric cancerwas studied ina nested-case control ... postmenopausal women may help elucidate the age-related incidence in postmenopausal females The observation that females appear to have a survival benefit compared to males [28,29] has led us...
... SNP alleles with higher frequencies are more likely to be ancestral than less frequently occurring alleles although there may be some exceptions Asthe 23G allele was more prevalent than the 2 3A ... reported data indicate a higher level of DNA adducts in subjects with the Asn allele The interpretation of this finding is a lower DRC for the Asn allele than the Asp allele This is also true for the ... harboring at least one 19007C allele may be associated with a deceased risk oflung cancer, the protective effect ofthe 19007C allele needs to be confirmedin other independent studies Furthermore,...
... analyses of selective as- treated samples rather than intent-totreat analysis Results based on the availability ofa complete set of assessments not generalize to the full sample of patients initiating ... Well-conceived and well-reported randomized clinical trials are, presumably, well-conceived and well-reported experiments Yet, as seen inthe rationale for the National Institute of Health’s annual ... exceeded the strength ofthe evidence When the same critical appraisal tools and methodological and statistical standards we have applied here are extended to the larger literature, the evidence...
... overhang is formed by exonuclease activity and invades the homologous doublestranded region ofthe other allele These steps of homology search and recombination are catalysed by two bacterial ... were sequenced andthe corresponding gene was identified by blast analysis cDNA cloning of CcCac 1L One ofthe interacting factors identified in our screen was found to encode the CcCac 1L C-terminus, ... dehydrogenase (CcG3PDH; bottom panel) (B) Western analysis ofthe rat anti-CcCac 1L IgG The cell extract at the meiotic prophase was examined (C) Nuclear localization of CcLim15 and CcCac 1L inthe nuclei...
... increase in aggregate demand, while also being instrumental to the strengthening ofthe exchange rate via the UIP schedule The latter strengthening in turn helps ease excess demand andin ationary ... t the real exchange rate is unchanged in line with the backward-looking nature of et in (15) The initial interest rate increase o¤sets the excess demand inthe goods market and thereby thein ... linear models ofthe type used here can explain the main features of EMEs, as well as ascertaining whether non-linearities can contribute to our understanding ofthe problem Fourth, thein ation...
... “wander” about the true bearing ofthe UE The variance of this wandering ofthe CofG has been obtained The dependence ofthe AoA estimation accuracy on the parameters ofthe spread source model has ... realisation (averaged over time) will, in general, be different from the ensemble statistics (averaged over all realisations and all time) So in practice, in any single realisation ofthe angle-spread ... purely by chance, be located on the left-hand side ofthe true UE bearing, which would bias the apparent (i .e. , estimated) bearing ofthe UE to the left Conversely, in another realisation, all of...
... bleomycin challenge Mean linear intercepts, lung desmosine and elastase burden Mean linear intercepts, lung desmosine and elastase burden in various strains of mice following bleomycin challenge (A) ... proteases and their naturally occurring inhibitors In particular, neutrophil elastase (NE), and other elastolytic proteases, such as cathepsin G, and macrophage elastase are thought to be the main ... purposes) Respiratory Research 2005, 6:83 It is well know that proteases released by inflammatory cells recruited at the site of inflammation may be involved inthe intracellular as well as extracellular...
... cohorts are affected by legalized abortion, the decrease in crime will level off at a lower plateau than before The third analysis is that ofthe staggered nature ofthe states’ legalization; New ... California, Washington, Alaska, and Hawaii all lifted the abortion ban before the Supreme Court made it national, so theoretically they should have seen an earlier decrease in crime 13 The results ... Methodology The model used inthe analysis of this data is relatively simple - it was originally proposed in Donohue and Levitt, and each related article has used a similar model The regression equation...
... Closing the gap Thelinkbetween project management excellence and long-term success Preface Closing the gap: Thelinkbetween project management excellence and long-term success is an Economist ... Then, days after the launch, the NASA team realised there wasa problem The images came back blurry because ofa flaw inthe telescope’s mirror—it was too flat on one edge bya few nanometres “There ... company andthe client 48 We determine whether we successfully met and closed out the contract 40 We evaluate the quality ofthe deliverables 40 We evaluate how effectively we identified and managed...
... When using CAPITAL and CURRENT as independent variables, we need to model the potential influences of changes and levels of these variables over many years We use five-year averages, which are ... data were available was limited The Bekaert, Harvey, and Lundblad 2000 study also used a 0,1 measure, but this measure, unlike the IMF’s, is linked to the date ofthe liberalization Eichengreen ... Kenya Korea Malaysia Mexico Morocco Nepal Netherlands Nicaragua Nigeria New Zealand Norway Pakistan Panama Paraguay Peru Philippines Portugal Rwanda Salvador Senegal Sierra Leone Singapore Spain...
... accustomed to tearing down other people's self-esteem at the office? The values and habits learned by practicing the five disciplines ofa learning organization serve to nurture the family as well as ... visions, and personal visions are always multifaceted—they always include deeply felt desires for our personal, professional, organizational, and family lives Lastly, the artificial boundary between ... members—often to a far greater degree than they realize Moreover, they fail to exploit a potential synergy that can exist between learning organizations, learning individuals, and learning families...
... knowledge improves behavior Instead, the causality may be reversed in that people may gain knowledge as they save and accumulate wealth, or there may be a third variable, for example, family experiences ... Average financial knowledge score, by financial practice index and index level Percent Financial knowledge score, by subsection Financial practice index and index level Overall score Credit management ... households’ financial-management behaviors While most studies have looked at financial knowledge at the aggregate level, this article explores the linkage between specific financial behaviors and...
... factors related to the development of literacy and research on the teaching and learning of literacy have been undertaken at ACER over the past five years; the paper on Factors Related to the Development ... reading, spelling, reading comprehension and listening comprehension was still evident at the end of Year and at the end of Year At the end of Year the differences betweenthe experimental and ... educational policy and research as has been the case in Australia This is particularly evident inthe United States, where a series of reports published over the last ten years has been influential in...
... a negative correlation because changes in cash flows and accruals are negatively correlated An increase in sales generates an increase in earnings, but tends to generate a decrease in cash flows ... shorter the earnings measurement interval, the more likely we will observe the phenomena we expect The shorter the period, the larger accruals are relative to cash flows (the larger the end-point ... serial correlations (Kendall, 1954) Since a relatively small number of annual observations of financial data are available, the negative bias inthe serial correlation estimates [equal to -VeT...
... Unless stated otherwise, the experimental setup and programmes ´ used inthe analysis were asin Hervas et al [13] The standard experimental conditions were as described by De la Cerda et al ... increased when a negatively charged residue was neutralized (D4 4A) , hardly changed when an adjacent positively charged residue was neutralized (K5 3A) , but decreased markedly when the charge of ... that assumes that only charges ofthe protein at the active site are relevant, and these can be represented bya disc of fixed radius and uniform charge The same analysis has been used for the interaction...