role of the us food and drug administration in cancer drug development

Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

Ngày tải lên : 19/02/2014, 07:20

... signatures in the sequences are present in both proteins, tyrosinases and catechol oxidases; these include the six histidine residues involved in the binding of a pair of copper ions and other conserved ... part of the defense system against wounding and infection by the pathogen [16] Thus, the timing and location of melanization seems to be essential for the prevalence of one of these two opposing ... browning of fruits and vegetables, and morphogenesis and fruiting body formation in fungi All of these processes involve melanin formation In the bacterial kingdom there are some examples of wellcharacterized...

14
849
0

Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf

Ngày tải lên : 07/03/2014, 03:20

... indicated basic region of ic3 of the D2 receptor and acidic region of the C-tail of the D1 receptor might be involved in the interactions between the two dopamine receptors In addition, the subcellular ... where Ri and Gi are the red and green intensities of voxel I, respectively, and Rav and Gav the average values of Ri and Gi, respectively It is used for describing the correlation of the intensity ... from the high levels of expression that are often achieved in heterologous system Results obtained in this study, concerning the dopamine D1 and D2 receptors and their interactions with the appropriate...

16
567
0

Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx

Ngày tải lên : 07/03/2014, 12:20

... protein chromophore of these bacteria The two recently discovered aminomutases, the phenylalanine 2,3-aminomutase (PAM) involved in taxol biosynthesis in Taxus chinensis [27] or T cuspidata [28] and ... of the Tyr110-loop in PAL in more detail Tyr-loop in phenylalanine ammonia-lyases Results and discussion Modeling the active conformation of the essential Tyr110-loop of parsley PAL Because of ... Constructing the ‘Tyr-loop-out’ variants of the bacterial PALs The ‘Tyr-loop -in models PlPALin and SmPALin were modiﬁed by replacing residues 50–85 (PlPALin) and 34–68 (SmPALin) with the corresponding...

16
502
0

Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx

Ngày tải lên : 16/03/2014, 23:20

... [11] The kinetics of the N-terminal arms swapping in the P19A-BSRNase is comparable to that of BS-RNase (Fig 5B) Interestingly, the amount of the MxM form at the plateau as evaluated by integrating ... have investigated the effects of mutation of two paradigmatic residues involved in the dislocation of BS-RNase N-terminal arms, i.e Pro19 and Leu28, located in the hinge peptide and in the intersubunit ... (D) The percentage of the MxM form as a function of the incubation time at °C (r) and 37 °C (d) is reported for each dimeric protein intrinsic ﬂexibility of this tract of the protein Yet, in the...

7
404
0

Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot

Ngày tải lên : 17/03/2014, 09:20

... SoxS In view of the redox-sensing function of the lipoate/dihydrolipoate couple of the complex (Fig 3) and the intimate link between this couple and E1, the E1 dissociation from the complex to bind ... Rather, the advantage appears to depend on the ability of the lipoyl group to protrude from the inner core of the complex, indicative of the biological signiﬁcance of the complex-bound lipoate interaction ... function of (a) concentrations of the reaction substrates and products, (b) kinetic properties of the component enzymes, E1, E2 and E3, and (c) their stoichiometry and interactions within the complex...

7
407
0

WORKING PAPER NO. 218 THE ZERO-INTEREST-RATE BOUND AND THE ROLE OF THE EXCHANGE RATE FOR MONETARY POLICY IN JAPAN potx

Ngày tải lên : 22/03/2014, 23:20

... rate The left-hand panels of Figure report the upward bias in the mean real rate and the downward bias in the variability of the real rate depending on the level of the nominal equilibrium rate of ... monetary policy in the presence of the zero bound In the following, we will show that such a prescription may focus on the role of base money and of the nominal exchange rate as instruments of monetary ... policy by expanding the supply of the monetary base and bringing down the short-term rate of interest Since prices of goods and services adjust more slowly than those on ﬁnancial instruments,...

53
586
0

the role of supply chain processes and information sharing in supply chain management

Ngày tải lên : 02/11/2014, 00:47

... effective information sharing on business performance Executives must balance the investment in information sharing and supply chain process iii Dedicated to My Grandfather, My Father, My Mother, and ... test the research hypotheses, thus improving the generality of the findings While the pilot study focuses on the first tier suppliers in auto industry, the large-scale study is based on a cross-industry ... dynamics and supply chain information sharing system dynamics The purpose of this dissertation is to investigate the influence of supply chain processes and information sharing on business performance...

265
543
0

The role of matrix metalloproteinases (MMP) and their inhibitor in influenza a virus induced host lung injury

Ngày tải lên : 13/10/2015, 16:41

... lung injury in mice infected with the mouse-adapted Influenza A/Aichi/2/68 P10 (H3N2) virus 97-98 Increase in MMPs expression and activity and their role in influenza virus-induced host lung injury ... (H3N2) P10 virus on the protein expression of these gelatinases, MMP-2 and MMP-9, in an in vivo murine model Influenza virus infection of an in vitro murine alveolar epithelial LA-4 cell line would ... to influenza virus infection, unlike the macrophages, they are important in eliminating the virus when the infected macrophages are non-functional (Fujisawa, 2001) Following the roles of the innate...

181
496
0

Talent strategies and the competitiveness of the US aerospace and defence industry

Ngày tải lên : 06/12/2015, 23:14

... they have, recruit employees into their fold and bring on the next generation of skilled workers Fewer and fewer scientists and engineers entering the ﬁeld in the 1980s and 1990s means that there ... strategies and the competitiveness of the US aerospace and defence industry Strengthening the domestic talent pipeline T Tapping America’s Potential: The Education for Innovation Initiative, ... over the coming years On the intake side, the number of US graduates within the crucial ﬁelds of science, technology, engineering and mathematics remains stubbornly low An anticipated reduction in...

17
201
0

Tài liệu Báo cáo khóa học: Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae pptx

Ngày tải lên : 19/02/2014, 12:20

... at the 3¢ terminus of the coding region Thus, the stop codon of SNO1 and SNZ1 was replaced with bases coding for the sequence LEHHHHH as a C-terminal extension The PCR Protein production and ... Sequencing of the mutated genes revealed that there was indeed a mutation on both of the genes In SNO1, the 199th G from the 5¢ terminus of the open reading frame was deleted to result in a frame-shift ... SNO3, SNZ2 and SNZ3 complement the defect The relationship of all of these genes remains to be clariﬁed Expression and puriﬁcation of Sno1p and Snz1p In light of the similarity in the amino acid...

8
649
0

Báo cáo khoa học: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo pptx

Ngày tải lên : 23/03/2014, 05:22

... that these inhibitory domain–domain interactions are relieved by binding of the metal to the N-terminus of the ATPase To further study the role of the Ccc2 N-terminus in the overall function of the ... [36,37] The current hypothesis involves domain–domain interactions between the N-terminus and other domains of the ATPase Indeed, in vitro studies of the puriﬁed N-terminus and catalytic loop of the ... that these two domains interact in the absence of copper and that their interaction is diminished by copper binding to the N-terminus [38] Such a domain–domain interaction has been proposed to hinder...

13
522
0

Báo cáo khoa học: The catalytic role of the distal site asparagine-histidine couple in catalase-peroxidases potx

Ngày tải lên : 23/03/2014, 21:20

... protein) and the corresponding fit are shown in Fig 4B The observed rate of cyanide binding to the ferric enzyme linearly increased with the concentration of cyanide The slope yielded the apparent ... another (wild-type protein: 0.57–0.61) The Reinheitszahl of Asn153fiAsp is in the range 0.42–0.45 and the peaks in the UV/Vis spectrum are at 408, 512 and 640 nm The small shoulder at 368 nm indicates ... investigated in this study The absorption spectrum of the Asn153fiAla variant resembles closely that of the recombinant wild-type enzyme in the resting state [7,12,13] exhibiting the typical bands of a...

8
290
0

Role of environmental self-auditing and audit policies in regulatory compliance

Ngày tải lên : 01/06/2014, 14:03

... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without...

121
277
0

báo cáo hóa học: " Factor structure of the Hospital Anxiety and Depression Scale in Japanese psychiatric outpatient and student populations" pdf

Ngày tải lên : 18/06/2014, 18:20

... (HADS-A) and depression (HADS-D) subscales each include items The conciseness of the HADS allows a high degree of usability in both clinical and research settings The reliability and validity of the ... 7, and 10, respectively) In order to confirm the robustness of the results, we reversed the order of the analyses Thus, we performed an exploratory factor analysis using the Group data and then ... shows the absolute indexes of the goodness -of- fit in the modified oblique models, Models A, B, and C Model A was the baseline model used to test the common factor pattern, while the magnitude of the...

9
533
0

báo cáo hóa học: " The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease" pot

Ngày tải lên : 18/06/2014, 19:20

... outcomes used as anchors We used the CRQ and the Feeling Thermometer as potential anchors to determine the minimal important difference of the HADS The CRQ is a widely used instrument in respiratory ... variable Using the equation one can estimate the minimal important difference of the instrument of interest In our analysis, we first assessed the correlation between the anchors (CRQ and Feeling Thermometer) ... performed the statistical analysis and drafted the manuscript MF participated in the design of the study, collection of the data and revised the manuscript SB revised the manuscript HJS participated in...

6
485
0

báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx

Ngày tải lên : 20/06/2014, 04:20

... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... Immunolocalization of VEGF, Flt-1 and Flk-1 in GCT samples We initially analyzed the expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing ... examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less than 10% of cells were positive), (intermediate staining;...

8
445
0

báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx

Ngày tải lên : 20/06/2014, 07:20

... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... Immunolocalization of VEGF, Flt-1 and Flk-1 in GCT samples We initially analyzed the expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing ... examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less than 10% of cells were positive), (intermediate staining;...

8
244
0

báo cáo hóa học:" Assessment of the structure of the Hospital Anxiety and Depression Scale in musculoskeletal patients" pdf

Ngày tải lên : 20/06/2014, 15:20

... common in patient populations The HADS consists of an anxiety and depression subscale, each containing seven items, making it quick and easy to use in clinical settings Since its publication in the ... outcome One of the issues facing clinicians wishing to screen for high levels of anxiety and depression among their patients is the choice of a screening tool In a hospital setting, the tool needs ... the HADS scale is increasing in popularity, particularly in clinical settings, because of its ease of administration and independence from physical symptomatology After reviewing over 70 journal...

9
540
0

báo cáo hóa học:" Structural ambiguity of the Chinese version of the hospital anxiety and depression scale in patients with coronary heart disease" doc

Ngày tải lên : 20/06/2014, 15:20

... participated in the design of the study and assisted in the drafting of the manuscript CM participated in the design of the study, performed the statistical analysis and assisted in the drafting of the ... conclusively Previous findings of the factor structure of the Chinese version of the HADS in Cantonese-speaking Chinese CHD patients in Hong Kong indicates clear and consistent superiority of three-factor ... detection utility and accuracy [16] The present study was designed to examine the underlying factor structure of the Chinese version of the HADS in a mainland Mandarin-speaking population of patients...

5
392
0

báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc

Ngày tải lên : 10/08/2014, 22:21

... between the BCL11B gene and the other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B ... acquisition of clinical data YQL and XH coordinated the study and helped to draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they ... extracted using the Trizol kit (Invitrogen, Carlsbad, CA, USA) and reverse transcribed into the first-strand cDNA using random hexamer primers and the reverse transcriptase Superscript II Kit (Invitrogen),...

7
410
0