role of the mitochondrial fission protein drp1 in synaptic damage and neurodegeneration

Báo cáo khoa học: Role of the plasma membrane leaﬂets in drug uptake and multidrug resistance ppt

Ngày tải lên : 29/03/2014, 08:20

... located within the cells The rapid initial quenching of the fluorescence was essentially complete within s after the addition of TMRM The extent of the initial quenching was linear with the outer ... that the active uptake of TMRM into the mitochondria interferes with the second phase of TMA-DPH quenching (Fig 2) Initially, there is significant inhibition of the quenching in the respiring cells, ... the blood–brain barrier and the epithelia lining the intestine and the nephrons It has been shown that the tight junctions pose a barrier to the movement of lipids between the outer leaflets of...

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The Role Of The United States Postal Service In Public Safety And Security doc

Ngày tải lên : 30/03/2014, 13:20

... type of offense for which the IS offers a reward and provides the name and description of the offense and the monetary amount of the reward “Best Practices for Mail Center Security: Incoming and ... security training to other federal, state, and local agencies 20 The Role of the United States Postal Service in Public Safety and Security The Role of the IS in Public Safety and Security The IS ... relaxing the Mailbox Rule; and (5) examine the experience of other countries in particular, the United Kingdom, Canada, and New Zealand in opening up their postal markets to competition, with the...

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Báo cáo khoa học: Fluorescence studies of the replication initiator protein RepA in complex with operator and iteron sequences and free in solution pdf

Ngày tải lên : 07/03/2014, 04:20

... indicator of stoichiometry In the case of 1IR, the t resulted in a binding stoichiometry of : 1, i.e dimer binding The reactant concentrations were too high to obtain relevant information on the binding ... rearrangement of the relative orientation of the two domains [7,9] The conformational change upon iteron binding may expose a recognition site for proteinprotein interaction, enabling coupling of recently ... quenching However, judging from the binding stoichiometry together with the shape of the binding curves (Fig 3), it is safe to conclude that the quenching does not affect the RepADNA binding equilibria,...

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Báo cáo khóa học: Assembly of the silk ﬁbroin elementary unit in endoplasmic reticulum and a role of L-chain for protection of a1,2-mannose residues in N-linked oligosaccharide chains of ﬁbrohexamerin/P25 ppt

Ngày tải lên : 16/03/2014, 16:20

... FEBS 2003 Role of L-chain in the elementary unit of fibroin (Eur J Biochem 271) 361 Table Determination of molar ratios of H-chain, L-chain, and fhx/P25 in the fibroin secreted into cocoons of a normal ... roles in the assembly of vesicular stomatitis viral glycoprotein [28,29], in uenza virus hemagglutinin [30,31], and IgM [32] in ER, a further role of N-linked oligosacharide chains of fhx/P25 in the ... the action of Golgi a1,2-mannosidases to yield only the 27-kDa molecule in the secreted fibroin In order to examine a role of L-chain in the protection of a1,2-mannose residues of fhx/P25 in the...

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Báo cáo khoa học: Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa ⁄ fa rats pptx

Ngày tải lên : 30/03/2014, 11:20

... [7,11,20] GL is one of four glycogen-targeting proteins expressed in liver [21–25] These proteins have binding sites for protein phosphatase-1 (PP1) and for glycogen, and they differ in their relative ... translocation of these proteins [26–28] The expression of GL and PTG, but not R6, in rat liver in vivo is insulin-dependent It declines during insulin deﬁciency and is restored by insulin treatment ... with inactivation of glycogen synthase and inhibition of glycogen synthesis The rate of glycogen synthesis, but not the activity of glycogen synthase, inversely correlated with the activity of...

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The Role of the Intensive Poultry Production Industry in the Spread of Avian Influenza pptx

Ngày tải lên : 31/03/2014, 08:20

... for the future? The rapidly expanding demand for animal protein in both developing and developed countries can only exacerbate the current situation The expanding poultry production industry increases ... calling itself the kitchen of the world’ CP have previously supplied Tesco, the largest UK supermarket chain; they are the biggest supplier of meat chicks in China and in Indonesia, where they ... Interestingly, in Laos there is next to no contact between ‘backyard’ farms and the intensive production farms of the capital; the capital’s intensive farms, on the other hand, are commonly integrated...

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Báo cáo khoa học: "the Role of Non-Timber Forest Products (NTFPs) in Livelihood Strategies and Household Economies in a Remote Upland Village in the Upper Ca River Basin, Nghe An, Vietnam" pdf

Ngày tải lên : 06/08/2014, 19:20

... (23.3%) The roles of NTFPs in the livelihood strategies were considered a gap-filling supplement during the agricultural season and for diversifying sources of income The roles of NTFPs in Que ... clusters and the indicators, we determined the livelihood strategies pursued by households From the results of the livelihood strategy analysis, we analyzed the role of NTFPs in the strategies and ... funerals, and other festivals Because cows and buffaloes are mainly free-range fed, and are walked to the market, the cost of raising them and transporting them to market is relatively low Chickens and...

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báo cáo khoa học: " In vivo imaging of the tonoplast intrinsic protein family in Arabidopsis roots" ppsx

Ngày tải lên : 12/08/2014, 03:21

... expression of TIP3;1 and TIP1;1 in Arabidopsis and found minimal overlap in the timing of their expression, with TIP3;1 being abundant in embryos of mature seeds and sharply declining during seed germination, ... z-stacks of the same root, separated by a black line B and C: xz projections of the image stack in panel a, revealing two cross-sections of the root axis, taken in the regions of the root indicated ... TIP2;3 and TIP4;1 would still be present in the tissues lacking TIP1;1 (Fig 2) It is therefore possible that these remaining isoforms compensate for the lack of TIP1;1 in the knockout On the other...

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Báo cáo y học: " Modulation of HIV-1-host interaction: role of the Vpu accessory protein" pps

Ngày tải lên : 13/08/2014, 01:20

... interactions of phosphoserines in Vpu and the WD boxes of b-TrCP Interactions between Vpu and CD4 result in the trans-ubiquination of the cytosolic tail of CD4 on lysine, serine and threonine residues These ... TM domain and ubiquitination of the cytosolic tail The findings of Magadan and colleagues supporting a role of Vpu in the retention of CD4 in the ER are not entirely consistent with those of a ... lineages The transmembrane domain of Tetherin evolved primarily during transition from the non hominoïd lineage to the hominoïd lineage, explaining why the Vpu protein inherited from the SIVgsn/...

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Characterisation of the BRCT DBL protein ECT2 in cell cycle regulation

Ngày tải lên : 11/09/2015, 16:04

... compartmenting of the protein The two tandem BRCT repeats on the N-terminus inhibit the C-terminus DH and PH domains, and regulate the nucleotide exchange activity of Ect2 Loss of the central NLS and the ... destabilization of the GTPase with the β-phosphate of the nucleotide [242, 246, 247] 1.3.1.2 The PH Domain The PH domain is invariably found on the C-terminus end of the DH domain, and these two domains function ... illustrate the biological importance of the PH domain and membrane targeting of the exchange factor by removing the PH domain of the exchange factor Lfc The transforming potential of Lfc in mouse...

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Mutational analysis of the TATA binding protein (TBP) in saccharomyces cerevisiae

Ngày tải lên : 12/09/2015, 08:20

... Figure 2.8 Interaction between Protein X and Protein Y Interaction of the two proteins brings about the reconstitution of a native-like ubiquitin The UBPs will cleave off RUra3, leading to the degradation ... The Split-Ubiquitin assay The ability to split the ubiquitin molecule into two halves with the N-terminus of ubiquitin attached to Protein X and the Cterminus to Protein Y and the reporter RUra3p ... for the analysis of the in vitro protein- protein interaction between Sua7(E202G)p and Tbp1(E186D)p Yeast cells expressing the depicted proteins were grown in medium lacking tryptophan and leucine,...

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Functions of the dynamin like protein VPS1 in actin organization in saccharomyces cerevisiae

Ngày tải lên : 16/09/2015, 15:54

... tyrosine kinases The binding between dynamins and these signaling proteins can be stimulated upon growth factor treatments, indicating the involvement of dynamin in cellular signaling pathway The ... correlate with their binding affinities to dynamin and synaptojanin in brain extracts Moreover, the inhibitory effects of the first SH3 domain (SH3A) of intersectin are on the early events of endocytosis ... representation of the domain organization in yeast formin homologues Bni1p and Bnr1p 48 1.17 Summary of the protein- protein interactions identified between dynamin and the components of actin cytoskeletal...

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The regulatory role of mixed lineage kinase 4 beta in MAPK signaling and ovarian cancer cell invasion

Ngày tải lên : 06/11/2016, 19:07

... catalytic domain containing the Zn2+-binding region and the collagen-binding domain (CBD), a hemopexin-like C-terminus connected to the catalytic domain by a hinge linker Activation of these MMPs ... the second tier of kinases in the MAPK signaling cascade The MAP2Ks are dual specificity kinases where they act as both tyrosine and serine/threonine kinases, and phosphorylate the tyrosine and ... stimulant, the N-terminal SH3 domain of MLK3 binds to a single proline residue that lies between the LZ and the CRIB domain, and maintains MLK3 in an inactive state by preventing dimerization and autophosphorylation...

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Investing in Nursing Education to Advance Global Health: A position of the Global Alliance for Leadership in Nursing Education and Science pptx

Ngày tải lên : 14/03/2014, 21:20

... demand for more nursing graduates, including government investment in additional seats, the opening of new nursing schools, and the introduction of new program models The demand for nurses and the ... Association of Schools of Nursing Council of Deans and Heads of UK University Faculties for Nursing and Health Professionals Council of Deans of Nursing and Midwifery (Australia and New Zealand) Forum of ... with the aging of the population and the documented increase in chronic disease, such as obesity and diabetes The decade between 1999 and 2009 also saw an increase in the number of master’s and...

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Báo cáo khoa học: Expression of the Pycnoporus cinnabarinus laccase gene in Aspergillus niger and characterization of the recombinant enzyme pdf

Ngày tải lên : 17/03/2014, 11:20

... from the dikaryotic strain I-937 of P cinnabarinus and 145 mgÆL)1 from the derived monokaryotic strain ss3 of P cinnabarinus In order to improve the secretion of the recombinant laccase, the laccase ... 0.5% of the molecular mass of the native laccase and and 10% for the recombinant laccase In the heterologous production of the P cinnabarinus laccase in P pastoris [14] or the T villosa laccase in ... active protein but with an hyperglycosylation increasing the molecular mass to 110 kDa as compared to the 70-kDa wild-type protein [14] The production level of the recombinant protein in Pichia...

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An empirical investigation of the relationship between a reduction in earnings variability and market returns

Ngày tải lên : 30/09/2015, 15:34

... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without...

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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

Ngày tải lên : 19/02/2014, 16:20

... N-terminal domain is involved in protein protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible From the comparative ... precursor protein, with the signal sequence and a proposed cleavage site based on the sequence of the mature bovine ESSS protein The truncated proteins in the three Chinese hamster mutant cell lines ... histochemical stain in the left panel Antisera against the SDHC subunit of complex II and against the Rieske protein of complex III revealed the presence of these complexes in all cells (Fig...

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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf

Ngày tải lên : 19/02/2014, 18:20

... at the base of the loop and may interact with other residues in the adjacent b2 and b3 strands, affecting conformation and tightness of the loop Next to this phenylalanine, the arginine residue ... domain in the processing of membrane-tethered mucins The mechanism by which the heavily glycosylated portion of these molecules is released at epithelial surfaces within the airway, the intestine ... shown in bold PCR conditions were as described previously The fragments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR The remaining portions of the polylinker introduced...

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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf

Ngày tải lên : 07/03/2014, 03:20

... (D1MUT, D2R1, D2R2, D2R3) These experiments were performed to determine the in uence of the introduced mutations on the localization of the receptor proteins and the degree of their colocalization ... indicated basic region of ic3 of the D2 receptor and acidic region of the C-tail of the D1 receptor might be involved in the interactions between the two dopamine receptors In addition, the subcellular ... trafﬁcking properties The binding experiments also pointed to a decrease in the density of the D2R variants in the cellular membrane; the number of D2 receptor binding sites decreased with the number...

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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

Ngày tải lên : 08/03/2014, 08:20

... similarly in yeast and in adrenal cells; in the latter, Adxp and not Adrp limits the activity of CYP11A1 and hence controls the extent of pregnenolone production [14] Protein partners involved in the ... Igs against the following organelle marker proteins: 3-PGK for cytosol, Pma1p for the PM, the 40-kDa protein for the ER and porin for mitochondria The distribution of heterologous proteins was ... synthesis The well-characterized StAR protein is involved in the rapid transport of cholesterol to the inner mitochondrial membrane [11] In contrast, the factors and processes responsible for the...

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