quot nghien cuu phat trien cong nghe nhan dang tong hop va xu ly ngon ngu tieng viet quot

Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt

Ngày tải lên : 08/03/2014, 02:20

... considered to be driven largely by interactions of arginine residues from motif VI (QRxGRxGR) in domain with the phosphate groups of ATP [15] It appears highly unlikely that TBBT binding could ... lead to such structural changes Finally, surface regions where the sugar and triphosphate moieties of ATP bind are highly polar (data not shown) Consequently TBBT must inhibit the helicase by ... previously [30], with certain modiﬁcations The bacteria were collected by centrifugation (5000 g for h at °C) and disrupted by sonication in lysis buﬀer (100 mM Tris/HCl pH 7.5, 20% glycerol,...

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Báo cáo y học: "Lymphopenia and autoimmune diseases" pps

Ngày tải lên : 09/08/2014, 01:23

... significantly elevated in their non-diabetic firstdegree relatives Another argument against a causative role for lymphopenia in human autoimmune diseases derives from the observation that lymphopenia ... activation is regulated by specialized T-cell subsets In lymphopenic animals, homeostatic expansion is enhanced as a mechanism of compensation, resulting in spontaneous autoimmune phenomena Lymphopenia, ... autoreactive T cells Human autoimmune diseases and lymphopenia Lymphopenia is not uncommon in several human autoimmune diseases Reduced total lymphocyte counts are observed in rheumatoid arthritis,...

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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx

Ngày tải lên : 09/08/2014, 06:22

... intentionally controlled is of the utmost importance The thymic derivation of Treg is genetically as well as developmentally regulated, but it seems to be constitutive and relatively stable Recruitment ... from synovial fluid reportedly had a significantly higher suppressive activity than those in peripheral blood of RA patients Notably, despite the presence of these highly functional Treg in synovial ... the result of unchecked B lymphocyte activation and antibody production, probably due to uncontrolled T cell hyper-responsiveness Both Th1 and Th2 responses are elevated, as demonstrated by the...

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Báo cáo y học: "Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report" doc

Ngày tải lên : 11/08/2014, 17:21

... (ANA), which had formerly been negative five years prior and weakly positive in 2004 (Figure 1C), was now strongly positive (>1:1280, homogeneous) in association with elevated anti-doublestranded ... methylprednisolone, 500 mg daily for three days, and intravenous immunoglobulin, 30 g daily, was started for further renal deterioration Despite this, urgent haemodialysis was required on 27 July for marked ... mimic SLE both clinically and serologically; the presence of highly specific autoantibodies for SLE such as antiSmith, anti-dsDNA and anti-nucleosome antibodies, distinguishes SLE [2] In our...

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autoimmunity and autoimmune diseases

Ngày tải lên : 13/08/2014, 09:37

... Molecular mimicry (infectious agents appear similar to self antigens)  Polyclonal lymphocyte activation (endotoxins cause such activation independent of specific antigens)  Emergence of sequestered ... TDTH cells against self-antigens POLYCLONAL LYMPHOCYTE ACTIVATION  A number of viruses and bacteria can induce nonspecific polyclonal B-cell activation (G- bacteria, CMV, EBV) ⇓ inducing the ... either in local sites or systemically, leading to phagocytic and complement mediated damage Tissue damage is caused mainly by complement activation and release of lytic enzymes from neutrophils -...

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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

Ngày tải lên : 26/10/2012, 09:39

... continuous data was evaluated by the O’Brien test for homogenicity of variances When necessary, an appropriate normalizing or variance stabilizing transformation was applied Analysis of variance was ... and categorical variables for the predictors of SVR were compared by using logistic regression and multivariate analysis (categorical data) as displayed in Table In multivariate analysis, SVR was ... and multivariate analysis were performed to identify independent predictors for SVR Statistical significance was considered with P value of 0.05 Odds ratio (OR) with 95% confidence interval (CI)...

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Báo cáo y học: "Hepatitis C Virus (HCV) Infection and Hepatic Steatosis"

Ngày tải lên : 02/11/2012, 09:51

... with hepatitis C absolutely deserve the extra means available for weight loss, not only for cardiovascular health but also to reduce the risk of fibrosis and ultimately cirrhosis Patients with ... of only 5.9 kg and a reduction in BMI by only kg/m2 may account for a significant reduction in both steatosis and fibrosis progression in patients with hepatitis C [16] Thus, our more motivated ... centrilobular region which is more commonly seen in NAFLD [22] This all infers that the hepatitis C virus may be directly inducing steatosis in these patients rather than simply being an unrelated finding...

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Báo cáo y học: "Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection"

Ngày tải lên : 02/11/2012, 09:51

... 57.7%, respectively; intention-to-treat analysis) Of 16 baseline HBV viraemic patients, five (31.3%) achieved HBV SVR, which correlated negatively to HCV genotype non-1b and HCV SVR Only one (6.3%) ... men In a multivariable logistic regression model, the HCC risk was similar (OR16.7), with only HBsAg or with only anti-HCV HCC risk with dual HBsAg and anti-HCV (OR, 35.3) was nearly equal to that ... failure (FHF) was closely related to concurrent HBV 58 chronic infection The incidence of FHF in patients with underlying chronic HBV infection was 23.1% (9/39), which is significantly higher than in...

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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"

Ngày tải lên : 02/11/2012, 09:56

... Table shows the respective dynamic ranges of quantification of the currently available assays, i.e the HCV RNA intervals within which quantification is accurate in the corresponding assay HCV ... exceptional with the current third-generation EIAs, almost exclusively observed in profoundly immunodepressed patients, hemodialysis patients or agammaglobulinemic subjects [16, 17] In patients ... mg daily, based on body weight less than or greater than 75 kg (it has been recently suggested that the heaviest patients could even benefit from a higher ribavirin dose, up to 1,600 mg daily)...

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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"

Ngày tải lên : 03/11/2012, 11:11

... panuveitis, which recovered only after a combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme disease affected a 31 year-old ... described in the specific section Figure 1: Geographical location of the province of Parma (Italy) References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in...

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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx

Ngày tải lên : 20/02/2014, 01:20

... have previously shown that the recombinant HCV RNA polymerase efficiently replicates the 341 nt of the 3¢-end of the HCV minus-strand RNA in vitro and that deletion of the 3¢ 45 nt greatly impaired ... shown previously that the 3¢-end of the HCV minus-strand RNA is replicated highly efficiently in vitro by purified viral polymerase NS5B [17] This high level of RNA synthesis is associated with the ... 5¢-end Alternatively, the elimination of this less stably structured domain decreased RNA synthesis by increasing the relative amount of structured regions giving rise to templates poorly replicated...

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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C ppt

Ngày tải lên : 06/03/2014, 01:20

... hepatitis B vaccine, however, temporary supply problems occurred with this vaccine in 2008 (adult and dialysis formulations of Recombivax HB) and 2009 (pediatric formulations of Recombivax HB and ... adequate supply of the vaccine in adult and dialysis formulations, and CDC released doses of pediatric vaccine from its stockpile To prevent future supply problems of the hepatitis B vaccine, the ... NCHHSTP NEDSS NETSS NGO NHANES NIDU NVAC OB/GYN OMH OR PEI PHIN POS PPO PY QALY RCT RIBA RNA RSV SAMHSA SARS SEP STD STRIVE TB TCM USPHS USPSTF VA vCJD VFC WHO Inactivated polio virus Methadone...

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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C doc

Ngày tải lên : 06/03/2014, 01:20

... hepatitis B vaccine, however, temporary supply problems occurred with this vaccine in 2008 (adult and dialysis formulations of Recombivax HB) and 2009 (pediatric formulations of Recombivax HB and ... adequate supply of the vaccine in adult and dialysis formulations, and CDC released doses of pediatric vaccine from its stockpile To prevent future supply problems of the hepatitis B vaccine, the ... may create a barrier to vaccination for some people Private health insurance has gaps for vaccination coverage because it does not universally cover all ACIP-recommended vaccinations for children...

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Diagnosis, Management, and Treatment of Hepatitis C: An Update docx

Ngày tải lên : 08/03/2014, 14:20

... polyethylene glycol (PEG) covalently linked to the standard interferon alfa-2b molecule, and peginterferon alfa-2a (Pegasys, Hoffmann-La Roche, Nutley, NJ) with a 40-kd branched PEG covalently ... Children who are acutely infected with HCV, like adults, are generally asymptomatic, but they are more likely than infected adults to spontaneously clear the virus and are more likely to have normal ... subcutaneously once weekly or peginterferon alfa-2a, 135 ␮g subcutaneously once weekly, together with ribavirin, 200 to 800 mg per day in divided doses, starting with the low dose and increasing gradually...

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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf

Ngày tải lên : 16/03/2014, 21:20

... Chatzidionysiou, A.A Baranov, E.I Alexeeva, L.S Namazova-Baranova, T.M Bzarova, S.I Valiyeva, R.V Denisova, K.B Isayeva, A.M Chomakhidze, E.G Chistyakova, T.V Sleptsova, E.V Mitenko, E.I Zelikovich, ... Federation 357 A.A Baranov, E.I Alexeeva, L.S Namazova-Baranova, T.M Bzarova, S.I Valiyeva, R.V Denisova, K.B Isayeva, A.M Chomakhidze, E.G Chistyakova, T.V Sleptsova, E.V Mitenko, E.I Zelikovich, ... suspect diabetes, especially if there is one child in the family with diabetes Main manifestations are: polyuria, polydipsia, polyphagia, progressive cachexia, glucosuria, hyperglycemia, increasing...

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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C pdf

Ngày tải lên : 22/03/2014, 17:20

... with stakeholders to develop, coordinate, and evaluate innovative outreach and education programs Such programs should be offered in a variety of languages and should be integrated into existing ... monitor incidence and prevalence of hepatitis B and hepatitis C in populations not fully captured by core surveillance Immunization Through the years, the hepatitis B vaccine has been effective ... in vaccination rates Therefore, the committee recommends that all states mandate the hepatitis B vaccine series be completed or in progress as a requirement for school attendance Because only...

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Báo cáo sinh học: " Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus " docx

Ngày tải lên : 18/06/2014, 18:20

... anti-sense RNA probe using the SP6 RNA polymerase For RPA assays, approximately × 106 cpm of the 32P-labeled anti-sense probe was added to 25 μg of RNA sample and then vacuum dried Hybridization was performed ... Adobe Photoshop computer software Western Blot Analysis Cell lysates were prepared from replicon cells and examined for the expression of Jak-Stat signaling protein by Western blot analysis Antibodies ... examined using phosphorylation specific commercially available antibodies (Fig 7B) It was observed that phosphorylation of Stat1 and Stat2 was strongly inhibited in all interferon resistant replicons...

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Báo cáo sinh học: " Hepatitis B virus and hepatitis C virus in pregnant Sudanese women" pot

Ngày tải lên : 18/06/2014, 18:20

... Secondly the differences Table 1: Showing the univarite and multivarite analysis for the possible risk factors for HBV sAg among pregnant women Variables Univarite analysis Multivarite analysis ... sero-prevalence of HBV and HCV among pregnant Sudanese women Around 5% and less than one percent of these women had been found to be positive for HBVsAg and HCV respectively Interestingly, this prevalence ... age were not significantly different between the sero-positive and sero-negative women (data not shown) Table 1, showing the results of the univarite and multivariate analysis None of the expected...

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Báo cáo sinh học: " The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus-6 (HHV-6), and human immunodeficiency virus-1 (HIV-1) in a single human T-cell" docx

Ngày tải lên : 18/06/2014, 18:20

... separately infected with HIV-1 (data not shown) All three viruses could productively infect CEM cells The general procedure we used to produce triply-infected cells was to sequentially infect ... This has been reported previously for HHV-6A [10], and HIV-1 [11], and HCV [5] All three viruses are cytolytic, so triply infected CEM cultures lasted for approximately three weeks The HHV-6A infected ... triply-infected K7 cell TEM of triply-infected K7 cell HIV-1 particle budding from the plasma membrane (arrow) Figure Enlargements of triply-infected cell from Figure Enlargements of triply-infected...

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Báo cáo sinh học: " Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries," pdf

Ngày tải lên : 18/06/2014, 22:20

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