pi3k ampk akt and pi3k erk1 2 pathways

báo cáo hóa học: " Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia" potx

Ngày tải lên : 19/06/2014, 22:20

... Hepatology 20 11, 54:687-696 13 17 18 19 20 21 22 23 24 25 26 27 28 29 Suh HS, Choi S, Khattar P, Choi N, Lee SC: Histone deacetylase inhibitors suppress the expression of inflammatory and innate ... mTOR and/ or PI3K/ Akt enhances prostanoid production and that PI3K/ Akt, GSK-3 and mTOR differently regulate the expression of mPGES-1 and COX -2 in activated primary microglia Therefore, these pathways ... kinase B) isoforms and facilitates the phosphorylation of Akt1 , Akt2 or Akt3 at Thr308/309/305 and Ser273/474/4 72, respectively, by the phosphatidylinositol-dependent kinases and [2] The phosphorylation...

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báo cáo khoa học: " Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma" potx

Ngày tải lên : 10/08/2014, 10:21

... against phosphorylated ERK1/ 2 (phospho -ERK1/ 2) , phosphorylated Akt (phospho -Akt) , phosphorylated c-Jun N-terminal kinase 1 /2 (phospho-JNK1 /2) , ERK1/ 2, Akt, and JNK1 /2 (B) ERK1/ 2 and Akt activation in ... following antibodies: antiphospho -ERK1/ 2 (Thr2 02/ Tyr204), anti-phospho -Akt (Ser473), anti-phospho-JNK1 /2 (Thr183/Tyr185), antiERK1 /2, anti -Akt, and anti-JNK1 /2 (Cell Signaling Technology, Beverly, ... of and 10 μM mevastatin The survival rates on exposure to 1, 2. 5, 5, and 10 μM of fluvastatin were 63.37%, 53.71%, 25 .45%, and 24 .08%, respectively, at 72 h (Figure 2B) Thus, the number of U251MG...

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Báo cáo khoa hoc:" VEGF receptors on PC12 cells mediate transient activation of ERK1/2 and Akt: comparison of nerve growth factor and vascular endothelial growth factor" doc

Ngày tải lên : 11/08/2014, 08:20

... Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain J Cell Biol 20 01, 1 52: 123 3- 124 6 20 21 22 23 Kaplan DR, Miller FD: Signal transduction ... Neurosci 20 02, 22 :10 621 -10 626 Jin KL, Mao XO, Greenberg DA: Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia Proc Natl Acad Sci U S A 20 00, 97:1 024 2-1 024 7 Matsuzaki ... short-lived and relatively small effect on ERK1/ 2 and Akt VEGF-induced neuroprotective signaling via VEGFR -2, NRP1 and the two above-mentioned signaling cascades was shown in hypoxic and glucose-deprived...

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Báo cáo khoa học: Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells pdf

Ngày tải lên : 16/03/2014, 01:20

... ª 20 09 FEBS 327 5 NGF induces miR -22 1 and 22 2 expression 18 19 20 21 22 23 24 25 26 27 28 K Terasawa et al proapoptotic BH3-only BCL -2 family member, is critical for neuronal apoptosis Neuron 29 , ... predicted target site for miR -22 1 ⁄ 22 2 We found that overexpression of either miR -22 1 or miR -22 2 had no The present study has demonstrated that, in PC 12 cells, miR -22 1 and 22 2 are transcriptionaly ... either miR -22 1 or miR -22 2 resulted in signiﬁcant (P < 0.05) FEBS Journal 27 6 (20 09) 326 9– 327 6 ª 20 09 The Authors Journal compilation ª 20 09 FEBS K Terasawa et al NGF induces miR -22 1 and 22 2 expression...

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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx

Ngày tải lên : 29/03/2014, 08:20

... line and primary cortical neuron cultures J Biol Chem 27 5, 122 00– 122 06 FEBS Journal 27 7 (20 10) 22 29 ª 20 09 The Authors Journal compilation ª 20 09 FEBS ERK1 ⁄ in neuronal death S Subramaniam and ... as AD and PD, can be a direct target for ERK1 ⁄ Studies with FEBS Journal 27 7 (20 10) 22 29 ª 20 09 The Authors Journal compilation ª 20 09 FEBS 25 ERK1 ⁄ in neuronal death S Subramaniam and K Unsicker ... (20 09) Sustained activation of ERK1 ⁄ by NGF induces microRNA -22 1 and 22 2 in PC 12 cells FEBS J 27 6, 326 9– 327 6 33 Stanciu M & DeFranco DB (20 02) Prolonged nuclear retention of activated extracellular...

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Supply Chain Management Pathways for Research and Practice Part 2 ppt

Ngày tải lên : 19/06/2014, 15:20

... Management,5 (2) ,5 -22 Baltacioglu, T., Ada, E., Kaplan, M.D., Yurt, O and Kaplan, Y.C (20 07) A new framework for service supply chains The Service Industries Journal, 27 (2) , 105 -24 22 Supply Chain ... A G (20 08), "Supply chain management and suppliers ’HRM practice", Supply Chain Management: An International Journal 13/4 pp 25 9 26 2 Sánchez, A.M and Pérez, M.P., (20 01) “Lean indicators and manufacturing ... Production Management 16, pp 24 -41 Lee-Mortimer, A (20 06), "A lean route to manufacturing survival", Assembly Automation 26 /4, pp265 27 2 Lewis, M (20 00), “Lean production and sustainable competitive...

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Báo cáo hóa học: " Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells" docx

Ngày tải lên : 20/06/2014, 01:20

... MEK/ERK and protein kinase A in virus multiplicitation J Biol Chem 20 01, 27 6:38353-38360 Page of (page number not for citation purposes) Virology Journal 20 08, 5:110 18 19 20 21 22 23 24 25 26 27 28 ... and 10 days post infection and 100 μg of protein lysate immunoblotted to detect phosphorylated ERK1/ 2 (p -ERK1/ 2) , total ERK1/ 2 and hantavirus nucleocapsid protein N Bands were subjected to intensity ... multiplicity of infection of 0.01 for 14 and 25 days Cell lysates (50 μg protein) were immunoblotted for detection of phosphorylated ERK1/ 2 (p -ERK1/ 2) or total ERK1/ 2 (A) Bands were subjected to intensity...

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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt

Ngày tải lên : 20/06/2014, 07:20

... a pro- 18 19 20 21 22 23 24 25 26 27 28 29 30 31 tein kinase C-dependent mechanism Molecular and Cellular Endocrinology 1991, 80:11 -20 Hunzicker-Dunn M, Maizels ET: FSH signaling pathways in immature ... of bands after background subtraction and are relative to white (value 0) and black (value 25 6) The blots each show a single band for Akt and p -Akt at about 60 kDa and each show a double band ... double band for Erk and p-Erk at about 44 and 42 kDa Experiment Effects of LH in combination with PD98059 and/ or LY2940 02 on cell number and secretion of androstenedione and progesterone from...

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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc

Ngày tải lên : 20/06/2014, 07:20

... maturation medium at 10 mM and stored at -20 °C SB203580, LY2940 02 and U0 126 were dissolved in dimethylsulfoxide (DMSO) at 20 mM and 10 mM, respectively, and stored at -20 °C The final concentration ... FSH and LH for 2. 5 h; H89: COCs were cultured with FSH, LH and H89 for 2. 5 h; SB: COCs were cultured with FSH, LH and SB203580 for 2. 5 h; LY: COCs were cultured with FSH, LH and LY2940 02 for 2. 5 ... protein and activation protein (AP)-1 proteins to a distal novel cluster of Page of (page number not for citation purposes) Journal of Ovarian Research 20 09, 2: 20 25 26 27 28 29 30 31 32 http://www.ovarianresearch.com/content /2/ 1 /20 ...

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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx

Ngày tải lên : 09/08/2014, 01:22

... phospho-MAPK (ERK1/ 2) (Thr2 02/ Tyr204), p44/ 42 MAPkinase (ERK1/ 2) , and p27 Kip1 were from Cell Signaling Technology (Beverly, MA, USA) Polyclonal rabbit antibodies against rat p15 INK4b, p21 WAF1/Cip1 and ... 18 19 20 21 22 23 24 25 26 27 inflammatory response and early death Proc Natl Acad Sci USA 1993, 90:770-774 Abdel-Wahab N, Weston BS, Roberts T, Mason RM: Connective tissue growth factor and regulation ... c-Myc, phospho -ERK1/ 2, and total ERK1/ 2 were detected throughout the experimental period The right lane indicates the result of 24 h treatment with 10% FBS; c-Myc and phospho -ERK1/ 2 appear distinctly...

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Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway" ppt

Ngày tải lên : 09/08/2014, 08:23

... Research & Therapy 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Vol No Gao et al toid arthritis: up-regulation by interleukin-1beta and glucocorticoids Arthritis Rheum 20 04, 50:3118-3 128 Vergne-Salle ... ligand system in cartilage Arthritis Rheum 20 01, 44 :27 68 -27 76 Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, et al.: T-cell-mediated 20 21 22 ... peptides J Biol Chem 20 02, 27 7:8741-8748 Barr RK, Kendrick TS, Bogoyevitch MA: Identification of the critical features of a small peptide inhibitor of JNK activity J Biol Chem 20 02, 27 7:10987-10997...

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Báo cáo y học: "Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes" pot

Ngày tải lên : 12/08/2014, 14:21

... CA, USA), and reacted with antibodies to phospho-Thr2 02/ Tyr204 ERK1/ 2 and total ERK1/ 2, phospho-Ser 21 7 /22 1 MEK1 /2 and total MEK1 /2, phospho-Ser338 cRaf, phospho-Ser445 B-Raf, phosphoThr 423 -PAK1, ... analysis showing ERK1/ phosphorylation using phospho-Thr2 02/ Tyr204 ERK1/ 2 (P -ERK1/ 2) and total ERK1/ 2 (T -ERK1/ 2) antibodies (f) Immunofluorescence analysis showing minimal phospho -ERK1/ 2 in control ... antagonist (2 μM GGT 121 33) for 30 minutes is shown along with the assessment of Ras-dependent phospho-Thr2 02/ Tyr204 -ERK1/ 2 (P -ERK1/ 2) 10 and 30 minutes post-activation Anti-total ERK1/ IgG (T -ERK1/ 2) ...

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Báo cáo y học: "CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation" doc

Ngày tải lên : 12/08/2014, 16:20

... matrix expression, and contraction In vitro: Page 16 of 18 (page number not for citation purposes) Respiratory Research 20 06, 7: 42 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 differential ... LY2940 02 µM LTD4 20 ng/ml EGF EGF + LTD4 µM LTD4 basal 20 ng/ml EGF EGF + LTD4 basal C P-EGF-R EGF-R 50 µM LY2940 02 200 nM wortmannin + - + - - + - + µM LTD4 ng/ml EGF D P -ERK1/ 2 ERK2 50 µM LY2940 02 ... Biol 20 03, 525 :1-5 Halayko AJ, Amrani Y: Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma Respir Physiol Neurobiol 20 03, 137 (2 3) :20 9 -22 2 Hamid...

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Tài liệu ô tô Haynes Peugeot 205 (Phần Service And Repair Manual) (2).pdf

Ngày tải lên : 23/08/2012, 10:31

... Lệnh vát góc - Chamfer 22 7- Lệnh tạo chi tiết dạng vỏ - Solid Shell Sư Phạm Kỹ Thuật Hưng Yên 19 20 20 21 22 Khoa Cơ Khí Hội sử dụng phần mềm ... 23 9- Lệnh tạo mặt nghiêng khối - Draft solid faces 23 10Các lệnh logíc cộng, trừ, hòa khối 24 11Lệnh Solid layout 24 12Làm việc với menu quản lý khối: 26 ... 26 IV Biên tập vẽ: 27 13Biên tập kích thước 27 14Làm việc với lớp: 28 15Làm việc với công cụ lệnh dấu đối tượng 29 Phần III: LẬP TRÌNH GIA CÔNG CNC...

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Dictionary Of Financial And Business Terms (2)

Ngày tải lên : 05/10/2012, 08:22

... based on profitability and is taxable as income A cash distribution may include capital gains and return of capital in addition to the dividend 22 Dictionary of Finantial and Business Terms Lico ... written Demand deposits Checking accounts that pay no interest and can be withdrawn upon demand Demand line of credit A bank line of credit that enables a customer to borrow on a daily or on-demand ... Also known as The Exchange More than 2, 000 common and preferred stocks are traded Founded in 17 92, the NYSE is the oldest exchange in the United States, and the largest It is located on Wall...

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Unit 12: Sports and Pastimes. Lessons 2

Ngày tải lên : 21/06/2013, 01:27

... kites they don’t have a tent They always walk to school and they are never late They always their homework They often go to the park Ba and Lan sometimes They go about twice a week go to the ... their kites they don’t have a tent They always walk to school and they are never late They always their homework Statements Ba and Lan go to the zoo three times a year They usually go to the ... Monday Tuesday Wednesday Thursday Friday Saturday * Ba and Lan sometimes go to the zoo * They are never late for school Exercise: She plays plays soccer...

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Tieng anh 7; Unit 9 At home and away- leson 2

Ngày tải lên : 28/09/2013, 06:10

... Souvenir shop d 2- Eating fish and crabs c 3- Going to the aquarium b 4- Seeing sharks, dolphins, turtles and many colorful fish a 5- Buying a cap e Souvenir shop 12- Eating fish and crabs 3- Going ... went to a food stall Mr and Mrs Robinson ate fish and crab and Liz ate noodles - Learning irregular verbs : (be / go / see / eat / take / buy / think) - Reading the text A2 and answering the questions ... turtles and many colorful fish b Buying a cap d a- Her parents went to the aquarium with her b- They saw sharks, dolphins, turtles and many different types of fish c- They bought a cap and a poster...

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GRIMM’S FAIRY TALES-THE ADVENTURES OF CHANTICLEER AND PARTLET (PART 2)

Ngày tải lên : 20/10/2013, 06:15

... by the great nut, and lay quite dead, and never moved any more Then Chanticleer was very sorry, and cried bitterly; and all the beasts came and wept with him over poor Partlet And six mice built ... the bough where it hung, and brought it to the bride; and then the bride gave him the silken cord, and he took the silken cord to the river, and the river gave him water, and he carried the water ... mountain, and will be choked by a great nut.’ But the bride said, ‘Run first, and bring me my garland that is hanging on a willow in the garden.’ Then Chanticleer ran to the garden, and took the garland...

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Tasks And Functions part 2

Ngày tải lên : 24/10/2013, 15:15

... 32bit shifted value Parity calculation Let us discuss a function that calculates the parity of a 32- bit address and returns the value We assume even parity Example 8-7 shows the definition and ... //input [7:0] addr_bus; //Constant function function integer clogb2(input integer depth); begin for(clogb2=0; depth >0; clogb2=clogb2+1) depth = depth >> 1; end endfunction endmodule 8.3.5 Signed ... ram ( ); parameter RAM_DEPTH = 25 6; input [clogb2(RAM_DEPTH)-1:0] addr_bus; //width of bus computed //by calling constant //function defined below //Result of clogb2 = //input [7:0] addr_bus; ...

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