ova induced inflammation and corticosteroid treatment in 6 weeks ad5 infected guinea pigs

Báo cáo y học: " Angiogenesis in Interstitial Lung Diseases: a pathogenetic hallmark or a bystander?" potx

Ngày tải lên : 12/08/2014, 16:20

... Research 20 06, 7:82 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin -induced pulmonary fibrosis J Immunol 1999, 162 :5511-5518 ... Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases J Allergy Clin Immunol 2001, 107 :66 4 -67 0 Katoh S, Fukushima ... ligands inhibit angiogenesis, CXCR3 ligands play a pivotal role in orchestrating Th1 cytokine -induced cellmediated immunity via the recruitment of mononuclear and CD4+ T-cells expressing CXCR3 and...

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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf

Ngày tải lên : 18/02/2014, 11:20

... Neuron 16, 67 5 68 6 Papadopoulos MC & Verkman AS (2007) Aquaporin-4 and brain edema Pediatr Nephrol 22, 778–784 Girouard H & Iadecola C (20 06) Neurovascular coupling in the normal brain and in hypertension, ... possible, in which pericytes induce and guide vessel sprouting In the developing human brain, migrating pericytes are found in front of growing vessels and pericyte-driven angiogenesis participates in ... origin [78] According to the monocyte hypothesis, during embryogenesis, and even in adults, migrating monocytes enter the brain via blood vessels and then differentiate into certain types of brain...

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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

Ngày tải lên : 18/02/2014, 11:20

... encoded in the human genome In addition, VEGF-E encoded in the Orf virus binds and activates only VEGFR-2 Anti-(VEGF-A) IgG and aptamer, as well as VEGFR tyrosine kinase inhibitors (multikinase inhibitors) ... phase: within 15 min) FEBS Journal 2 76 (2009) 463 6– 464 3 ª 2009 The Author Journal compilation ª 2009 FEBS 463 7 Therapeutic aspects of VEGF in brain diseases M Shibuya and neuropilin-1 [2] VEGF-A ... VEGF-D, binds and activates this receptor, resulting in the proliferation and migration of lymph ECs and lymphangiogenesis [13] Angiogenesis in brain diseases Brain stroke Stroke is induced through:...

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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx

Ngày tải lên : 18/02/2014, 11:20

... angiogenesis in tumor cell systems [66 ,67 ] Whether similar pathways are activated in cerebral neurovascular repair and remodeling remains to be determined, but given the emphasis on targeting JNK in acute ... volume and severity of infarcts and the absolute number of circulating CD34+ and CD133+ cells (both thought to be markers for EPCs) [69 ] In clinical stroke patients, an increase in circulating EPCs ... barrier leakage in the ischemic brain J Clin Invest 1 06, 829–838 Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A & Greenberg DA (2003) VEGF -induced neuroprotection, neurogenesis, and angiogenesis...

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Báo cáo khoa học: Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma ppt

Ngày tải lên : 07/03/2014, 05:20

... these include angiostatin, endostatin, tumstatin, PEDF, SPARC (secreted protein, acidic and rich in cysteine), tissue inhibitor of metalloproteinases (TIMPs) and TSP1 An emerging concept is to view ... of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis Cancer Res 66 , 1313–1319 Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown ... + +++ ++ In contrast, HNK and RCC cell lines differed in their ability to induce angiogenesis Conditioned media (CM) from P 769 and other RCC cell lines were potently angiogenic in rat and mouse...

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Báo cáo khoa học: Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization pot

Ngày tải lên : 30/03/2014, 11:20

... alcohol-associated increase in CNV size we measured the levels of 14 06 cyclin E and cyclin E ⁄ CDK2 by western blot in alcohol-fed rats We found a 3.0-fold increase in cyclin E and cyclin E ⁄ CDK2 levels in ... p27Kip, a cyclin kinase inhibitor Thus, the increased expression of cyclin E and cyclin E ⁄ CDK2 appeared to be the result of increased production and not decreased cyclin kinase inhibition Studies ... peroxidase and then rinsed well in NaCl ⁄ Pi The slides were rinsed and incubated for 20 with serum from the same species as the origin of secondary antibody for blocking nonspeciﬁc binding After rinsing,...

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Báo cáo toán học: " A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy" potx

Ngày tải lên : 20/06/2014, 20:20

... (RE) and corticothalamic (CT) projection cells, along with local inhibitory interneurons in cortex (IN) In this model, SWDs are initiated and terminated by slow timescale currents in TC cells In ... through nonlinear brain modeling and bifurcation analysis Cereb Cortex 20 06, 16: 12 961 313 11 Wendling F, Hernandez A, Bellanger JJ, Chauvel P, Bartolomei F: Interictal to ictal transition in human ... initiation and termination and of inter-ictal dynamics is certainly not applicable to the case of absence seizures occurring during the waking state Other models, such as the mean-eld model introduced...

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báo cáo hóa học:" A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy" pptx

Ngày tải lên : 21/06/2014, 17:20

... (RE) and corticothalamic (CT) projection cells, along with local inhibitory interneurons in cortex (IN) In this model, SWDs are initiated and terminated by slow timescale currents in TC cells In ... through nonlinear brain modeling and bifurcation analysis Cereb Cortex 20 06, 16: 12 961 313 11 Wendling F, Hernandez A, Bellanger JJ, Chauvel P, Bartolomei F: Interictal to ictal transition in human ... initiation and termination and of inter-ictal dynamics is certainly not applicable to the case of absence seizures occurring during the waking state Other models, such as the mean-eld model introduced...

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Báo cáo y học: "Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study" ppt

Ngày tải lên : 09/08/2014, 01:23

... ± 19* CD3 synovium 83 ± 46 14 ± CD68 intimal lining layer 67 ± 27 47 ± 27 CD68 synovial sublining 112 ± 46 36 ± 18 Epidermal counts represent positive cells/mm Dermal and synovial counts are shown ... effects of infliximab It is known from clinical experience that after weeks of infliximab therapy a beneficial clinical effect can be observed in both skin lesions and inflamed joints in PsA In addition, ... Two weeks after the first infusion of infliximab a significant and clinically relevant decrease in DAS was observed At week 16 the mean DAS was 3 .6 ± 0 .6, as compared with 6. 0 ± 0.5 at baseline...

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Báo cáo khoa học: "Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study." pdf

Ngày tải lên : 09/08/2014, 09:20

... 1999, 38:829-838 doi:10.11 86/ 1748-717X -6- 66 Cite this article as: Riesterer et al.: Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic ... obtained by dividing NGD in mice treated with PTK787 plus IR by the AGD in mice treated with IR alone Riesterer et al Radiation Oncology 2011, 6: 66 http://www.ro-journal.com/content /6/ 1 /66 Page ... density in response to the Riesterer et al Radiation Oncology 2011, 6: 66 http://www.ro-journal.com/content /6/ 1 /66 different treatment modalities, aCD31-stained tumor vessels were counted in histological...

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Báo cáo y học: "Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis Peter Ahnert and Holger Kirsten" pps

Ngày tải lên : 09/08/2014, 10:21

... arthritis, including covariates Arthritis Rheum 2004, 50:2757-2 765 Horton MA: The αv β3 integrin ‘vitronectin receptor’ Int J Biochem Cell Biol 1997, 29:721-725 Ruegg C, Mariotti A: Vascular integrins: ... in one cohort but not in another and may appear with smaller effect size in large, multi-center cohorts Competing interests In a recent hypothesis-free, genome-wide association study for RA in ... European ancestries Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct...

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Báo cáo y học: "Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study" pptx

Ngày tải lên : 09/08/2014, 13:22

... mediate vascular inflammation in predisposed individuals In patients with inflammatory abdominal aortic aneurysms, active smoking and female gender were associated with high-grade tissue inflammation ... role in aortic wall compliance by regulating the elastin/collagen activity [12-14] 17-β-Estradiol increases the elastin/ collagen ratio, reflecting an increase in distensibility of aorta and consequently ... selected and unselected controls (P = 0 .61 ) Acute-phase reactants The pre-operative ESR and CRP measurements in the cases and controls are presented in Table ESR was determined in 13 cases and 22...

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Báo cáo y học: " Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy" pps

Ngày tải lên : 11/08/2014, 03:20

... fibrosis [ 56] Proinflammatory cytokines in urinary obstruction TNF-α and IL-1 The prototypical pro-inflammatory cytokines, TNF-α and interleukin-1 (IL-1), play a major role in the recruitment of inflammatory ... function in ureteral obstruction in rats Kidney Int 2004, 66 :1 365 -1375 Chevalier RL: Promise for gene therapy in obstructive nephropathy Kidney Int 2004, 66 :1709-1710 Grande et al Journal of Inflammation ... in leukocyte recruitment after UUO Selectins Selectins and their ligands mediate the initial contact between circulating leukocytes and the vascular endothelium resulting in capture and rolling...

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Báo cáo y học: "Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy" pptx

Ngày tải lên : 11/08/2014, 06:22

... fibrosis [ 56] Proinflammatory cytokines in urinary obstruction TNF-α and IL-1 The prototypical pro-inflammatory cytokines, TNF-α and interleukin-1 (IL-1), play a major role in the recruitment of inflammatory ... function in ureteral obstruction in rats Kidney Int 2004, 66 :1 365 -1375 Chevalier RL: Promise for gene therapy in obstructive nephropathy Kidney Int 2004, 66 :1709-1710 Grande et al Journal of Inflammation ... in leukocyte recruitment after UUO Selectins Selectins and their ligands mediate the initial contact between circulating leukocytes and the vascular endothelium resulting in capture and rolling...

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Báo cáo y học: "CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis" ppt

Ngày tải lên : 11/08/2014, 08:21

... the inflammatory cells including neutrophils, macrophages, eosinophils and T lymphocytes (TLs) in the modulation of tissue injury in IPF [5-8] Recently, we shown that in IPF tissue, infiltrating ... paucity of interstitial inflammation, the role of inflammatory response in the modulation of tissue injury and fibrosis still remains under investigation [19,20] In the present study among all inflammatory ... Journal of Inflammation 2007, 4:14 study and has given final approval of the version to be published CR contributed in the coordination of all investigators and has given final approval of the...

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Báo cáo y học: " Hemoglobin a and b are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD" potx

Ngày tải lên : 12/08/2014, 11:22

... higher in the control than in the IPF lungs (1 .6 fold) in the standard Western blot In addition, the levels of Hbb complexes were higher in the standard and nonreducing Western blots (4 .6 and 5.1 ... significance of Hb and its subchains have not been investigated in lung diseases In this study, Hba and Hbb monomers and complexes were investigated in more detail in normal lung and lung specimens ... USA 1999, 96: 664 3 -66 47 Wride MA, Mansergh FC, Adams S, Everitt R, Minnema SE, Rancourt DE, Evans MJ: Expression profiling and gene discovery in the mouse lens Mol Vis 2003, 9: 360 -3 96 Bhaskaran...

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Báo cáo y học: " Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis" pdf

Ngày tải lên : 12/08/2014, 11:22

... PDE6C, PDE6D, PDE6G and PDE6H mRNAs were expressed in the human lung PDE6A, PDE6B, PDE6C and PDE6G showed no significant alterations in the IPF lungs as compared to donor lungs In contrast, PDE6D ... for PDE6A (~105 kDa), PDE6B (~105 kDa), PDE6D (~17 kDa) and PDE6G/H (~11 kDa) subunits PDE6A and PDE6B blocking peptide studies were carried out to reconfirm the specificity of PDE6A and PDE6B immunoreactivity ... drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors Invest Ophthalmol Vis Sci 2005, 46( 9):3 060 -3 066 38 Wan KF, Sambi BS, Frame M, Tate R, Pyne NJ: The inhibitory...

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Báo cáo y học: " Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis" pdf

Ngày tải lên : 12/08/2014, 14:20

... clinical parameters examined and the CCL22 and CCL17 levels in BAL fluid We next examined the correlation of the BAL fluid chemokines with indices of lung function tests in IPF patients An inverse ... chemokine CCL22 are members of the CC chemokine family, and CCR4 was identified as their specific receptor [5 ,6] CCL17 and CCL22 have been recognized as Th2 chemokines, and their involvement in ... Characteristics and Lung Functions Sar CVD-IP HV Male/female 18/1 3/3 3 /6 6/0 Age (range) 67 .0 ± 1.9 (48-83) 58.5 ± 23.2 (24- 76) 59.4 ± 14.8 (33- 76) N.D (20-24) Smoker 16* † 6* PaO2/FIO2 Histological and...

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Báo cáo y học: " Growth factors in idiopathic pulmonary fibrosis: relative roles" ppt

Ngày tải lên : 12/08/2014, 18:20

... Binding of TNF-α to TNF-α receptor (TNF-αR) activates the cyclooxygenase-2 (COX-2) pathway and induces synthesis of prostaglandins including prostaglandin E2 (PGE2) and 6- keto-prostaglandin F1α ... appears to slow progression of IPF when administered to patients [15] Insulin-like growth factor-1 and insulin-like growth factor-binding proteins Insulin-like growth factor-1 (IGF-1) stimulates ... useful in vitro properties of inhibiting Fas-mediated epithelial cell apoptosis and inducing fibroblast apoptosis, and is currently undergoing clinical trials in Mexico However, preliminary results...

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Báo cáo y học: "Objective cough frequency in Idiopathic Pulmonary Fibrosis" pot

Ngày tải lên : 13/08/2014, 10:20

... distressing and disabling symptom in patients suffering from IPF Currently treatment is not effective and a larger study, including longitudinal data, is needed to investigate the underlying mechanisms, ... manuscript KH and AH both contributed to data collection, analysis and interpretation ALK, KH and AH were involved in drafting and revising the manuscript JAS and JEE were both involved in the study ... design and conception They were also involved in the analysis and interpretation of the data and had substantial input regarding the drafting and revision of the manuscript All authors have read and...

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