microtubule associated protein1 light chain 3 map1lc3 abnormal mitochondria and decreased expression of superoxide dismutase sod 2 in elcs

Báo cáo y học: " Simvastatin inhibits TGFb1-induced fibronectin in human airway fibroblasts" ppsx

Ngày tải lên : 12/08/2014, 14:20

... FTI -27 7 (Figures 3A and 3B) These findings indicate a predominant involvement of GGT1, but not FT, in the TGFb1-induced profibrotic response of human airway fibroblasts In line with these findings, ... anti-inflammatory effects of statins in murine and rat models of allergic asthma [ 32 ,33 ] and COPD [11, 12] Moreover, statins reportedly suppress ex vivo airway responsiveness in animal models [34 ,35 ] ... et al: Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer J Clin Oncol 20 00, 18: 927 -941 22 Standards for the diagnosis and care of patients with...

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Báo cáo y học: " TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by " pot

Ngày tải lên : 12/08/2014, 14:20

... purposes) Respiratory Research 20 09, 10:100 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z: TGF-beta1 induces human alveolar epithelial ... myofibroblasts in asthma J Immunol 20 03, 171(1) :38 0 -38 9 Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH: Bone marrowderived progenitor cells in pulmonary fibrosis J Clin Invest 20 04, 1 13( 2) :2 43- 25 2 Iwano ... Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma Thorax 20 02, 57(4) :30 9 -31 6 http://respiratory-research.com/content/10/1/100 33 34 35 36 37 38 39 40...

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Báo cáo khoa học: Expression and physiological role of CCN4⁄Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes potx

Ngày tải lên : 07/03/2014, 10:20

... (CCN3) regulation in the growth plate and CCN FEBS Journal 27 4 (20 07) 1655–1665 ª 20 07 The Authors Journal compilation ª 20 07 FEBS T Yanagita et al 19 20 21 22 23 24 25 family member expression in ... proliferation and differentiation, but CCN4 splicing variants in chondrocytes 26 27 28 29 30 31 32 33 34 not hypertrophy of cultured articular chondrocytes J Cell Physiol 1 92, 55– 63 Rachfal AW ... CCN2 ⁄ CTGF, thus result in increased proteoglycan synthesis [22 , 23 ] Moreover, rCCN2 ⁄ CTGF effectively increased both the ALPase activity and the matrix calciﬁcation of RGC cells [24 ,25 ] In...

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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx

Ngày tải lên : 16/03/2014, 18:20

... Tissue inhibitor of metalloproteinases -3 (TIMP -3) is an extracellular matrix -associated protein with a distinctive pattern of expression in mouse cells and tissues J Biol Chem 26 9, 935 2 936 0 26 Qin ... containing the corepressors N-CoR and SMRT [34 ,36 ] Phosphorylation by JNK causes a reduction in c-Jun ubiquitination and FEBS Journal 27 2 (20 05) 19 12 1 926 ª 20 05 FEBS HDAC inhibitors and Timp-1 expression ... sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene J Biol Chem 27 4, 22 197 22 207 Norman JT, Clark...

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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf

Ngày tải lên : 12/08/2014, 14:20

... of transforming growth Page of (page number not for citation purposes) Respiratory Research 20 09, 10 :36 20 21 22 23 24 25 http://respiratory-research.com/content/10/1 /36 factor-beta (1) and interferon ... Foundation of China (30 500 23 2 ); the Specialized Research Fund for the Doctoral Program of Higher Education (20 060159006); and the Liaoning Provincial Natural Science Foundation (20 0 721 02) 18 19 ... USA) at 37 °C, in 5% CO2 To detect quantities of TGF-β1 in BALF, CCL-64 cells were plated at × 1 03 cells/well in 96-well plates and cultured in FBS-free DMEM at 37 °C in 5% CO2 for h Ten μl of untreated...

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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"

Ngày tải lên : 25/10/2012, 11:10

... a 180 .25 ±111. 82 b Diabetic treated group 29 4. 13 89.97a 20 8. 13 76. 43 170.00±76.91 1.5h 98 .38 24 .44 150. 13 56. 23 2h 93. 88 30 .70 130 . 63 47.67c 2. 5h 76.75 33 .01 92. 63 46.12d 3h 75 .38 34 .99 87.88±46.76 ... 0h 131 .75±15.50 Blood glucose (mg/dl) 0.5h 1h 127 . 63 12. 68 104.75 20 .55 Diabetic control group 30 0. 63 104.69a 24 4. 13 107.03b 22 2.75±104.81 b 20 1 .38 ±91.64 b 20 9.50±87.61 a 2 03. 75±100 .30 a 180 .25 ±111. 82 ... Science Foundation of China (No: 30 671007, 30 300165) and the grant from the Traditional Chinese Medicine Administration of Zhejiang Province, China (No: 20 10ZB075) 20 9 10 11 12 13 14 15 16 17 Chen...

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Báo cáo khoa học: Regulatory feedback loop between NF-jB and MCP-1-induced protein 1 RNase pdf

Ngày tải lên : 29/03/2014, 22:21

... F2-R2, F3-R2 and F4-R2 (Fig 3) , containing the first exon of the ZC3H12A gene, first intron and first three codons of the ZC3H12A coding sequence, were prepared with F2, F3, F4 and R2 primers and ... Community’s FP6: MTKD-CT -20 06-0 425 86 and LSHM-CT -20 06 036 9 03 and Polish Ministry of Scientific Research and Information Technology: 63 ⁄ 6PR-UE ⁄ 20 07 ⁄ and 33 9 ⁄ 6PR-UE ⁄ 20 07 ⁄ 5904 References ... constructs (F2-R4, F2-R6, F2-R7 and F2-R8, Fig 3) were prepared in a two-step manner First, the F2-R2 promoter region was cloned into the pGL4.17[luc2 ⁄ Neo] vector using F2 and R2 primers and XhoI...

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báo cáo hóa học: " Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors" ppt

Ngày tải lên : 19/06/2014, 22:20

... 19 20 21 22 23 24 25 26 27 28 29 30 31 32 Griffin WS, Yeralan O, Sheng JG, Boop FA, Mrak RE, Rovnaghi CR, Burnett BA, Feoktistova A, Van Eldik LJ: Overexpression of the neurotrophic cytokine ... role of cytokines in the pathophysiology of epilepsy Brain Behav Immun 20 08, 22 :797-8 03 Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, 3rd, Araoz C: Brain interleukin and ... aging, the brain shows increased microglial activation and expression of IL-1 [21 ], as well as neuronal expression of both ApoE and βAPP [35 ] The ability of IL-1β to induce βAPP expression [30 ,...

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Báo cáo y học: "α Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism" pps

Ngày tải lên : 09/08/2014, 01:23

... 1999, 1 32 4 : 32 80 - 32 93 Cheshire JL, Williams BRG, Baldwin AS Jr: Involvement of 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 double-stranded RNA-activated protein kinase in the synergistic ... resulted in a small, but not significant, increase in levels of proMMP -2 and active MMP -2 in the media C2-ceramide-induced regulation of MMP -2 is abrogated by inhibition of PKR R48 To determine a ... increases levels of MT1-MMP (data not shown) The increased expression and activation of MMP -2 and -9, induced by C2-ceramide treatment of chondrocytes, is a novel finding and the significant inhibitory...

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Báo cáo y học: "Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs" pdf

Ngày tải lên : 09/08/2014, 10:23

... time-dependent gene expression patterns and involves Page 12 of 13 (page number not for citation purposes) 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 intracellular calcium and cyclic ... II in constructs cultured under free-swelling conditions in the presence and absence of the p38 MAPK inhibitor SB2 035 80 In the absence of the cytokine, the expression levels of iNOS and COX -2 ... increase in the expression levels of both iNOS and COX2 (Figure 2) COX -2 expression appeared to be more sensitive to the cytokine and to the presence of SB2 035 80 (Figure 2b), suggesting that COX -2 activation...

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Báo cáo y học: "Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 14:22

... day in splenocytes of mice with GPI-induced arthritis (Figure 2c, left panel) In the joints of the same mice, upregulation of TIARP mRNA and protein was noted at days 14 and 28 , and the expression ... expressed mainly in CD11b+ cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied by joint swelling), especially in hyperplastic synovium Overexpression of the human ... arthritis Serial changes in TNFα concentrations in (a) serum and (b) arthritic joints and (c) TIARP mRNA and protein expression in spleens (left and middle panels) and arthritic joints (right panel)...

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Báo cáo y học: " Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats" docx

Ngày tải lên : 10/08/2014, 05:21

... washed in PBS, incubated in biotinylated secondary antibody for 60 min, washed again in PBS, and then incubated in an avidin-rich solution for 60 After a final wash, positive biotin-avidin binding ... Patterson C: Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins J Clin Invest 20 07, 117 : 32 11 - 32 23 Sharma S, Ying J, Razeghi P, ... implicated in skeletal muscle catabolic conditions and in the development of cardiac fibrosis [29 ,30 ] Interstitial and myocardial fibrosis has been reported in HIV-infected patients [31 , 32 ], and while...

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báo cáo khoa học: " Rice Hypersensitive Induced Reaction Protein 1 (OsHIR1) associates with plasma membrane and triggers hypersensitive cell death" potx

Ngày tải lên : 11/08/2014, 11:21

... categories in plants Trends Plant Sci 20 05, 10:117- 122 22 23 24 25 26 27 Giuliani C, Consonni G, Gavazzi G, Colombo M, Dolfini S: Programmed cell death during embryogenesis in maize Ann Bot 20 02, 90 :28 7 -29 2 ... member of the Band 7-domain-containing proteins (Figure 1) Many of these proteins are lipid raft -associated and may cluster to form membrane micro-domains, and in turn recruit multi-protein complexes ... pollination-induced petal senescence in petunia Plant Physiol 20 00, 122 : 1 32 3- 133 4 Cacas JL: Devil inside: does plant programmed cell death involve the endomembrane system? Plant Cell Environ 20 10,...

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Báo cáo y học: "Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF)" pdf

Ngày tải lên : 12/08/2014, 11:22

... actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts J Cell Biol 19 93, 122 (1):1 03- 111 36 Yamauchi K, Inoue H: Airway remodeling in asthma and ... ALK2 J Biol Chem 1998, 2 73( 40) :25 628 -25 636 52 Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH: Inhibition of allergen-induced airway remodeling in Smad 3- deficient mice J Immunol 20 07, ... by transforming growth factorbeta1-induced release of extracellular fibroblast growth factor -2 and phosphorylation of p38 MAPK and JNK J Biol Chem 20 05, 28 0( 52) : 430 00- 430 09 10 Jinnin M, Ihn H,...

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Báo cáo y học: " Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication" ppsx

Ngày tải lên : 13/08/2014, 05:21

... representation of pEGFP-N3 vector containing pre-miR29a and 29 b (B) Expression of hsa-mir -29 a and 29 b confirmed by quantitative real-time PCR Data show the expression levels of mir -29 a and 29 b from ... stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR 93 expression Immunity 20 07, 27 :1 23 - 134 Matskevich AA, Moelling K: Dicer is involved in protection against influenza ... 20 07, 27 : 435 -448 21 22 23 24 25 26 27 28 29 30 Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, Saïb A, Voinnet O: A cellular microRNA mediates antiviral defense in human cells...

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Báo cáo y học: " Distinct expression profiles of TGF-β1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infections" pot

Ngày tải lên : 13/08/2014, 09:20

... transforming growth factor http://www.retrovirology.com/content /3/ 1 /37 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 beta signaling through interaction with CREB-binding protein/p300 Blood 20 01, ... http://www.retrovirology.com/content /3/ 1 /37 smad4 smad3 smad7 104 * 101 10-1 21 28 28 16 21 13 1 10 BI BI 28 28 21 21 13 16 10 BI BI 28 28 21 21 13 16 10 10 -3 10 -2 BI 104 1 03 1 02 AGM Relative expression 1 02 MAC 1 03 * 101 ... Retrovirology 20 06, 3: 37 http://www.retrovirology.com/content /3/ 1 /37 16 21 28 28 BI BI 1 3 28 6 1 3 8 10 10 * 13/ 16 21 13 13 13/ 16 16 21 21 28 28 BI 3 28 6 AGM MAC il-10 BI 16 21 28 10 10 6 8 BI gata -3 BI...

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Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc

Ngày tải lên : 18/02/2014, 14:20

... (LSHM-CT -20 06- 036 9 03, MTKD-CT -20 06-0 425 86 and COST Action BM06 02) and by the Polish Ministry of Scientiﬁc Research and Information Technology (2 P05A01 127 , 63 ⁄ 6PRUE ⁄ 20 07 ⁄ and 33 9 ⁄ 6PR-UE ⁄ 20 07 ... (D141, E185, D 226 , D244) in PIN domains involved in binding Mg2+ ions are conserved in all three sequences Other conserved residues are R2 63, V 139 and N144 Determination of the MCPIP domain architecture ... equivalent levels of IL-1beta MCPIP protein as an RNase 19 20 21 22 23 24 25 26 27 28 mRNA show unequal IL-1beta protein accumulation but similar polyribosome proﬁle J Immunol 1 53, 27 7– 28 6 Dinarello...

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Tài liệu Báo cáo khoa học: Transduced human PEP-1–heat shock protein 27 efﬁciently protects against brain ischemic insult pptx

Ngày tải lên : 18/02/2014, 17:20

... effects of PEP-1–HSP27 against brain ischemia 20 21 22 23 24 25 26 27 28 29 30 31 Cu,Zn -superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells FEBS Lett 485, 1 63 167 ... against brain ischemia 32 33 34 35 36 37 38 39 40 J J An et al damage in different brain regions following transient cerebral ischemia in gerbils Neurosci Res 41, 23 3 24 1 Wang Q, Sun AY, Simonyi ... prostaglandins and cytokines [34 36 ] Ionized calciumbinding adaptor molecule (iba-1) is a calcium-binding protein that is speciﬁcally expressed in microglia in the brain and plays an important role in...

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Báo cáo khoa học: Adipophilin protein expression in muscle – a possible protective role against insulin resistance pot

Ngày tải lên : 06/03/2014, 09:22

... Journal 27 7 (20 10) 761–7 73 ª 20 09 The Authors Journal compilation ª 20 09 FEBS 771 Adipophilin protein expression in muscle 20 21 22 23 24 25 26 27 28 29 30 7 72 J de Wilde et al regulation of human ... 12 21 )2. 49 )2. 16 0. 036 0. 024 Phb Tbb5 Tuba1c Hspd1 68 86 69 67 24 29 22 28 12 1.64 )1.69 )2. 26 2. 40 0. 028 0.0 43 0.045 0.001 Anxa1 Pgk1 Eno1 Aldoa Hspa8 Vdac1 64 64 90 72 106 91 29 28 48 35 25 ... E, Mensink M & Hesselink MK (20 09) Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid 31 32 33 34 35 36 37 38 39 40 41 accumulation and type...

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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx

Ngày tải lên : 15/03/2014, 11:20

... pcDNA3.1-myc-TSC1 ( 12 133 ), pcDNA3-Flag-TSC2 (14 129 ), pcDNA3-Flag-TSC2-S 939 A (14 1 32 ), pcDNA3Flag-TSC2-T1462A (14 130 ) and pGEX-2TK-14 -3- 3 beta FEBS Journal 27 7 (20 10) 21 80 21 91 ª 20 10 The Authors ... gene products, 21 90 17 18 19 20 21 22 23 24 25 26 27 28 Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb Curr Biol 13, 125 9– 126 8 Gao X, Zhang ... TSC2 distribution with IGF-1 stimulation M Miyazaki et al 29 30 31 32 33 its interaction with 14 -3- 3 J Biol Chem 27 8, 136 63 136 71 Liu MY, Cai S, Espejo A, Bedford MT & Walker CL (20 02) 14 -3- 3 interacts...

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