dose response or dose effect curves in in vitro experiments and their use to study combined effects of neurotoxicants

Tài liệu Báo cáo " Changing of shoreline during the Late Quatemary in relationship with geodynamics and their affect to the coastal environment of the Red River " docx

Ngày tải lên : 13/02/2014, 12:20

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Báo cáo hóa học: "Research Article Novel Heuristics for Cell Radius Determination in WCDMA Systems and Their Application to Strategic Planning Studies" potx

Ngày tải lên : 21/06/2014, 23:20

... in [32] Using this tool we present a study carried out for Spain The objective of this study is to compare the diﬀerences in the number of Node Bs and in the total network investment cost using ... 7.3 0.88 0.88 Log normal fading margin (dB) UL intercell interference ratio DL intercell interference ratio Sectors Fast fading margin (dB) Soft handover gain Interference margin (dB) 1.75 0.25 ... service i per sector Miusers and the user density ρi as follows (note that a Node B may be divided into several sectors Each sector corresponds to a cell): Rt i = DL users MDL i · NSectors π · ρi...

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automatic letter-colour associations in non-synaesthetes and their relation to grapheme-colour synaesthesia

Ngày tải lên : 22/12/2014, 21:17

... between projector and associator subtypes, manifested as greater connectivity in inferior temporal cortex near the fusiform gyrus in projectors as compared to associators This has led to the idea ... types of cone photoreceptors: short (S), medium (M), and long (L) cones, maximally sensitive to ~430 nm (corresponding to blue), ~530 nm (corresponding to green), and ~560 nm (corresponding to red), ... committee of the College of Science and Engineering, University of Glasgow All participants gave written informed consent prior to inclusion in the study All participants had normal or corrected -to- normal...

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Báo cáo khoa học: "The response of dehydrated Douglas fir (Pseudotsuga menziesii) pollen to three in vitro viability assays and their relationship to actual fertility" doc

Ngày tải lên : 08/08/2014, 23:22

... Jett and Frampton, 1990) and conductivity (Webber and Bonnet-Masimbert, 1989) response The effect of preconditioning pollen by hydration or in vitro assay response and, therefore, in and the correlation ... 1991; and unpublished data) compared to more passive pollinator types (ie, paintbrushes and misting pollinators) It should be possible, then, to influence the proportion of applied male parents in ... 68% The effect of rehydrating pollen prior to in vitro assay increased pollen moisture content of ≈ 26% and produced the greatest increase in assay response for conductivity and germination...

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Báo cáo y học: " Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors" pdf

Ngày tải lên : 09/08/2014, 10:23

... is a nine-organ disease severity scale in which for each organ system a score of to is applied, with being normal and denoting end-stage organ involvement [19] We also recorded statin use, cumulative ... experiments, and was involved in drafting the manuscript or revising it critically AJS, CGMK, and HB participated in the conception and design of the study and were involved in drafting the manuscript or ... factors, like increasing age and dyslipidemia, accounted for increased IMT values in SSc patients and controls After the first reports suggesting an increased prevalence of macrovascular involvement...

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Báo cáo khoa học: "PreS1 epitope recognition in newborns after vaccination with the third-generation Sci-B-Vac™ vaccine and their relation to the antibody response to hepatitis B surface antigen" potx

Ngày tải lên : 12/08/2014, 04:21

... vaccine was stored and transported at 2–8°C The same batch of vaccine was used throughout the study The vaccinees received three doses of vaccine according to a 0, 1-, and 6-month schedule [21] Study ... N-terminal part is believed to play a major role in mediating virus attachment and entry into hepatocytes [3] Within the preS1 protein, the 21–47 amino acid epitope was shown to mediate binding to ... bearing a deletion in the 26–30 amino acid sequence of the preS1 receptor binding site was noninfectious and hence deficient in viral entry [3], further supporting the importance of this domain...

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Báo cáo y học: "Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice" pot

Ngày tải lên : 12/08/2014, 11:22

... necessary In summary, our results provide unique insight into strain- and welding fume-dependent genetic factors involved in the mouse lung response to welding fume The gene regulation and network interconnectivity ... weeks in the B6 strain intriguing [29] The dysregulation of the calgranulins S100A8 and A9, in addition to CCL2 and IL8Rβ, warrants further investigation into a possible delayed inflammatory, ... expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes Arch Toxicol 2009 14 Antonini JM, Lawryk NJ, Murthy GG, Brain JD: Effect of welding fume...

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Báo cáo y học: "Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype" ppsx

Ngày tải lên : 14/08/2014, 20:22

... biotransformation to toxic-reactive intermediates within the liver From a preliminary dose finding study, three doses were selected corresponding to a 'sub-toxic', 'moderately toxic' and 'toxic' dose ... histopathology and clinical chemistry), referred to as 'phenotypic anchoring', allowed investigators to gain new insight into the processes involved in the adverse effects on target tissues [12-15] In addition ... according to the mode of action of the included compounds, but also according to the severity and character of the response irrespective of inducing compound Furthermore, this variability in response...

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Báo cáo y học: "Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men"

Ngày tải lên : 26/10/2012, 09:48

... were formed within the study base with one group of cases and two different control groups The information on smoking history was obtained by interviews We interviewed informants (spouses or other ... uncertain of the age when smoking began A validity study in Shanghai was conducted where the surviving spouse was the informant and both husband and wife had reported their smoking habits in the ... can lead to saving of money and time;11-12 (3) all possible confounding factors (known or unknown) and interaction effects between groups are balanced by using large matching populations In contrast,...

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Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works

Ngày tải lên : 07/11/2012, 15:01

... main kinds of essay: narrative and informative Narrative essays are short writings devoted to true stories told from either the first person or the third person point of view While a short story ... techniques in storytelling Technique is one of the five major elements of storytelling in association with plot, theme, point of view, character and setting Technique has to with the structuring of the ... people’s house, especially to their friends’ for a party And the thing they often bring along is often a drink, such as beer, a bottle of 20 champagne or wine or any of their favorite drinks so...

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A computational study to investigate the effects of insulation and EGR in a diesel engine

Ngày tải lên : 05/09/2013, 16:11

... (BSFC) of the IDI engine to increase and the total engine efficiency to decrease compared to that of a DI diesel engine Because of these disadvantages of the IDI diesel engines, most engine research ... in the case of baseline engine makes the proposed model a reliable tool to be used for exploring new engine concepts 45 50 Experimental model motoring 40 Experimental model motoring 35 Pressure ... He also worked as a Professor and Head of department in the Department of Mechanical Engineering, Vidya Vikas Institute of Technology, Andhra Pradesh, India He has 14 years of teaching and research...

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A study of some linguistic features of expressions describing the villains in kiều story and their english translational equivalents

Ngày tải lên : 26/11/2013, 13:21

... features of EDVs in Ki u’s Story and their equivalents in the English versions - To discuss the effectiveness of translation of EDVs in Ki u’s Story into English - To suggest some implications for ... behavior, the state… of the figures in had to remember when trying to understand their meaning order to show the attitude or the implication of the author Moreover, readers would find them interesting ... methods EDVs in Ki u’s Story: 3.2 SAMPLING - The meaning of EDVs in Ki u’s Story might not be Ninety verses containing EDVs are collected in the Vietnamese understood by looking them up in Vietnamese...

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Tài liệu Báo cáo khoa học: Identiﬁcation of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae docx

Ngày tải lên : 20/02/2014, 01:20

... strain was grown in media lacking leucine The other strains were grown in media containing leucine Complementing abilities of LEU2, UTR1 and YEF1 for the growth defects of the pos5 mutant To conﬁrm ... vector complemented the poor growth of the pos5 cell on SG solid medium and on and in solid and liquid media lacking arginine (Fig and Table 6), thereby supporting the partial contribution of ... Doubling time of WT (BY4742) and pos5 mutants Means of two independent experiments are provided Arginine concentrations are speciﬁed in parentheses in mgÆL)1 In this study, 20 mgÆL)1 arginine...

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Ngày tải lên : 08/03/2014, 08:20

... activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation of Ó FEBS 2003 GSK-3 and ... GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin However, one of the potential ... Zucker rats, inhibition of the kinase using a selective organic inhibitor (CT 98014) had no stimulatory or insulin potentiating effect on glucose uptake This inhibitor also failed to stimulate...

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Báo cáo khoa học: Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A pdf

Ngày tải lên : 08/03/2014, 10:20

... Binding of the two conserved domains in Ba and PR72 to the A subunit of PP2A Fragments of rat Ba and human PR72 encompassing ASBD and were tested for binding to GST and GST-A by incubation for ... subunit binding domains (Eur J Biochem 269) 547 A subunit binding domains In this study, we used the B56a isoform as a model regulatory protein to identify structural elements involved in the interaction ... peptides [25] and imaged using a Molecular Dynamics PhosphorImager RESULTS AND DISCUSSION Identi®cation of two A subunit-binding domains in B56a To determine the minimal region of B56 that interacted...

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Báo cáo Y học: Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difﬁcile pdf

Ngày tải lên : 08/03/2014, 22:20

... presence of saturating concentrations of the metal cofactor Together, these data are indicative of two modes of substrate binding (i.e open and closed) The closed, active form of UDP-Glc binding is ... MUG binds to the toxin with an affinity of 15 ± lM at °C The 15 lM binding affinity is similar in magnitude to the lM Kd measured for UDP-Glc binding to the related C sordellii lethal toxin (catalytic ... significant coupling between the binding of UDP-Glc and the Mg2+ cofactor This finding implies that one of the roles of this ion may be to stabilize the TcdA–UDP-Glc complex prior to formation of any mechanistic...

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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf

Ngày tải lên : 15/03/2014, 00:20

... shedding and nonproteolytic functions, such as binding to adhesion molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to ... progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed with the action of MMP-3, ... tetracyclines, lacking antibiotic activities, may inhibit MMPs by binding to metal ions such as zinc and calcium This family of inhibitors, including metastat (COL-3), minocycline and doxycycline, cause limited...

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MOB RULE IN NEW ORLEANS: ROBERT CHARLES AND HIS FIGHT TO DEATH, THE STORY OF HIS LIFE, BURNING HUMAN BEINGS ALIVE, OTHER LYNCHING STATISTICS pdf

Ngày tải lên : 15/03/2014, 03:20

... alleys and into houses of anybody who would take them in, breaking into the homes of defenseless colored men and women and beating aged and decrepit men and women to death, the police and the legally ... white women—were out on their stoops and peeping over their galleries and through their windows and doors, shouting to the crowd to go on with their work, and kill Negroes for them "Our best wishes, ... became more anxious to make converts than to obtain subscribers, and the more conservative darkies began to get afraid of him Meanwhile he got into touch with certain agitators in the North and made...

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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx

Ngày tải lên : 16/03/2014, 18:20

... compared to control binding reactions (lanes O) The amount of complex formed may be small and /or not form a sharp band due to a lack of stability or a change in conformation during electrophoresis ... electrophoretic gel mobility shift assays (EMSAs) To assay the binding of Ets factors to the PS1 promoter, the proteins were synthesized from the corresponding pCIbased vectors by in vitro transcription–translation ... expression vector integrated in pC1 (ERM) or the same amount of empty vector (pC1) The amount of protein in each assay was used as an internal standard (B) PS1 sequences upstream or downstream...

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Báo cáo " Teaching efl writing in Vietnam: Problems and solutions - a discussion from the outlook of applied linguistics " doc

Ngày tải lên : 22/03/2014, 10:20

... writing The issue of giving feedback to students’ writing is related to the notion of being correct in English According to Davies [2], correct writing is effective writing in its context because ... input into intake, the instruction should be psycholinguistically motivated For instance, the input provided prior writing can be given through reading since reading and writing go hand in hand Learners ... being able to present descriptive adequacy and explanatory adequacy in their writing, which, in fact, seem to be neglected in most grammar textbooks today The combination of writing with reading...

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