a new and testable hypothesis for the etiology of alzheimer s disease

Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

Ngày tải lên : 07/03/2014, 10:20

... AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of extracellular metals and a decrease in the levels of intracellular metals Here, we have ... is of particular relevance These authors demonstrated that an increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase ... neurodegeneration, but their development is the result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some of the consequences...

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báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc

Ngày tải lên : 11/08/2014, 12:21

... data) and studies of disease- associated molecules and their assemblies beyond the pathway-centric view To address data integration, sophisticated approaches are needed to segment the image data ... proteomics and transcriptomics) and brain imaging to cognitive assessments The adoption of a systems approach to study AD will demand integration of heterogeneous data (such as molecular and image data) ... validate, such as in diseases of the central nervous system One recent example is a metabolomic study of Huntington s disease [55], for which early disease markers were sought in patients and a transgenic...

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Báo cáo y học: " RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus" pot

Ngày tải lên : 13/08/2014, 05:21

... cursors to the formation of intrinsic viral microRNAs (vmiRNAs) named the HIVaINR antisense RNA miRNAs or HAAmiRNAs [14] Others have suggested the possibility for HIV microRNAs encoded by the sense ... near-complementary base-pairing (Figure and additional file 1) Primary HIVaINR antisense RNA has the potential to form precursorlike microRNAs and HAAmiRNAs, as discussed above (Figure 3c) In mammals, maturation ... the human host cell proteins and RNA polymerase in transcription of its mRNAs and genomic RNA[13] It is perhaps not surprising that it would also make an antisense RNA to enable a mechanism for...

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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx

Ngày tải lên : 05/03/2014, 23:20

... important to accurately diagnose dementia as early as possible This chapter outlines the basic elements of a clinical diagnostic evaluation for Alzheimer s disease (AD) and other dementias; and also ... visual analysis of scans, describes how quantification with clinically available and friendly software tools can be employed to assist with analysis, and then illustrates a straightforward approach ... lost in familiar surroundings, the physician can assess visuoconstruction or the ability to copy and produce figures on demand, such as a cross, square, and cube The physician can also assess...

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The Handbook of Alzheimer’s Disease and Other Dementias doc

Ngày tải lên : 14/03/2014, 21:20

... Hypothesis Carmela R Abraham 262 viii Contents Other Mechanisms of Neurodegeneration Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki 277 10 Rational Therapeutics for Alzheimer s Disease and ... clinical and scientific research into the causes, mechanisms, and treatment of Alzheimer s disease and related dementias The first of these was establishing the National Institute on Aging at the National ... inhibitors, the first class of drugs approved by the FDA for treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s...

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Báo cáo y học: "Variations in the transcriptome of Alzheimer''''s disease reveal molecular networks involved in cardiovascular diseases" potx

Ngày tải lên : 14/08/2014, 21:20

... elements in disease associated genes Figure Steps taken to analyze Alzheimer' s disease using laser capture microdissected microarray data Steps taken to analyze Alzheimer' s disease using laser capture ... Online Mendelian Inheritance in Man and the Genetic Association Database These sources assign diseases to gene identifiers and then DAVID maps the diseases to the DAVID database through the gene identifiers ... with cardiovascular diseases and diabetes EASE [15] uses the Genetic Association Database [16] and Online Mendelian Inheritance in Man to determine the association of genes with various diseases/conditions...

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Getting Started With ASP.NET ASP.NET is a new and powerful technology for writing dynamic web pages.

Ngày tải lên : 06/11/2013, 00:15

... contains several subdirectories: q \iissamples \homepage contains some example classic ASP pages q \iissamples \sdk contains a set of subdirectories that hold classic ASP pages which demonstrate ... via something known as the Java Virtual Machine (JVM), and there are several standard and non-standard tags that are used to add Java applets to a web page These tags tell the ... JavaScript, it isn't casesensitive and is therefore less fussy about the particulars of the code Although this "advantage", makes it a lot slower and less efficient The biggest drawback is that...

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Pelvic floor muscle training and adjunctive therapies for the treatment of stress urinary incontinence in women: a systematic review doc

Ngày tải lên : 28/03/2014, 14:20

... appraisal scores and resolved disagreements in scoring by discussion Details of the quality assessment are provided [see additional files &5] with studies ranked according to their quality assessment ... be guaranteed All relevant studies with an English language abstract were located for assessment against the inclusion criteria Date of the last search was 20 May 2005 Individual strategies were ... 1 0s/ 2 0s, 40 reps, sets/ week Weekly individual sessions NR NA 5s/ 5s, 10 reps (max), seated/standing, sets/ day 3s/ 3s, 15 reps, (submax) set/day sustained (submax) rep, set/day clinic visits Arvonon...

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Báo cáo sinh học: " Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons" docx

Ngày tải lên : 18/06/2014, 22:20

... CTGGCTAACGACTACATCTCCAGRGAYGARCT-3' 5'-GGCAGTTTCAAGGCTGTGAATTTYTTYGARCG-3' 5'-CCGTAAGAAATGGTGGTCCTGACRAAYTGNGG-3' 5'-CCGTAGGCGATGGTCGTCCTAACRAAYTGNGG-3' 5'-TACAAAATACAGCGAGTGATANATRAARCA-3' ORF ... Standard curves cellular gene assays RV2 rhadinovirus and Standard curves obtained from the RV2 rhadinovirus and OSM reference cellular gene assays A) The standard RV2 assay was performed on purified ... herpesvirus (KSHV)/human herpesvirus 8, the only known human rhadinovirus, is associated with classical and AIDS-related Kaposi 's sarcoma, primary effusion lymphoma and multicentric Castleman 's disease...

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báo cáo hóa học:" Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons" pot

Ngày tải lên : 20/06/2014, 04:20

... CTGGCTAACGACTACATCTCCAGRGAYGARCT-3' 5'-GGCAGTTTCAAGGCTGTGAATTTYTTYGARCG-3' 5'-CCGTAAGAAATGGTGGTCCTGACRAAYTGNGG-3' 5'-CCGTAGGCGATGGTCGTCCTAACRAAYTGNGG-3' 5'-TACAAAATACAGCGAGTGATANATRAARCA-3' ORF ... Standard curves cellular gene assays RV2 rhadinovirus and Standard curves obtained from the RV2 rhadinovirus and OSM reference cellular gene assays A) The standard RV2 assay was performed on purified ... herpesvirus (KSHV)/human herpesvirus 8, the only known human rhadinovirus, is associated with classical and AIDS-related Kaposi 's sarcoma, primary effusion lymphoma and multicentric Castleman 's disease...

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Báo cáo hóa học: " A combination of hard and soft templating for the fabrication of silica hollow microcoils with nanostructured walls" pptx

Ngày tải lên : 21/06/2014, 04:20

... TEM, SEM and SAXS NV participated in TEM observations and in spectroscopic measurements CS, AL-Q and TI participated in the preparation and revision of the manuscript as well as in giving access ... inner mesostructure forms in the bulk solution and some of those particles also adhere to the silica layers on the surface of CMCs Finally, upon calcination, the CMCs (hard templates) and amphiphilic ... CMCCOOHs used as templates have been burnt off and silica coils are left over, although also non-CMC-templated silica particles are obtained mixed with the coils, as isolated silica particles can also...

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báo cáo hóa học:" Research Article A New Conservative Difference Scheme for the General Rosenau-RLW Equation" pot

Ngày tải lên : 21/06/2014, 11:20

... like to express their sincere thanks to the referees for their valuable suggestions and comments This paper is supported by the National Natural Science Foundation of China nos 10871117 and 10571110 ... and give the errors in the sense of L2 -norm and L∞ -norm of the numerical solutions under various steps of τ and h at t 60 for p 2, and The three tables verify the second-order convergence and ... good stability of the numerical solutions Tables 4, 5, and shows the conservative law of discrete mass Qn and discrete energy En computed by scheme 2.3 – 2.5 for p 2, and Figures 1, 2, and plot the...

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Báo cáo y học: "A unified framework of immunological and epidemiological dynamics for the spread of viral infections in a simple network-based population" ppt

Ngày tải lên : 13/08/2014, 16:21

... was a stochasticallyvaried random variable Results Equilibrium analyses For a single-person where A1 ,1 = 0, the equations in the basic model are associated with three equilibria The first is a ... CTLs and other immune responses, in the form of additional state equations, and their effect on the transmission of specific microparasite infections is also an important area of ongoing study ... simultaneously describes broad categories of diseases dynamics at both cellular and organismal levels Under a unified framework, continued molecular research on disease pathogenesis and host-pathogen...

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Development of a new elastic path controller for the collaborative wheelchair assistant

Ngày tải lên : 11/09/2015, 09:59

... A sensor-based navigation and automatic obstacle avoidance system was developed in [45] It can navigate for the wheelchairs and automatically avoid obstacles by using sensory information This ... fulﬁllment of real-time obstacle avoidance tasks and therefore ﬁts for the dynamic environments Elastic roadmap [59] is an extension of elastic band and elastic strip, which applies a hybrid system ... is successful in assisting in daily life tasks and for mobile service robots, but the main disadvantage is that this kind of path controller does not take users’ special intentions and needs...

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Tài liệu Closing the gap between research and practice: Foundations for the acquisition of literacy pptx

Ngày tải lên : 17/02/2014, 06:20

... of phonics was a necessary and essential component of any program for the teaching of beginning readers Despite the range of programs studied and the various other factors associated with reading ... teaching of literacy in classrooms across Australia The essential characteristic of a holistic approach to language learning, as identified by van Kraayenoord and Paris, is that it does not focus instruction ... Australian First Steps Program and the Victorian Early Years Literacy Program, as well as intervention programs such as Reading Recovery There have also been various state assessment programs that have...

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INFLUENTIAL MARKETING: A NEW DIRECT MARKETING STRATEGY ADDRESSING THE EXISTENCE OF VOLUNTARY BUYERS doc

Ngày tải lên : 23/03/2014, 04:21

... the Canadian Imperial Bank of Canada (CIBC), uses SAS as their only business intelligence software for all aspects of data analysis In this section, we discuss the basics of a decision tree A ... number of appearances in the negative class As an example, suppose positive samples consist of 5% of the entire data set An item, A = a1 , has appeared in 8% of the negative class If n is used and set ... cost matrix C (i, j ) , which specifies the cost of classifying a sample of true class j into class i Instead of considering all samples as equal, a sample of the class of interest is assigned a...

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$báo cáo hóa học:"Necessary and sufficient condition for the smoothness of intersection local time of subfractional Brownian motions" docx$

báo cáo hóa học:"Necessary and sufficient condition for the smoothness of intersection local time of subfractional Brownian motions" docx

Ngày tải lên : 18/06/2014, 15:20

... sub-fBms, a rather special class of self-similar Gaussian processes The aim of this paper is to prove the existence, smoothness, regularity of the intersection local time of S H and S H , for H = and ... class of self-similar Gaussian processes, which preserves many properties of the fractional Brownian motion This process arises from occupation time ﬂuctuations of branching particle systems ... semimartingale nor a Markov process unless H = 1/2, so many of the powerful techniques from stochastic analysis are not available when dealing with S H The sub-fBm has self-similarity and long-range...

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Báo cáo hóa học: " Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits" pot

Ngày tải lên : 18/06/2014, 16:20

... used as an irrelevant negative control Statistical analyses Statistical analyses were performed using a one-way ANOVA parametric test and Bonferroni/Newman-Keuls analysis of variance using the ... prepared the manuscript; EP performed animal immunisations, CTL assays, tumour cell cultures, and production of recombinant proteins; SP performed ELISA assays, statistical analyses, assisted animal ... non-stimulated pre-immune PBMCs, and normalized against β-actin expression Ex-vivo CTL activity was seen in all of the animals The cytokine analysis only assesses the type of response of antigen-specific...

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$Báo cáo hóa học: " Necessary and sufficient condition for the smoothness of intersection local time of subfractional Brownian motions Guangjun Shen" pptx$

Báo cáo hóa học: " Necessary and sufficient condition for the smoothness of intersection local time of subfractional Brownian motions Guangjun Shen" pptx

Ngày tải lên : 20/06/2014, 23:20

... Doukhan et al [26]) Therefore, it seems interesting to study the so-called intersection local time for sub-fBms, a rather special class of self-similar Gaussian processes The aim of this paper is to ... interesting properties of sub-fBm, such as short-/long-range dependence and self-similarity, it can be widely used in a variety of areas such as signal processing and telecommunications( see Doukhan ... semimartingale nor a Markov process unless H = 1/2, so many of the powerful techniques from stochastic analysis are not available when dealing with SH The sub-fBm has self-similarity and long-range...

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Báo cáo hóa học: "Research Article Trace Inequalities for Matrix Products and Trace Bounds for the Solution of the Algebraic Riccati Equations" pot

Ngày tải lên : 22/06/2014, 03:20

... time-consuming and computationally diﬃcult, particularly as the dimensions of the system matrices increase Thus, a number of works have been presented by researchers to evaluate the bounds and trace bounds ... trace, tr A , A , A , d A the inverse, the transpose, the diagonal elements, the singular values of A, respectively, aii di A If A ∈ Rn×n is an arbitrary symmetric matrix, then and deﬁne A ii ... is hard to solve the ARE, and there is no general method unless the system matrices are special and there are some methods and algorithms to solve 1.4 ; however, the solution can be time-consuming...

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