... endocrine tissues, but also, e.g. in endothelial cells,lung, heart, lymphoid tissues/cells and in the central nervoussystem [24–28]. The gene is shown t o be up-regulated byfluid shear stress [25], ... drugs in medicine. The physiologicalresponse and sensitivity to glucocorticoids varies [1–3], but the m olecular basis of glucocorticoid r esistance is notcompletely understood. Thus our result ... reduction of TIF2expression by antisense oligodeoxynucleotides inhibits lig- and- stimulated ER transcriptional activity and DNA syn-thesis in MCF-7 cells, this constituting evidence of the roleof...