use of fast responding voltage sensitive dyes for large scale recording of neuronal spiking activity with single cell resolution

Báo cáo sinh học: "Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" pot

Ngày tải lên : 19/06/2014, 08:20

... commonly used for pseudotyping retroviruses because it is highly stable and confers an exceptionally wide host range, because of the binding of VSV-G to a cell surface lipid We therefore chose ... titers of 107 TU/ml (in 293 cells) or greater were obtained, which enabled 5– 10 TU /cell to be used for infection of 106 PBLs With this approach it was possible to achieve stable transduction of ... chimeric anti-tumor T cells, forming basis for immunotherapy of many different human cancers Mouse cells and human lymphocytes MD45 cells, a murine cell NK-like T cell line, were obtained from...

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báo cáo hóa học:" Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" docx

Ngày tải lên : 20/06/2014, 04:20

... commonly used for pseudotyping retroviruses because it is highly stable and confers an exceptionally wide host range, because of the binding of VSV-G to a cell surface lipid We therefore chose ... titers of 107 TU/ml (in 293 cells) or greater were obtained, which enabled 5– 10 TU /cell to be used for infection of 106 PBLs With this approach it was possible to achieve stable transduction of ... chimeric anti-tumor T cells, forming basis for immunotherapy of many different human cancers Mouse cells and human lymphocytes MD45 cells, a murine cell NK-like T cell line, were obtained from...

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Báo cáo khoa học: "A System for Large-Scale Acquisition of Verbal, Nominal and Adjectival Subcategorization Frames from Corpora" pot

Ngày tải lên : 17/03/2014, 04:20

... inspection of unclassifiable examples during development of the classifier These consisted of e.g some occurrences of phrasal verbs with complex complementation and with flexible ordering of the preposition/particle, ... output For adjectives only of the 30 gold standard SCFs are unseen, resulting in better recall (57.6% vs 47.2% for nouns) For verbs, subcategorization acquisition performance often correlates with ... classification, this is an example of the frame adj-obj -for- to-inf, shown in Figure 2, (using AVM notation in place of COMLEX s-expressions) Part of the output of RASP for this sentence is shown in...

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Báo cáo khoa học: "Efﬁcient Inference of CRFs for Large-Scale Natural Language Data" docx

Ngày tải lên : 23/03/2014, 17:20

... 368 s for ours) and 7∼12 times faster for decoding (2.881 ms for M ALLET, 5.028 ms for C RF ++, and 0.418 ms for ours) This result demonstrates that learning and decoding CRFs for large- scale ... performs 5∼50 times faster for training (1,774 s for M ALLET, 18,134 s for C RF ++, Experiment We evaluated our method on six large- scale natural language data sets (Table 1): Penn Treebank3 for ... Therefore, it counterbalances the extra computations in β recursion This is a common practice in implementation of input and output joint feature functions for large- scale problems This scheme uses...

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báo cáo hóa học: "Use of medications by people with chronic fatigue syndrome and healthy persons: a population-based study of fatiguing illness in Georgia" pptx

Ngày tải lên : 18/06/2014, 19:20

... group The profile of NSAID use differed between persons with CFS and Well controls Among persons taking NSAIDs, 49.1% of the users in the CFS group used ibuprofen compared to the 37.7% of users in ... range 1–18) Overall, 85.8% of the entire sample (430 of 501) used at least one drug: 92.9% of CFS, 83.7% of ISF and 83.9% of the Well group The mean number of drugs used per person in the CFS ... (p-value for linear trend = 0.004, for the whole groups, p-value for linear trend = 0.22 for the subgroups on antidepressants) However, no one reported use of thyroid hormones for the purpose of augmenting...

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báo cáo hóa học:" Use of medications by people with chronic fatigue syndrome and healthy persons: a population-based study of fatiguing illness in Georgia" doc

Ngày tải lên : 20/06/2014, 16:20

... group The profile of NSAID use differed between persons with CFS and Well controls Among persons taking NSAIDs, 49.1% of the users in the CFS group used ibuprofen compared to the 37.7% of users in ... range 1–18) Overall, 85.8% of the entire sample (430 of 501) used at least one drug: 92.9% of CFS, 83.7% of ISF and 83.9% of the Well group The mean number of drugs used per person in the CFS ... (p-value for linear trend = 0.004, for the whole groups, p-value for linear trend = 0.22 for the subgroups on antidepressants) However, no one reported use of thyroid hormones for the purpose of augmenting...

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Báo cáo y học: "A case study evaluating the use of clozapine in depression with psychotic feature" docx

Ngày tải lên : 08/08/2014, 21:20

... evidence supporting use of clozapine was rather limited The approach allows clinicians to use relatively weak evidence with other clinical skills It necessitates the use of innovative practice ... that clozapine use was responsible for the improvement It could be argued that the use of amitriptyline could have contributed; however, it had been used on several previous occasions with no benefit ... (of the same original databases) yielded no further evidence supporting the use of clozapine in depression with psychotic symptoms, other than a single case report [9] which described a case of...

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Báo cáo y học: "A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass" ppt

Ngày tải lên : 12/08/2014, 12:20

... because controlling inflammatory activity at early stages may prevent bone loss [17-19] The aim of this study was to analyze the patterns of GC use and the reasons for its use in a population of ... orally, and only 17.3% of patients were under treatment with GCs at the end of the study In addition, the prescription of the drug was adjusted to the profile of Figure Evolution of bone-mineral density ... http://arthritis-research.com/content/12/2/R50 (a) Page of Percentage of patients 50 40 30 20 10 Baseline 12 24 Time (months) (b) Percentage of patients 20 15 10 0 100 200 300 mg of prednisone/month Figure Use of glucocorticoids...

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Báo cáo y học: "Hybrid dynamic/static method for large-scale simulation of metabolism" pptx

Ngày tải lên : 13/08/2014, 23:20

... after a two-fold increase of metabolite A (+) Perturbation Boundary Static part + + of kinetic properties for large- scale metabolic pathways Therefore, the applicability of the dynamic method has ... employed for large- scale analyses of metabolism [4,15,16] Assuming a steady-state condition, MFA provides a flux distribution as the solution of the mass balance equation without the need for rate ... experiments required for dynamic models of large- scale metabolic pathways by replacing suitable enzyme reactions with a static module The optimal conditions for this method are (a) a system with few bottleneck...

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Báo cáo y học: "Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome" ppt

Ngày tải lên : 14/08/2014, 14:21

... to establish measures of accuracy that are useful for the evaluation and integration of upcoming datasets We established two benchmarks for assessing the quality of large- scale human protein interaction ... of the incompleteness of the network The 'degree' of the network is defined as the average number of links per protein and captures the connectivity of the network Except for Reactome, each of ... reliability of high throughput observations Mol Cell Proteomics 2002, 1:349-356 von Mering C, Krause R, Snel B, Cornell M, Oliver SG, Fields S, Bork P: Comparative assessment of large- scale datasets of...

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Tài liệu Báo cáo khoa học: "Joint Feature Selection in Distributed Stochastic Learning for Large-Scale Discriminative Training in SMT" pdf

Ngày tải lên : 19/02/2014, 19:20

... to large scale scenarios The algorithm takes an average over the ﬁnal weight updates of each epoch instead of keeping a record of all weight updates for ﬁnal averaging (Collins, 2002) or for ... (wz,t,i,j ) end for wz,t,i+1,0 ← wz,t,i,P end for end for Collect/stack weights W ← [w1,t,S,0 | |wZ,t,S,0 ]T Select top K feature columns of W by norm and for k ← K v[k] = end for end for return ... each of size S ← I/Z; distribute to machines Initialize v ← for epochs t ← T − 1: for all shards z ∈ {1 Z}: parallel wz,t,0,0 ← v for all i ∈ {0 S − 1}: Decode ith input with wz,t,i,0 for...

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Báo cáo khoa học: "Leveraging Reusability: Cost-effective Lexical Acquisition for Large-scale Ontology Translation" potx

Ngày tải lên : 08/03/2014, 02:21

... arrangement of keyword phrases presents another issue: some concepts, while not of great value for access to segments of video, may be important for organizing other concepts and for browsing ... The task of translating large ontologies can be recast as a problem of implementing fast and efficient processes for acquiring task-specific lexical resources We developed a method for prioritizing ... structure in large- scale ontology translation In Proceedings of the 11th Annual Conference of the European Association for Machine Translation Oslo, Norway Our thanks to Doug Oard for his contribution...

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Báo cáo khoa học: Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide docx

Ngày tải lên : 23/03/2014, 13:20

... cytometer with CELLQUEST software Cytograms were acquired with 104 cells Assessment of cellular uptake by CE-LIF The cells were overlaid with 0.2 mL of a prewarmed (37 °C) solution of the ﬂuorescent ... the mean of 30–40 cells or cell cluster ± SEM Fig Inﬂuence of 10)5 M nociception on the beating rate of CM measured on day of culture without and with pretreatment with either 0.2 lM of II or ... the beating rate of CM measured on day of culture without and with pretreatment with either 0.2 lM of I or II on day and after seeding The basal beating rate of the CM on day of culture was 191...

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Mining Console Logs for Large-Scale System Problem Detection docx

Ngày tải lên : 30/03/2014, 16:20

... count Dimensions of the vector consist of (the union of) all useful message types across all groups, and the value of a dimension in the vector is the number of appearances of the corresponding message ... message groups because often multiple log messages together capture a single behavior of the system, and thus an anomalous pattern in the message groups is often a better indication of a particular ... efﬁcient: With a small constant dimension for each vector, its runtime is linear in the number of vectors, so detection can scale to large logs yn = PPT y = Cn y, where P = [v1 , v2 , , vk ], is formed...

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Báo cáo khoa học: "Distributed Word Clustering for Large Scale Class-Based Language Modeling in Machine Translation" docx

Ngày tải lên : 31/03/2014, 00:20

... algorithm for obtaining word classifications for predictive class-based language models with which we were able to use billions of tokens of training data to obtain classifications for millions of words ... number of iterations, the worst case complexity of the algorithm is in: pre suc O(I · (2 · B + Nv · Nc · (Nc + Nc ))) When using large corpora with large numbers of bigrams the number of required ... number of times w occurs in the training corpus before any word in c, N (w, c), is also stored Together with the counts stored with the vocabulary partitions, this allows for efficient updating of...

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scalable decentralized object location and routing for large scale peer to peer systems

Ngày tải lên : 28/04/2014, 13:40

... performance in terms of the expected number of routing hops and the number of messages exchanged as part of a node join operation This section focuses on another aspect of Pastry’s routing performance, ... to of make larger and larger strides with no possibility of returning to a node within any node encountered on the route, where is the distance of the routing step taken away from node Therefore, ... a list of subscribers is stored on the node with nodeId numerically closest to the topicId of a topic, where the topicId is a hash of the topic name That node forms a rendez-vous point for publishers...

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synthesis of large-scale uniform mulberry-like zno particles with

Ngày tải lên : 06/05/2014, 13:27

... (001) face to form some longer rectangle ZnO while the formation of smaller ZnO particles with Fig SEM images of ZnO prepared (a) with TEA (b) without TEA (c) with equimolar NaOH and (d) with equimolar ... However, the size of mulberry-like ZnO particles changed a little with different amounts of TEA In the case of a high TEA concentration, large- scale mulberry-like ZnO particles with uniform size were ... limitation of OH- concentration When NaOH was used, the large number of OH- also promoted the growth of ZnO along Caxis Moreover, the alkalinity of this reaction solution was stronger It was hard to form...

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báo cáo hóa học: " Quality of life among adolescents with sickle cell disease: mediation of pain by internalizing symptoms and parenting stress" pdf

Ngày tải lên : 18/06/2014, 19:20

... of adolescents with SCD The results of this study further establish the association of sickle cell pain with physical domain and psychosocial domain of HRQOL for teens with SCD Importantly, with ... understanding of the association of pain with health-related quality of life (HRQOL) is necessary for improved management of pain and other health outcomes among youth with sickle cell disease (SCD)[7] for ... association of pain frequency with psychosocial aspects of HRQOL as measured by the self-esteem scale of the Child Health Questionnaire (CHQ) (range of -.12 to -.34 for self-esteem compared with -.48...

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báo cáo hóa học:" Double disadvantage: a case control study on health-related quality of life in children with sickle cell disease" potx

Ngày tải lên : 20/06/2014, 15:20

... proportion of children with SCD with impaired HRQoL (≥1 SD below the mean) was similar to the proportion of healthy siblings with impaired HRQoL However, the proportion of children with SCD with impaired ... five-point scale Within each domain, item scores are summed and transformed to a T value Children in the European norm population have a mean score of 50 with a standard deviation (SD) of 10, with ... calculated [22] for comparison of the proportion of children with SCD with impaired HRQoL to the proportion of children in the Dutch norm population In the Dutch norm population, 16% of children...

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Báo cáo hóa học: " Adaptive antenna selection and Tx/Rx beamforming for large-scale MIMO systems in 60 GHz channels" pptx

Ngày tải lên : 21/06/2014, 01:20

... performance requirement in order to guarantee that the actual performance of the selected subset meets the requirement with minimum number of selected antenna Performance of adaptive beamforming ... considered as an extra dB increase in noise figure Performance of antenna selection with fixed size The performance of Algorithm for antenna selection in a single run is shown in Figure Both the G-circle ... single- run performance of the antenna selection algorithm in [10] is also shown In Figure 5, the average performance of 100 runs for the above schemes is plotted in a larger span of iterations...

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