the use of lenses to improve quality of life following brain injury

Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc

Ngày tải lên : 30/03/2014, 11:20

... documented on the effect of B[a]P on adipocyte function, one of the main sites of storage We therefore decided to address the question of B[a]P toxicity on adipocytes, and speciﬁcally to test its ... loss Whether these elements form part of the cause of metabolic dysfunction leading to the accumulation of fat mass remains to be determined Available epidemiological data addressing the implication ... unknown whether environmental pollutants exert a toxic effect on the adipocyte itself This led us to question whether the pollutant had a negative impact on one of the key functions of the adipocyte,...

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BIOTECHNOLOGY MOLECULAR STUDIES AND NOVEL APPLICATIONS FOR IMPROVED QUALITY OF HUMAN LIFE potx

Ngày tải lên : 28/06/2014, 15:20

... of Human Life the rational use of essential medicines; the safety of the patients; and the guarantee of certified laboratories On the other hand, the struggle against the resistance to the antimicrobial ... compounds was the issue of the World Day of the Health of 2011 (April 7) On this occasion, the WHO called to contain the spread of the resistance to the antimicrobial compounds by means of a set of politics ... for Improved Quality of Human Life taken of the sea together with the algae cells, or have been the result of a contamination in the algae culture These mixed populations that are present in the...

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Báo cáo y học: " Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4" pot

Ngày tải lên : 13/08/2014, 05:21

... Conclusion: The inferred ancient origin of HTLV-4 coinciding with the appearance of Homo sapiens, the propensity of STLVs to cross-species into humans, the fact that HTLV-1 and -2 spread globally following ... and HTLV-3 [27] The absence of PDZ suggests that the HTLV-4 Tax may be more phenotypically similar to the HTLV-2 than the HTLV-1 Tax Furthermore, the high amino acid identity of the Tax4 and Tax2 ... implemented in the BEAST software package [73] For each analysis, we used the calibration dates discussed above as a strong prior for the time of the most recent common ancestor (tMRCA) of the HTLV1Mel/HTLV-1a,b...

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Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps

Ngày tải lên : 13/08/2014, 14:20

... also effective at suppressing the proliferation, inducing apoptosis and improving the sensitivity of these cancer cells to the cytotoxic effects induced by chemotherapeutic drugs, vincristine ... medulloblastoma cells via the down-regulation of the expression levels of the SHH ligand and the GLI-1 transcriptional effector of the hedgehog cascade, b-catenin, the phosphorylated forms of Akt and NF-B ... combination therapy with other cytotoxic agents acting on multiple molecular targets as chemopreventive treatment in the diet or to improve the efficacy of the current gemcitabine-based chemotherapeutic...

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Tài liệu Plug and Play Splitter Architectures Drive Operational Savings doc

Ngày tải lên : 21/12/2013, 07:17

... but that has improved to about 16.5 dB today Together, these improvements have resulted in more budget for loss – and a good place to use some of that is in adding a connector to the splitter ... connectors to both the F1 and the splitter, running the tests, cutting off the connectors, and re-splicing the F1 to the splitter input This process is both time consuming and costly Benefits of ... connect it to the splitter input Several factors attributed to the decision to connectorize this process First, as volumes have increased, connector quality has improved significantly in the last...

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Tài liệu TRADITIONAL AND NOVEL RISK FACTORS IN ATHEROTHROMBOSIS pptx

Ngày tải lên : 12/02/2014, 16:20

... its breakdown Apoptosis of endothelial cells may lead to erosions of the endothelial layer, enabling circulating blood to come into contact with the pro-thrombotic contents of the plaque (Figure ... that the majority of AMIs are caused by lesions that are only mildly stenotic What is more, they may cause little in the way of clinical symptoms until they rupture, leading to the often dramatic ... lead to sudden rupture of the plaque with endothelial disruption, causing haemorrhage of circulating blood into the core of the plaque (Figure 8) This may be particularly likely to occur following...

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Traditional and Novel Risk Factors in Atherothrombosis Edited by Efraín Gaxiola pot

Ngày tải lên : 07/03/2014, 20:20

... its breakdown Apoptosis of endothelial cells may lead to erosions of the endothelial layer, enabling circulating blood to come into contact with the pro-thrombotic contents of the plaque (Figure ... that the majority of AMIs are caused by lesions that are only mildly stenotic What is more, they may cause little in the way of clinical symptoms until they rupture, leading to the often dramatic ... lead to sudden rupture of the plaque with endothelial disruption, causing haemorrhage of circulating blood into the core of the plaque (Figure 8) This may be particularly likely to occur following...

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Coronary Artery Disease – New Insights and Novel Approaches Edited by Angelo Squeri pdf

Ngày tải lên : 08/03/2014, 00:20

... branches off the left coronary artery and encircles the muscle to supply blood to the lateral side and back of the heart, and the left anterior descending artery, which supplies the blood to the front ... to the front of the left side of the heart The right coronary artery, on the other hand, branches into the right posterior descending and acute marginal arteries to supply blood to the right ventricle, ... predominant in the conversion of IDL to LDL and the conversion of post-prandial TG-rich HDL into the post absorptive TG-poor HDL Thus, the enzyme contributes to the regulation of plasma TG levels...

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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Ngày tải lên : 08/03/2014, 09:20

... palmitoyl, to the N-terminus of the peptide [20] The development of these Ômore potentÕ peptide inhibitors ﬁrmly established that PR dimerization was a rational target for the development of AIDS therapeutics, ... polynucleotidyltransferase that catalyzes the integration of the DNA copy of the viral genome into the genome of the host cell In order to accomplish this goal, IN has evolved to catalyze two separate reactions, ... selection frequency of in 106 Further analyses of the selected peptides identiﬁed the peptide IVQVDAEGG as an inhibitor of PR dimerization, which when tethered in a head -to- head or a tail -to- tail fashion...

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Báo cáo khoa học: "Formal aspects and parsing issues of dependency theory Vincenzo Lombardo and Leonardo Lesmo" potx

Ngày tải lên : 17/03/2014, 07:20

... from the grammar The selection is carried out by matching the head of the rules with the words of the sentence The second step follows Earley's phases on the dependency rules, together with the ... But to execute the action of the completer, one of the sets must have the index equal to one of the positions, so O(n + 21DI ICI) Thus, the completer costs O(n 7+3 ID[ ICI) The phase predictor, ... inserting the AGR features in the category label (in a similar way to the +EX feature in the grammar G1); the comments on the right help to follow the events; the separator symbol I helps to keep...

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Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays pptx

Ngày tải lên : 23/03/2014, 06:20

... that the I2020T mutation causes a decrease in the kinase activity of LRRK2 in the context of LRRKtide; this is possibly due to the critical role of this residue in the activation loop of the kinase ... signiﬁcantly affect the phosphorylation of the peptide, whereas mutation of threonine to alanine (LRRKtide T–A) completely blocked the ability of the peptide to be phosphorylated (Fig 3B) Therefore, LRRK2 ... are due to increased activity of the protein and not just to the presence of an extra phosphorylation site The mutation also affects the apparent Km of ATP, indicating that it modiﬁes the active...

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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Ngày tải lên : 23/03/2014, 07:20

... decrease of the amount of HIP-1–HIPPI heterodimer and apoptosis induction The effect of HIP-1 may depend not only on the amount of the interacting proteins but also on the afﬁnities of interacting ... cells induces apoptosis following the intrinsic pathway [17,21] The pseudodeath effector domain (pDED) of HIP-1 (Fig 1) alone is able to induce apoptosis; Phe398 of HIP-1 (within the pDED) is critical ... proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in translocation of HIPPI into the nucleus and that of other transcriptional regulators...

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Goethe and the Molecular Aesthetic ppt

Ngày tải lên : 23/03/2014, 13:20

... convert the results into visual images of the molecules, another process that used to take months because the positions of atoms at each of hundreds of planes or levels of the molecule had to be ... us to use all available methods These include making a more conscious eﬀort to use the methods of delicate empiricism, to use the aesthetic, to foster the interplay of the perceptual and the ... relative to the question comes the interpretation and evaluation of the data: does it support the original hypothesis? Then it is back to testing, to further investigating the validity of the results...

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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx

Ngày tải lên : 23/03/2014, 17:20

... quality of life/ health-related quality of life 2.1 Quality of life QoL is defined as the perception of a person’s life in the cultural and value systems in which he or she lives in regards to his ... localized to the collagen of the penile tunica and corpus cavernosum 120 Furthermore, AGEs and their receptors have been described to elevate the activity of endothelin-1, a vasoconstrictor, in ... levels of NO for many reasons The small diameter of the cavernosal arteries and the eminent amount of endothelium and smooth muscle (per gram of tissue compared to other organs) may make the penile...

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NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES doc

Ngày tải lên : 28/03/2014, 22:20

... centers in Boston (average life expectancy of 21 years) and Toronto (average life expectancy of 30 years) The difference appeared to be related to the use of a diet higher in fat in Toronto, supported ... in Chapter 10 They analyze stress and the stress response in relation to surgical stress, the determinants of the host response to stress, and the role of cytokines as mediators of the stress response ... consumption of 20 to 30 grams of soluble ﬁber per day The NCEP panel allows total fat to range from 25 to 35% of total calories, provided consumption of saturated fats and trans fatty acids is low.65 The...

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Báo cáo khoa học: Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase⁄oxidase potx

Ngày tải lên : 30/03/2014, 08:20

... peak of 787 identical to that of the authentic FAD standard The m ⁄ z peak at 825 represents the K+ adduct of released FAD cofactor The m ⁄ z peaks of 348 and 458 represent the [M + H]+ ion of ... of a deprotonated l-proline at the C4 position of the FAD cofactor and abstraction of a substrate proton by the N5 atom of the ﬂavin, a contemporary mechanism of ﬂavoprotein-catalyzed amine oxidation ... inside the cuvette The temperature was recorded during temperature equilibration prior to the reaction at both the top and the bottom of the cuvette to detect any temperature gradient in the assay...

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Báo cáo khoa học: Structural aspects and biological properties of the cathelicidin PMAP-36 pot

Ngày tải lên : 30/03/2014, 20:20

... report on the use of chemically synthesized dimeric and monomeric peptides to probe the effect of these structural factors on the biological antimicrobial and hemolytic activity of both the hydrophobic ... BMAP-28 The amidated form would further increase the charge of the dimer to +28 (see Table 1) Here we further investigated the expression of this protein and performed a Western-blot analysis of total ... on the surface of both the E coli and S aureus cells The dimeric peptide, in particular, can be seen to have caused the complete collapse of the membrane in E coli, and severe disruption of the...

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Imaging of the Breast – Technical Aspects and Clinical Implication Edited by Laszlo Tabar pptx

Ngày tải lên : 30/03/2014, 22:20

... opinions of professionals and experts from the executive committee of the Society of Breast Imaging and the members of the Breast Imaging Commission of the ACR These recommendations are intended to ... addition, the relationship of the tumor to the skin, pectoral muscle and thoracic wall must be accurately described Enhancement of the pectoral muscle or skin is one of the most reliable signs for the ... administration of contrast agent In these cases, signal intensity of the cyst is often slightly increased on the non-enhanced T1-weighted image due to the proteinacious content of the cyst Due to the high...

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Báo cáo khoa học: Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes Formation of modiﬁed and oxidized particles pot

Ngày tải lên : 31/03/2014, 01:20

... earlier than that of Trp in the MG system With GA the loss of these two amino acids occured too rapidly to determine an order of reaction Loss of Arg occurred prior to either of these other amino acids ... [29] To complement the above markers of oxidative damage to apoB, analysis of the potential loss of other amino acid side chains (Trp, Lys and Arg), that would be expected to be targets of glycation ... overall net positive charge on the particle (i.e the total contribution of Arg, Lys, and protonated His residues together with the N terminus, relative to Glu, Asp, and the C terminus) Minor increases...

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Báo cáo khoa học: "ON REPRESENTING GOVERNED PREPOSITIONS AND HANDLING "INCORRECT" AND NOVEL PREPOSITIONS" ppt

Ngày tải lên : 31/03/2014, 18:20

... one of the participants as the "agent" of the transfer of information Our data document the substitution of the GOAL marker for the CO-THEME marker; this may reflect the tendency of English to ... recognition of the type of error, and therefore principled relaxation of the constraints Furthermore, a principled relaxation of the constraints depends in many instances on knowing the relationship ... representation At issue is how the system recognizes the arguments of the predicate 111 At one end of the spectrum is an approach which allows any marking of arguments if the type of the argument is correct...

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