the use by governmental regulatory agencies of quantitative structure activity relationships and expert systems to predict toxicity

Báo cáo khoa học: Characterization of HbpR binding by site-directed mutagenesis of its DNA-binding site and by deletion of the effector domain pot

Ngày tải lên : 07/03/2014, 17:20

... protomer contacts the DNA The objectives of this work were to identify critical motifs in the binding site for HbpR and to examine the necessity of the sensing A-domain of HbpR for DNA binding The ... DA-HbpR and the A-domain of XylR was found to be incapable of activating the hbpC promoter (not shown) Hence, we conclude that the A-domain of HbpR is needed to activate the ATPase activity of the ... larger than the sequences of the palindromes [19,21], but the exact contribution of nucleotides in the binding site contacted by the proteins is not known The current hypothesis of hexameric...

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Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling ppt

Ngày tải lên : 23/03/2014, 13:20

... properties PKA regulatory subunits control the release of catalytic subunits from the inactive tetramer complex upon binding of cAMP to the regulatory subunit-dimer Thus, we examined whether PKA activity ... allowed us to conclude that HIP/ PAP did not alter overall PKA activity but increased native PKA activity The expression of the Ca catalytic, and the RIa and RIIa regulatory subunits of PKA, well ... expressed anywhere other than the cytosol and the cytoplasmic surfaces of membranes [29] On the other hand accurate subcellular distribution of HIP/PAP had not been studied and thus it was considered...

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Báo cáo y học: "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis" potx

Ngày tải lên : 09/08/2014, 07:20

... in the lining layer and at the pannus lesion, induce the synthesis of numerous inflammatory mediators and matrix-degrading enzymes via the activation of the transcription factor NF-κB and the ... In addition, the CD36 molecule, a member of the scavenger receptor family, has been shown to bind the complex of S100A8/A9 and AA and induce uptake of exogenous AA into the endothelial cells ... DNA-binding activity of NF-κB by EMSA As shown in Figure 7a, the NF-κB activity was induced by S100A8/A9 in a dose-dependent manner, verifying the activation of NF-κB by S100A8/A9 To further determine the...

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Báo cáo y học: "Effects on respiratory function of the head-down position and the complete covering of the face by drapes during insertion of the monitoring catheters in the cardiosurgical patien" pot

Ngày tải lên : 12/08/2014, 18:20

... oxygen is the presence of the drapes completely covering the face In these patients, the only contributing factor to the difference between time and the basal time is the covering of the face by drapes; ... compressed by the weight of the abdominal content, and increases the pulmonary blood volume in the dependent parts of the lungs under the effect of both gravity and the increase in cardiac output [7] The ... room Monitoring of the patients The main data on the general characteristics of the patients (age, weight, preoperative LVEF, preoperative therapy) are reported in Table 1; the times of the headdown...

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Báo cáo y học: "Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression" pptx

Ngày tải lên : 14/08/2014, 14:21

... predictor, the ROC curve would follow the left and top boundaries of the figure For a useless predictor, the ROC curve would be a diagonal line between the origin and the upper-right corner These ... threshold of 0.675 selected 4% of probe sets, of which 32% yielded QTLs composing 75% of QTLs The availability of RNA from unrelated tissues, brain and HSC, allowed us to consider the question of whether ... panel the smaller inset shows the entire range of P-values and the larger figure shows the smallest 200 to 300 P-values The dashed line in the inset shows the expected distribution for random...

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1236 song for present perfect we are the champions by queen part 2 of 3

Ngày tải lên : 25/08/2016, 17:39

... through And I need go next on andpart on and on and Now listen to to the and And I need go next on andpart on and on and Now listen to to the and on write the present perfect in the on write the ... gonna lose And I ain't gonna lose 1 Venter – Negative subject + haven’t / hasn’t + past participle of the main verb Put the lines of the chorus into the Put the lines of the chorus into the correct ... ‘cos And we’ll keep on fighting to the And we’ll keep on fighting to the We are the champions, my friend We are the champions, my friend We are the champions We are the champions We are the champions...

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A study on pronunciation errors made by fourth year students of english at vinh university and suggested solutions

Ngày tải lên : 18/12/2013, 10:03

... behind and below the close front position The “close” position is where the tongue is closest to the roof of the mouth Lips are spread The tongue is tense, and the sides of the tongue touch the ... When soft palate is down, it closes the way to the mouth and opens the way to the nose So the airstream goes to the nose, the Nasl sound produced The table below shows the place and manner of articulation ... one The palato- alveolar sound needs the tongue tip, blade and rims to be close against the alveolar rigde and side teeth, the front of the tongue to be raised and when the air is released, there...

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Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx

Ngày tải lên : 20/02/2014, 03:20

... fragmentation and DNA laddering are characteristics of the apoptotic nucleus, and the ﬁnal DNA degradation step in the autophagosome may correspond to the phagocytosis of apoptotic bodies by macrophages The ... in the autophagosome together, the mitochondria taken in the autophagosome might be broken, once they were incorporated into the autophagosomes These observations led us to an idea that the apparently ... To elucidate the role of the mitochondrion as a key effector we studied the localization of mitochondria during the death process and the levels of mitochondrial nuclease activity Using two different...

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Research " ECONOMIC ANALYSIS OF PRODUCTION STRUCTURE, TECHNOLOGICAL CHANGE, AND PRODUCTIVITY GROWTH FOR THE U.S FOOD AND KINDRED PRODUCTS SECTOR " docx

Ngày tải lên : 07/03/2014, 02:20

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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells potx

Ngày tải lên : 17/03/2014, 10:20

... tubulin to assemble into and disassemble from microtubules Assembly and disassembly were determined by monitoring each type of tubulin by immunoblot and by radioactivity Results are the mean ± S.D of ... incorporation of [14C]nitrotyrosine or [14C]tyrosine into tubulin, the protein preparations were processed to compare the abilities of tyrosinated and nitrotyrosinated tubulin to assemble into and to disassemble ... Experimental values were standardized relative to total tubulin loaded, by dividing the optical density of each band stained with antibodies to Glu- and nitrotyrosinated tubulin by that of an identical...

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The mandibles of a mantis are strong and sharp enough to cut human flesh potx

Ngày tải lên : 02/04/2014, 21:21

... từ đó) The mandibles of a mantis are strong and sharp enough to cut human flesh 2 Các bạn di chuột vào cụm từ để biết chức cụm câu: The mandibles of a mantis are strong and sharp enough to cut ... money I will buy a motorbike.” – Nếu có đủ tiền, mua xe máy - The mandibles of a mantis are” – Hàm bọ ngựa “mandibles”- hàm (sâu bọ), danh từ số nhiều từ “mandible” , động từ to be” chia “are” ... not old enough to get married viết lại câu sau: I am too young to get married.( Tôi trẻ để lập gia đình) , (Tôi trẻ lập gia đình được) Hoặc “He spoke too quickly for us to understand (Anh nói nhanh...

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Dự án nông nghiệp " Major Cropping Soils of Gia Lai Province, Vietnam, and Soil Constraints to Productivity of Major Upland Crops Grown by Smallholders " ppt

Ngày tải lên : 21/06/2014, 04:20

... input cropping systems should be directed toward the use of minimal P rates applied in bands or pockets close to the seed, and the use of crops with low P-demand Band or spot placement of water-soluble ... Province, and document the specific soil requirements of these crops/cropping systems link soil constraints to the soil requirements of the major upland crops and develop management guidelines for the ... tolerance to Al and/ or Mn toxicity such as maize and coffee unless a comprehensive liming program is undertaken a-: These soils require a liming program if they are being used to grow crops of...

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Báo cáo hóa học: " Our vision for this new SpringerOpen Access journal, Psychology of Well-Being: Research, Theory and Practice, is to promote a distinctly eclectic approach to investigating well-being. When the prospect of " pdf

Ngày tải lên : 21/06/2014, 06:20

... feel the research climate and resources are now supportive of these types of challenges Well-being research has increased substantially over the past decade and the demand to disseminate these ... substantial and there is promise of ongoing and even more innovative progress with the high calibre of scholars currently dedicated to well-being research, many of whom we are fortunate to have on ... within the field of positive psychology but from a broad range of disciplines and perspectives Now we need to focus more intensely on understanding the specific mechanisms involved in the process of...

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Báo cáo y học: " 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block" pdf

Ngày tải lên : 09/08/2014, 07:20

... represents the number of mothers and the second represents the total number of samples tested The data take into account the number of samples collected from each mother, which differs from to Thus, ... available to study A total of 192 sera from mothers were tested all together All of the women gave informed consent to participate, and the study was approved by the Ethics Committee at the Paris Bichat-Claude ... reactivity of sera with the Ro52 and Ro60 proteins was examined The 192 sera from 41 mothers of group I and from 25 mothers of group II were then tested for their ability to react in the ELISA...

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Báo cáo y học: "Detection of Chlamydia trachomatis-DNA in synovial fluid: evaluation of the sensitivity of different DNA extraction methods and amplification systems" pps

Ngày tải lên : 12/08/2014, 11:22

... -20°C because this leads to loss of sensitivity to detect the organism A storage temperature of -20°C was chosen due to practicability reasons In our and other laboratories [20,23,27,28], the extracted ... according to the manufacturer's protocol Figure summarizes the above described algorithm of sample analysis Statistical analysis Definition of the number of EB relative to IFU was conducted by standard ... repetition of amplification analysis Method and differ in the contents of the added extraction buffers Exact contents of the buffers supplied are subject to patent of Qiagen (Hilden, Germany) and not...

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Báo cáo y học: "The evidence base for chiropractic treatment of musculoskeletal conditions in children and adolescents: The emperor''''s new suit" pdf

Ngày tải lên : 13/08/2014, 14:20

... the titles of the case reports and found 35 studies of dislocations Excluding dislocations, we were able to identity 23 studies describing the effect of manual therapy in children Eleven of these ... in relation to the effectiveness of manual therapy for spinal disorders in the young population As for the rest of the musculoskeletal system, only one randomised trial of temporomandibular disorder ... that documents the type of pediatric patients chiropractors treat, the type of treatments offered, the effect of these treatments, and potential side effects This means that randomized controlled...

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Báo cáo y học: "Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition" docx

Ngày tải lên : 13/08/2014, 22:22

... Figure The GSH/GSSG ratio of the prototype and expanded models The GSH/GSSG ratio of the prototype and expanded models The prototype model (A) and the expanded model (B) Page of 11 (page number not ... hexokinase and pyruvate kinase, and the maximum activity of these enzymes was allowed to change according to the ratio of GSH and GSSG The equations and parameters used are derived from the literature ... evidence of the disease until the RBCs are exposed to oxidant stress The compensatory effect of the de novo GSH synthesis and GSSG export pathways may thus help to explain why many varieties of G6PD...

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Báo cáo sinh học: " Assignment of CPS1, OTC, CRYD2, ARG2 and ASS genes to the chicken RH map" pot

Ngày tải lên : 14/08/2014, 13:22

... was derived from the chicken ortholog by comparison with those of the human and frog, and then the primer-pair for CPS1 was redesigned inside of the sequence Since the exon-intron structure was ... with the highest lod score of 19.22, and to NCKAP1 with the second highest lod score of 16.49; LANCL1 and NCKAP1 are located on GGA7 (Tab II) These results, together with the fact that the retention ... Table I The results were used to assign the ﬁve genes via a mapping tool which is a clone of the porcine IMpRH server [10] Distances and log of odds (lod) scores were calculated according to Lange...

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Báo cáo y học: "Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase" potx

Ngày tải lên : 14/08/2014, 17:22

... compute the position of the cluster, we calculated the distance between the start of the protein and the start of the cluster, and between the end of the cluster and the end of the protein We then took ... consensus and compared the frequency of matches to the cy motif in the clb5 specific proteins with the frequency in the rest of the proteins above the cutoff (Figure 8b) Although the frequency of cy ... using the binomial distribution, and combined these P values by multiplying them together by assigning a P value to their product using the Q-fast algorithm [19] We note that the subregion with the...

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Developing business strategy for the 5-year period (2010 - 2015) of Vinaconex - Alphanam Infrastructre Development and Investment JSC

Ngày tải lên : 26/03/2015, 09:35

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