the role of oxidative stress and antioxidant treatment in experimental diabetic neuropathy
báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
Ngày tải lên :
20/06/2014, 04:20
... BMP-2, the yin and yang of mineralization:
Contrast of effect of 24 hours of treatment with FGF-2 or BMP-
2 on fold increase in abundance of mineralization-related gene
expression. Mineralizing ... visualized the mineralizing
cells with 2% Alizarin Red. After rinsing in distilled
water and air drying the samples, we mounted the cov-
erslips on microscope slides using Fluoromount and
examined and ... result in loss of
ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing gene expression, cell growth and
BMP-2 in gene expression and mineralization of bone.
Materials and...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
Ngày tải lên :
20/06/2014, 07:20
... Li
4
Abstract
Introduction: The difficulty in re-growing and mineralizing new bone after severe fracture can result in loss of
ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing ... visualized the mineralizing
cells with 2% Alizarin Red. After rinsing in distilled
water and air drying the samples, we mounted the cov-
erslips on microscope slides using Fluoromount and
examined and ... BMP-2, the yin and yang of mineralization:
Contrast of effect of 24 hours of treatment with FGF-2 or BMP-
2 on fold increase in abundance of mineralization-related gene
expression. Mineralizing...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
Ngày tải lên :
20/06/2014, 00:20
... oxida-
tive stress. The observed increase of reducing species in
urine would mirror an increased level in blood originat-
ing from a response to oxidative stress in the body mon-
itored by the urinary ... only 10% of urate is excreted in the urine (the
remaining 90% being recirculated by the renal system
[3]), an increase of this antioxidant in blood will also
lead to an increase in urine. The fact ... H,
Savant Instruments Inc.). The final volume was deter-
mined by gravimetry, assuming that the entire methanol
was removed during the conc entration in the SpeedVac
and that the d ensity of the remaining...
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx
Ngày tải lên :
18/02/2014, 11:20
... only critical
for the stability of the dimer, it may also be involved in
maintaining the integrity of the active site. These results
clearly suggest that the dimer interface in the Y74W*
mutant ... bond with the backbone CO of F102. Fur-
thermore, the orientation of the side chain of the two
residues brings the guanidinium plane and the aro-
matic ring of F102 into close proximity, with ... elevated temperature and
in the presence of denaturants [27].
Extending these studies, we examine here the effect
of increasing the bulk of the residue at position 74.
Surprisingly, the Y74W mutant...
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The effects of oxidative stress on female reproduction: a review ppt
Ngày tải lên :
05/03/2014, 16:20
... and/ or
compensatory hyperinsulinemia increase the availability
of both circulating androgen and androgen production
by the adrenal gland and ovary mainly by decreasing sex
hormone binding globulin (SHBG) [134].
Polycystic ... resulting in increased levels of
the SO an ion [209]. The mechan ism of placental NAD
(P)H activation is still unclear, but the above findings
may assist in elucidating the role of OS in the patho ... catalyzes
the formation of NO from O
2
and L -arginine using
NADPHasanelectrondonor[24]andarecomprisedof
the following isoforms: neuronal NOS (nNOS or N OS I),
inducible NOS (iNOS or NOS II), and endothelial...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Ngày tải lên :
07/03/2014, 16:20
... by the amount of internalized agonist
[20]. As the internalization is expressed in percentage
of total binding, decreasing the binding affinity of the
Role of helix 8 and C-termini in bradykinin ... FEBS
The role of helix 8 and of the cytosolic C-termini in
the internalization and signal transduction of B
1
and B
2
bradykinin receptors
Alexander Faussner
1
, Alexandra Bauer
1
, Irina Kalatskaya
1
, ... activation of the receptor, and
subsequently of the G protein, leads to a change in the
environment of helix 8 resulting in the loss of the heli-
cal structure. Mutation of specific residues in their
model...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
Ngày tải lên :
07/03/2014, 21:20
... near the flexible C terminus of SNase.
Changes in the fluorescence intensity of W140 reflect
a change in the surrounding hydrophobic environment
of the tryptophan and thus indicate a change in the
overall ... (DC
p
) and difference of
DC
p
of mutant from wild-type (%) were determined
and the results for the wild-type protein and 20
mutants are given in Table 1. The DH
cal
and T
m
of the
wild-type protein ... at a heating
rate of 1 Cặmin
)1
. The melting point (T
m
) was obtained
directly from the DSC curve. The enthalpy change (DH
cal
)
was calculated by the integration of the curve covering area
(T
m
was...
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- 0
The role of sentence stress in enhancing english speaking competence of HPU english majors
Ngày tải lên :
17/03/2014, 16:12
... Sentence stress organizes the words in the sentence into logically connected
thought groups by joining the unstressed syllables to the main stressed
syllable in the group and marking the end of the ... lose their stress. The most important words in
the sentence receive stronger stress. The last stressed word in the sentence
receives the strongest stress with the help of falling or rising intonation. ... distinguish between four levels of stress: major
sentence stress, major word stress, minor word stress and unstressed.
Thus, in the sentence: “I walked home in the rainstorm”.
‗I‘, in , and...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
Ngày tải lên :
23/03/2014, 07:20
... discoideum to oxidative
stress, and we now show the response of this organism to oxidative stress
and the role of PARP during development. We used hydroxylamine (HA)
to induce in situ generation of H
2
O
2
and ... development.
HA-induced oxidative stress activates PARP within
5 min (Fig. 4A,B), and its role during oxidative stress
is further confirmed by the use of low concentrations
of benzamide. Preincubation of cells ... H
2
O
2
and monitored the effect of
benzamide, a PARP inhibitor, on oxidative stress- induced changes in
D. discoideum development. Interestingly, oxidative stress resulted in PARP
activation within...
- 8
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- 0
Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
Ngày tải lên :
23/03/2014, 07:20
... fragmentation using mass
spectrometry, by incubating Grx2 in standard buffer
for 30 min or 2 h in the presence of n-PT. After incu-
bation, standard Grx2 and fragments recovered by fil-
tering the incubation ... incubated without the RS or Grx2; Grx2-incubated, samples
incubated in the presence of the RS plus Grx2 at the indicated
concentrations. Anti-FLAG, loading control performed as described
in Experimental ... (Grx1 and Grx2) and
five monothiolic glutaredoxins. These isoforms differ
in their location and response to oxidative stress,
among other factors [9,11,18–22]. Evidence indicates
that Grx2 is the...
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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
Ngày tải lên :
23/03/2014, 15:21
... result
from the modifications in the interactions between the
catalytic glutamates and the residues R97 and Y331,
indicating that these residues play a role in the modulation
of the Sfbgly50 pH optimum.
Sequence ... m
M
Bicine buffer 7.0–8.5). The
pH stability of Sfbgly50 was checked by incubation in the
same buffers for a time equal to the assay time and then
determining the activity remaining at the optimum ... [10,12].
Nevertheless, it is not possible to assume that the same is
occurring in the mutant R97M, because there is no data on
the interactions between the substrate and the arginine
residue.
Finally, another...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
Ngày tải lên :
30/03/2014, 11:20
... unsure of the mechanism
of DNA-induced stabilization of the protein, and whe-
ther it is related to the normal RNA-binding function
of coat protein, as RNA binding had no effect.
The increased ... understood, and we have investigated these
questions in this work. We sought to determine the
role of protein–RNA and protein–protein interactions
in virus stability, measuring the effects of urea,
GdnHCl ... leaving behind an intact capsid.
The dlFG version of coat protein is dimeric and
therefore lacks both the protein–protein and protein–
nucleic acid interactions that normally occur within
the...
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- 0
the role of labour mobility and informal networks for knowledge transfer
Ngày tải lên :
01/06/2014, 11:20
... analyzing the determinants of venture capital investment in the
United States between 1986 and 1998, they find that the likelihood of a ven-
ture capitalist investing in a given target declines ... of industrial clustering.
The organizations of the first economy, either because of their charter to do
research as in the case of universities and R&D laboratories, or as a by-
product of ... A
number of compelling themes emerge from the chapters. First, the flow and
spillover of knowledge requires the interaction of multiple analytical units of
analysis, spanning the cognitive process of...
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Báo cáo hóa học: " The role of feed-forward and feedback processes for closed-loop prosthesis control" doc
Ngày tải lên :
19/06/2014, 08:20
... people act in anticipation of
their actions in the absence of ext ernally-a rising cues.
The formation and maintenance of internal models has
been studied in healthy individuals (reviewed in [17]),
but ... important step in understanding the
human-machine interface.
By manipulating feedforward and feedback uncertainty
we have shown that the seemingly trivial task of grasp-
ing and lifting objects ... (left) and second (right) phases of training. Subjects performed significantly worse in the absence of either
source of feedback.
Saunders and Vijayakumar Journal of NeuroEngineering and Rehabilitation...
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- 503
- 0
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