... our incomplete under-
standing ofthe relation between enzyme properties and
conformational flexibility limits the exploitation ofthe full
potential of protein engineering inthe redesign of psychro-
philic ... designed on the basis of side-chain packing criteria
from a modelled structure ofthe enzyme resulted in restor-
ation ofthe energy of activation to the levels ofthe native
enzyme andin an increased ... designed with the aim of reducing the spatial
constraints originating from the side-chain interactions
between Tyr269 and Ala261 (Fig. 2C). The main difference
between the G261A and G261A/Y269A...
... OS-fitness ofthe clone, the ratio ofthe specic
absorbance inthe presence of 10 lgặmL
)1
HEL to that
in the absence of HEL was taken as an index.
To analyze the effect ofthe type of each FR2 ... antigen in itself [7,20]. At
least for these antibodies, theroleofthe V
L
domain
might be to increase the affinity by supporting the V
H
domain. The phenomenon may also be observed in
the chain ... correlation between the antigen-
binding affinity andthe V
H
⁄ V
L
interaction, especially inthe presence of a
set of particular V
L
residues. The effect ofthe H39 mutation on the wild-
type variable...
... mountain; (b) lava IS-PART of vol-
cano, and moreover it is a part coming from the
inside; and (c) fragments of lava have all the prop-
erties of lava, the following question semantic
TheRoleof ... example, inthe case of question
Q209: “Who invented the paper clip ?”, the
expected answer type is PERSON and so is the
subject ofthe verb invented , lexicalized as the
nominalization inventor. ... Iditarod ?”, since the definition of Word-
Net sense 2 of noun harness contains the bigram
“pull cart” and both sled and cart are forms of
vehicles, the alternation ofthe pair of keywords
pull,...
... their brand attitude, may
suggest an interesting implication for the
new brand advertising strategy. Instead of
focusing on the content ofthe message
which only emphasizes the benefits of ...
This finding is just reverse ofthe finding of
Belk (1973).
Ruth, Brunel, Otnes (1999) classified
categories of gift-giving into public
occasion (i.e., Christmas, Chinese New
Year), individual ... to be aware ofthe new product
and has initial favorable emotion with its
brand after receiving the gift.
REFERENCE
1. Annamma Joy, “Gift giving in Hongkong andthe continuum of social ties”,...
... control of glycolysis and glycogen synthesis by glucokinase overexpres-
sion. The validity of S4048 for testing theroleof Glc6P was supported by
its lack of effect on glucokinase binding and its ... be
explained by sequestration of Glc6P derived from glu-
cokinase and hexokinase I in distinct pools [3,24], or
by the involvement of mechanisms, additional to
Glc6P, in mediating the effects of glucokinase ... vs. 1.5 ± 0.1). These results
suggest that the increase of Glc6P inthe presence of
S4048 was caused by the inhibition of Glc6P hydro-
lysis inthe absence of detectable changes in glucose
phosphorylation.
S4048...
... documents and find that the fea-
ture vectors corresponding to some of these docu-
ments (particularly the short ones) have all zeroes
in them. In other words, none ofthe bigrams from
the training ... one in which the
author himself likes the movie, andinthe other,
the author’s cousin likes the movie. The over-
generalization resulting from these “stemmed” re-
lations renders dependency information ... extracting objective materials and re-
moving them from the reviews is not effective in
terms of improving performance. To determine the
reason, we examine the n-grams andthe depen-
dency relations...
... located in a gene cluster and three of them are
P450 enzymes. The FUM6 protein (CYP505B1) inter-
venes in one ofthe first steps in fumonisin synthesis by
hydroxylation ofthe polyketide-amino acid ... required for
breaking the plant’s defence but, on the other hand,
alkanes serve as nutritional input during the initial col-
onization steps. Insect cuticle consists of protein and
chitin, and is covered ... tight
binding affinity was demonstrated towards lauric acid,
resulting inthe synthesis of mainly x-1 hydroxylated
lauric acid, suggesting a roleinthe lipid oxidative
metabolism. Interestingly, the...
... the transaction from the vantage point of firm A, the floating-
rate payer. The cost of synthetic floating-rate financing is determined by the
cost of servicing fixed-rate debt plus the net cost of ... to the desire on the part
of firms to hedge cash flows against the effects of interest rate volatility. The
timing ofthe appearance of interest rate swaps, coming as it did during a pe-
riod of ... argue, trading in
interest rate swaps has helped to complete forward markets and to lower the
cost to firms of managing their exposure to interest rate risk.
The Role for Hedging inthe Theory of Corporate...
... bridging the
A’ and G b-strands ofthe I27 protein during the main unfold-
ing barrier.
[39]
To further validate this view and gain insight into
the roleof solvent hydrogen bonds in protein unfolding, ... rapidly, causing the unfolding of one of
the I27 modules inthe chain. Unfolding then extends the over-
all length ofthe protein, relaxing the pulling force to a low
value. As the slack inthe length ... Snapshot ofthe b-strands A’ and G ofthe I27 protein
showing the protein backbone only for simplicity. C) Snapshot ofthe b-
strands A’ and G ofthe I27 protein showing 4 D
2
O molecules bridging the
protein...
... absurdities, often raise the imagination, and move the heart: when made the materials of poetry,
and adorned by the skill andthe eloquence of an ardent and superior mind, they instruct the understanding, ... prostitutions, andthe standard of their
opinions on the subject of good andof evil. Under this influence, they would enter, if not restrained by the
laws ofcivil society, on a scene of violence ... the preservation ofthe individual, while they continue to operate inthe manner
of instinctive desires; are nearly the same in man that they are inthe other animals; but in him they are sooner
or...
... (glycero-)sphingolipids. In addition the
fatty acid chains ofthe phospholipids composing
these rigid domains are generally more saturated than
those inthe lipids ofthe surrounding membrane. In
fact, this ... cluster in
response to extracellular stimuli andthe size of the
domains containing those clusters has been estimated.
In summary, multiple lines of evidence have helped to
argue in favour ofthe ... carefully.
Isolation of lipid rafts ⁄ caveolae is very often the first
step inthe biochemical analysis oftheroleof these
domains in cellular signalling. After disruption of cells,
lipid rafts...
... 484–487.
23. Brines, R.D. & Brock, J.H. (1983) The effect of trypsin and chy-
motrypsin on thein vitro antimicrobial and iron-binding proper-
ties of lactoferrin in human milk and bovine colostrum. ... Berkel* and Jan H. Nuijens
Pharming, Archimedesweg, Leiden, the Netherlands
Lactoferrin (LF) is an iron-binding glycoprotein of the
innate host defence system. To elucidate theroleof N-linked
glycosylation ... 2004 Tryptic susceptibility of lactoferrin variants (Eur. J. Biochem. 271) 683
Theroleof N-linked glycosylation inthe protection of human
and bovine lactoferrin against tryptic proteolysis
Harrie...
... Director ofthe Prosperity Institute of Scandinavia,
Jönköping International Business School (charlotta.mellander@jibs.se).
Kevin Stolarick Research Director ofthe Martin Prosperity Institute in ... %
within
CS
%
within
Income
Total %
within
CS
%
within
Income
Count %
within
CS
%
within
Income
Count %
within
CS
%
within
Income
Count %
within
CS
%
within
Income ... Director ofthe Martin Prosperity Institute and Professor of
Business and Creativity at the Rotman School of Management, University of Toronto,
(florida@rotman.utoronto.ca).
Charlotta Mellander*...
... consumers may be unaware ofthe information
on the label, they may not know the region/area of origin or they may fail to interpret
what they mean. Furthermore, many other brands and trademarks, owned ...
During the interviews 46% ofthe total sample selected the Mortadella with the PGI
mark, 43% the one without the PGI mark andthe remaining 11% stated no preference.
The Mortadella with the ...
improve the information environment by either supplying missing information or by
increasing the flow of information between suppliers and consumers. A label is intended
to help consumers distinguish...
... M, Wolff MH: Roleofthe protein kinase PKR
in the inhibition of varicella-zoster virus replication by beta
interferon and gamma interferon. J Gen Virol 2005, 86(Pt
1):1-6.
61. Sainz BJ, Halford ... KOS-GFP spread inthe eyes or periocular
skin of scid mice during the first 6 days p.i. (Fig. 6A). In
contrast, CyP treatment enhanced the spread of KOS-GFP
into the periocular skin of scid mice ... impair the capacity of a
scid mouse to limit HSV-1 spread from the site of
inoculation.
Role of peripheral WBCs in innate resistance to HSV-1
The lack of effect of NK cell depletion on innate...