the role of caga protein signaling in gastric carcinogenesis — caga signaling in gastric carcino

Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc

Ngày tải lên : 12/08/2014, 18:20

... surfactant protein D plays an important role in delaying the appearance of pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence ... currently in the process of investigating these questions In summary, the absence of lung surfactant protein D increases the persistence of pneumococcal colonisation and infection in the upper ... required to further elucidate the role of SP-D in regulating adaptive immune responses in vivo The potential of truncated recombinant forms of SP-D as a new therapy for infectious and inflammatory...

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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot

Ngày tải lên : 13/08/2014, 03:20

... concluded that the Available online http://ccforum.com/content/10/6/239 Figure The role of the protein C pathway in the endothelial cell APC modulates endothelial phenotype by inhibiting thrombin production, ... because this is the site of protein C activation, the endothelium contains the receptor for APC (EPCR), and the endothelium contains the PARs, which may also mediate APC signaling [24] Evidence ... small interfering RNA (siRNA) targeting the enzyme responsible for S1P production, sphingosine kinase-1, blocked the barrierenhancing signaling of APC In addition, siRNA targeting the S1P receptor...

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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx

Ngày tải lên : 22/03/2014, 18:20

... rapidly, causing the unfolding of one of the I27 modules in the chain Unfolding then extends the overall length of the protein, relaxing the pulling force to a low value As the slack in the length ... bridging the A’ and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... trajectories of individual proteins Indeed, using these techniques, it becomes possible to explore the role of the solvent environment in protein collapse[42] and the dynamics of protein folding.[47] Therefore,...

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Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt

Ngày tải lên : 30/03/2014, 14:20

... both ADAM10 and TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials ... dose-dependent increase in the shedding of ACE (Fig 3B,C), with a 12-fold increase in the amount of soluble ACE in the CHO cell medium observed with 500 lM APMA The effect of APMA on the shedding of ACE ... cells in the absence or presence of APMA Following this second incubation, the level of sAPPa in the medium was examined (Fig 4A,B) There was no signiﬁcant difference in the level of sAPPa in the...

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The role of ORF3 protein in the molecular pathogenesis of porcine circovirus 2 infection

Ngày tải lên : 10/09/2015, 08:38

... the genome The sequence to the 3’ of the stem-loop structure contains the hexamer repeats CGGCAG which act as the binding site for the Rep proteins The numbering of the nucleotide begins in the ... play a role in determining the pathogenicity of the PCV2 infection (Ramamoorthy et al., 2009) This thesis describes the role of ORF3 in the pathogenesis of the PCV2 virus infection at the systemic ... Our findings on the molecular activity of ORF3 have also led us to speculate other potential uses for the protein In the third part of the thesis, the role of ORF3 mediated apoptosis in the egress...

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The role of cyclops nodal signaling in zebrafish early embryogenesis

Ngày tải lên : 15/09/2015, 17:09

... representation of the TGFβ signaling from cell membrane β to the nucleus The TGFβ ligand initiates signaling by binding to and bringing together type I and type II receptor serine/threonine kinases on the ... Smad proteins consist of two conserved domains: the N-terminal MH1 domain and the C-terminal MH2 domain These domains are connected by a proline-rich linker region The MH1 domain has DNA-binding ... 6.4 Table of Contents Figure 6.5 Figure 7.1 Figure 7.2 xi The pro-domain of Cyc is involved in ligand-inhibitor Interactions 160 Hypothesized levels of Nodal signaling in the induction of different...

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The role of prion protein in breast cancer cell metabolism

Ngày tải lên : 12/10/2015, 17:36

... readings of all standards, controls and samples, including the no -protein control The values for the protein standards were plotted with a linear regression line through the standard points The protein ... aspects of PrP In humans, PrP is initially synthesized as a pre-pro-PrP of 253 amino acids in the cytosol PrP contains a hydrophobic N-terminal signal peptide of 22 amino acids while the last 22 amino ... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer...

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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc

Ngày tải lên : 21/02/2014, 01:20

... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...

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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf

Ngày tải lên : 22/02/2014, 04:20

... our incomplete understanding of the relation between enzyme properties and conformational ﬂexibility limits the exploitation of the full potential of protein engineering in the redesign of psychrophilic ... Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant W260K/A219N (as reﬂected by a threefold increase of the ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The...

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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding afﬁnity pptx

Ngày tải lên : 07/03/2014, 12:20

... evaluate the OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the type of each ... antigen binding, this ‘increasing the affinity by increasing the VH ⁄ VL interaction’ might represent a mechanism of increasing Fv affinity This is also supported by the kinetic study of purified ... enhancement in VH ⁄ VL interaction significantly improved the antigen-binding affinity of Fv, similarly to the level of scFv (Table 2) Some single VH domains of anti -protein IgG, including HyHEL-10...

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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt

Ngày tải lên : 08/03/2014, 05:20

... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining the role of statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings of the 6th Applied ... hypernyms in the answer semantic form Step 3: The assessment of the similarities of dependencies In the third step, two classes of similar dependencies are considered, generating unications of the ... example, in the case of question Q209: Who invented the paper clip ?, the expected answer type is P ERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor...

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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx

Ngày tải lên : 14/03/2014, 14:20

... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content of the message which only emphasizes the benefits of the ... birthday This finding is just reverse of the finding of Belk (1973) Ruth, Brunel, Otnes (1999) classified categories of gift-giving into public occasion (i.e., Christmas, Chinese New Year), individual ... situational conditions of gift-giving may differ according to characteristics of the gift-giving occasion, whether the presentation of the gift is public, private, or anonymous, and whether the gift is...

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The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf

Ngày tải lên : 15/03/2014, 10:20

... important for explaining wilt In the case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college Further, when net worth is included in the model, Black youth are ... youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this money for...

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Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf

Ngày tải lên : 16/03/2014, 14:20

... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a speciﬁc inhibitor of glucokinase [5] and also a nuclear ... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydrolysis in the absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... [31], for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes incubated with 15...

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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc

Ngày tải lên : 17/03/2014, 04:20

... the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model is likely to ... Following Pang et al (2002), we use frequency as presence In other words, the ith element of the document vector is if the corresponding unigram is present in the document and otherwise The resulting ... relation is capturing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...

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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

Ngày tải lên : 22/03/2014, 16:21

... biological functions The proteins displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis (2–6% amino acid identity) This can be explained in part by their bifunctional ... enzymes The FUM6 protein (CYP505B1) intervenes in one of the ﬁrst steps in fumonisin synthesis by hydroxylation of the polyketide-amino acid at C-14 and C-15 (Fig 3) Fum6 deletion mutants of F verticilloides ... strong indications for the involvement of a bacterial P450 in the hydroxylation of octane in Rhodococcus rhodochrous, the role of bacterial P450s in alkane degradation in addition to the well-established...

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The Role of Interest Rate Swaps in Corporate Finance doc

Ngày tải lên : 22/03/2014, 17:20

... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost of the ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing of the appearance of interest rate swaps, coming as it did during a period of volatile ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk The Role for Hedging in the Theory of Corporate...

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The Role of Digital Identity Management in the Internet Economy doc

Ngày tải lên : 23/03/2014, 23:21

... explains some of the key concepts and outlines some of the basic IdM processes The range of conceptions of identity is very broad The examination of the following concepts is for the purposes of ... to take into account in the assessment of the security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security  In the case of sensitive ... accounts within the organisation The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information Nonetheless, there can...

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Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot

Ngày tải lên : 30/03/2014, 02:20

... than those in the lipids of the surrounding membrane In fact, this fatty acid composition favors a tighter packing of phospholipids and cholesterol, increasing the rigidity of these domains [32–35] ... muscarinic receptors, endothelin receptors, rhodopsin) are located in lipid rafts [65–70] where they are in close proximity to their transducing GTP-binding protein (Gs, Gi, Go, Gq and transducin ... extraction during lipid raft isolation Moreover, these studies have provided some insights into the signiﬁcance of the localization of the P2X7 receptors in lipid rafts regarding the regulation of intracellular...

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Báo cáo khoa học: Tertiary structure in 7.9 M guanidinium chloride ) the role of Glu53 and Asp287 in Pyrococcus furiosus endo-b-1,3-glucanase pot

Ngày tải lên : 30/03/2014, 04:20

... contribution of ions as cofactors in protein folding [38] and in the design of variants of proteins with enhanced stability [14] Changes in the denatured states induced by mutation affect protein stability ... binding of calcium to the mutant proteins in native conditions The single and combined mutations dramatically decrease the thermodynamic stability of the proteins with a signicant decrease of ... contribute to the optimization of electrostatic charges balance of pfLamA in the native state, independently of their interaction with calcium The role of electrostatic interactions in protein stability...

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