the impact of lipid induced alterations in drug lp binding pro les on drug pharmacodynamics

Sustainable Globalization and Emerging Economies: The Impact of Foreign Direct Investment in Thailand

Ngày tải lên : 08/11/2013, 23:15

... become the financial hub of the ASEAN region The Government of Singapore Investment Corporation (GIC) made significant investment in Thailand, both in the financial institutions sector and the industry ... involving joint ventures, being concentrated in the automotive and electronics industries (OECD, 1999a) Due to the economic recession in Japan in the early 1990s, the share of Japanese investment in Thailand ... reviewed in this section, there are a number of theories that attempt to explain the flow of FDI The Eclectic Paradigm theory is the most useful for analyzing the implication of FDI in economic...

14
768
1

Tài liệu Báo cáo khoa học: "The Impact of Query Reﬁnement in the Web People Search Task" docx

Ngày tải lên : 20/02/2014, 09:20

... ngrams beginning or ending with a stopword Using the Stanford Named Entity Recognition Tool3 we obtained the lists of persons, locations and organizations mentioned in each document Additionally, ... clusters of size >=3 son dataset in the WePS corpus contains a total of 100 documents, and 10 of them belong to a British politician named James Patterson The WePS-2 corpus contains a total of 552 ... Artiles, Julio Gonzalo, and Satoshi Sekine 2007 The semeval-2007 weps evaluation: Establishing a benchmark for the web people search task In Proceedings of the Fourth International Workshop on...

4
459
0

a study on the impact of cost reduction measures in a chieving the competitive advantages in footwear industry

Ngày tải lên : 13/03/2014, 14:20

... understand definition as well as functions of accounting clearly first 2.1.1 Definition of accounting In general, accounting is a process of collecting, recording, reporting information To go into details, ... needs of the organization Secondly, cost accounting can determine selling price that cost accounting provides detailed information about the composition of total cost for determining action of the ... According to Gary Hamel, he argues that “ business concept innovation is the foundation for value creation in the new economy” These new business concepts will often relate a reconfiguration of the...

62
489
0

Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc

Ngày tải lên : 23/03/2014, 04:21

... whether the decrease in binding afﬁnity in the other chimeras was the result of protein instability and misfolding or was merely a byproduct of the localization of chimeras in the ER, cells expressing ... thawed on ice, the protein concentration was determined using BSA as standard The binding reaction was set up using the Binding Buffer (Hanks buffer, 25 mm Hepes, pH 7.5, BSA 0.1%) containing the ... of homo-oligomeric crosslinking for C5aR and AT1R-YFP Because the rate of cross-linking depends on the proximity of the side groups, the ﬂexibility of the structures containing the cysteine probes,...

15
365
0

Báo cáo toán học: " The impact of blood pressure hemodynamics in acute ischemic stroke: a prospective cohort study" ppt

Ngày tải lên : 20/06/2014, 20:20

... hypertension in the early course of AIS [17], and promising results of current research on hemodynamic augmentation in AIS, a cautious approach to treatment of hypertension in AIS is the call of the ... improved outcome It is indeed the next step in clinical investigation, but not quite ready for implementation into clinical practice before the hypothesis is definitively investigated in a controlled ... hypothesis-generating study that asks whether pharmacologic control of these blood pressure fluctuations would result in improved clinical outcomes PATIENT CONSENT: This protocol was approved by the department...

18
340
0

báo cáo khoa học: " High resolution melting analysis for the detection of EMS induced mutations in wheat SbeIIa genes" doc

Ngày tải lên : 11/08/2014, 11:21

... larger product showed the inclusion of the intron V, whereas the smaller one was found to contain a deletion of the first seven nucleotides of exon VI The presence of the intron V in the longer ... reduced showing the intervention of NMD mechanism to prevent the production of a non functional protein The set of the three single and double null genotypes showed an increase in amylose content ... fragments was the probability of finding deleterious SNPs (mutations affecting splicing sites or introducing stop codons) considering the types of transition mutation generally induced by EMS...

14
487
0

báo cáo khoa học: " The role of complex genomic alterations in neuroblastoma risk estimation" pot

Ngày tải lên : 11/08/2014, 12:20

... suggestion is supported by the finding of only 2% flat genomic profiles in another study in which a tumor content of 60% had been used for sample selection [6] Because of the rare occurrence of neuroblastomas ... chromosomal alterations, the clinical outcome of these patients has so far remained elusive Nevertheless, the routine application of array-CGH in clinical practice might be considerably limited by the ... hybridization Competing interests The authors declare that they have no competing interests Page of Authors’ contributions MF and FB drafted the manuscript and gave approval of the final version Acknowledgements...

4
227
0

Báo cáo khoa học: "The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study" pdf

Ngày tải lên : 12/08/2014, 23:20

... improve clinical outcomes In our study, each of the five interventions in the 6-hour sepsis bundle and each of the four interventions in the 24-hour sepsis bundle is backed by the SSC guidelines ... focus on increasing compliance with these evidencebased interventions in appropriate patients Additional files The following Additional files are available online: Additional File The sepsis care ... bundle are based on scientific evidence Clinically, the aim of introducing bundles into clinical practice is primarily to improve process reliability, although the final endpoint in bundle development...

7
394
0

Báo cáo y học: "Further cautions for the use of ventilatory-induced changes in arterial pressures to predict volume" docx

Ngày tải lên : 13/08/2014, 21:21

... loading Second, lung injury associated with sepsis probably increased the presence of zone II Page of conditions in the lungs, so this cause of PPV is not volume responsive These studies further ... but these swings should be minimally responsive to volume infusion because they are minimally related to right heart ﬁlling Based on the above analysis, how can the poor predictive values of PPV ... This can be explained as follows When the lung is in West Zone III, lung in ation produces a negligible load on the right ventricle [5]; but when it is in West Zone II, lung in ation can markedly...

2
220
0

fishea and robeb-the impact of illegal insider trading in dealer and specialist markets - evidence from ~0

Ngày tải lên : 31/10/2014, 12:09

... Some of the information is available on news wires and America Online the night before, but only after the close of trading in the U.S Thus, if the IWS information is valuable, its impact on stock ... 75% of the companies mentioned in the column In other words, in the six months preceding the brokers’ Business Week scheme, the IWS column had an impact on the prices of featured stocks In Panel ... out They can be explained by the fact that the information in the IWS column is impounded into the opening price or the first few trades on Fridays Thus, the intraday returns show no impact of the...

36
593
0

Uric acid levels and the risk of contrast induced nephropathy in patients undergoing coronary angiography or PCI pdf

Ngày tải lên : 24/08/2016, 14:06

... 2 Introduction Contrast Induced Nephropathy (CIN) is one of the most common complications of procedures that require the use of contrast media [1,2] and is commonly defined as an increase in ... species [12] The use of contrast media superimposed acute vasoconstriction, caused by the release of adenosine and endothelin, with the reduction in renal blood flow to the outer medulla, consequent ... solubility The use of contrast media superimposed acute vasoconstriction, caused by the release of adenosine and endothelin, with the reduction in renal blood flow to the outer medulla, consequent...

6
314
0

Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Ngày tải lên : 07/03/2014, 03:20

... downregulation of P-gp at both the mRNA and protein levels (Fig 4A) Inhibition of the PI3K/Akt pathway decreased the expression of P-gp induced by PrPC at both the mRNA and protein levels, suggesting ... releasing rates to each other because of their toxicity effect (P > 0.05) (Fig 3) The results indicated that inhibition of the PI3K/Akt signaling pathway leads to inhibition of PrPC -induced cell drug ... decreasing the transcriptional activation of P-gp Continuing from our previous work, it further reveals the function of PrPC in the MDR of cancers Over recent years, many investigations have focused on...

10
448
0

báo cáo hóa học:" Quality of life and the impact of drug toxicities in a South African community-based antiretroviral programme" docx

Ngày tải lên : 20/06/2014, 08:20

... significant improvement in HRQoL over 12 months of HAART, with the bulk of this improvement occurring within the first three months on treatment Internationally, there is concern about the impact of HAART-related ... and increasing survival among these patients, there is a growing need to understand the impact of HAART use on the quality of lives of HIVinfected individuals [4-8] There is a sizeable body of ... counsellors were trained in the administration of the HRQoL instrument The quality of life questionnaire was administered at each of the following scheduled visits: screening, baseline, week 16, week...

13
444
0

Báo cáo y học: "Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in the TREAT Asia HIV Observational Database (TAHOD" pdf

Ngày tải lên : 10/08/2014, 05:20

... individual drug The physician reports the major reason believed to be underlying the reason for stopping a drug Reasons include treatment failure, clinical progression/hospitalisation, patient decision/request, ... load at initiation of combination treatment, previous AIDS defining illness, calendar year, number of combination, type of treatment (d4T/3TC/NVP; combinations of ART with NNRTI no PI, other than ... Figure Duration of first, second and third combination treatment Duration of first, second and third combination treatment combination for a median of 3.2 (1.2 – 6.3) years Out of the 1846 patients,...

10
537
0

Effects of anti malaria drug artesunate in the treatment of rhinovirus induced asthma exacerbation

Ngày tải lên : 09/09/2015, 11:16

... that the induction of ICAM-1 promoter activity was critically dependent on up-regulation of NF-κB protein binding to the -187/-178 NF-κB binding site on the ICAM-1 promoter The increase of ICAM-1 ... more conserved compared with the residues in other site of the surface These conserved sites have been shown to be the binding sites of the receptors and thus block the binding of the neutralizing ... exacerbation of the Th2 response in HDM -induced allergic asthma On the basis of the RV -induced asthma exacerbation mouse model, we test the effects of anti-malarial drug Artesunate in the treatment of...

172
712
0

Báo cáo y học: "The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey"

Ngày tải lên : 25/10/2012, 11:00

... restricted for the first three days of therapy by NARP, the consumption of these quinolones was unsurprisingly high Besides that the use of oral quinolones for maintenance may contribute to the significant ... observe the full impact of the NARP Fourth, we calculated antibiotic consumption in grams instead of using daily defined dose (DDD) to evaluate the consumption because of some concerns The DDD ... time after cessation or decline in the level of drug use [30] Enne et al showed that a huge decrease in sulphonamide prescribing in the UK did not have an effect on the prevalence of resistance http://www.medsci.org...

6
692
0

The Impact of Signal Bandwidth on Indoor Wireless Systems in Dense Multipath Environments

Ngày tải lên : 20/11/2012, 11:36

... wavefront in the direction of propagation [3] as shown in Figure 2.1 Consideration of wavelets originating from all points on XX’ leads to an expression for the field at any point on YY’ in the form of ... Refraction Refraction is defined as the bending of the normal to the wavefront of a propagating wave upon passing from one medium to another where the propagation velocity is different [53] The most ... radiated from the antenna, which by definition is contained in the far-field region of the antenna The far-field region is defined as the region in which the propagating waves exhibit local plane wave...

210
712
0

Tài liệu From Burden to “Best Buys”: Reducing the Economic Impact of Non-Communicable Diseases in Low- and Middle-Income Countries pdf

Ngày tải lên : 20/02/2014, 19:20

... damages incurred as a result of its use The designations employed and the presentation of the material in this overview not imply the expression of any opinion whatsoever on the part of the World ... estimation of the economic impact of chronic noncommunicable diseases in selected countries” WHO Working Paper Department of Chronic Diseases and Health Promotion (CHP), 2006 Size of the Problem: ... this impact It brings together findings from two recently completed studies that can inform international policy dialogue, including the UN High-Level Meeting on NCDs Their findings shed light on: ...

12
799
1

Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx

Ngày tải lên : 21/02/2014, 01:20

... asset portfolio rather than solely the poultry income, thereby providing a more accurate measure of the impact of the disease If one looked only at the impact of HPAI on the income from poultry ... No information is available on the costs of culling, diagnostic testing of samples, cleaning and disinfection, and other administrative costs (Obi, Oparinde, and Maina 2008) Regarding the impacts ... bird raised The Poisson regression model is the development of the Poisson distribution presented in Equation to a nonlinear regression model of the effect of independent variables x i on a scalar...

40
759
0