that the passions of the mind are helped by a celestiall season and how necessary the constancy of the mind is in every work

Most cases of STEMI are caused by a thrombotic occlusion of a larger coronary artery (5). The pptx

Ngày tải lên : 18/06/2014, 12:20

... systems capable of performing out of- hospital of treatment (Class IIa) In the ERC and ACC/AHA guidelines, fibrinolysis is the preferred strategy in the absence of contraindications and when the expected ... strategy is supported by recent registry data (82-84) and study data (85) Facilitated PCI In contrast to pharmacoinvasive therapy, the strategy of facilitated PCI relies on the idea that early initiation ... repivarin, fondaparinux, and enoxaparin requires dose reductions in patients with renal impairment Because of increased intracranial bleeding risk (41), enoxaparin is also given in reduced doses in...

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Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc

Ngày tải lên : 21/02/2014, 09:20

... But mathematics is applied in a variety of ways, in a vast panorama of disciplines And the applications are many and varied Other disciplines often like to reduce their theories to mathematics ... publisher Klaus Peters is himself a Ph.D in mathemat16 There is a grand tradition in mathematics of not leaving a trail of corn so that the reader may determine how the mathematical material was ... acquaint the reader with the culture of mathematics: who mathematicians are, what they care about, and what they We also give indications of why mathematics is important, and why it is having...

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Báo cáo khoa học: The domains carrying the opposing activities in adenylyltransferase are separated by a central regulatory domain ppt

Ngày tải lên : 30/03/2014, 08:20

... Inhibition of PII-UMP binding by R domain mAbs 5A7 and 39G11 This table shows the initial deadenylylation activity of AT stimulated only by PII-UMP, in the presence and absence of the R domain mAbs 5A7 ... domain of aspartokinasehomoserine dehydrogenase I [21] Removal of either of the activity domains resulted in a decrease in the regulation of the activity of the remaining domain The binding of PII ... 5C) and the binding of either effector protein disrupts the interaction, so the N and R domains are separated, allowing AT to adopt the ‘open conformation’ The further changes that occur in the...

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Báo cáo y học: "Etanercept versus etanercept plus methotrexate: a registrybased study suggesting that the combination is clinically more efficacious" pptx

Ngày tải lên : 09/08/2014, 01:23

... underscore that the VAS pain is not included in the formula for calculating the DAS28 In as much as any baseline imbalance in the outcome of interest would tend to bias towards finding a greater effect ... by VAS showed a statistically significant difference R348 The DAS28 values following the initiation of etanercept therapy are shown in Fig A statistically significant decrease in disease activity ... 100 mm visual analogue scale; patient pain, patient assessment of pain by 100 mm visual analogue scale; physician global, physician’s assessment of global disease activity by five-point scale (0–4);...

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sloan - don't blame the shorts; why short sellers are always blamed for market crashes and how history is repeating itself (2010)

Ngày tải lên : 03/11/2014, 18:31

... populism and capitalism, rural and urban America, Main Street and Wall Street The economic crisis that began in 2007 was caused by banks that had overvalued assets on their books—assets that they ... hands had never worked the land, thereby exacerbating an already deepseated distrust of banks and paper in all its forms As John Adams said: The stock-jobbers will become the praetorian head of ... is the most studied period of American financial history How did we get the immediate reaction to the crisis so wrong and repeat many of the mistakes that were made in the aftermath of the crash?...

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Báo cáo khoa học: Differences in substrate speciﬁcities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes potx

Ngày tải lên : 23/03/2014, 13:20

... CPB2.8 has Asn60, Asp61 and Asp64 whereas CPB3 has Asp60, Asn61 and Ser64 Interestingly, CPB18, which also has Asp60, Asn61 and Ser64 but also Tyr84 and Asn18 instead of the His84 and Asp18 in CPB2.8, ... calculated according Wilkinson [30] as well as by using Eadie–Hofstee plots The standard derivations of Km and kcat determinations were in no case higher than 5% of the obtained value HPLC analysis ... Juliano, L & Juliano, M .A (2001) S1 subsite speciﬁcity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing...

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Discover the Hidden Talents in Your Workforce pdf

Ngày tải lên : 27/06/2014, 20:20

... leaders and identify the areas that need development Let’s say an employee scored high in the area of critical thinking, but had a low score in assertiveness As a manger, you’ll know the areas ... like the ProfileXT™, measures thinking and reasoning skills, behavioral traits, occupational interests and performance Managers can use the assessment results to compare employees with other ... require them to step up and think outside the box Challenging employees is also a great motivator! Make the project seem as if it is a reward for their meaningful contributions and a chance to...

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Báo cáo khoa học: "Factors that predict outcome of intensive care treatment in very elderly patients: a review" potx

Ngày tải lên : 12/08/2014, 22:21

... preparing the manuscript SEdR interpreted data and participated in preparing the manuscript AA-H analyzed and interpreted data ML interpreted data All authors read and approved the final manuscript ... prognosis of complicating conditions that are frequently present in older patients and that are underreported in administrative databases Examples of these are malnutrition and delirium Low body mass ... based on data obtained during the first 24 hours after ICU admission and that they not take into account complications that may develop during treatment It has been shown that the accuracy of...

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Tài liệu Báo cáo khoa học: Efﬁcient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf

Ngày tải lên : 18/02/2014, 08:20

... STAT1 STAT3 and STAT1 are generally recognized to be antagonistic, with STAT3 functioning as a proliferation activator and STAT1 as an inhibitor [23–25], this antagonism is further illustrated ... in cardiac ischaemia, the action of STAT3 is protective and that of STAT1 increases cardiomyocyte apoptosis [41,42] Thus, the inhibition of STAT3 using decoy ODNs that are not strictly STAT3-speciﬁc ... Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells Oncogene 20, 2499–2513 Kanda N, Seno H, Konda Y, Marusawa H, Kanai...

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HUMAN PERFORMANCE: Role of General Mental Ability in Industrial, Work, and Organizational Psychology docx

Ngày tải lên : 06/03/2014, 05:20

... Table are from a principal components analysis of 64% of the broad occupational categories (and 86% of jobs) in the 1970 census That analysis used all job analysis data then available that could ... celestial navigation, passing and failing training, and an overall performance composite made by summing the other criteria As much as years elapsed between ability testing and collection of the training ... rolls), passing and failing training, and an overall performance composite made by summing the other criteria For navigators, the criteria included academic grades, work samples of day and night...

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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf

Ngày tải lên : 18/02/2014, 08:20

... that the 500 kDa bc1 sub-complex present in the DISP strain also contained the subunit Qcr9p and the chaperone Bcs1p In the DBCS1 strain, on the other hand, ISP and Qcr10p were both missing in ... amounts in both yeast strains Therefore, the reason for the disappearance of the bc1 dimer in the yeast strain in which Qcr10p is missing remains unknown On the basis of all the above reported results, ... assistance of speciﬁc chaperone proteins is also required The available data indicate that the accessory factor Bcs1p is involved in the binding of ISP to an immature bc1 intermediate Yeast cytochrome...

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Tài liệu Báo cáo khoa học: The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of a- and b-chitin doc

Ngày tải lên : 18/02/2014, 08:20

... to and degrade individual polymer chains First, the chains are degraded by both endochitinases, that attack the chitin chain randomly, and exochitinases, that attack the chitin chains from either ... LlCBP3 3A In the presence of LlCBP3 3A, the fast initial phase was maintained longer than in the absence of LlCBP3 3A, indicating that LlCBP3 3A acts synergistically with LlChi1 8A However, the effect of ... separate cloning of the chitinase and CBP, as the N-terminus of the latter protein should be free of non-native amino acids after removal of the afnity tag (because amino acid one of the mature...

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Tài liệu Protest Fee Schedule for Thunder Cars: Protestor must verify with the INEX inspector that the proper tools are available to check protested items ppt

Ngày tải lên : 19/02/2014, 04:20

... 1/16 of an inch is 0.990” for the intake port and 0.830” for the exhaust port No port alterations of the intake or the exhaust below the seat are permitted O-ringing the head gasket seal area is ... result in an immediate disqualification and confiscation of all of the following parts: the entire upper end (including the head, the valves, the head gasket, etc.) as well as the pistons and cylinder ... are mandatory Gloves must have “SFI” tag or wording included on care label stating that they are flame retardant 6 ROLL BAR PADDING: Roll bar padding (SFI-45.1) on all bars within one foot of...

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Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt

Ngày tải lên : 20/02/2014, 02:21

... the cycle, the C-terminal tail of TAP2 induces a conformation in NBD2 that is nonpermissive for ATP binding The resulting ADP-binding state of TAP2 and the C-terminal tail of NBD1 allow binding ... ScaI-fragment containing the TMD and core NBD of TAP1 In the case of 2V1, the 1.8 kb ScaI-fragment containing the C-terminus of TAP1 was ligated to the 3.8 kb ScaI-fragment containing the TMD and ... C-terminal tail and results in an ÔATP-onÕ state of TAP2 The structural alteration in TAP2 a ects ATP binding of TAP1 via allosteric cross-talk of the core NBDs and induces ATP hydrolysis in NBD1...

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Tài liệu Báo cáo Y học: Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis docx

Ngày tải lên : 22/02/2014, 04:20

... chloroform and upper aqueous phases In the absence of CMP and in both +PIS and –PIS strains, a release of label in the aqueous phase was observed after incubation To calculate the liberation of radioactivity ... being compiled in our laboratory, are obtained, with the aim of understanding how PtdIns synthase functions and is regulated ACKNOWLEDGEMENTS The authors thank A Zachowski, E Ruelland and A Jolliot-Croquin ... time, that a PtdIns synthase from Arabidopsis is able to catalyse both de novo synthesis of PtdIns and the exchange of the inositol moiety, but it is still uncertain by what mechanism this exchange...

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Default Risk Cannot Explain the Muni Puzzle: Evidence from Municipal Bonds That Are Secured by U.S. Treasury Obligations ppt

Ngày tải lên : 15/03/2014, 03:20

... Guam, and Virgin Islands) is exempt from state taxes in every state In most states, the capital gains tax is applied to gains on municipal bonds whether issued in state or out of state As a result, ... prior to January 1, 1986 or post-January 1, 1986 Standard errors are in parentheses and t-statistics are in square brackets and time-series correlation into the estimation The GLS estimates are presented ... with the Fama and Miller hypothesis The positive and signiﬁcant intercept terms in panels A and B are inconsistent with the Fama and Miller hypothesis, but similar to Trzcinka’s ﬁnding In sum,...

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Nano means one billionth major aspects of nanotechnology what is it how did it come about what are the social implications

Ngày tải lên : 15/03/2014, 22:13

... irregular protein from the cell on the lower right, and a cylindrical gear made by molecular manufacturing at top left (F) shows two atoms in the protein, (G) reveals the nucleus of the atom as a tiny ... atoms spell out a familiar logo A demonstration on the molecular level A nano-motor manipulated by two laser beams Major Aspects of Nanotechnology •What is it? How did it come about? •What are ... - Deals with moleculues between one and one hundred nanometers in diameter Manipulating individual atoms and manufacturing from the bottom up Major Aspects of Nanotechnology •What is it? •How...

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Báo cáo khoa học: The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme doc

Ngày tải lên : 16/03/2014, 04:20

... and Leu148 (the innermost peptide bond, near the catalytic site) The atoms shaping the binding environment of the terminal sulfur atom of CoA are listed in Table and shown in Fig Apart from the ... Cys89 is coloured dark blue His156 at the entrance of the pantetheine-binding cavity is coloured orange Note how the CoA interacts mainly with the loop domain and Cys89 (C) A detailed view of the ... catalytic cysteine) and the C-terminal domain The third domain, referred to as the loop domain, protrudes out of the N-terminal domain The loop domain covers the catalytic site and provides the...

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