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Basic immunology functions and disorders of the immune system

Basic immunology functions and disorders of the immune system

Ngày tải lên : 04/08/2016, 15:18
... University of California San Francisco, School of Medicine San Francisco, California Andrew H Lichtman, MD, PhD Professor of Pathology Harvard Medical School Brigham and Women’s Hospital Boston, ... is compounded by the development of integrated curricula in many medical schools, with reduced time for didactic teaching and an increasing emphasis on social and behavioral sciences and primary ... address the perceived needs of both medical school and undergraduate curricula and to take advantage of the new understanding of immunology We have tried to achieve several goals First, we have presented...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot

Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot

Ngày tải lên : 09/08/2014, 14:22
... cytokines Recombinant mouse IFN-γ was derived from the supernatant fluid of Mick cells, a Chinese hamster ovary (CHO) cell line developed in our laboratory [18] IFN-γ was purified by affinity chromatography ... characteristics of IL-17 using the CIA model As IFN-γ is counteracting the development of Th17 cells, we chose to induce CIA in IFN-γR knock out (KO) mice Through neutralization of IL-17 using monoclonal ... (IRF)1-/- mice, on a C57BL/6 background, were from Dr David E Levy of the New York University School of Medicine (New York, USA) and from Dr Tak Mak of the Ontario Cancer Institute (Ontario,...
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Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity" pptx

Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity" pptx

Ngày tải lên : 09/08/2014, 01:23
... these observations by demonstrating that antibodies produced by aged mice immunized with phosphorylcholine immunogens are not only of lower affinity and avidity but are also less protective against ... response despite reduced antibody response to nominal antigen Cell Immunol 1991, 135:519-525 Franceschi C, Monti D, Sansoni P, Cossarizza A: The immunology of exceptional individuals: the lesson of ... M, De Martinis M: Immunosenescence and infectious diseases Microbes Infect 2001, 3:851-857 Benschop RJ, Cambier JC: B cell development: signal transduction by antigen receptors and their surrogates...
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Báo cáo y học: "Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis" ppsx

Báo cáo y học: "Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis" ppsx

Ngày tải lên : 09/08/2014, 08:23
... 2006, 54:1390-1400 Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N, Anderson DR: Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20 ... autoimmunity? Clin Immunol 2002, 104:1-13 Neumann E, Barnum SR, Tarner IH, Echols J, Fleck M, Judex M, Kullmann F, Mountz JD, Scholmerich J, Gay S, et al.: Local production of complement proteins in ... 24 Parekh RB, Dwek RA, Sutton BJ, Fernandes DL, Leung A, Stanworth D, Rademacher TW, Mizuochi T, Taniguchi T, Matsuta K, et al.: Association of rheumatoid arthritis and primary osteoarthritis...
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Báo cáo y học: "Tumor-infiltrating effector cells of α-galactosylceramide-induced antitumor immunity in metastatic liver tumor" pdf

Báo cáo y học: "Tumor-infiltrating effector cells of α-galactosylceramide-induced antitumor immunity in metastatic liver tumor" pdf

Ngày tải lên : 11/08/2014, 10:23
... Sato H, Kondo E, Koseki H, Taniguchi M: CD1drestricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides Science 1997, 278:1626-1629 Brossay L, Chioda M, Burdin N, Koezuka Y, Casorati ... NK1.1 molecule as a NKT cell marker However, it was hard to determine the optimal conditions to achieve constant numbers of discrete nodules, since MC38 cells sometimes showed diffuse invasive ... Vehicle-treated mice Representative data of two experiments are shown metastasis to the liver Thus, we chose the Colon26 liver metastasis model in Balb/C mice for this study Although Balb/C mouse strain...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf

Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf

Ngày tải lên : 12/08/2014, 16:20
... particular rhinovirus infections, in school-age children hospitalized due to CAP [19] Such infections have to be considered in the context of asthma attacks in children as well as in asthma and COPD ... (MyD88)dependent way, whereas bronchoconstriction depended on resident cells as indicated by experiments with chimeric mice [223] In studies using TLR4-deficient chimeric mice, expression of TLR4 ... Z'graggen BR, Neff TA, Jamnicki-Abegg M, Suter D, Schimmer RC, Booy C, Joch H, Pasch T, Ward PA, Beck-Schimmer B: Inflammatory response of tracheobronchial epithelial cells to endotoxin Am J Physiol...
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A study of the mechanisms of immunity to pasteurella haemolytica infection

A study of the mechanisms of immunity to pasteurella haemolytica infection

Ngày tải lên : 30/09/2015, 05:52
... pneumonic Intrabronchial P by numbers of heat-killed of numbers large had of to in achieved which form failed suspension A, acute 1964) of was material success was three infected chorioallantoic ... Titrations of sera types of P haemolytica antigens dilution conjugate using at 1/200 comparable achieve at absorbance 4Experiment of cross-reaction P haemolytica and 161-163 SSE Al-A12 to 400 nm ... Vaccines against protected Pasteurella challenge When non-specific haemoly-" P observed the Escherichia also The of P of in spleen investigated little intraperitoneal against protected T10 of 12...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"

Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"

Ngày tải lên : 31/10/2012, 15:12
... There are two major intracellular apoptosis-signaling cascades; mitochondrial pathways and death receptor pathways [4] Mitochondrial pathways are regulated by various proapototic and antiapoptotic ... proteins involved in apoptosis, including the expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) ... hypoxia-related markers of trophoblastic cells Materials and methods Cell line and cell cultures The human choricarcinoma cell line JAR was obtained from American Type Culture Collection (Manassas, VA, USA)...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta

Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta

Ngày tải lên : 03/11/2012, 11:24
... dramatic peribronchial and perivascular infiltration was produced in all mice (Figure 2) Airway reactivity measurements Airway hyper-responsiveness (AHR) to metacholine (Acetyl-β methylcholine chloride, ... the presence of increasing concentration of metacholine Mice challenged i.n with OVA (black symbols) had significantly greater responsiveness to metacholine than their respective PBS controls (white ... Immunol 2006; 118:1234-41 [44] Xu B, Aoyama K, Kusumoto M, Matsuzawa A, Butcher EC, Michie SA, Matsuyama T, Takeuchi T Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp

Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp

Ngày tải lên : 05/09/2013, 09:08
... limits the process The development of novel vacuum light (VUV) sources over the last few years (Chiron et al., 2000), has opened up new possibilities for in-situ generation of hydroxyl radicals ... 102, 5542-5550 Chemviron Carbon (1997) The AOT Handbook, Advanced Oxidation Technologies, Brussels Chiron, S., Fernandez-Alba, Rodriguez, A., and Garcia-Calvo, E (2000) Pesticide chemical oxidation: ... homogentisic acid, a tyrosine metabolite, FEBS Letters, 432, 13-16 Hoffmann, M.R., Martin, S.T., Choi, W Bahnemann, D.W (1995) Environmental applications of semiconductors photocatalysis, Chem...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS

ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS

Ngày tải lên : 05/09/2013, 09:08
... Epstein, S and Mayeda, T (1953) Variation of 18O content of waters from natural sources Geochim Cosmochim Acta, Vol.4, 213-24 Fiella, M., Belzile, N and Chen, Yu-Wei (2002) Antimony in the environment: ... (-47.9 ‰) before the precipitation event Interestingly, it continued to decrease with time, reaching -50.1 ‰ at 1200 of Oct 24 -10 δD (‰) -20 -30 -40 -50 -60 -10 -8 -6 -4 -2 δ18O (‰) river water ... precipitations varied from -4.9 to -8.7 ‰ in separate samples Its amount-weighed mean was -6.0 ‰ (Fig 4) Machida and Kondoh (2001) showed that the relationship between δD and δ18O in shallow ground water...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake

Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake

Ngày tải lên : 05/09/2013, 09:38
... to inhibit cytchrom oxidase activity and is reduced by its reductase under aerobic conditions Biochim Biophys Acta., 1017, 57-62 Casey, T.G., Ekama, G.A., and Wentzel, M.C (1999) Filamentous organism ... Waterqual, CD-ROM Smolders, G.J.F, van der Meij J., van Loosdrech, M.C.M and Heijnen, J.J (1994) Stoichiometric model of the aerobic metabolism of the biological phosphorus removal process Biotechnol...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc

Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc

Ngày tải lên : 13/02/2014, 06:20
... measure the choices and actual behaviours directly, but only the hypothetical choices: we asked whether women would consider using and would stop or continue using In addition, hypothetical choices ... action of FP in terms of whether these may influence a woman's decision to choose an FP method or continue to use the chosen method We also investigated which opinions and characteristics were ... satisfaction with the chosen method as well as minimize user errors It is also important to acknowledge that women have different preferences and can accordingly make a choice of the method best...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

Ngày tải lên : 14/02/2014, 18:20
... Nyrkova IA, Bell M, Harding R, Carrick L, McLeish TCB, Semenov AN & Boden N (2001) Hierarchical self-assembly of chiral rod-like molecules as a model for peptide b-sheet tapes, ribbons, fibrils, and ... result in oligomerization and fibrillation [14,61–64] In general, amyloid formation in vitro can be achieved by destabilizing the native state of the protein under conditions in which noncovalent interactions ... driving force for fibril formation is a structural rearrangement within the oligomeric granules achieved by shear stress FEBS Journal 278 (2011) 2263–2282 ª 2011 The Authors Journal compilation...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt

Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt

Ngày tải lên : 16/02/2014, 15:20
... 100 ing protein in Escherichia coli Mol Microbiol 5, 951– 957 Britton RA, Powell BS, Court DL & Lupski JR (1997) Characterization of mutations affecting the Escherichia coli essential GTPase ... potential growth rate-regulated checkpoint in Escherichia coli Mol Microbiol 27, 739– 750 March PE, Lerner CG, Ahnn J, Cui X & Inouye M (1988) The Escherichia coli Ras-like protein (Era) has GTPase activity ... has an essential role in growth rate and cell cycle control in Escherichia coli J Bacteriol 173, 2265–2270 Okamoto S & Ochi K (1998) An essential GTPbinding protein functions as a regulator for...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

Ngày tải lên : 18/02/2014, 06:20
... differences in body fatness in children and adolescents? Nutr Metab Cardiovasc Dis 16, 294– 301 Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, Luke A, Schoeller DA, DeLany JP, Butte ... Clin Endocrinol Metab 92, 2041–2045 Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K, Balletshofer B, Machicao F, Fritsche A & Haring HU (2008) Identification and characterization ... Corona G, Mannucci E, Schulman C, Petrone L, Mansani R, Cilotti A, Balercia G, Chiarini V, Forti G & Maggi M (2006) Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf

Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf

Ngày tải lên : 18/02/2014, 08:20
... F, Bernadac A & Hatchikian EC (1995) Isolation and characterization of the pyruvate-ferredoxin oxidoreductase from the sulfate-reducing bacterium Desulfovibrio africanus Biochim Et Biophys Acta-Protein ... Crystalline pyruvate oxidase from Escherichia coli II Activation by phospholipids J Biol Chem 246, 1575–1582 49 Bertagnolli BL & Hager LP (1991) Activation of Escherichia coli pyruvate oxidase enhances ... medial cluster [28] Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron...
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Tài liệu Báo cáo khoa học: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters pdf

Tài liệu Báo cáo khoa học: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters pdf

Ngày tải lên : 18/02/2014, 17:20
... acetylcholinesterase indicate that BuChE can act in the central nervous system as a surrogate acetylcholine-hydrolysing enzyme [5] Both cholinesterases also display noncholinergic activities Cholinesterase ... catalytic centre Cholinesterases are structurally related hydrolases [1] Acetylcholinesterase (EC 3.1.1.7) plays a key role in the cholinergic system in terminating the action of acetylcholine, but ... cholinergic pathway and can use butyrylcholinesterase to hydrolyze acetylcholine Neuroscience 110, 627639 Grisaru D, Sternfeld M, Eldor A, Glick D & Soreq H (1999) Structural roles of acetylcholinesterase...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Ngày tải lên : 19/02/2014, 16:20
... cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4 Proc Natl Acad Sci USA 93, 46444648 Raner, G.M., Chiang, E.W., Vaz, A.D.N & Coon, M.J ... optical perturbations were also observed upon O2 binding to so-called class I P450s, comprising mitochondrial and bacterial isozymes such as CYP11A1 [2224] and CYP101 [25,26], respectively The rapid ... protonation, the calculated proton afnity being )442.1 kcalặmol)1 [45] The proton-delivering machinery has been recognized to involve a highly conserved active-site threonine residue [46,47]...
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