specificity of the involvement of peripheral and central cytokines in different components of sickness behavior

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

Ngày tải lên : 14/02/2014, 19:20

... zinc ion each, and binds to the minor groove of the DNA [6] Dmrts were originally described to play important roles during sex determination in flies and worms by regulating several aspects of ... at higher levels in testes than ovaries The deep interest in Dmrt1 in the field of sex determination in fish came with the discovery of a dmrt1 homologue on the Y chromosome of the fish medaka (Oryzias ... studied in the context of gonadal induction and maintenance, illuminating its important function But what about the other dmrt genes? Table summarizes the expression pattern of these genes in fish...

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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc

Ngày tải lên : 19/02/2014, 06:20

... to examine whether these loops are actually involved in DNA binding Because aromatic residues are involved in the ssDNA binding by bacterial single stranded DNA-binding protein (SSB) and human ... monomer of poly(dT), showing that the changes were mainly due to the binding of the ﬁrst DNA, while the binding of the second DNA had less in uence (Fig 5A) To ensure that the estimation of the protein:poly(dT) ... octameric ring with DNA These differences in the higher ordered structures of Rad51 and Dmc1 with the DNA may reﬂect the different DNA binding modes of these proteins Interestingly, even the conservative...

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Báo cáo khoa học: In vitro analysis of the relationship between endonuclease and maturase activities in the bi-functional doc

Ngày tải lên : 17/03/2014, 10:20

... statement and suggests that the RNA binding site is still available and its binding afﬁnity is not altered by the presence of DNA in the DNA binding site Interestingly, when nM RNA and 10 nM ... release of the cleavage products from the protein The amplitudes of the initial burst (2.78 and 2.83 nM) gave a ratio of DNA/protein of 0.94 : As will be discussed further, these data indicate ... increase the stability of the protein and slowed the reaction rate (data not shown) The inclusion of 5–10% glycerol increased stability two- to ﬁvefold, depending on the preparation of protein,...

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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot

Ngày tải lên : 19/06/2014, 22:20

... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... production in murine brains within 24 hours In contrast, the intracerebral injection of murine Page of (page number not for citation purposes) Journal of Neuroinflammation 2004, 1:13 recombinant TNF (in ... writing of the manuscript DP and IY performed the experimental i.c.v injection experiments WE contributed to the interpretation of the results and writing of the manuscript Acknowledgments The...

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Báo cáo hóa học: " Research Article Analysis of the Tradeoff between Delay and Source Rate in Multiuser Wireless Systems" docx

Ngày tải lên : 21/06/2014, 11:20

... the computation of the variance of the blocks (the evaluation of the mean of the blocks is straightforward), which comes down to the computation of the expectation E[cu [n]cu [n + m]] The joint ... constraint Moreover, the in uence of the scheduling algorithm and the channel conditions (SNR, target BER) are captured in the mean and the variance mu and σu Thus, the evaluation of the user rates comes ... to obtaining the mean and the variance of the channel process seen by user u: (20) The delay constraint formed by the pair (Dt , ε) can be diﬀerent for each user Nevertheless, we maintain the 3.2...

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Báo cáo khoa học: "Evaluation of the nuclear DNA content and GC percent in four varieties of Fagus sylvatica L" potx

Ngày tải lên : 08/08/2014, 14:21

... determined for the common beech and the tortuosa variety, after propidium iodide and mithramycin stainings Results are listed in table II In F sylvatica, the GC content was 40.0 ± 0.2 %; in the tortuosa ... 3.5 %), indicatthat DNA content in the tortuosa variety is the same as in the common beech Furthermore, in replicated analyses of common beech with or without tortuosa, the coefficients of variation ... at the low end of the range of known 2C genome sizes, as for instance Musa acuminata (1.2 pg), Vitis vinifera (1.0 pg) or Phaseolus augustii (1.1pg) [4, 11] The GC content was then determined...

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Báo cáo lâm nghiệp: " A flow cytometric evaluation of the nuclear DNA content and GC percent in genomes of European oak species" pptx

Ngày tải lên : 08/08/2014, 18:21

... ploidy level of Quercus plants on the basis of genome size relative to a standard plant of known ploidy MATERIALS AND METHODS The plant material was leaves of in vitro cloned plantlets of Q petraea ... calculation is based on only the first subpopulation of nuclei, the 2C peak, avoiding the higher levels Yet another source of variation can be the in vitro procedure However, the propagation procedure ... Willd and Q robur L Petunia hybrida cv Px Pc (2C 2.85 pg; 41 % GC) was selected as an internal standard The Q petraea and Q robur clones originated from donor trees in northeastern France (Lorraine)...

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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc

Ngày tải lên : 09/08/2014, 01:24

... distress in the acute phase, which in two mice had high scores However, the symptoms in these strains did not proceed in relapses as they did in the QD and B10.Q mice, and therefore resulted in a ... pathogenesis of both diseases [16,18,19] and T cells are required in order to induce disease [10,20] No data have been reported on the role of cytokines in RP, either in patients or in the corresponding ... MIRP On the other hand, the murine MIRP and CIA models are both dependent on B cells for the induction of clinical symptoms [16,17] In addition, the complement system plays a major role in the pathogenesis...

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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc

Ngày tải lên : 12/08/2014, 02:20

... they are homologues of host genes The most obvious of these is the collection of genes that are involved in altering or maintaining photosynthetic function of the host The most well studied and ... enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising the psbA mRNA in the cyanobacterium Synechocystis [64], altering structure of PSII ... all involved in the degradation of host DNA at the start of infection [45] The lack of homologues of these genes is not limited to cyanomyoviruses, with the marine phage KVP40 also lacking these...

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Báo cáo khoa học: "The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs" pot

Ngày tải lên : 12/08/2014, 18:22

... increased amount of hybrid fibres can be seen in trained muscles of man and rat [13] The aim of this study was to examine the effect of the PRKAG3 mutation on both the metabolic profile and the fibre ... semitendinosus in the carriers and the non-carriers of the PRKAG3 mutation are presented in Table The CS activity was higher (P < 0.05) in the carriers of the PRKAG3 mutation than in the non-carriers ... 0.05) in m biceps femoris and m longissimus dorsi in the carriers than in the noncarriers Discussion The main new finding of this study is, that after exercise training the PRKAG3 mutation influences...

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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf

Ngày tải lên : 13/08/2014, 05:21

... concentrated in the C2 region The four N-glycosylation sites in C2 and the site in the beginning of V3 were highly conserved in all patients throughout infection which is strongly indicative of convergent ... important role in the folding of the glycoproteins, in infection and in evasion from the host immune response (reviewed in [69]) We found that, as for HIV-1 [51,58], the majority of potential N-glycosylation ... References Competing interests The authors declare that they have no competing interests Authors' contributions NT designed and coordinated the study PB performed most of the cloning and sequencing experiments...

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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt

Ngày tải lên : 13/08/2014, 15:21

... surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the ... blockade of C5aR has recently been described to reduce the LPS-induced activation in the paraventricular nucleus and the central amygdala [81] Thus, as we are beginning to gain novel insights into the ... facilitating adhesion and transmigration of neutrophils and monocytes into the brain tissue Especially the anaphylatoxin C5a is known to be a strong inducer of ICAM-1, VCAM-1 and various selectins...

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Báo cáo y học: "Endothelial Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients" potx

Ngày tải lên : 14/08/2014, 07:21

... for inflammation and bacterial infection in clinical routine, CRP and PCT reached AUC statistics of 0.524/0.531 and 0.545/0.550 In comparison with these biomarkers of organ dysfunction and inflammation, ... analyses, including markers of inflammation/infection (CRP, PCT), hepatic (albumin, international normalized ratio (INR)) and renal (creatinine) function at admission, suPAR remained an independent ... D1D2D3 and D2D3 In a previous study on different forms of suPAR and prognosis in HIV infected patients, the combined clinical value of suPAR D1D2D3 and suPAR D2D3 (’bulk suPAR’) was compared to the...

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In this paper, we investigate the relationship between migration and species distribution in multizone environment. We present a discrete model for migration of three competing species over three zones. We prove that the migration tactics of species leads

Ngày tải lên : 16/10/2015, 09:09

... F (the so-called structure function [5]) and vector (X1 , Xn , W1 , Wp ) where n is the number of components of the models (and leaves of the DFT) and p is the number of PAND gates in the ... cases, the simulation is performed on processors and the initial paths are in black while the correction step is in dotted red lines of the simulation For instance in the left part of Fig 1, the ... of the events occurring in the subtrees Now, we change the initial step of the simulation When we draw the random number, we check if un < S In that case we trigger the event in the subtree and...

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The u s presidency and executive power in the works of thomas pynchon, philip roth and cormac mccarthy

Ngày tải lên : 08/11/2015, 00:06

... discussed the presence of the Cold War in the Border Trilogy and The Road, and the influences of both the Reagan and Clinton administrations on McCarthy’s fiction Other critics have interrogated the ... Dixon on the one hand and the reader on the other must reconnoitre the slips and slides of history, the twists and turns of the unexpected, the dark remains of the day.”77 Evidently then, Pynchon ... from the 1960s to the 1980s is marked in Vineland, unmistakeably, by the rise of first Nixon, and then Reagan The immense power of the executive branch to affect the lives, inner and outer, of individual...

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Sumary: The difference of the culture between Vietnam and US (lesson in the university)

Ngày tải lên : 29/02/2016, 14:27

... fruit as the thanks of yours - Acquaintances When acquaintances meet together in the street, they often smile together if they are at the same age If they are different about the age, the younger ... to the burial ground After three days of mourning, the family visits the tomb again, or worship the opening the grave After 49 days, the family stops bringing rice for the dead to the altar And ... finally, after 100 days, the family celebrates, or the end of the tears After one year is the ceremony of the first anniversary of the relative's death and after two years is the ceremony of the...

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Construing the world: conceptual metaphors and event-construal in news stories potx

Ngày tải lên : 07/03/2014, 17:20

... the defiant character of Tony Blair at the very beginning of the story and provides an apt introduction of the battle construal by introducing the readers to the theme of aggression/opposition: ... quit on the eve of making history by becoming the Labour Prime Minister who has served the longest single period And he crushed the Chancellor's hopes of moving into No10 by saying: "There is ... generality, and specificity in imagining and describing a situation Language plays an important part in this, since different linguistic expressions establish different construals One of the best-known...

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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc

Ngày tải lên : 07/03/2014, 21:20

... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In ... binding site is included in the C-terminal domain of the ask molecule, and this binding is independent of the susceptibility of the a-actinin isoform to calpain proteolysis Identiﬁcation of the ... to the origin of interactions [9,10,12,27] with the targets, the stability of complexes in the resting stage [3,48] and the activation state [7,33] of the binding calpain The topology of the interface...

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Báo cáo khoa học: "INTEGRATING TEACHING THE ENGLISH TENSE: NAIVE AND FORMAL GRAMMARS IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING" pdf

Ngày tải lên : 18/03/2014, 02:20

... underlying the choice and conjugation of an English verb tense One of the main concerns in designing the knowledge base for this module has been that of maintaining the wealth of ideas and intuitions ... for the speaking time, i.e., the interval during which the sentence is being uttered Since the number of the potential temporal relations holding between the time intervals contained in the sentence ... describing an exercise since a lot is left to the insight of the exercise coder Different implementers can thus describe the same exercise in a different way and obtain therefore different, often incompatible,...

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Connecting Developmental Constructions to the Internet: Identity Presentation and Sexual Exploration in Online Teen Chat Rooms pot

Ngày tải lên : 23/03/2014, 03:20

... they are creating and, more to the point, co-creating their Internet environment through processes of social interaction The theoretical question then becomes, what are they creating and what role ... vary in terms of the virtual socialization that occurs within them, and researchers studying adolescents and the Internet need to examine different online environments separately Accordingly, ... testing whether the more secure environment of monitored chat would lead to more extended active involvement in the conversation on the part of individual participants and greater disclosure of information...

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