serotonin and dopamine interactions in rodents and primates implications for psychosis and antipsychotic drug development

Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

Ngày tải lên : 16/03/2014, 11:20

... studies including investigations in human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity ... Adh4 is found in the epithelial lining of upper GI tract including the tongue, esophagus and stomach, but not in the small and large intestines In the rat, Aldh1 is present higher up in the GI tract ... the villi and in the intestinal glands, while submucosal glands were empty In jejunum and ileum, Adh1 1214 mRNA showed a similar expression pattern as described for duodenum In colon and rectum,...

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báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care" docx

Ngày tải lên : 20/06/2014, 08:20

... (age and CD4+ cell count) Table Number and incidence rates of opportunistic infections in the initial 24 months after ART initiation, and percent underreporting of OI events in routine clinic ... discontinuation and modification This gives a total error rate (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related toxicities, and 83% and 58% for ART discontinuation ... patients in the routine clinic database who also initiated ART between April 2004 and April 2005, and who were not enrolled into the research cohort; and the 6421 patients in the routine clinic database...

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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

Ngày tải lên : 09/08/2014, 10:21

... suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may ... γf and γt, as described above The value for Qf, the volumetric flow rate and the spine and brain CSF volumes are taken from Bergsneider [12] The values used for the volumes of the brain and spine ... kshedNb,t,i+γfkadhNb,f,i)] where Ds and Db are the doses administered in a single fraction to the spinal and brain compartments, respectively Scenario I In this scenario (Figure 3), results following a standard course...

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Effective and coordination in Lao PDR Policy Implications for power sector development.PDF

Ngày tải lên : 03/11/2016, 22:29

... mechanisms for streamlining aid coordination The government made institutional adjustments for aid coordination in 2004, transferring the function to the Ministry of Foreign Affairs The Department of International ... competent people working on the agenda, Laos needs to improve the local capacity Funding for training such as English language training, report writing and basic specialized trainings in order to support ... SWGs for energy and mining The review of continuous effort to improve SWGs, it continues to recommends 19 To clarify roles and responsibilities of SWGs That includes the linkages in the NGPES and...

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Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc

Ngày tải lên : 08/03/2014, 16:20

... TATA-binding-protein-associated factors and initiator-binding proteins Mol Cell Biol 17, 2973–2984 32 Weis, L & Reinberg, D (1992) Transcription by RNA polymerase II: initiator-directed formation ... putative Sp1 binding sites are present In addition, the promoter B region contains numerous putative transcription factor binding sites including GATA-boxes, Oct-1, ets-1, AP-1, NF-jB and C/EBP sites ... binding sites detected using TRANSFAC are indicated above the sequence and are represented by horizontal lines sites that could be important for promoter activity in pig cells, such as GATA- and...

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Innovations in Credit Risk Transfer: Implications for Financial Stability docx

Ngày tải lên : 22/03/2014, 20:20

... Corporate Investment and Financing Policies The Journal of Finance 48, 1629–1658 Froot, K and J Stein (1998) Risk Management; Capital Budgeting and Capital Structure Policy for Financial Institutions: ... relief against selling costs For example, in the case of selling costs arising from information about borrower quality that is held privately by banks, Leland and Pyle [1977] use a signalling equilibrium ... reduction in the costs of raising external capital for loan intermediation As suggested by Froot, Scharfstein, and Stein [1993] and Froot and Stein [1998], we expect an equilibrium in which a...

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Poultry of the Middle in the U.S.: ‘Implications for Sustainable Producers & Scaling Up’ pdf

Ngày tải lên : 23/03/2014, 21:20

... basic research using the Internet and interviewing key informants Multiple key informants were identified through contacts in the industry and on the Internet Informants were interviewed by telephone ... by processing technology Stunning, killing and plucking Birds are stunned to render them unconscious before killing in most processing plants While required by law in Europe and used in slaughterhouses ... producer or of the grocery chain where sold Changes in dietary preferences have had a major influence in creating increased demand for poultry in the U.S in the past 40 years In 1960, poultry was 16%...

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Competency-based education in the health professions: Implications for improving global health doc

Ngày tải lên : 28/03/2014, 21:20

... usage, “standard” refers to learner performance and contrasts with the frequent use of “standard” in reference to a “standard curriculum” and even a “standardized examination.” Defining the curriculum ... considered In Australia, for example, the provincial government struggled to change the health outcomes for key chronic diseases for remote, rural and Indigenous populations However, using a training ... and reflect national, professional and client stakeholders, including learners Such competency definitions are intended, among other things, to communicate priorities in a memorable and meaningful...

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Báo cáo hóa học: " miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy" docx

Ngày tải lên : 18/06/2014, 16:20

... FACs analysis, cells were incubated with mAb at 4°C for 30 min, washed twice in staining buffer, and fixed in 500 μl of 2% paraformaldehyde in PBS Cells were stored in the dark at 4°C until analysis ... silencing in non-human primates Nature 2008, 452:896-899 Cheng AM, Byrom MW, Shelton J, Ford LP: Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and ... functions Our findings indicate that the tumor-bearing host down-regulates miR-17-92 in T cells (Fig and 4) Interestingly, not only are STAT6-/- T cells resistant to tumor-induced inhibition of...

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Báo cáo y học: "RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis" ppsx

Ngày tải lên : 12/08/2014, 16:20

... factors for hours for gene expression analysis and 24 hours for protein expression studies The chosen time points and concentrations of growth factors were determined and established in previous and ... expression and induction in cyclin D1 protein, reflecting results of cyclin mRNA expression A representative blot from one of the IPF derived cell lines is shown in Fig 2c Data shown in fig 2a, 2b and ... containing the protein was recovered and assayed for total protein using a commercial microplate assay (Bio-Rad, Hemel Hempsted, UK) 25 µg of total protein was combined with sample buffer and...

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Role of hydrogen sulfide in the cardiovascular system implications for treatment of cardiovascular diseases

Ngày tải lên : 01/10/2015, 17:27

... first renin inhibitor, aliskiren, was approved by the Food and Drug Administration for use in the United States in March 2007 Aliskiren binds to the active site of renin and prevents the binding of ... 72 4.2.7 Sirus red staining for collagen 73 4.2.8 Toluidine blue staining for mast cells 73 Liu Yi Tong 4.2.9 Immunostaining for renin, mast cells and cell nuclei ... Renin is the rate-limiting enzyme involved in renin-angiotensin system Renin elevation occurs during pathological states of renal ischemia (renin in systematic circulation) or cardiac remodeling...

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Placing Bank Supervision in the Central Bank Implications for Financial Stability Based on Evidence from the Global Crisis

Ngày tải lên : 29/08/2016, 08:24

... several countries (including Belgium, Hungary, and the United Kingdom) went on to reform their institutions for financial sector supervision, including bringing bank supervision and macroprudential ... al (2014) examine determinants of the 2007–09 banking We assume, as is common in the literature (Masciandaro, Pansini, and Quintyn 2011), that the mandate for financial stability and macroprudential ... estimating a probit model All robustness tests support and, on occasions, reinforce our baseline results Interestingly, when we use the Reinhart and Rogoff (2011) definition of banking crises, placing...

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Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through speciﬁc protein interactions in the methionine synthase–methionine synthase reductase complex docx

Ngày tải lên : 18/02/2014, 08:20

... of MS During primary turnover, the homocysteine-binding domain (dotted barrel) and the CH3-H4-folate binding-domain (black barrel) form discrete complexes with the cobalamin-binding domain (dark ... (light grey) and the C-terminal activation of hMS (grid-barrel) interact with the cobalamin-binding domain For more information on hMS conformational substates, see [5] and [33] cob(II)alamin], an ... containing 100 lgÆmL)1 zeocin Several transformed colonies were streaked onto plates containing 1000 lgÆmL)1 zeocin to select for colonies containing multiple copies of the integrated cDNA for...

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Báo cáo khoa học: Supramolecular calsequestrin complex Protein–protein interactions in chronic low-frequency stimulated muscle, postnatal development and ageing pot

Ngày tải lên : 08/03/2014, 10:20

... TRI and the CSQ-binding element JUN, show decreased protein–protein interactions during ﬁber type shifting and the ageing process Reduced protein coupling between the major elements regulating ... to study complex formation in developing, transforming and ageing skeletal muscle ﬁbers Blot overlays are a technically challenging approach to studying complex protein–protein interactions between ... Edgbaston, UK) and sequence similarities determined with the BLAST-P program RESULTS To complement previous domain binding studies and chemical crosslinking analyses of triadic protein–protein interactions, ...

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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx

Ngày tải lên : 16/03/2014, 19:20

... step in the development of novel therapeutics for these currently incurable diseases, we also need to understand in detail the environmental modulators for each disorder in order to inform drug development ... made in identifying genetic factors contributing to PD in recent years [135] Low concordance for clinical disease in monozygotic twins indicates environmental in uences on PD [136], and the ﬁnding ... genes in uencing age of onset have been identiﬁed, including a polymorphism in an allele for a noncoding TAA repeat in the GluR6 kainate receptor [9,10], apolipoprotein Ee2e3 genotype [11], and...

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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot

Ngày tải lên : 16/03/2014, 22:20

... electrostatic forces and also van der Waals’ interactions play an important role in stabilizing the DNA drug complex The NH amide atoms of the drug in particular form H-bonds with thymine O2 and adenine ... calculations of the interaction between (A) the amidinium end and bases A25, T8 and G9; and (B) the guanidinium end and bases A5, T28 and A6 Intermolecular geometry constraint according to the crystal ... However, it is interesting that the guanine amino group may be in uenced by this contact We compared the interaction energies in both a planar and a nonplanar guanine G9 amino group The HF interaction...

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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx

Ngày tải lên : 30/03/2014, 11:20

... protein–protein and protein–RNA interactions in virus stability is not completely understood, and we have investigated these questions in this work We sought to determine the role of protein–RNA and ... coat protein dimers and their selfassembly into an icosahedral capsid, while selectively encapsulating a single copy of viral plus-strand RNA by the coat, and ignoring viral minus strands and host ... covalently link them To facilitate purification, both dlFG and a single-chain dimer, sc-dlFG, contain an N-terminal six-histidine nickelaffinity tag Using intrinsic fluorescence of Trp residues, extrinsic...

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Báo cáo khoa học: Redox-sensitive loops D and E regulate NADP(H) binding in domain III and domain I–domain III interactions in proton-translocating Escherichia coli transhydrogenase potx

Ngày tải lên : 31/03/2014, 09:20

... protein concentration and substrate content Protein concentrations were determined using the bicinchoninic acid assay with bovine serum albumin as standard [18] The content of bound NADPH in the ... rather indirect, it is conceivable that the tight binding of NADP(H) in the occluded state of domain III directly or indirectly involves G430 and/ or the conformation of loop E An interesting possibility ... B.G (2000) Interactions of the NADP(H)-binding domain III of proton-translocating transhydrogenase from Escherichia coli with NADP (H) and the NAD (H) -binding domain I studied by NMR and site-directed...

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Báo cáo sinh học: " Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach" pdf

Ngày tải lên : 18/06/2014, 18:20

... primer binding sites) of the DPOL gene [2] was carried out in a nested format with the degenerate and deoxyinosine-containing (deg/dI) primers DFA, ILK and KG1 in the first PCR round and TGV and ... specificity for the glycoprotein B gene and for the major DNA binding protein gene of cytomegaloviruses For the amplification of the gB gene, deg/dI primers were used in a nested format (Table ... ribose and forces the conformational transition from the B-type to the A-type [12] The introduction of LNAs into DNA and RNA improves the hybridization affinity and increases the melting temperature...

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