recent advances in understanding the link between autophagic cell death pathways and tumor development pdf

Báo cáo y học: "Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells" pdf

Ngày tải lên : 11/08/2014, 21:22

... to explain the differential growth kinetics and, by extension, the cytopathogenesis of the prototypic RSV A2 strain and the clinical isolates To determine whether the differential CPE between ... isolate in HEp-2 cells influence growth kinetics of the clinical isolates in PBECs Cells were scraped into the medium and harvested every 24 h post infection Virus growth kinetics were determined ... resulted in some cell rounding and limited monolayer disruption However, there was no evidence of syncytium formation in these cells Interestingly, RSV BT4a-infected PBECs and mock-infected controls...

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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations

Ngày tải lên : 03/10/2015, 20:57

... thymidines and disruption DNA and RNA synthesis As a result, the cell undergoes apoptosis by “thymineless” death Interestingly, part of the interest in the cancer stem -cell concept comes from the ... implications between cancer stem cells and the pathways responsible for colorectal cancer development Lastly, possible relations to therapeutic responses were also examined In this thesis, the findings indicated ... dysfunction The MMR system is composed of at least seven proteins including, MLH1 and MSH2 The MLH1 and MSH2 protein are essential in the mismatch repair machinery and mutations in MLH1 and MSH2...

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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"

Ngày tải lên : 03/11/2012, 09:57

... transforming non receptor tyrosine kinase activity [4], and the finding of EGFR, the first receptor tyrosine kinase paved the way to the understanding of the role and significance of tyrosine kinase in ... sheet and one α helix, while the C terminal domain is a large cytoplasmic domain that is mainly α helical ATP binds in the cleft in between the two lobes and the tyrosine containing sequence of the ... to cell proliferation in the absence of ligand in glioblastomas, ovarian tumors and non small cell lung carcinoma [12] Point mutations either in the extracellular domain of the FGFR results in...

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Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance doc

Ngày tải lên : 22/03/2014, 18:20

... proliferation and metaplasia involving the terminal air-space (13) Others, though, are of the opinion that the scar represents a desmoplastic reaction and is the result, rather than the cause, of tumor ... observed in five patients (9.8%), and mediastinal lymphadenopathy in 42 (82.4%) The stage of non-small -cell lung cancer was I in ten patients, II in two, IIIA in four, IIIB in 11, and IV in 20 At the ... form of the tumor was consolidative Calcification within the tumor was seen in 20 patients (39.2%), and was located eccentrically in 15 cases and centrally in five Cavitation within the tumor was...

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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx

Ngày tải lên : 18/06/2014, 16:20

... cancer cell lines Six NSCLC cell lines consisting of three adenocarcinoma cell lines (A549, H522 and H358), two large carcinoma cell lines (H460, H661), and one squamous cell carcinoma cell line ... participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and...

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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx

Ngày tải lên : 18/06/2014, 16:20

... components of tumor stroma and involved in the process of invasion (Figure 1.) Furthermore, the interactions between cancer cells and tumor stroma termed as ‘invasion pattern’ corresponding to the dynamic ... http://www.translational-medicine.com/content/8/1/101 Page of 11 Figure Co-evolution of tumor cells and their microenvironment in cancer invasions Both of tumor cells and their microenvironment are involved in cancer invasions ... macrophages infiltration in developing neoplasms is now well recognized, and infiltrating macrophages play an important role in tumor cell invasion into surrounding normal tissues [24,25], including...

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Báo cáo y học: "Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance" ppt

Ngày tải lên : 10/08/2014, 05:21

... competing interests 12 Authors' contributions DN conceived of the study, and participated in the design, data analysis, interpretation of data, drafting and revising the paper AK participated in the ... SO-CD4 The independent variables included age, sex, baseline CD4 cell counts, body mass index (BMI), baseline hemoglobin, initial ART regimen, magnitude of CD4 increase in first months and Hepatitis ... differences in CD4 counts depending on the specific OIs Despite viral suppression, 14% and 30% of the OIs in the first months of therapy occurred among patients with SO-CD4 using the CD4 increase and...

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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot

Ngày tải lên : 10/08/2014, 09:22

... examined if invasion of the tumor was suspected at the surgical margins The histopathological findings were classified according to the World Health Organization criteria, and the UICC TNM staging ... specimens, including the primary tumor and resected hilar and mediastinal lymph nodes, were examined to determine both the tumor histology and the extent of lymph node metastases Intraoperative ... We investigated the association between total number of involved lymph nodes including hilar and mediastinal lymph nodes, and survival We also investigated the association between skip mediastinal...

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báo cáo khoa học: "Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma" ppt

Ngày tải lên : 10/08/2014, 10:20

... cancer-related death only Cases were included according to the following inclusion criteria: having archived formalin-fixed, paraffin-embedded specimens available; having complete clinicopathological and ... graded into four groups: + : < 5% of tumor cells stained; ++ : 5-25% of tumor cells stained; +++ : > 25-50% of tumor cells stained; ++++ : > 50% of tumor cells stained A patient was considered CTA-positive ... immunohistochemistry analysis and manuscript writing SXC and AMD were responsible for the study design and manuscript writing All authors read and approved the final manuscript Competing interests The authors...

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Báo cáo y học: " Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases" pptx

Ngày tải lên : 12/08/2014, 11:21

... component in pulmonary inflammation/infection and may represent a promising marker and therapeutic target in respiratory diseases The expression, regulation and clinical significance of sCD14 and mCD14 ... in symptoms over the preceding months, and none reported a change in airway symptoms in the months prior to the study BAL was performed for further diagnostic clarification The asthma group included ... patients used inhaled bronchodilators and nine asthma patients used inhaled corticosteroids Spirometry and flow volume curves were performed according to the ATS guidelines [14] The clinical indication...

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Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot

Ngày tải lên : 12/08/2014, 15:22

... pain was assessed using the five sub-scales, which included knee pain while walking on a flat surface, going up and down stairs, at night while in bed, sitting or lying, and standing upright These ... account for the correlated readings within an individual and examine the association between changes in WOMAC scores (pain, function, and stiffness) and continuous changes in BML size Standard diagnostic ... = 704) and the subjects included in the current study (n = 395) There was a small difference in the WOMAC pain scores between the subjects in the current study [mean pain score 3.2 (standard...

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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot

Ngày tải lên : 16/03/2014, 01:20

... miR-21 suppress the growth of breast cancer cells in vitro and in xenografts in mice [48] miRNAs as biomarkers in cancer Their fundamental role in development and differentiation, and their pervasive ... accelerating the cell cycle, including cyclin D and retinoblastoma [56,57] Moreover, alterations in the machinery responsible for processing miRNA contributes to tumorigenesis, and impairment ... overexpressed in CLL, promoting the survival of leukemia cells [31] Indeed, there is a reciprocal relationship between the expression of miR-15a and miR-16-1 and of Bcl-2, and the heterologous...

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NUTRITION AND METABOLISM Underlying Mechanisms and Clinical Consequences pdf

Ngày tải lên : 22/03/2014, 19:20

... characterization of the many bioactive molecules that are synthesized and secreted by adipose cells (adipokines) The adipokines and other molecules synthesized in the stomach, intestines, pancreas, and other ... types I and II diabetes and reviews the ﬁndings that link these diseases genetically The interaction between the central and peripheral nervous systems, the endocrine system, and molecules synthesized ... research interest in the factors in uencing energy balance, and intensiﬁed research efforts on the links between obesity and its complications It has also created an increasing demand for the study...

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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot

Ngày tải lên : 30/03/2014, 09:20

... adenocarcinomas, which arise from the glandular tissue (6) It can grow along the lining of the epithelium into the wall of the colon and rectum and invade the digestive system (7) In addition, the ... epithelial and nonepithelial types The epithelial type is further subdivided into serous, mucinous, endometrioid and clear cells On the other hand, the nonepithelial is granulosa cells, mixed germ cells ... also induced significantly in tumor These include MMP1, MMP3, MMP14 and MMP7 Other cell- cell adhesion-related molecules for examples laminins (LAMA4, LAMA5, LAMB1, LAMB2 and LAMC2) and integrins...

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cell cycle control mechanisms and protocols methods in molecular biology - tim humphrey, gavin brooks

Ngày tải lên : 08/04/2014, 12:50

... resulting in cells that are already in G2 at the time of cell separation (14) The G2/M transition is the major control point in the cell cycle of fission yeast and determines the timing of entry into ... but cytokinin is the dominant one in the shoot meristem Both the signaling pathways and the way they affect the cell cycle are the subject of active research and debate, but some common principles ... mitosis, in which the mitotic nuclear membrane, remains intact In addition, S cerevisiae is distinct from other eukaryotic cells in that the mitotic spindle begins to form during early The Budding and...

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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx

Ngày tải lên : 18/06/2014, 15:20

... setting of cancer, tumorigenesis RAGE is the link between inflammatory pathways and pathways promoting tumorigenesis and metastasis Characterizing the role of RAGE in vivo and in vitro can be broadly ... this family differ from each other mainly in the length and sequence of their hinge regions and the C-terminal extension region after the binding loops Ca++ binding induces a large conformational ... at the cell surface or at intracellular vesicles and induce their clustering on the cell surface For example, S100 dimers and higher-order multimers bind several receptors including TLR4, and...

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báo cáo hóa học: " Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer" pot

Ngày tải lên : 18/06/2014, 19:20

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báo cáo hóa học: "Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer" pot

Ngày tải lên : 18/06/2014, 22:20

... Group Am J Clin Oncol 1982, 5(6):649-655 Wyrwich KW, Nienaber NA, Tierney WM, Wolinsky FD: Linking clinical relevance and statistical significance in evaluating intra-individual changes in health-related ... self-care and confined to bed more than 50% of waking hours); MID – minimally important difference; SEM – standard error of the mean; SD – standard deviation forthcoming in the literature in explicitly ... ASP, MN and DC were responsible for the conception of the study ASP and DC acquired the data ASP performed the data analysis and drafted the manuscript MN and DC revised it critically for intellectual...

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Báo cáo hóa học: " Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients" pot

Ngày tải lên : 21/06/2014, 01:20

... containing colistin < μg/ml resulted in complete bacterial killing Based on these findings, the currently used colistin dosing regimens might not provide the most effective therapy and therefore ... Optimizing colistin dose based on PK/PD properties The optimal dose of colistin has not been determined in the ICU setting, because since there is a lack of relative clinical studies In addition, there ... concentrations The PK/PD relationship of colistin against P aeruginosa has been examined recently in a vitro model A significant finding of the study was that colistin efficacy against P aeruginosa was...

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Báo cáo y học: "The Inventory of Personality Organisation: its psychometric properties among student and clinical populations in Japan" pptx

Ngày tải lên : 08/08/2014, 23:21

... measured using concepts matching the therapeutic theory described above Understanding a client's personality organisation is important when planning treatment and observing its results, but the primary ... Thus, in the final factor analyses each factor contained a reduced number of items that belonged to the same category as defined in the original study [8] In order to confirm the stability of the ... in an acute phase of their illness, and most of them had been attending the clinic for years In order to guarantee the anonymity of the participants' responses, we had no means of investigating...

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