overview of carotenoid function in the skin

Báo cáo khoa học: "An overview of oak silviculture in the United States: the past, present, and future" pdf

Ngày tải lên : 08/08/2014, 23:22

... studies initiated in the 1940s by the US Forest Service to determine the growing space requirements of the upland oaks One of the most useful results of Gingrich’s work was the development of a ... second-growth stands of sprout origin Despite the high percentage of oak in these stands, most were understocked, unhealthy, and in a run-down condition as a result of indiscriminate cutting, grazing, fire, ... charts are routinely used to evaluate stand denstity in oak stands to determine the need for thin- ning In addition to developing the stocking chart, Gingrich also discovered that the greatest...

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Báo cáo khoa học: "Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast" pdf

Ngày tải lên : 09/08/2014, 03:21

... shown that there is increased expression of tenascin at the dermal-epidermal junction overlying the spindle cell proliferation in DF, but not in DFSP Moreover, there is an increasing body of evidence ... On the other hand, the immunohistochemical profile of the tumour included intense positivity for CD34 (Figure 4) These histological and immunohistochemical findings therefore established the ... accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Competing interests The authors declare that they have no competing interests...

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Báo cáo khoa học: "Cystatin C: unsuited to use as a marker of kidney function in the intensive care unit" pot

Ngày tải lên : 12/08/2014, 22:21

... EJ: Cystatin C improves the detection of mild renal function in older patients Ann Clin Biochem 2003, 40:648-655 Den Hollander JG, Wulkan RW, Mantel MJ, Berghout A Is cystatin C a marker of glomerular ... declare that they have no competing interests References 532 Villa P, Jiménez M, Soriano MC, Manzanares J, Casasnovas P: Serum cystatin C as a marker of acute renal dysfunction in critically ... thyroid-stimulating hormone, which confounds extrapolation of published data in this population We feel that future studies to evaluate this issue are warranted Competing interests The author(s)...

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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot

Ngày tải lên : 17/03/2014, 09:20

... domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted connections indicate binding interactions to the catalytic ... association involves the ATP-using C-terminal domains interacting near the base of that side of the wedge outside; the N-terminal domains form the outside of the wedges The wedge pockets have ... by an insulinactivated pathway [2] Impaired functioning in insulininduced down-regulation of PDK4 (due to lack of insulin or insensitivity to insulin) deleteriously leads to overexpression of PDK4...

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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc

Ngày tải lên : 17/03/2014, 17:20

... protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured testicular cells To investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular ... protein metabolism in these cells Histone is rich in the basic amino acids, lysine and arginine, but contains no cysteine Protamine, which is replaced for hitstone via transit proteins during ... level of GR in the epithelia of the epididymis (Fig 1) As the epididymis is rich in sulfoxidase, the oxidation of sulfhydryls in the sperm head and tail would be mediated by this enzyme in a speciﬁc...

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Báo cáo khoa học: Identiﬁcation of preferred substrate sequences for transglutaminase 1 – development of a novel peptide that can efﬁciently detect cross-linking enzyme activity in the skin pot

Ngày tải lên : 23/03/2014, 06:20

... Analysis of the reactivity of the K5 peptide with casein in the presence of TGases The time-dependent incorporation of biotinylated peptides (pepK5, pepK5QN and pepT26) into casein was examined in the ... cross-linking of keratinocyte proteins into organized protein structures lead to the formation of the CE Although the cooperative action of several TGases in the keratinocytes plays a role in this ... expressed in keratinocytes [13–18], and are involved in cross-linking of the structural proteins to form the CE at distinct intracellular sites [8,18] In the current model of TGase function, ...

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Báo cáo khoa học: Identiﬁcation of an antibacterial protein as L-amino acid oxidase in the skin mucus of rockﬁsh Sebastes schlegeli pot

Ngày tải lên : 30/03/2014, 10:20

... glycoprotein consisting of 75-kDa subunits by SDS ⁄ PAGE, partly because of the scarcity of the protein of interest In this study therefore we isolated the antibacterial protein, SSAP, from the skin ... superfamily lectins via its sialylated glycan moiety results in the production of locally high concentrations of H2O2 in or near the binding interface The role of the glycosyl substituents of LAOs in biological ... the mediator of the activity of SSAP 130 Discussion This study is the ﬁrst to discover an LAO with antibacterial activity in the skin mucus of a teleost and to reveal the involvement of LAO in...

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Báo cáo sinh học: " Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" potx

Ngày tải lên : 18/06/2014, 19:20

... blocks and used for the following staining procedures Page of 10 For viewing of gross histology, sections were fixed in 100% ethanol and then stained with hematoxylin and eosin using standard procedures ... efficacy of the NBD peptide in cardiac muscles of dko treated mice Both NF-B DNA binding activity, as well as nuclear levels of the p65 subunit of NF-B were elevated in the dko heart In general, ... contractile dysfunction in dko mice occurs through the inhibition of the NF-B signaling pathway Lastly, we investigated whether NBD treatment of dko mice resulted in an improvement in cardiac histopathological...

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Báo cáo hóa học: " Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function" docx

Ngày tải lên : 20/06/2014, 01:20

... glycosylation These findings are intriguing given that these three cysteine residues are absolutely conserved not only in the F proteins of other Pneumovirinae, but also in the F proteins of the Paramyxovirinae ... To determine the contribution of the individual cysteine residues in the extracellular domain (ECD) to its functions, a panel of mutations in which each cysteine residue in the ECD of the HRSV ... cysteine residues in the extracellular domain in protein expression and cell fusion of the HRSV F protein and represents the first analysis of the contribution of the cysteine residues of the...

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báo cáo hóa học:" Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" doc

Ngày tải lên : 20/06/2014, 03:20

... blocks and used for the following staining procedures Page of 10 For viewing of gross histology, sections were fixed in 100% ethanol and then stained with hematoxylin and eosin using standard procedures ... efficacy of the NBD peptide in cardiac muscles of dko treated mice Both NF-B DNA binding activity, as well as nuclear levels of the p65 subunit of NF-B were elevated in the dko heart In general, ... contractile dysfunction in dko mice occurs through the inhibition of the NF-B signaling pathway Lastly, we investigated whether NBD treatment of dko mice resulted in an improvement in cardiac histopathological...

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báo cáo hóa học:" Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period" pdf

Ngày tải lên : 20/06/2014, 04:20

... components in the bearing couple when revising for this indication While it is too early to comment on the clinical outcomes of these prostheses, the main determinants of success in these patients ... absence of infection Cystic lesions were noted behind the acetabular component in cases but the cup was grossly loose in only one of these There was evidence of gross collapse of a segment of the ... bearing These should theoretically confer increased range of movement theoretically allowing a higher level of function Prior to having their primary procedures these patients were all involved in...

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báo cáo hóa học:" Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period" pptx

Ngày tải lên : 20/06/2014, 07:20

... components in the bearing couple when revising for this indication While it is too early to comment on the clinical outcomes of these prostheses, the main determinants of success in these patients ... absence of infection Cystic lesions were noted behind the acetabular component in cases but the cup was grossly loose in only one of these There was evidence of gross collapse of a segment of the ... bearing These should theoretically confer increased range of movement theoretically allowing a higher level of function Prior to having their primary procedures these patients were all involved in...

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báo cáo hóa học: " Audio segmentation of broadcast news in the Albayzin-2010 evaluation: overview, results, and discussion" potx

Ngày tải lên : 21/06/2014, 02:20

... successfully applied in [4,10,13] and many other studies Taking into account the increasing interest in the problem of audio segmentation, on the one hand, and the existence, on the other hand, of a rich ... using a hierarchical organization of the detection process One of the most important decisions when using this kind of architecture lies in the orderings of the detection modules, since some of ... “Music.” The second row of the confusion matrix indicates that 26.5% of the hypothesized speech is in fact “Speech over noise.” This is the main reason of the high proportion of false alarms for the...

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Báo cáo y học: "Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation" pot

Ngày tải lên : 10/08/2014, 05:21

... linear regression analysis by plotting the specific binding of the radioligand on X-axis and bound/free on Y-axis The maximal binding is a measure of the total number of receptors present in the ... half the specific binding was defined as EC50, which is same as IC50 The affinity of the receptor for the competing drug is designated as Ki and is defined as the concentration of the competing ... data was analysed according to Scatchard, 1949 [35] The specific binding was determined by subtracting non-specific binding from the total The binding parameters, maximal binding (Bmax) and equilibrium...

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báo cáo khoa học: "The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin’s protective mechanisms against UVA radiation" pps

Ngày tải lên : 11/08/2014, 00:22

... process of obtaining the nanoemulsion In the case of the bands group in the range of 1150-1250 cm-1, characteristic of ester groups (-C-O stretching), an increase in the intensity of the bands is ... reflected in the decrease of its transmittance from 96% to 56% This is also explained by the increasing of the quantity of propolis from 27% v/v to 35% v/v in the nanoemulsion High lycopene content of ... Assessment of anti-inflammatory action was achieved by evaluating the inhibition of rat paw edema induced by a 2% solution of carrageenan The percentage inhibition of edema was calculated using the...

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Báo cáo y học: "Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients" doc

Ngày tải lên : 12/08/2014, 11:22

... changes in the airway The first step of assessing the potential importance of these cells in the inflammatory process would be to assess their numbers and function within the airways Therefore, in ... this study we have extended the findings of our previous study to investigate, within induced sputum, the number and cytotoxic function of the three main classes of human killer cells; CD8 + ... Glucocorticosteroids The Nottingham Local Research Ethics Committee approved the study protocol and written informed consent was obtained from the 26 subjects before entering the blinded study Of these, the 11...

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Báo cáo y học: " Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig" ppsx

Ngày tải lên : 12/08/2014, 14:20

... that in non-smokers and COPD patients, thereby indicating that endothelial dysfunction is present at the origin of the disease [2] The impairment of endothelial function results from changes in the ... the effect of contraction to NE by including it in the model The significance of the independent factors was assessed by the common ANOVA F-test using the type-3 sum of squares The adequacy of ... funding support and contributed in the analysis of the data JAB conceived the study, raised funding support, participated in the design and implementation of the study, and in the revision of the...

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Báo cáo y học: "Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis" pps

Ngày tải lên : 12/08/2014, 14:22

... and CD204+ in SSc skin, without changing the total number of macrophages To answer the question why the infiltration of activated macrophage is increased in SSc skin, we then examined PBMCs positive ... collagen bundles in the skin of SSc patients (Figure 1) When the cell number in randomly selected areas (per 10,000 μm2) was counted, the number of CD68+, CD163+ or CD204+cells in the skin of SSc patients ... (iii) in the right panel The right panel shows increased number of peaks in CD204 histogram in SSc patients The number of peaks is shown on the ordinate * P < 0.05 as compared with the value in...

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Báo cáo y học: "Identification of motifs that function in the splicing of non-canonical introns" doc

Ngày tải lên : 14/08/2014, 20:22

... motifs Strengthening the PY tract eliminates the role of the C-rich motifs We next investigated the role of the PY tract in LCAT intron splicing We mutated the PY tract to determine whether the C-rich ... lower affinities Binding of U2AF65 to low-scoring PY tracts In order to asses the relationship between the S65 score and observed U2AF65 binding affinities, we evaluated the binding of recombinant ... eliminates the role of the C-rich motifs Strengthening the PY tract eliminates the role of the C-rich motifs (a) LCAT intron with the mutations shown in blue above the WT sequence BPS, branchpoint...

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Role of SPHK2S1P signalling in regulating mitochondrial function in the MPTP induced mouse model of parkinsons disease and in the MPP treated MN9D cells

Ngày tải lên : 09/09/2015, 08:12

... 1.10.5.1 Sphingosine kinases and S1P in the brain 28 1.10.5.2 S1P receptors in the CNS 29 1.10.5.3 Role of Sphingosine kinases and S1P in neurodegeneration 30 1.11 Aims of the present ... underlying the cause of Parkinson’s disease (PD) has attracted the attention of manyresearchers in the last few decades In spite of the recent technical advances in the field of neuroscience, the ... implicated in PD pathogenesis, the expression pattern of TNFα and iNOS in the SNc of the MPTP-induced mouse model was analysed It was observed that there was an increase in the levels of XX TNF and iNOS...

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