opportunities challenges and successes in the development of medicines for the treatment of addiction

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

Ngày tải lên : 14/02/2014, 22:20

... tissue and gastrointestinal tract, as well as other sites, are known to reach the CNS to effect changes in feeding behavior and energy expenditure Thus, insulin, leptin and ghrelin, as well as other ... closely and rapidly with reciprocal changes in the levels of the orexigenic and anorectic Signaling mediators in the treatment of obesity neuropeptide expression in the hypothalamus [22] Thus an increase ... previously, the brain is not a major user of long-chain fatty acids making a brain-speciﬁc isoform intriguing CPT1c was identiﬁed and cloned from in silico sequences as a highly homologous member of the...

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Báo cáo khoa học: Adipocyte hyperplasia and RMI1 in the treatment of obesity doc

Ngày tải lên : 06/03/2014, 01:20

... disruption of the homeostasis between food intake and energy expenditure, and therefore factors affecting these processes are the focus of extensive research targeting the development of effective ... positive interaction between the molecules The increased expression of RMI1 and E2Fs thereby regulates the cell cycle, leading to adipocyte hyperplasia and the development of obesity Further studies ... at each phase of the cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors and the retinoblastoma protein (RB), as well...

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Báo cáo y học: "The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report" potx

Ngày tải lên : 08/08/2014, 23:21

... effective in the treatment of psychotic major depression, and the switch to sertraline worsened the psychotic symptoms in the patient The mechanisms underlying the opposite effects of these two ... fluvoxamine binds to sigma-1 receptors in the intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved in the active mechanisms of fluvoxamine [19] Interestingly, ... that activation of the dopaminergic system by the inhibition of dopamine transporter may be involved in the mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case,...

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Báo cáo y học: " Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review" pdf

Ngày tải lên : 12/08/2014, 01:21

... of the healthcare system is not satisfactory There are limitations in the reimbursement of anti-HBV therapy, either in the selection of agent or the duration of dosing Therefore, lamivudine and ... approved the final manuscript Competing interests The funding source had no influence on study design, in the collection, analysis, and interpretation of the data, in the writing of the manuscript, ... telbivudine are more widely used in treatment of CHB In this systematic review, we focus on the comparison of the efficay of lamivudine and telbivudine in the Figure Effect of telbivudine vs lamivudine...

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Báo cáo y học: "Formulas Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study" docx

Ngày tải lên : 13/08/2014, 08:21

... vasoconstrictive Page of (page number not for citation purposes) effect of the combination of the two drugs in comparison to epinephrine alone in the first minute of CPR with an increase of CPP This increase ... pressures and short-term survival, in comparison to the single use of epinephrine This study adds some evidence to the existing literature of the epinephrine-vasopressin combination benefits and further ... receptors in pigs (lysine vasopressin) and in humans Available online http://ccforum.com/content/12/2/R40 (arginin vasopressin) [34] In addition, the experimental animals were anesthetized and the...

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Risk Factors Affecting the Development of Tuberculosis Infection and Disease in Household Contacts of Patients with Pulmonary Tuberculosis pptx

Ngày tải lên : 29/03/2014, 03:20

... in the second group and 18% were infected in the third group Besides they treated of cases in the first group because of active disease [16] In former two studies it is seen that the risk of infection ... the number of male patients was higher in the index cases, but the number of female patients was higher in contacts determined active disease In our opinion, the reason of this findings were that ... presence of cavity in the chest radiograph of index case increased the frequency of TB in household contacts In our country, Kolsuz et al found the frequency of TB in close contact of TB cases...

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nanotalk. conversations with scientists and engineers about ethics, meaning, and belief in the development of nanotechnology, 2006, p.378

Ngày tải lên : 04/06/2014, 15:19

... an otherwise inaccessible world of other, and in so doing, to see that they are included in the reflection of the public mirror of the nanotechnology initiative One interesting aspect of the ... matters of public policy and ethics in the nanotechnology initiative Their primary skills and principal interests in nanotechnology lie with the business of their own research groups, inside of their ... emerges in the public discourse to establish the meaning and significance of that technology For example, developments in in-vitro fertilization, recombinant DNA/genetic engineering, mapping of the...

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Cooperation programs and agricultural rural developmen:Development of clam culture for improvement and diversification of livelihoods of the poor coastal communities in Central Vietnam - MS10 " pot

Ngày tải lên : 21/06/2014, 06:20

... in the last six monthly report (refer MS9) The list of farmers participating in the demonstration trial and their particulars are provided in the table The table provided the information of the ... Role of local extension centers in the demonstration: • The extension centers will provide input in selecting the household by collecting the back ground information and verification of the farmer ... enterprise by providing technology for clam breeding and producing artificial spat 6.3.2 Increasing in production and benefit from clam culture in the intertidal areas The success of intertidal trials...

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Education and training in the development of high quality human resources in vietnam at present

Ngày tải lên : 22/07/2014, 17:56

... whole matters of the development of high-quality human resources as well as those of the education and training sector, but studies the role of education and training in the development of human resources ... human resources in our country; concentrating the study in higher institutions in Vietnam at present - Studying the realities of the role of education and training in the development of high-quality ... resources in certain higher institutions in Vietnam at present - In term of time scope, the thesis studies the role of education and training in the development of high-quality human resources in Vietnam...

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Báo cáo khoa học: "Effects of Protein Source and Energy Substrates on the In Vitro Development of Bovine Embryos in a Two-step Culture System" ppsx

Ngày tải lên : 07/08/2014, 17:22

... effects of different protein sources supplemented in culture media on the in vitro development of bovine embryos, and to examine the effects of glucose, phosphate and citrate upon the developmental ... 149-157 19 Pinyopummintr, T and Bavister, B D Development of bovine embryos in a cell-free culture medium: effects of type of serum, timing of its inclusion and heat inactivation Theriogenology ... strategy for optimizing blastocyst production Moreover, in the early developmental stages, the stimulation of glycolysis would result in insufficient ATP production and the inhibition of embryo development...

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báo cáo khoa học: "Instrument development, data collection, and characteristics of practices, staff, and measures in the Improving Quality of Care in Diabetes (iQuaD) Study" pptx

Ngày tải lên : 10/08/2014, 10:23

... positively inclined towards performing the behaviours These two groups of measures will together form a large part of our explanatory variables in explaining variation in rates of performing the behaviours ... the clinical management behaviours of individual clinicians and the organisations they work in In the United Kingdom, patients are managed by the integrated activities of clinical and non-clinical ... processing), and for one other the computer record contained a physiological measure reflecting the performance of the behaviour across several links and interactions with other factors in a causal...

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Báo cáo khoa học: "The role of body mass index and diabetes in the development of acute organ failure and subsequent mortality in an observational cohor" doc

Ngày tải lên : 13/08/2014, 03:20

... reflect the opinions or views of the ARIC study or the NHLBI The coauthors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the ... analytic cohort Outcome variables The primary outcomes of interest were the risk of the development of acute organ failure within three years of the baseline examination, in- hospital mortality related ... independent variable in the analysis and could not explain the results even though the infection rate and the duration of mechanical ventilation were not increased in the obese group Studies of critically...

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Báo cáo y học: "Complexity and integration in the control of inner-ear development" pot

Ngày tải lên : 14/08/2014, 08:20

... tidal wave of discovery of hundreds of deafness genes in human families and mouse models and have gained tremendous understanding of the roles of these genes in inner-ear development and function ... identified, and complementary studies in the mouse and zebrafish provide an avenue for understanding the roles of these genes in ear development and function Two new protein-coding genes implicated in ... elucidation of genes contributing to complex-trait hearing impairment is in its infancy and is far behind the investigation of the genetics of other complex diseases Gene-environment interactions and...

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The Development Continuum Change and Modernity in the Gayo Highlands of Sumatra, Indonesia

Ngày tải lên : 14/05/2015, 10:07

... covered in drying candlenut (kemiri1) fruits and coffee (kopi) beans lining the main road In between the towns, dense tropical forest encased both sides of the road and steep inclines led to the ... grateful to my thesis committee, Profs Ammarell, Collins, and Duschinski, for their support, encouragement, and patience in reading drafts of the chapters and offering theoretical and practical ... current financial situation of the family Most of the subsistence needs of the people of Aih Nuso come from the surrounding rivers and forests with the main exception being that most of their rice...

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Education and training in the development of high quality human resource in vietnam at present (TT)

Ngày tải lên : 19/08/2015, 13:11

... resources and the role of education and training in the development of high-quality human resources in Vietnam at present - Clarifying the real situation of the role of education and training in the development ... Marxism – Leninism, Ho Chi Minh Thoughts, standpoints, paths of the Party and policies of the State of Vietnam on the development strategies of education and training, and the development of human ... performance of the role of education and training in the development of high-quality human resources in Vietnam at present 3.1.1 Achievements of and causes for the performance of the role of education and...

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The role of cholesterol sequestration and accumulation in the endocytic pathway in development of neurodegenerative diseases

Ngày tải lên : 14/09/2015, 14:06

... provide insight into the mechanism of the molecular basis of neurodegeneration in NPC1 disease and therapeutic strategies for treatment of this disorder ix List of Figures Figure 1.1 Rab proteins involved ... Effect of cAMP or forskolin on the expression of rab7, rab9, rab5 and rab11 in neuron by western blotting 81 Figure 4.4 Effect of cAMP and forskolin treatment on [H3] cholesteryl oleate formation in ... other cholesterol binding proteins, such as sterol carrier protein 2, caveolin, StAR protein, or MLN64 The structure of the apo form of bovine NPC2 has been solved, revealing an immunoglobulin-like...

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The Duality of Memory and Communication in the Implementation of a Multiprocessor Operating System

Ngày tải lên : 12/09/2012, 15:05

... Finally, the kernel informs the hardware physical map module of the new virtual to physical mapping With the exception of the hardware validation, all of these steps are implemented in a machine-independent ... be built, maintained and accessed using these techniques 8.1 Emulating Operating System Environments During the 1960’s the notion of a virtual machine base for operating systems development became ... and has been shown to outperform 4.3bsd in several benchmarks of overall system performance [1] A key and unusual element in the design of Mach is the notion that communication (in the form of...

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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

Ngày tải lên : 25/10/2012, 10:51

... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous...

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Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"

Ngày tải lên : 26/10/2012, 09:48

... provide written informed consent Use of other natural health products, including glucosamine and chondroitin, one month prior to study and during the study, other than multivitamin and mineral supplements ... contains 375 mg of glucosamine HCl (USP Grade) and 300 mg of chondroitin sulfate (USP Grade) The subjects were instructed to take two G+C capsules in the morning and two in the evening for a ... extracts contain the amino acids found in the framework of human cartilage In addition, these amino acids are required for the synthesis and repair of connective tissue throughout the body These products...

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