nuclear receptor coregulators promising therapeutic targets for the treatment of prostate cancer

Báo cáo sinh học: "Therapeutic dendritic cell vaccine preparation using tumor RNA transfection: A promising approach for the treatment of prostate cancer" pps

Ngày tải lên : 14/08/2014, 19:22

... around the world to search for new therapeutic options [5]; one of these options involves the use of Dendritic Cell (DCs) immunotherapy Clinical trails based on DCs have been conducted for the treatment ... one-third of these patients progress to incurable metastatic disease, for which there are few treatment options The chemotherapy currently used has limited efficacy [3,4] This lack of treatment ... molecules should be used instead of small peptides because of the diversity of the HLA molecules found in these populations Furthermore, vaccines for at least the first two doses should be prepared...

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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps

Ngày tải lên : 08/08/2014, 17:20

... demonstrated by further clinical study Additional studies appear warranted for the use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in the treatment of late stage prostate cancer Acknowledgements ... seen before treatment once treatment ended (Fig 1a and 1b) Thirteen of the 17 patients had a successful outcome; a decrease in PSAV and a lengthening of PSDT (Table 2) The probability of 13/17 ... compensate for their elevated BMI values Both patients subsequently became “responders” In addition, 15 of 17 patients opted to continue Apatone therapy following the 12 week trial The PSA values of these...

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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

Ngày tải lên : 07/03/2014, 10:20

... With the loss of biometal homeostasis placed central to all of these AD-related neurodegenerative mechanisms, the modulation of metal bio-availability has strong potential in the therapeutic treatment ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and ﬁbrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the AD brain Subsequent to an early report demonstrating that the...

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báo cáo khoa học: "New targets for the treatment of follicular lymphoma" potx

Ngày tải lên : 10/08/2014, 22:20

... understanding of the biological factors underlying the development of FL The identification of new targets and development of novel targeted therapies is imperative to exploit the biological indolence of ... apoptosis of lymphoma cells which additionally confer resistance of these cells to chemotherapeutic drugs [29] In the recent past, Bcl-2 has been established as a target for improving the treatment of ... shown to interact with the hydrophobic cleft of MDM2, thus mimicking the binding of the helical portion of p53 However, one of the enantiomers of this racemic mixture of compounds was found to...

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báo cáo hóa học:" Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer" pdf

Ngày tải lên : 18/06/2014, 15:20

... well-documented therapeutic target, the exact function of CD52 remains unknown In the ID8VEGF tumors, VLC account for the vast majority of tumorassociated host hematopoietic cells, thus the majority of the ... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... collected at the University of Pennsylvania or the University of Michigan After obtaining informed patient consent, ascites was collected either intraoperatively or at the time of therapeutic...

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báo cáo khoa học: "Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer" pps

Ngày tải lên : 09/08/2014, 01:24

... guidelines for the screening and selection of patients for Page of 10 APBI [22,23], and these guidelines formed the basis for patient selection in the EBT multicenter study [20] Of the 65 patients ... during the 5-day treatment period Patient compliance with the treatment regimen was excellent Patients expressed satisfaction with the conduct of the study as well as the delivery of the radiotherapy ... maintain the distance from the balloon to the skin surface The greater the volume of the balloon, with the attendant compression of adjacent breast tissue, the more fully the target breast tissue...

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Báo cáo khoa học: "Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial cancer" ppsx

Ngày tải lên : 09/08/2014, 09:20

... clinical trial of vaginal EBT for the treatment of endometrial cancer EBT treatment was delivered successfully for all 48 fractions of treatment in this study The EBT device performed as expected ... given the option of treating with an EBT prescription dose of 6.0 Gy x to the vaginal surface or 8.0 Gy x to the vaginal surface Treatment planning was performed according to the standard of care ... Rotmensch J, Wazer DE: A dosimetric comparison of xoft axxent electronic brachytherapy and Ir192 hdr brachytherapy in the treatment of endometrial cancer Brachytherapy 2008, 7(4):351-4 Rivard MJ, Davis...

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báo cáo khoa học: "Angiogenesis inhibitors in the treatment of prostate cancer" pdf

Ngày tải lên : 10/08/2014, 22:21

... in cancer therapy The advent of an entirely new class of anti -cancer therapies has required an understanding of the differences between angiogenesis inhibitors and more conventional chemotherapeutic ... role for PDGFtargeted therapy in the treatment of prostate cancer PDGFR was seen as the most commonly amplified transcript when aspirates from prostate cancer bone metastases were evaluated for ... from these clinical trials will hopefully clarify the role of angiogenesis inhibitors in the arsenal of prostate cancer therapies List of Abbreviations CRPC, Castrate-resistant prostate cancer; ...

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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"

Ngày tải lên : 26/10/2012, 10:04

... system, in the distal segment of the tubule Inhibition of glucose reabsorption in the kidney, mediated by the SGLT cotransport system, represents a promising therapeutic target for the control of hyperglycemia ... finding supports the use of other glucose analogues, such as the thioglycosides we studied, for the treatment of hyperglycemia In contrast, a possible side effect of thioglycoside treatment is glycosuria ... larvae of beetles (Chrysomelidae) Their synthesis has been previously described [31-33] For the purpose of the present study the thioglycosides used were selected and grouped based on their differences...

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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

Ngày tải lên : 18/06/2014, 16:20

... stability and their responsiveness to the IL-2 can be controlled by different miRNA therefore opening new avenues for potential therapeutic targets for the prevention and treatment of autoimmune ... as a therapeutic agent in the context of autoimmunity Genetic evidence for a role of IL-2 in autoimmunity The IL-2-IL-2R pathway plays an essential role in the development of T1 D and other autoimmune ... IL-2/IL-2R pathway for therapeutic purposes Given the strong link between IL-2 and autoimmunity, it seems appealing to consider the use of IL-2 as a Page of 12 therapeutic tool for T1 D However,...

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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique

Ngày tải lên : 26/10/2012, 09:32

... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...

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Báo cáo y học: "Endoscopic thoracic laminoforaminoplasty for the treatment of thoracic radiculopathy: report of 12 case"

Ngày tải lên : 26/10/2012, 09:57

... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results of the study All twelve patients (10 males, females) completed the surgery without...

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Behavior of Nitrite Oxidizers in the Nitrification/Denitrification Process for the Treatment of Simulated Coke-Oven Wastewater

Ngày tải lên : 05/09/2013, 09:38

... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each of the samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...

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Contact-Adsorption-Regeneration-Stabilization Process for the Treatment of Municipal Wastewater

Ngày tải lên : 05/09/2013, 09:38

... with the increased HRT of the adsorption tank From an engineering application point of view, the appropriate operational parameters of the recycle ratio, HRT of the regeneration tank, HRT of the ... in the PO43 P removal These results revealed that the selection of the operational parameters of the CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT of the regeneration tank, HRT of the adsorption tank and SRT of the system were evaluated The removal efficiency...

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Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx

Ngày tải lên : 14/02/2014, 22:20

... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... beyond the confines of the lymph nodes to other parts of the body, is generally defined as stage IV of the American Joint Committee on Cancer (AJCC) tumour node metastases (TNM) system or stage D of ... represents 12% of all new cancer cases in women and 14% of all new cancer cases in men The incidence of colorectal cancer increases with age In people between the ages of 45 and 49 years the incidence...

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Hydroxyurea for the Treatment of Sickle Cell Disease docx

Ngày tải lên : 05/03/2014, 10:20

... reported on the efficacy and/or effectiveness of hydroxyurea treatment of hematologic diseases, the toxicity of hydroxyurea in the treatment of any disease, and the barriers to the treatment of sickle ... reviewer reconciled the results of the first two reviewers in the case of the randomized trials 29 For the other study designs, the results of the two reviewers were averaged The quality assessment ... reliability of the instruments used A pair of reviewers each performed the quality assessment independently In the case of the RCTs, a third reviewer reconciled the results of the first two reviewers; for...

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Critical evaluation of diagnostic aids for the detection of oral cancer docx

Ngày tải lên : 06/03/2014, 02:21

... respectively One of the weaknesses of this study is the small sample size In addition, the majority of the lesions examined appear to be of the Class I type, rather than Class II lesions for which the technology ... appropriate to the purpose of the test? Use examiners representative of the target or primary clinical providers of the test? Show evidence that the test can distinguish cancer/ precancer from other conditions ... only 14 of these evaluated the ability of the dye to identify oral cancers that would not otherwise have been diagnosed by unaided clinical examination Unfortunately, these studies are of limited...

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Practice Parameters for the Management of Rectal Cancer (Revised) potx

Ngày tải lên : 15/03/2014, 01:20

... insensitive Therefore, routine liver function tests are not warranted.32 TREATMENT CONSIDERATIONS Surgery is the mainstay of treatment for rectal cancer The risk of recurrence is dependent on the TNM ... 48, No PRACTICE PARAMETERS FOR RECTAL CANCER screening the colon and rectum for neoplasms.18 The sensitivity of colonoscopy for colon cancer is typically in the range of 95 percent.19–21 Colonoscopy ... removal of lymphovascular vessels up to the origin of the primary feeding vessel is adequate.56–58 Thus for rectal cancer, this is at the origin of the superior rectal artery, just distal to the...

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Báo cáo khoa học: A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer ppt

Ngày tải lên : 22/03/2014, 15:21

... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... altering the rate of internalization of the receptor or influencing the intracellular trafficking The proteome of the target cell also influences the pathway We have observed large differences in the ... of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs for the treatment of cancer, ...

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Pelvic floor muscle training and adjunctive therapies for the treatment of stress urinary incontinence in women: a systematic review doc

Ngày tải lên : 28/03/2014, 14:20

... evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis of the ... exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing of physical therapy for SUI Some ... effective for the treatment of SUI The other studies in the review were considered for the generalisability of their findings to clinical practice by identifying the patient populations from which the...

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