nonlinearities in sensitivity to time implications for oscillator based representations of interval and circadian clocks

Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc

Ngày tải lên : 08/03/2014, 16:20

... independent of TATA-binding-protein-associated factors and initiator-binding proteins Mol Cell Biol 17, 2973–2984 32 Weis, L & Reinberg, D (1992) Transcription by RNA polymerase II: initiator-directed formation ... promoter of the long form of b1,4-galactosyltransferase contains 12 Sp1 binding sites, and is active in a variety of cell types [42, 43] Two putative NF-jB binding sites have been found in promoter ... found to be also the most expressed transcript in PEC-A cells (80–90%) and Fig Kinetics of a1,3GalT mRNA isoforms induction in pPAEC (A) and PEC-A cells during TNFa activation (B) The expression of...

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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

Ngày tải lên : 16/03/2014, 11:20

... studies including investigations in human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity ... corresponding rat tissues show expression only in duodenum, colon and rectum In both mouse and rat, Adh4 is found in the epithelial lining of upper GI tract including the tongue, esophagus and stomach, ... been shown to be toxic to DA neurons both in vitro and in vivo [38,39] Intracellular formation of aldehydes might be associated with the speciﬁc vulnerability of DA neurons in SN and in line with...

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Innovations in Credit Risk Transfer: Implications for Financial Stability docx

Ngày tải lên : 22/03/2014, 20:20

... Total value V (q) of the CLO structure to the issuer (retained and issued), net of effort costs The response to increasing the cost π of effort is, at first, for the issuer to retain more risk in ... sets of firms underlying bespoke and index products A notorious example of the ineffectiveness of delta hedging of tranches occurred with the rating downgrade of General Motors (GM) debt in May, ... Coordinating Corporate Investment and Financing Policies The Journal of Finance 48, 1629–1658 Froot, K and J Stein (1998) Risk Management; Capital Budgeting and Capital Structure Policy for Financial...

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Poultry of the Middle in the U.S.: ‘Implications for Sustainable Producers & Scaling Up’ pdf

Ngày tải lên : 23/03/2014, 21:20

... Research for this study involved basic research using the Internet and interviewing key informants Multiple key informants were identified through contacts in the industry and on the Internet Informants ... resulting from small size and volume of production are overcome with an increase in specialization of product and by creating or buying into the necessary infrastructure in their own form of integration ... to the federal government and to increase the demand for chicken in the marketplace and among consumers Print and television advertising were used to stimulate demand for chicken By the 1970s,...

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Competency-based education in the health professions: Implications for improving global health doc

Ngày tải lên : 28/03/2014, 21:20

... customized to the specific assessment needs at hand.18 Implications for competency -based education in resource poor settings Resources for health are finite and, regardless of the setting, often felt to ... level of performance on a designated competency In this usage, “standard” refers to learner performance and contrasts with the frequent use of “standard” in reference to a “standard curriculum” and ... of the populations to a set of competencies for the workforce to be trained In other words, it guides decisions about what graduates of the educational programs must be able to do, in order to...

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Báo cáo hóa học: " miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy" docx

Ngày tải lên : 18/06/2014, 16:20

... were incubated with mAb at 4°C for 30 min, washed twice in staining buffer, and fixed in 500 μl of 2% paraformaldehyde in PBS Cells were stored in the dark at 4°C until analysis Flow cytometry ... vivo and in vitro assays, and was one of the two primary writers of the paper KS was involved in the conception of the study, further designing of the experiments, and took a primary role in culturing ... factors and a type-2 promoting cytokine (IL-4) down-regulate miR-17-92 in T cells miR-17-92 is expected to play pivotal roles in T cell functions We therefore sought to determine whether ectopic...

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báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care" docx

Ngày tải lên : 20/06/2014, 08:20

... according to World Health Organization (WHO) 2006 Page of and Uganda Ministry of Health guidelines [8] The firstline ART for adults and adolescents is stavudine or zidovudine, plus lamivudine, and ... (age and CD4+ cell count) Table Number and incidence rates of opportunistic infections in the initial 24 months after ART initiation, and percent underreporting of OI events in routine clinic ... toxicities, and 18 (51%) and 11 (32%) of the 86 cited reasons for ART discontinuation and modification This gives a total error rate (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related...

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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps

Ngày tải lên : 09/08/2014, 08:22

... [39], and lymphocytes [40] Each of these different cell types appears to utilize 11β-HSD1 to atten- Figure cytokines Induction of 11β-HSD1 expression is specific for inflammatory cytokines (a) ... persistence and treatment of inflammation Conclusion Stromal cells play a pivotal role in normal, physiological inflammation and persistent inflammatory disease by expressing factors such as cytokines and ... and separated by thin-layer chromatography (TLC) using ethanol:chloroform (8:92) as the mobile phase TLC plates were analyzed using a Bioscan imaging detector (Bioscan, Washington, DC, USA) and...

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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

Ngày tải lên : 09/08/2014, 10:21

... necessary to suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one ... medulloblastoma potential doubling times (Tpot) of 25 to 82 hours described in the work of Ito et al [14] The study by Ito et al also reported an observed clinical doubling time of 480–576 hours Since ... accounted for in the model by incorporating modulating efficiency factors for transfer of viable cells from the CSF to solid tumor and from solid tumor to CSF, γf and γt, respectively, which range in...

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Báo cáo y học: "RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis" ppsx

Ngày tải lên : 12/08/2014, 16:20

... committing them to cell division) This function is facilitated through binding and activation of cyclin-dependent kinases (CDK) and 6, with phosphorylation of the retinoblastoma protein (Rb), and ... growth factors for hours for gene expression analysis and 24 hours for protein expression studies The chosen time points and concentrations of growth factors were determined and established in previous ... driver in fibroblastmediated growth factor expression and myofibroblast formation [6,7] In this study we have explored the role of cyclin D1 and interaction with RhoA signalling to determine key influences...

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Báo cáo y học: "Burns: learning from the past in order to be fit for the future" pps

Ngày tải lên : 13/08/2014, 20:21

... managed to restore and preserve organ function Prevention of inadequate perfusion, due to burn fluid loss, remains the top priority for initial management Advances in fluid management have led to a ... http://ccforum.com/content/14/1/106 antimicrobial dressings or early excision and grafting is the key to avoid burn wound infection and its extension to systemic infection [8-10] The timing and extent ... superficial into deep burns, the need for fasciotomies and abdominal compartment syndrome A recent approach has led to conversion of a formula-driven process to a more critical care approach using more...

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Báo cáo sinh học: "Mixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference" pdf

Ngày tải lên : 14/08/2014, 13:22

... account for eﬀects of infection status on SCS and produces an estimate of prevalence of infection, plus a probability of status (“infected” versus “uninfected”) for individual cows, given the data and ... prior to each of these two vectors The missing data includes now β0 , β1 , a and z, and the joint density of the missing data and of the observations is proportional to (8) Pertinent distributions ... j,k) where n0 and n1 = n − n0 are the number of indicator variables zi falling into each of the two groups in sample j at iteration k The imputations of z and a in the E–step need to be modiﬁed...

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LOCAL TAXES AND GOVERNMENT CHOICE OF PUBLIC GOODS IN a SPATIAL EQUILIBRIUM MODEL IMPLICATIONS FOR CHINAS LOCAL PUBLIC FINANCE REFORM AND URBAN GROWTH PATTERN

Ngày tải lên : 10/09/2015, 09:07

... land to nonagricultural land for production uses This interpretation of land as public capital investment is not seen often in the literature For succinctness, the land input is suppressed in ... is referred to land rent (or land value), and others consist of both land and its improvement (Arnott and MacKinnon, 1977; Polinsky and Rubinfeld, 1978; Brueckner, 1981; Lin, 1986) In this study, ... distinguishing public capitals Matsumoto (2004) differentiated public capital into two types: one complementing to immobile factor and the other complementing to mobile factor respectively in...

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Role of hydrogen sulfide in the cardiovascular system implications for treatment of cardiovascular diseases

Ngày tải lên : 01/10/2015, 17:27

... renin inhibitor, aliskiren, was approved by the Food and Drug Administration for use in the United States in March 2007 Aliskiren binds to the active site of renin and prevents the binding of ... of renin-angiotensin system (RAS) Renin is the first and rate limiting enzyme of RAS, catalyzing the cleavage of angiotensinogen to form angiotensin I (Ang I) Under the action of angiotensin converting ... 2, TNF-α, IL-6 and IL-8 levels 106 Therefore, inhibition of leukocyte transmigration and inhibition of cytokine release are possible mechanisms for H2S-induced anti-inflammatory and cardioprotective...

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Livelihood improvement in adaptation to climate change for fisherman Aquaculture farming combines with mangroves forest

Ngày tải lên : 28/05/2016, 08:28

... to the shrink and severely damage of mangrove forest surface Each year Vietnam lost about three percent of mangrove forest (Vietnam Administration of Seas and Islands - VASI) decreasing the total ... number of hectas of the mangrove forest will increase In fact, the ecoshrimp in , in the period 2009 - 2012, the leader of Duyen Hai districts , Tra Vinh province has invested tens of billion for ... model 2.6 The intended beneficiaries of project According to the Department of Forestry, the forestation at the rate of 70% of the mangrove area to 30% of shrimp farming area, contribute to improve...

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Placing Bank Supervision in the Central Bank Implications for Financial Stability Based on Evidence from the Global Crisis

Ngày tải lên : 29/08/2016, 08:24

... sector oversight to foster financial stability and in early-warning models of banking crises by testing whether differences in financial sector institutions can help predict banking crises and ... monitoring of banks and creating incentives for private agents to exert corporate control improve bank performance and stability Rogoff (2011) The conditioning set of variables in our model of ... several countries (including Belgium, Hungary, and the United Kingdom) went on to reform their institutions for financial sector supervision, including bringing bank supervision and macroprudential...

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Effective and coordination in Lao PDR Policy Implications for power sector development.PDF

Ngày tải lên : 03/11/2016, 22:29

... adjustments for aid coordination in 2004, transferring the function to the Ministry of Foreign Affairs The Department of International Cooperation will also be strengthened in its role of monitoring ... distinguishes several levels of aid coordination: - Information sharing and consultation, to understand the activities, plans, and perspectives of other actors - Strategic coordination, to reach ... Effort of Government of Lao PDR The government of Laos has given the role for aid coordination to the Department of International Cooperation placed in the Committee of Investment of Planning...

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APPENDIX A TO PART 136 METHODS FOR ORGANIC CHEMICAL ANALYSIS OF MUNICIPAL AND INDUSTRIAL WASTEWATER pot

Ngày tải lên : 05/03/2014, 21:20

... laboratory is responsible for maintaining a current awareness file of OSHA regulations regarding the safe handling of the chemicals specified in this method A reference file of material data handling ... sample to come to ambient temperature prior to introducing it into the syringe Remove the plunger from a mL syringe and attach a closed syringe valve Open the sample bottle (or standard) and carefully ... samples containing a concentration of C, in µg/L a 13 Estimates based upon the performance in a single laboratory b Due to chromatographic resolution problems, performance statements for these isomers...

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APPENDIX A TO PART 136 METHODS FOR ORGANIC CHEMICAL ANALYSIS OF MUNICIPAL AND INDUSTRIAL WASTEWATER: METHOD 604—PHENOLS docx

Ngày tải lên : 05/03/2014, 21:20

... calibration standards at a minimum of three concentration levels for each parameter of interest by adding volumes of one or more stock standards to a volumetric flask and diluting to volume with ... calibration standards at a minimum of three concentration levels for each parameter of interest by adding volumes of one or more stock standards to a volumetric flask and diluting to volume with ... define the working range of the detector Using injections of 2-5 µL, analyze each calibration standard according to Section 11 and tabulate peak height or area responses against the mass injected...

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APPENDIX A TO PART 136 METHODS FOR ORGANIC CHEMICAL ANALYSIS OF MUNICIPAL AND INDUSTRIAL WASTEWATER: METHOD 605—BENZIDINES pdf

Ngày tải lên : 14/03/2014, 20:20

... chloroform extract in a 250 mL separatory funnel 10.3 Add a-50 mL volume of chloroform to the sample bottle and repeat the extraction procedure a second time, combining the extracts in the separatory ... program consist of an initial demonstration of laboratory capability and an ongoing analysis of spiked samples to evaluate and document data quality The laboratory must maintain records to document ... as a safeguard against laboratory contamination 8.1.4 The laboratory must, on an ongoing basis, spike and analyze a minimum of 10% of all samples to monitor and evaluate laboratory data quality...

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