neuronal insulin receptor signaling a potential target for the treatment of cognitive and mood

Báo cáo khoa học: Distribution of the extrinsic proteins as a potential marker for the evolution of photosynthetic oxygen-evolving photosystem II ppt

Ngày tải lên : 23/03/2014, 15:21

... shown) The behavior of this band in the diatom is thus similar to that of the PsbPlike protein in cyanobacteria [3,12] The fact that C gracilis, P gyrans, L japonica and U pinnatiﬁda contained bands ... optimizing the availability of Ca2+ and Cl– cofactors for water oxidation in the green lineage In fact, all of the thylakoid membranes from diatoms (C gracilis and P tricornutum), a haptophyte (P gyrans) ... PsbQ are 61 and 29% between spinach and C reinhardtii, respectively In addition, the green algal and higher plant PSII did not react with any antibodies against the cyanobacterial and red algal...

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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

Ngày tải lên : 18/06/2014, 16:20

... Health Center, 1650 Cedar Avenue, Montreal, H3G 1A4 , Qc, Canada Full list of author information is available at the end of the article thymic and peripheral CD4+ T cells in humans and mice, and ... type diabetes subjects Immunogenetics 2010, 62:101-107 36 Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, et al: Genetic association ... and state of activation, may not accurately reflect the status and behavior of their counterparts localized in the target organ In this latter regard, there is experimental evidence that the blood...

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Báo cáo y học: "Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease" pdf

Ngày tải lên : 09/08/2014, 01:21

... components of the complement cascade and analyzed the activities of the alternative complement activation pathways [24] Serum levels of C3, Factor B and D, hemolytic activity of the alternative pathway, ... limit the power of our statistical analysis and make our data vulnerable to a statistical type II error Therefore, our data not allow for advocating complement serum levels as a new biomarker ... Fisher’s exact test as appropriate Data are expressed as mean ± SD b Four anorexia patients were in the hospital less than weeks; therefore they did not have a follow-up and are excluded NA = not applicable...

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Báo cáo y học: " APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication" pot

Ngày tải lên : 13/08/2014, 05:21

... 5'ATCCAAGACGGAATTCACGCCGCAGGAGAAAGAAGCTATAG-3'; the 3' primer for the APOPEC3G-UBA2 fusion was 5'-ATCGTACTCGAAGCTTCTAACTCAGGAGGAAGTTGGCAG-3'; and the 3' primer for the APOPEC3G-UBA2* fusion was 5'-ATCGTACTCGAAGCTTCTAACTCAGagcGAAGTTGGCAG-3' ... used for the U and M plasmid was 5'-ATCCAAGACGGAATTCGTTTTCCTGATTCTGGAG-3' The UBA2 gene fragment was amplified from plasmid pcDNA3.1HHR2 3A by PCR The 5' primer used was 5'ATCCAAGACGGAATTCACGCCGCAGGAGAAAGAAGCTATAG-3'; ... construction of all three plasmids was 5'-GCGCGCGCGCCTCGAGACCATGAAGCCTCACTT-3'; The 3' primers used for the construction of the E plasmid was 5'-ATCCAAGACGGAATTCCTAGAACTCGTTTTCCTGATTCTGGAG-3' and the...

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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

Ngày tải lên : 07/03/2014, 10:20

... Modulation of metal availability for treating AD P J Crouch et al research attention as potential therapeutic targets Plaques and NFTs, however, cannot be regarded as ‘upstream’ causative factors ... Furthermore, an increase in extracellular metals can catalyse Ab oligomerization and aggregation, and the amyloid plaques that subsequently form may then exacerbate intracellular metal deﬁciency ... down-regulated by decreased availability of intracellular Cu [83] and up-regulated by increased availability of Cu [84] Collectively, these data present a strong case for the native role of APP ⁄ Ab...

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Báo cáo khoa học: "A multidisciplinary approach for the treatment of GIST liver metastasis" docx

Ngày tải lên : 09/08/2014, 07:21

... The mainstay of surgical therapy in primary or metastatic disease is to achieve a complete resection with negative margins [7] Conventional chemotherapy and radiation therapy may have minor adjunctive ... of Cajal [1] They affect mostly males between the ages of 50 and 70, and are usually found incidentally at early stages [1-4] Large or advanced lesions may present with a variety of clinical findings, ... Kubota K, Makuuchi M, Kusaka K, Kobayashi T, Miki K, Hasegawa K, Harihara Y, Takayama T: Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional...

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Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx

Ngày tải lên : 11/08/2014, 08:22

... contributions KKB, SAH and EBH performed all of the in vivo studies and analyzed the data LH performed all the in vitro studies and analyzed the data MB designed and prepared the formulations for the p38 ... MD, Malfait AM, Arner E: The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation Osteoarthritis Cartilage 2001, 9:539-552 Samad TA, Moore KA, Sapirstein ... animals were disarticulated and the tibial plateau imaged using an Optimas image analyzer The tibial plateau was used for image analysis because it provided a relatively flat surface compared...

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Báo cáo sinh học: "Therapeutic dendritic cell vaccine preparation using tumor RNA transfection: A promising approach for the treatment of prostate cancer" pps

Ngày tải lên : 14/08/2014, 19:22

... significant clinical benefits like disease stability in 80% of patients after 2–3 doses of vaccine The mean survival rate was 13 months for melanoma patients and months for renal cell carcinoma patients ... very small prostate tumors This, in association with radical prostatectomy and radiation therapies, has contributed to increasing the curative indexes [2] After several years of primary therapy, ... 5th day of differentiation, cells presented low levels of CD80 (a maturation marker) and CD86 (an early maturation marker) Furthermore, the percentage of cells expressing CD 1a and CCR7 was also...

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Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt

Ngày tải lên : 19/02/2014, 05:20

... hypothalamus and pituitary, and ataxias [24,25] Type IIa RPTPs have also been implicated in the development of the neuromuscular system In Drosophila, DLAR and DPTP69D are required for guidance of ... that PTPd and an isoform of LAR can interact homophilically [39] and that LAR can also bind heterophilically to the laminin–nidogen complex [40] Heparin sulfate proteoglycans (HSPGs) have also ... identiﬁed as potential ligands for PTPr [41], and recently syndecan and dallylike, both HSPGs, have been reported as functional ligands for DLAR in Drosophila motor axons and neuromuscular synaptogenesis...

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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

Ngày tải lên : 19/02/2014, 12:20

... subunits, an a6 /a3 chimera consisting of the extracellular ligand-binding domain of the a6 subunit and the transmembrane and intracellular domains of the a3 subunit was used in this study PIA selectively ... release in the rat striatum (A) Nicotine acts at somatodendritic nAChR in the substantia nigra pars compacta and at presynaptic nAChR in the striatum (B) a- Conotoxin MII was one of the ﬁrst antagonists ... confocal microscopy and immunocytochemical studies, Nayak et al [90] hypothesized that a4 and a3 (or a6 ) subunits are present on separate nerve terminals in the striatum, and that a mecamylamine- and...

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Báo cáo y học: "Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study" pdf

Ngày tải lên : 12/08/2014, 11:22

... greater than or equal to two and past injury and surgery were not excluded Therefore, the joints of these participants may already be further along the pathological pathway of structural change ... Development of criteria for the classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association ... Measurement of cartilage volume The volumes of individual cartilage plates (medial and lateral tibia) were measured from the total volume by manually drawing disarticulation contours around the cartilage...

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A potential target for tuberculosis drug discovery

Ngày tải lên : 26/11/2015, 22:38

... RNA also adds 11 amino acid tag (AANDENYALAA) to the incomplete protein Proteins tagged with the SsrA peptide are targeted for degradation The C-terminal Ala-Ala residues are critical for SsrA ... Clp ATPase belongs to the AAA+ superfamily of ATPases AAA+ proteins are generally modulated by a group of otherwise unrelated proteins termed adaptor proteins An adaptor protein serves as an accessory ... requirement of ATP hydrolysis, usually by ATPases of the AAA or AAA+ superfamily (ATPases associated with various cellular activities) (Neuwald et al., 1999) These ATPase chaperones or chaperonins...

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Báo cáo y học: "tatin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 08:22

... O2 and treated with atorvastatin for the indicated times and then RNA was extracted using the RNeasy kit (Qiagen Ltd, Crawley, UK) Total RNA was separated on a 1% agarose/formaldehyde gel, transferred ... by atorvastatin and the hypoxia of CD59 (P < 0.05) Analysis of the effects of statins on NO bioavailability has suggested that the isoprenoid intermediates geranylgeranyl pyrophosphate and geranylgeraniol, ... individual experiments ± the standard error of the mean Data were analysed using one-way or two-way analysis of variance with Bonferroni correction Normalized data were analysed using the Wilcoxon Rank...

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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique

Ngày tải lên : 26/10/2012, 09:32

... de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the current study include a lack of comparison group and lack of blinding ... men; mean age 64, range 22-89) were included Length of follow-up was at least years with a maximum of years Location of facet pain was cervical in 45, thoracic in 15, and lumbar in 114 patients ... low back pain Pain Physician 1999;2:59-64 Manchikanti L, Pampati V, Fellows B, et al The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents...

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Tài liệu "Promoting healthy diets and physical activity: a European dimension for the prevention of overweight, obesity and chronic diseases" doc

Ngày tải lên : 14/02/2014, 13:20

... diseases” I STATE OF PLAY AT EUROPEAN LEVEL I.1 Unhealthy diets and lack of physical activity are the leading causes of avoidable illness and premature death in Europe, and the rising prevalence ... a common forum for action the European Platform for Action on Diet, Physical Activity and Health was launched in March 2005 The Platform brings together all relevant players active at European ... groups be addressed? V.8 V.8.1 A coherent and comprehensive approach aimed at making the healthy choices available, affordable and attractive involves taking account of mainstreaming nutrition and...

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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx

Ngày tải lên : 15/02/2014, 13:20

... 1996 Other BCG preparations are available for treatment of bladder cancer; these preparations are not intended for use as vaccines Vaccine Dose, Administration, and Follow-up BCG vaccination ... sexes and all races Cases of TB among children

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Tài liệu Đề tài " A shape theorem for the spread of an infection " pdf

Ngày tải lên : 16/02/2014, 06:20

... Thus, the left-hand sides of (3.31) and (3.60) are the same for this choice of Λ We leave it to the reader to check that the right-hand side of (3.60) is at least as large as the right-hand side of ... z, and (2.6) At any site z at which the particles in σ (2) have type A, the particles also have type A in σ (1) Let A (·, ρ) be the random-walk paths associated to the various particles and ... present case we can take πB = A , which has the great advantage that the path of ρ does not depend on the paths of the other particles This is the reason why the case DA = DB is special We proved...

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Tài liệu OUTLINES OF DAIRY BACTERIOLOGY A CONCISE MANUAL FOR THE USE OF STUDENTS IN DAIRYING docx

Ngày tải lên : 16/02/2014, 22:20

... most available in the form of organic compounds, such as albuminous material Carbon in the form of carbohydrates, as sugar or starch, is most readily attacked by bacteria Inasmuch as the bacteria ... from another As far as these characters can be used, they are taken, but in addition, many characteristics of a physiological nature are added The way that the organism grows in different kinds of ... frequently the cans are not cleaned immediately upon arrival at the farm, so that the conditions are favorable for rapid fermentation Many of the taints that bother factories are directly traceable...

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Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx

Ngày tải lên : 18/02/2014, 02:20

... tell the target to stop being dirty or threaten to fine those who remain dirty, rather than offering the target a brand of soap and a rationale as to why the soap's benefits and rewards are superior ... of the set of MOA are lacking Figure I presents an overview of the relationship among (1) targets who are prone, resistant, or unable to date-date the manager's goals; (2) the target' s MOA; and ... Influencing the Selection of Education, Marketing, and Law There are many other variables that can influence managers in their selection of education, marketing, and/ or law as classes of strategic...

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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

Ngày tải lên : 19/02/2014, 06:20

... transcriptional regulation: TRANSFAC, TRRD and COMPEL Nucleic Acids Res 26, 362–367 47 Takahashi S, Takahashi Y, Ito K, Nagano T, Shibahara S & Miura T (1999) Positive and negative regulation of the human ... Functional analysis of cDNAs for two types of human heme oxygenase and evidence for their separate regulation J Biochem (Tokyo) 113, 214–218 Takeda K, Ishizawa S, Sato M, Yoshida T & Shibahara S ... R, Takahashi K, Takeda K, Furuyama K, Kaneko K, Takahashi S, Tamai M & Shibahara S (2004) Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal...

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