murine models t cells b lymphocytes innate immune system

Báo cáo khóa học: Collectins Players of the innate immune system docx

Ngày tải lên : 07/03/2014, 15:20

... thought that this is a mechanism used by the parasite to attract infectable monocytes to the site of infection [198] MBL also binds to several developmental stages of the multicellular blood ... O-glycosylated [49,50] The repeat GlyX-Y pattern in both MBL and SP-A is interrupted, which is thought to introduce a kink or region of ﬂexibility into the protein, enabling the trimeric subunits to ... of both SP-A and SP-D to stimulate chemotaxis of alveolar macrophages did not seem to be mediated by the lectin activity of both proteins, as it was not inhibitable by sugars, and for SP-A at...

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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx

Ngày tải lên : 18/06/2014, 15:20

... infiltration in vivo [23], and it inhibits the activity of osteoclasts [24] While the mechanisms of interaction of AST with innate immune cells are not fully elucidated, recent studies show that ... Relative Hemoglobin Content anti-angiogenic effects We therefore tested the ability of AST to inhibit angiogenesis in animals gene targeted for the IL-12 p40 subunit Again, AST completely lost its ... Mat Control AST/Mat AST Mat 0.00 Control AST/Mat AST Mat Control 0.05 1.0 0.8 0.015 0.01 0.010 AST/Mat AST 0.000 Mat AST/Mat AST Mat 0.00 Control AST/Mat AST Control 0.005 Mat Relative expression...

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Báo cáo y học: " Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit" pdf

Ngày tải lên : 14/08/2014, 07:21

... glutamine (black bars) and 20 trauma patients without glutamine and used as controls (white bars) Samples were obtained at the beginning of the treatment (Day 0); at the end of the treatment (Day ... on the activation of TLRs [28] The phagocytic capability of both groups studied before the beginning of the treatment, or at the end of the treatment (Day 6) or at Day 14 was not significantly ... intervention with two groups: trauma patients treated with TPN supplemented with glutamine and those receiving TPN without glutamine Random selection was based on a computer-generated list that...

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Báo cáo y học: " T cells and post menopausal osteoporosis in murine models" doc

Ngày tải lên : 09/08/2014, 10:20

... women treated with autologous BM transplants develop thymic hypertrophy and a resurgence of thymic T cell output that contributes to the restoration of a wide T cell repertoire [29], although the ... of T cell activation elicited by estrogen deficiency is similar to that triggered by infections, Page of (page number not for citation purposes) the intensity of the events that follow estrogen ... studies on highly purified BM cells have revealed that ovx increases the production of TNF by T cells, but not by monocytes [13], and that earlier identification of TNF production by monocytes...

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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine ﬁbrosarcoma L929 cells doc

Ngày tải lên : 18/02/2014, 13:20

... mechanism that controls the crosstalk between apoptosis and autophagy remains to be elucidated The results of the present study suggest that the L929 cells induced by oridonin exhibit both autophagic ... NF-jB in oridonin-induced apoptosis and autophagy, and found that they both inhibited apoptosis but promoted autophagy We demonstrate that p38 contributed to NF-jB activation, which inhibited ... treatment However, this augmentation was obviously blocked by NAC employment, indicating that ROS might contribute to the translocation of Bax to the mitochondria and subsequently cause the release...

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Báo cáo khoa học: Recruitment of transcription complexes to the b-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells docx

Ngày tải lên : 07/03/2014, 12:20

... 5¢GTCCCCTTTTCATTGTAATGC-3¢; mouse3¢HS 2B: US, 5¢-GGACCCTGCCTTGCTGTGTG-3¢ and DS, 5¢-GGAA ACAGGGTACCAGTGAATG-3¢; mouse bmajor-globin: US, 5¢-CACCTTTGCCAGCCTCAGTG-3¢, DS, 5¢-GGTT TAGTGGTACTTGTGAGCC-3¢; ... US 5¢-AGTCAATTCTCTACTCCCCACCCT-3¢ and DS 5¢-ACTGCTGTGCTCAAGCCTGAT-3¢; ⁄ 2ﬂank, US 5¢-TT AAAGCCTCATTATCTCCAAACCA-3¢ and DS 5¢-GTG TGCACTGGGTGGGTAGA-3¢; mouse necdin: US 5¢-AC TCTTCTGGCTTCCCAAC-3¢ ... TTTCCCTGATGAGGATTCAATGG-3¢ and DS 5¢-CCC ACACATGGTCATCTATCTGAGC-3¢; mouse HS2 core: US 5¢-TTCCTACACATTAACGAGCCTCTGC-3¢ and DS 5¢AACATCTGGCCACACACCCTAAGC-3¢; ⁄ 2ﬂank, US 5¢-CTATTTGCTAACAGTCTGACAATAGAGTAG-3¢...

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Báo cáo khóa học: CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes doc

Ngày tải lên : 23/03/2014, 12:20

... these data suggest that these domains are not obligate for the stabilization of the dimers, but rather must contribute to the overall stability of the dimers Crystallographic analysis of the Aplysia ... half-life, it was also possible that these mutations would affect the enzyme activity of the proteins To test the enzyme activity of the CD38 mutants, membrane homogenates from the various Ba/F3 transfectants ... dimer stabilization but contribute to the overall stability of the dimers, particularly upon detergent solubilization It has been reported that inappropriate folding of proteins or inappropriate...

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Báo cáo sinh học: "Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" pot

Ngày tải lên : 19/06/2014, 08:20

... preventing recognition by cytotoxic T cells Antibodies on the other hand retain their ability to recognize native antigens but in case of tumors their potential effects are compromised by their ... strategies will be required to prepare other metastatic sites for retention of adoptively transferred T bodies Unlike the signal transduction events that follow ligand binding by the natural TCR, ... shared with many persistent viruses http://www.virologyj.com/content/3/1/8 Though it has been established that human tumors may express multiple antigens that can be recognized by cytotoxic T lymphocytes...

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báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx

Ngày tải lên : 19/06/2014, 22:20

... resistant to the potential toxic effects of microbial and neutrophil products In contrast, it has been reported that in severe bacterial and fungal ependymitis, the layer of epithelial cells ... unaffected This study was undertaken to decipher some of the intrinsic pathways expressed by reactive brain epithelial cells to control bystander cytotoxic properties of the local innate immune ... inflammatory mediators New data emphasise the key role of brain epithelial cells to integrate and further orchestrate the local innate immune response with the production of innate components of the...

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báo cáo hóa học:" Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" docx

Ngày tải lên : 20/06/2014, 04:20

... preventing recognition by cytotoxic T cells Antibodies on the other hand retain their ability to recognize native antigens but in case of tumors their potential effects are compromised by their ... strategies will be required to prepare other metastatic sites for retention of adoptively transferred T bodies Unlike the signal transduction events that follow ligand binding by the natural TCR, ... shared with many persistent viruses http://www.virologyj.com/content/3/1/8 Though it has been established that human tumors may express multiple antigens that can be recognized by cytotoxic T lymphocytes...

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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps

Ngày tải lên : 09/08/2014, 01:23

... distinctions still remain between the surface phenotype of TR and primed T cells, but they are more relative than absolute For example, although both primed T cells and TR cells express CD25, the latter ... active rate of turnover [24] An anergic state also seems to be closely related to TR cells suppressive ability because if it is broken there is a concomitant loss of regulatory activity both ... mediate its effects in a membraneproximal manner [53] The level at which these anti-inflammatory cytokines operate to maintain tolerance is also uncertain, but it might be through the inhibition...

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Báo cáo y học: "Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells" ppsx

Ngày tải lên : 09/08/2014, 01:24

... deficient in B and/or T cells WT To understand the role of B and T cells in antibody-mediated inflammation, mice deficient in either B cells or T cells or both were injected with a combination of two ... CAIA because mice deficient in both T cells and B cells are more susceptible to arthritis than their control littermates There are several possible explanations for this observation Clearly, B cells ... as Thy-1+ and L 3T4 +Lyt-2[32] Conclusions The recognition of CII by T cells is critical to the establishment of autoimmune arthritis in CIA However, it is debatable whether T cells are capable...

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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot

Ngày tải lên : 09/08/2014, 01:24

... suggested that the TR responses are specific for selfantigens It is thought that TR cells in mice represent those thymocytes with the highest affinity for self-peptide but that are below the threshold ... fittest T cells to survive in a nutrient-limiting environment in order to proceed to become memory T cells Evidence that this balancing act involves both cytokines and CD4+CD25+ TR cells has been ... propose that these cells act by inhibiting further proliferation of T cells as the inflammatory process has peaked and nutrients are limiting This allows a limited number of the most fit T cells to...

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Báo cáo y học: "Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis" pps

Ngày tải lên : 09/08/2014, 10:23

... disease-relevant models could potentially lead to the identification of therapeutic targets Competing interests The authors declare that they have no competing interests The Scientific Basis of Rheumatology: ... late activation of NF- B Signalling through TLR4 results in phosphoprylation and activation of protein tyrosine kinases (TKs) The Tec family member Btk interacts with the Toll/IL-1 receptor (TIR) ... upregulates the soluble form of the TNFR rather than the membrane bound form, which in turn would inhibit inflammation [123] To confound the matter further, it has been shown repeatedly that in...

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báo cáo khoa học: "eneration of diffuse large B cell lymphomaassociated antigen-specific Va6/Vb13+T cells by TCR gene transfer" pdf

Ngày tải lên : 10/08/2014, 22:21

... suggesting that the TCR transgene vector bIa yielded a better function of human antigen-specific TCR-redirected T cells than did vector aIb Cytotoxicity of TCR gene-transduced CD3 +T cells against Toledo ... common antiDLBCL cytotoxicity, which was thought to target the TAA of DLBCL This study provides substantial new data for a better understanding of the strategy of adoptive immunotherapy in DLBCL Acknowledgements ... which aim directly at autologous lymphoma cells It is a pity that we were unable to obtain patients’ autologous lymphoma cells as target cells With respect to the most commonly distributed human MHC...

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Báo cáo y học: " Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment" ppt

Ngày tải lên : 12/08/2014, 01:21

... Hepatitis B surface antigen (HBsAg), HBeAg, antiHBc, anti-HBe and anti-HBs were quantified by radioimmunoassay (Abbott Laboratories, Abbott Park, IL, USA) HBV DNA was measured using the Amplicor HBV test ... memory T cells in patients with chronic hepatitis B We selected 20 HBeAg-positive CHB patients who were treated with telbivudine 600 mg/day for 48 weeks After 48 weeks of treatment, patients became ... T cells from chronic hepatitis B (CHB) patients (a) Representative dot plots showing the expression of CD127 on CD8 T cells in one CHB patient and one healthy control The numbers on the right...

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Báo cáo y học: "Analysis of the 5''''UTR of HCV genotype 3 grown in vitro in human B cells, T cells, and macrophages" potx

Ngày tải lên : 12/08/2014, 04:20

... We are reporting the isolation and replication of HCV from patients infected by type strains of HCV These new isolates can be cultured in both B and T cells By contrast to type strains of HCV, ... Statement on Management of Hepatitis C: 2002 NIH Consens State Sci Statements 2002, 19:1-46 Tarantino G, Craxi A: Optimizing the treatment of chronic hepatitis due to hepatitis C virus genotypes ... therefore the isolation system for HCV-3 replicated virus which had a 5'UTR similar to HCV-1 This was unexpected, but suggested that there were some HCV-1 in the blood of patient 314 that preferentially...

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Báo cáo y học: "Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis" doc

Ngày tải lên : 12/08/2014, 11:23

... results of these studies are summarized in Table Thus, overall, the results obtained with MSC treatment for CIA are inconclusive This is in contrast to transfer of Treg cells for the treatment of ... demonstrated by the addition of inhibitors of these enzymes - GW274150 and indomethacin [8,36], respectively - to the co-cultures The addition of these inhibitors resulted in the abrogation of the ... arthritis in all groups at day 35 fArthritic scores were not significantly different between control treatment and treatment with wild-type or IFN-gR KO DBA/1 MSCs or C57BL/6 MSCs or with Treg cells...

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Báo cáo y học: "New role for Agrin in T cells and its potential importance in immune system regulation" ppsx

Ngày tải lên : 12/08/2014, 12:20

... importance of the actin cytoskeleton in the spatiotemporal formation of the IS and T cell activation [33] Nonetheless, there is still a lot to be learned about the function of Agrin in T cells Its ... the INF system A working hypothesis on the function of Agrin in the immune system Although the number of studies investigating the function of Agrin in the immune system is limited at present, ... as yet unknown modiﬁcation of Agrin that endows it with higher aggregating activity, and furthermore redistributes the protein to the site of the IS where it may facilitate antigen presentation...

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Báo cáo y học: " Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of b-receptor affinity in murine models of asthma" pdf

Ngày tải lên : 12/08/2014, 13:22

... was not affected by albuterol treatment These observations also suggest that the airways are not negatively affected by albuterol but rather that the periphery of the lung is sensitive to adverse ... chronic albuterol treatment were not attributable to epithelial disruption because albuterol was not affected by PLL instillation In addition, the smooth muscle did not seem to be involved because ... lung phenotype whether induced by allergen inhalation or broncho constriction with MCh and that this ability is not related to the b2 -receptor but is due to some other property of the albuterol molecule...

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