... tissue damage is often present On the other hand, MSCs may also actively participate in initiating AD [3], they have the potential to favour spread of melanoma metastases [4] and, although mostly ... animal based, cellular and biochemical systems A model of vasculogenesis in a SCID mouse was presented as an example Conclusion The potential antiproliferative and immunodulatory role of MSCs ... (CTL) lysis is affected by MSCs On the other hand, the same group from the Karolinska Institute showed that MSCs reduce the formation of CTLs via a soluble factor, but they are not themselves subject...
... glass coverslips, tissue culture plastic wells and poly-L-lysine coated surfaces as controls Statistical analysis Results are presented as mean ± standard error ofthe mean (SEM) Statistical analyses ... potential use of HUMSCs for cell based therapies and tissue engineering for heart diseases Differentiating HUMSCs into cardiomyocytes was less examined and the functional characteristics of HUMSCs differentiated ... differentiated human umbilical cord mesenchymalstemcells We assessed viability ofthecellsof sheets at room temperature No indication of cell apoptosis was noticed from the PNIPAAm coated surfaces...
... AD affected brain, metal dyshomeostasis is evident in the form ofa substantial increase in the levels of extracellular metals and a decrease in the levels of intracellular metals Here, we have ... is of particular relevance These authors demonstrated that an increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase ... neurodegeneration, but their development is the result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some ofthe consequences...
... of this stage the person who carries out the risk assessment – the assessor – has identified the site to be considered and the context forthe risk assessment During this stage the assessor collects ... the assessor has an outline conceptual model forthe site and knows the context ofthe risk assessment The assessor has also identified pollutant linkages that require further detailed assessment ... confirmed for evaluation If appropriate, the assessor uses generic assessment criteria to assess one or more pollutant linkages The final part of this stage is consideration ofthe next steps: this can...
... encephalomyelitis virus (TMEV) is a positive sense single-stranded RNA (ssRNA) virus ofthe Picornaviridae family [12] TMEV establishes a persistent CNS infection in susceptible mouse strains that results ... lysates yield 3-5 X 108 PFU and a pooled batch was used as a viral stock If necessary the viral stock was diluted in DMEM before inoculation Assessment of clinical signs Approximately 30 µl of ... triplicate Statistical analyses The statistical significance ofthe differences between experimental groups (two-tailed p value) was analyzed with the unpaired Student s t-test using the InStat Program...
... data) and studies of disease-associated molecules and their assemblies beyond the pathway-centric view To address data integration, sophisticated approaches are needed to segment the image data ... proteomics and transcriptomics) and brain imaging to cognitive assessments The adoption ofa systems approach to study AD will demand integration of heterogeneous data (such as molecular and image data) ... Page of Author information MO is a Research Professor of systems biology and bioinformatics His main research areas are metabolomic applications in biomedical research and integrative bioinformatics...
... Journal of Medical Case Reports 2008, 2:239 distinctive phases: a prepulseless (inflammatory or systemic) phase and a pulseless phase Clinical disease preceding the pulseless phase of TA will ... months, without any known reason His initial examination was remarkable for dysarthria, discrete right hemiplegia and gait ataxia The National Institutes of Health Stroke Scale score was Also, marked ... fulfill the diagnostic criteria ofthe American College of Rheumatologists for TA, which are based on advanced disease [2] As histological diagnosis is usually impractical, angiography, and, more...
... RFLP and sequence analysis ofthe CP gene Data from all the tests positively identified the virus as PVM Sequence analysis of these PVM isolates and eight other known PVM strains/isolates showed ... below) Bioassay Tissue sap from PVM positive samples based on initial ELISA and RT-PCR tests were inoculated onto healthy potato (Russet Burbank) and indicator (C quinoa) plants Tissue sap was diluted ... RFLP analysis for confirmation ELISA Potato tubers and leaves as well as indicator plants were screened forthe presence of PVM by a standard double antibody sandwich ELISA using commercial coating...
... represent FS, CA, ES, and IS Determine the value of FS and CA variables, whereas means the worst and means the best Determine the value of ES and IS variables, whereas -1 means the best and -6 means ... capabilities ofthe enterprise Human Resources: the qualifications and skills ofthe staff and employees ofthe business Financial Resources: the financial capacity ofthe business Strengths: the strengths ... means the worst Calculate the average score for FS, CA, ES, and IS Plus the points on the horizontal axis and mark the results, plus the points on the vertical axis and check the results Draw a...
... were made for each subject using a bubble goniometer to assess the clinical outcome Patients were also evaluated using the Harris hip score rating system [22] Statistical Analysis Data was subjected ... manuscript AB, MGZ, MSM, RED, MAM ensured the accuracy ofthe data and analysis All authors have read and approved the final manuscript Additional material Additional file Summary of patients treated ... tightness ofthe tensor fascia lata and the iliotibial band, and an assessment of hip abduction range of motion for adductor muscle tightness; D) The patient had no existing clinical or radiographic...
... ofthe incubated cells was analyzed using the WST-1 assay (Roche Diagnostics GmbH) This assay is based on the cleavage of stable tetrazolium salt WST-1 by metabolically active cells to an orange ... promoter activations that is based on the analysis of individual cells within a population It has been described that the physical properties of nanoscale materials can interfere with the analysis of ... cavities enables a high number of cavities on each chip and facilitates the performance of many independent assays on one plate The funnelshaped cavities avoid the appearance of meniscuses, and therefore,...
... effectiveness we used serious NSAID ulcer complications as the main outcome measure The number of cases was calculated using the risk estimates ofthe first part of this study Costs were calculated ... estimated using a bootstrap procedure [5] Statistical analyses were performed with SPSS for Windows, version 12.0.1 (SPSS, Chicago, IL, USA) Bootstrap analyses were performed using the software ... package S- plus (TIBCO Software Inc., Palo Alto, California, USA) professional version 6.0 Cost effectiveness To calculate the incremental cost effectiveness ratio (expressed as net costs per serious...
... effectiveness we used serious NSAID ulcer complications as the main outcome measure The number of cases was calculated using the risk estimates ofthe first part of this study Costs were calculated ... estimated using a bootstrap procedure [5] Statistical analyses were performed with SPSS for Windows, version 12.0.1 (SPSS, Chicago, IL, USA) Bootstrap analyses were performed using the software ... package S- plus (TIBCO Software Inc., Palo Alto, California, USA) professional version 6.0 Cost effectiveness To calculate the incremental cost effectiveness ratio (expressed as net costs per serious...
... methods Survival analysis was performed by the Kaplan-Meier method using the SPSS 13.0 software Results Characteristics ofthe patients Characteristics ofthe patients at the time of diagnosis are ... possible to assess the remission status Overall survival (OS) was defined as the time from the start of treatment to death by any cause or to the termination of observation Statistical methods ... percent of patients achieved CR, the estimated years OS rate was 53%, whereas for patients with M5, the estimated OS rate at years was 75% In our study, the response results of HA are comparable...
... 10% The response rates were 8%, 14%, and 13% for anaesthesiologists, surgical oncologists, and breast care nurses, respectively The response rates differed statistically significant across these ... Respondents' and hospital characteristics Variable N Professional discipline of respondents, % Anaesthesiologists Surgical oncologists Breast care nurses Age, years Sex, % male Work experience, years ... group of health care professionals is less closely associated with the subject ofthe survey compared to surgical oncologists and breast care nurses Respondents may thus have had less affinity...
... 10% The response rates were 8%, 14%, and 13% for anaesthesiologists, surgical oncologists, and breast care nurses, respectively The response rates differed statistically significant across these ... Respondents' and hospital characteristics Variable N Professional discipline of respondents, % Anaesthesiologists Surgical oncologists Breast care nurses Age, years Sex, % male Work experience, years ... group of health care professionals is less closely associated with the subject ofthe survey compared to surgical oncologists and breast care nurses Respondents may thus have had less affinity...
... study The average age ofthe healthy individuals was 40.6 years (range, 21 to 62 years), and this group included 12 females and 14 males The characteristics ofthe RA patients are summarized in Table ... Table S1 (Additional file 1) Health assessment questionnaires were completed by each patient, and disease activity scores were calculated on the basis ofa 28-joint count and a visual analogue scale ... would therefore be the most suitable candidates for aggressive therapy, but this hypothesis requires validation in a prospective study of early RA patients Approaches that regulate Th17 cells or...
... Limitations of this study The study has limitations The first limitation is the modest sample size of 24 participants Despite this, the authors present real and statistically significant positive ... mean VAS values in the ENAR group were maintained In assessing any therapy whilst obtaining a statistically significant result is important, a far more relevant indicator of ultimate usefulness ... the relatively small sample size, care must be exercised when comparing the results with large non-specific population datasets such as the Austral- ian NHS data This is a significant achievement...
... concern of intravenous transplantation of MSCs is whether the MSCs can migrate into and proliferate in the target tissues, which is the basis of therapeutic effects of MSCs In adults, MSCs remain the ... intravenous injection ofstemcells as a therapeutic strategy is less investigated in the treatment of femoral head necrosis Safety is a critical concern of intravenous transplantation of MSCs Whether ... was smooth and round, and the articular cartilage was transparent and glossy (A) After freezing, the femoral head was pale in the absence of normal glossiness and smoothness (B) A fraction of articular...