mechanisms of host protection and pathogen evasion of immune response during tuberculosis

Báo cáo hóa học: " HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future" pdf

Ngày tải lên : 18/06/2014, 16:20

... is that the quality and the quantity of the immune response generated by the vaccine is different to those of the natural infection The main characteristics of the immune response following VLPs ... generation of long-life memory immune cells that, after re-exposure to the relevant antigen, generate a potent immune response preventing HPV infection? The mechanisms of long-term immune -protection ... induction of the immune memory should be assessed by means of Page of evaluating immune responses to additional doses of vaccine administered at planned intervals following completion of the primary...

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Báo cáo y học: "Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cell" pdf

Ngày tải lên : 09/08/2014, 01:24

... immune evasion and would also be a suitable target of anti-tumor immunotherapy Costimulation and various regulatory T cells: FOXP3, GITR, and ‘anti-suppression’ To understand how the T cell response ... molecule–ligand pairs With the original costimulatory ligand pairs of B7-1/B7-2 and CD28/CTLA-4 there is now a fairly detailed biochemical and cell biological understanding of their properties and their ... there is differential regulation of Th1 and Th2 cells by these ligands B7-H3 and B7x: last-ditch regulators of the peripheral tissues? B7-H3 and B7x (also called B7-H4 and B7-S1) are the most recently...

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Báo cáo y học: "Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury" potx

Ngày tải lên : 13/08/2014, 21:21

... damage and organ dysfunction, are there mechanisms, independent of the physiological immune response, that gain a leading role for the distribution of leukocyte accumulation? Materials and methods ... contributions AP and BN conceived of the study, participated in its design and coordination, and drafted the manuscript VS and AH carried out the adhesion assays JR and HAH participated in the design of the ... are frequently observed during the time course of severe sepsis, various constellations of PMN and endothelial activation were combined Maximal activation of both PMN and HUVEC was considered...

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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx

Ngày tải lên : 09/08/2014, 01:22

... analysis of downregulated genes in functional category of immune response Network-based analysis of downregulated genes in the the functional category of immune response (a) Network and (b) Network ... analysis ofof upregulated genes in the functional category of immune response (a) Network 1, (b) Network 2, (c) Network 3, Network-based analysis upregulated genes in the functional category of immune ... genes of the immune response category were further investigated by utilizing network-based analysis A cluster of the TLR family (that is, TLR1, TLR2, TLR4, and TLR5) and another cluster of FcRs...

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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx

Ngày tải lên : 09/08/2014, 13:22

... analysis of downregulated genes in functional category of immune response Network-based analysis of downregulated genes in the the functional category of immune response (a) Network and (b) Network ... analysis ofof upregulated genes in the functional category of immune response (a) Network 1, (b) Network 2, (c) Network 3, Network-based analysis upregulated genes in the functional category of immune ... genes of the immune response category were further investigated by utilizing network-based analysis A cluster of the TLR family (that is, TLR1, TLR2, TLR4, and TLR5) and another cluster of FcRs...

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The ancient origin of NF kb ikb and thioredoxin and their roles in immune response

Ngày tải lên : 14/09/2015, 22:25

... electrophoretic analysis of Cr-TRX1 in non-reducing (DTT) and reducing (+DTT) conditions MALDI-TOF Mass Spectrum of 16 kDa and 32 kDa bands of CrTRX1 Fluorescence emission spectra of reduced and oxidized ... Localization of CrNFκB and CrIκB in horseshoe crab hemocytes Expression of CrNFκB, CrIκB and CrFC Involvement of NF-κB signaling pathway in the transcription of CrIκB and CriNOS The effects of NF-κB ... THANK YOU! i Table of Contents Acknowledgements Table of Contents Summary List of Tables List of Figures List of Abbreviations List of Primers An Overview of Objectives, Approaches and Findings in...

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Báo cáo y học: "Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model" pdf

Ngày tải lên : 11/08/2014, 08:21

... grade), and sixteen to seventeen years of age (high school) [13] In India, a single dose of BCG vaccine is given within one week of the birth of child The incidence of TB in India is very high and ... Bliss L: Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi Lancet 1992, 339:636-639 Pulickal AS, Vincent G, Fernandez G: Comparison of the Prevalence of Tuberculosis Infection ... Kashyap et al., Assessment of immune response to repeat stimulation with BCG vaccine using in vitro PBMC model Journal of Immune Based Therapies and Vaccines 2010, 8:3 Page of ...

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Báo cáo y học: "Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis" ppsx

Ngày tải lên : 12/08/2014, 17:21

... abnormality in immune response and suppression of cell cycle in BM may contribute to the pathogenesis of RA Conclusions BM cells from RA patients had abnormal functional networks in immune response and ... defense response (1.62E-09), and immune response (9.89E-11) were the three most significant gene categories that corresponded with response to external stimulus Fifty-six of the 67 genes in response ... data and statistical analysis, and drafted and revised the manuscript HS and CA assisted with the acquisition of data and analysis RS performed mRNA expression analysis with microarrays YS and...

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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf

Ngày tải lên : 12/08/2014, 16:20

... of pathogen- lung epithelial interactions Recognition of entering pathogens by lung epithelium A prerequisite for the initiation of host responses is the recognition of pathogens by the host immune ... liberation of immunodulatory cyto- and chemokines and up-regulation of adhesion molecules mediates the acute immune response by e.g recruitment of leucocytes to the site of infection and modulates ... complex response of the lung epithelium to pathogen recognition reflects the great variety of stimuli and signalling pathways activated The epithelial response includes production and secretion of...

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fixed-film anaerobic digestion mechanisms of pathogen reduction and impacts on virus adsorption to soil

Ngày tải lên : 13/11/2014, 16:19

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Host viral interactions host factors in coronavirus replication and coronaviral strategies of immune evasion

Ngày tải lên : 09/09/2015, 10:07

... FOUR: HOST- VIRUS INTERACTION (II): CHARACTERISATION OF HOST ANTIVIRAL MECHANISMS AGAINST CORONAVIRUS INFECTION AND CORONAVIRAL STRATEGIES OF IMMUNE EVASION 4.1 CHARACTERIZATION OF HOST ANTIVIRAL MECHANISMS ... In the second part of the thesis, we focused on understanding the interplay between coronavirus infection and host cell innate immune response Coronaviral strategies of immune evasion were also ... the 5’- and 3’ UTR, and TRS of leader (TRS-L) and each ORF (TRS-B), and this is mediated by protein-RNA and protein-protein interactions comprising of both viral and cellular proteins Many of the...

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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development

Ngày tải lên : 14/09/2015, 08:24

... the mechanisms of initiation of the immune response to E coli and on aspects of invasiveness, pathogenicity and the persistence of E coli This may provide a strategy for improving the efficacy of ... host immune response and DCs can respond to microbial pathogens and their components with a high degree of plasticity (41) The eventual maturation of DCs is influenced by diverse endogenous and ... and pathogens have an important role in stimulating the subsequent adaptive immune response and shaping its development The innate immune system is an ancient system comprising of cells and mechanisms...

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Molecular interactions of tectonin proteins in host and pathogen recognition

Ngày tải lên : 14/09/2015, 08:38

... feedback of FC and C2/Bf in regulating the upstream pathogen- recognition assembly conceivably strengthens the immune response 1.2 Recognition of pathogens and activation of the innate immune ... the assembly of PRRs to prompt the innate immune response 1.7 Structures of hCRP, TtCRP and LpCRP 10 1.8 The structure of TL-1 11 1.9 Oligomers of TPL-1 and GBP 11 1.10 An example of a beta-propeller ... and enhancers of immune response 1.2 Recognition of pathogens and activation of the innate immune system 1.2.1 Pathogen recognition receptors - CRP and GBP as key innate immune molecules ……………………………………………...

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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS

Ngày tải lên : 05/09/2013, 09:08

... composition of 2H and 18O The compositions of the isotopes 2H (D) and 18O were analyzed to obtain δD (‰) and δ18O (‰), respectively, which are defined as the relative deviation of the parts per thousand ... precipitation event during Oct 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow ... in the δD of precipitations (a) , the river water (c), and the accumulated rainfall (b) Journal of Water and Environment Technology, Vol.3, No.2, 2005 In response to the major part of the raining...

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Tài liệu CONVENTION ON THE PROTECTION AND USE OF TRANSBOUNDARY WATERCOURSES AND INTERNATIONAL LAKES doc

Ngày tải lên : 18/02/2014, 04:20

... application and operation of best available technology and results of research and development; (c) Emission and monitoring data; (d) Measures taken and planned to be taken to prevent, control and reduce ... consequences of the choice of particular activities and products, their use and ultimate disposal; (b) The development and application of codes of good environmental practice which cover all aspects of ... coordinated assessments of the conditions of transboundary waters and the effectiveness of measures taken for the prevention, control and reduction of transboundary impact The results of these assessments...

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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deﬁciency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

Ngày tải lên : 18/02/2014, 06:20

... pathophysiological mechanisms of obesity-induced androgen deﬁciency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... endothelium dysfunction and ED [130,131], the concept of androgen deﬁciency reinforces the important role of androgens in vascular health and erectile function Summary and conclusions Visceral ... dysfunction and on features of the metabolic syndrome Andrologia 40, 44–48 110 Saad F, Gooren LJ, Haider A & Yassin A (2008) A dose -response study of testosterone on sexual dysfunction and features of...

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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Ngày tải lên : 19/02/2014, 16:20

... lifetimes of carbon-centred radicals derived from a diverse set of substrates are on the order of about 10)10 s [98] Moreover, the randomness of the apparent intramolecular KIEs for unrearranged and ... result in a drastic diminution of polymerization products derived from aniline and some of its p- and N-substituted congeners, while formation of p-hydroxylated and dealkylated metabolites was ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse...

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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the ﬁsh species Seriola quinqueradiata pot

Ngày tải lên : 08/03/2014, 08:20

... species composition of PtdIns Fatty acid composition of phospholipids from tissues of yellowtail and rat Brain, heart, liver, spleen, kidney and ovary of yellowtails were isolated, and total lipids ... Protein kinase C activity in the spleen of trout (Salmo gairdneri) and the rectal gland of dogﬁsh (Scyliorhinus canicula), and the eﬀects of phosphatidylserine and diacylglycerol containing (n-3) ... phosphatidylserine (PtdSer), PtdIns and sphingomyelin The fatty acid compositions of PtdCho, PtdEtn, PtdSer and PtdIns of brain, heart, spleen, kidney and ovary of yellowtail were investigated (Tables...

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The evolution of host use and unusual reproductive strategies in Achrysocharoides parasitoid wasps pot

Ngày tải lên : 14/03/2014, 16:20

... a third of known species of this genus Regarding the effect of taxa sampling on the reconstruction of ancestral host use, most of our species are European, reﬂecting the most detailed host data, ... conservation of host use) using Permutation Tail Probability tests (PTP utility in PAUP*) These compare the number of host change steps in the actual tree with the number of steps observed in 10 000 randomized ... Fig Lines connect host plants with their speciﬁc parasitoids Fig Comparison of parasitoid and host (moth) phylogenies The host phylogeny is from Lopez-Vaamonde et al (2003) and the parasitoid...

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Báo cáo khoa học: Modeling hydration mechanisms of enzymes in nonpolar and polar organic solvents potx

Ngày tải lên : 16/03/2014, 10:20

... precise picture of water at the surface of the protein, we looked at the number of water molecules within a specific layer of 0.25 nm from the surface of the protein (Fig 3), and the ratio of Fig Average ... 2431 ˆ N M Micaelo and C M Soares Modeling hydration mechanisms of enzymes of time Final parameters and standard errors are shown in supplementary Table S2 The residence times of the water molecules ... significant role in solvating the enzyme, and also takes part in the modulation of the structural and dynamic properties of the enzyme It is also of note that ethanol and acetonitrile are significantly...

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