inhibition of vascular endothelial growth factor vegf and stem cell factor scf receptor kinases as therapeutic targets for the treatment of human diseases

Báo cáo khoa hoc:" VEGF receptors on PC12 cells mediate transient activation of ERK1/2 and Akt: comparison of nerve growth factor and vascular endothelial growth factor" doc

Ngày tải lên : 11/08/2014, 08:20

... PC12 cells express the high-affinity receptor tyrosine kinases VEGF receptor and (VEGFR-1, VEGFR-2) as well as the low-affinity receptor neuropilin1 (Fig 2) These receptors are expressed on the cell ... activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells Comparison of the effects of nerve growth factor and epidermal growth factor Biochem ... surface of (a-d) proliferating and (e) differentiated PC12 cells Immunodetection of VEGF receptors expressed on the cell Immunodetection of VEGF receptors expressed on the cell surface of (a-d)...

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báo cáo khoa học: " The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)" pptx

Ngày tải lên : 11/08/2014, 20:20

... mediators of angiogenesis which are vascular endothelial growth factor (VEGF) and basic growth factor (bFGF) In angiogenesis, a number of growth factors (for example Angiopoietin-1, Platelet derived growth ... Effect of hyperbaric oxygen on the growth factor profile of fibroblasts Arch Facial Plast Surg 2004, 6:31-5 22 Ladoux A, Frelin C: Hypoxia is a strong inducer of vascular endothelial growth factor ... Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients Br J Cancer 1997, 76:238-43 27 Kondo S, Asano M, Suzuki...

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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

Ngày tải lên : 18/02/2014, 11:20

... Shibuya Therapeutic aspects of VEGF in brain diseases [3] The BBB mainly consists of a strong interaction between vascular endothelial cells and astrocytes, and the tight junctions of vascular endothelial ... Activities of vascular endothelial growth factor (VEGF) family members PlGF, placenta growth factor; T.F svVEGF, Trimeresurus ﬂavoviridis, snake-venom vascular endothelial growth factor Ligands Binding ... vivo, and may be a therapeutic target for diseases involving the degeneration of motor neurons VEGF- A also binds and activates VEGFR-1, and so could be another candidate for the treatment of motor...

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Báo cáo khoa học: The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1 docx

Ngày tải lên : 23/03/2014, 07:20

... cell lines expressing chimeric receptors consisting of the extracellular domain of either human VEGFR-1 or murine VEGFR-2 and the transmembrane and cytoplasmic domains of the erythropoietin receptor ... 3D) The interactions of the VEGF mutants with VEGFR-1 and VEGFR-2 were further tested in bioassays that detect receptor binding and cross-linking at the cell surface These assays made use of BaF3 ... C-terminus of ORFVNZ 2VEGF increases its afﬁnity for VEGFR-1 and VEGFR-2 To investigate the role of the ORFVNZ 2VEGF C-terminus in receptor speciﬁcity, we tested the ability of the VEGF mutants...

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báo cáo hóa học: " Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients" ppt

Ngày tải lên : 19/06/2014, 22:20

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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx

Ngày tải lên : 09/08/2014, 01:23

... Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ... concentrations of the sVEGFR-1 in patients with SSc sVEGFR-1 has a strong antagonistic activity and neutralises the effects of VEGF; it plays a pivotal role in the generation of vascular diseases such as ... specific for endothelial cells It interacts with two receptor tyrosine kinases, VEGFR-1 (flt) and VEGFR-2 (flk) A defect in VEGF receptors could account for VEGF signalling abnormalities in SSc The human...

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Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers" doc

Ngày tải lên : 09/08/2014, 06:22

... angiostatic factors The aim of the present study was to analyze whether a decrease of the angiogenic factors VEGF and bFGF and an increase of the angiostatic factor endostatin contribute to the impaired ... increase of angiostatic factors, another strategy for the treatment of ischemic symptoms in SSc is the inhibition of angiostatic factors rather than a further increase of VEGF Angiostatic factors ... induced and outweigh the inhibitors, resulting in the initiation of angiogenesis [4] Among the angiogenesis inducers, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor...

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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt

Ngày tải lên : 09/08/2014, 07:20

... and metalloproteinase; VEGFR, vascular endothelial growth factor receptor; vWF, von Willebrand factor for the primers and probe and the absence of DNA polymorphisms were ascertained using BLASTN ... in the synovium during RA begins at the early stage of the disease and is crucial for progression of the synovitis [13] Vascular endothelial growth factor (VEGF) , which has five different isoforms ... fibroblasts (SFs) were treated with 10 ng/ml TNF-α and/ or 40 ng/ml VEGF1 65 for 24 h, and then the expression of ADAM15, vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2 and neuropilin-1...

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Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants" pps

Ngày tải lên : 09/08/2014, 08:23

... The splice variants of vascular endothelial growth factor (VEGF) and their receptors J Cell Sci 2001, 114:853-865 Thomas KA: Vascular endothelial growth factor, a potent and selective angiogenic ... (NO) radicals and O2.- [20] Therefore, the present study was performed to investigate the expression of VEGF, VEGF- 121 and VEGF- 165 splice variants and VEGF receptors (VEGFR-1 and VEGFR-2) after ... Role of vascular endothelial growth factor in the regulation of angiogenesis Kidney Int 1999, 56:794-814 Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) ...

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Báo cáo y học: "Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury" pps

Ngày tải lên : 12/08/2014, 14:20

... VEGF isoforms at the mRNA level we went on to assess the release of the soluble isoforms (VEGF1 21, VEGF1 65) by the cultured cells ATII cells express significant amounts of VEGF1 21 and VEGF1 65 ... leakage of intrapulmonary VEGF into the vascular bed [27-30] We therefore assessed expression of VEGF and its specific isoforms by immunohistochemistry and isoform-specific RT-PCR (as isoform-specific ... variants of vascular endothelial growth factor (VEGF) and their receptors J Cell Sci 2001, 114(Pt 5):853-865 Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW: The vascular endothelial growth...

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Báo cáo y học: " Vascular endothelial growth factor: an angiogenic factor reflecting airway inflammation in healthy smokers and in patients with bronchitis type of chronic obstructive pulmonary disease?" ppsx

Ngày tải lên : 12/08/2014, 15:21

... Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF: Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor ... determinant of vascular endothelial growth factor (VEGF) upregulation in the airways even before the occurrence of respiratory symptoms The fact that VEGF upregulation positively correlates with the ... regulator of angiogenesis [4,5], and a trophic factor that is required for the survival of endothelial cells, inducing endothelial cell proliferation [6], while its withdrawal leads to endothelial cell...

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Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease" docx

Ngày tải lên : 14/08/2014, 14:21

... Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor- 2, but only neuropilin-2 functions as a receptor for the ... N: The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF Mol Biol Cell ... Eriksson U: Vascular endothelial growth factor B, a novel growth factor for endothelial cells Proc Natl Acad Sci USA 1996, 93:2576-2581 The first identification of the VEGFR1 ligand, VEGF- B Baldwin...

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Tài liệu Báo cáo khóa học: A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA Potential role in mRNA stabilization pptx

Ngày tải lên : 19/02/2014, 12:20

... Schematic of the VEGF 5¢-UTR CSD site The coordinates for the VEGF RNA probes 44 and V1 are indicated relative to the start of the VEGF mRNA (+ [58] (B) Balb/c 3T3 1) ﬁbroblast cytoplasmic extract was ... Post-transcriptional regulation of vascular endothelial growth factor by hypoxia J Biol Chem 271, 2746–2753 17 Shih, S.-C & Claﬀey, K.P (1999) Regulation of human vascular endothelial growth factor mRNA stability ... direct formation of the CSD/PTB cytoplasmic complexes on the VEGF 5¢ -and 3¢-UTR Functional role of VEGF CSD/PTB binding sites The stability of VEGF mRNA is increased by stress conditions such as...

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Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt

Ngày tải lên : 19/02/2014, 16:20

... (1993) The vascular endothelial growth factor (VEGF) isoforms: diﬀerential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF Mol Biol Cell ... Characterization of vascular endothelial growth factor s eﬀect on the activation of protein kinase C, its isoforms, and endothelial cell growth J Clin Invest 98, 2018–2026 29 Takahashi, T., Ueno, ... Donner, D.B (2000) Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation J Biol...

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Báo cáo sinh học: " Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow" ppt

Ngày tải lên : 18/06/2014, 22:20

... a metastatic nodule or being free of microscopic tumor, and the percentage of bones positive for metastases was calculated for the total number of bones sites The number of recorded metastases ... metastases The metastasis volume was then obtained for each bone segment as follows: the number of recorded metastases per bone segment (maximum of 10) was Page of 14 multiplied by the average ... free of microscopic tumor The percentage of bones positive for metastasis was calculated for the total number of mice in each group (metastasis incidence) In addition, metastasis volume was estimated...

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báo cáo hóa học: " Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients" pot

Ngày tải lên : 19/06/2014, 22:20

... mononuclear cells; PCR: polymerase chain reaction; PI3-K: phosphatidylinositol 3 -kinases; SOD1: superoxide dismutase 1; VEGF: vascular endothelial growth factor; VEGFR1: VEGF receptor- 1; VEGFR2: VEGF receptor2 ... sclerosis; VEGF- A, vascular endothelial growth factor- A; CCL2, chemokine ligand-2; PBMCs, peripheral blood mononuclear cells and differentiation of VEGF receptor (VEGFR1), VEGFR2 and chemokine receptor ... Expression of vascular endothelial growth factor (VEGF) and its receptors in human neuroblastoma Eur J Cancer 1999, 35:445-449 13 Ebihara N, Yamagami S, Yokoo S, Amano S, Murakami A: Involvement of CC...

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báo cáo hóa học: " Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor" pot

Ngày tải lên : 19/06/2014, 22:20

... to better prognosis List of abbreviations VEGF, vascular endothelial growth factor; VEGFR1, vascular endothelial growth 16 factor receptor 1; PI3K, Phosphoinositide 3-kinase; AMD, age-related macular ... with VEGF inhibition TUNEL-positive cells increased when VEGFR1 Fc was injected after PDT (F-H) The thickness of photoreceptor cell layer in the center of the lesion was measured (I) and the number ... Beckendorf A, Naumann GO: Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF) , VEGF 23 receptor 3, and pigment epithelium-derived factor Invest Ophthalmol Vis...

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Báo cáo y học: " Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung" docx

Ngày tải lên : 12/08/2014, 13:22

... TaqMan assays Real-Time PCR probe and primers name, symbol and ID Gene Symbol Assay ID Vascular endothelial growth factor A Vascular endothelial growth factor B Vegfa Vegfb Placenta growth factor ... development of COPD The aim of this study was to examine the expression profile of the well-established pro-angiogenic VEGF family members, VEGFA, VEGFB and PlGF, and their receptors, VEGF R1 and VEGF ... of VEGF Ligands in Endothelial Cell Wound Healing We next examined the effects of PlGF and VEGFB on pulmonary microvascular endothelial cell regeneration and repair using a scratch assay in endothelial...

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Báo cáo y học: " Vascular endothelial growth factor as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis-type of COPD" pot

Ngày tải lên : 12/08/2014, 15:20

... cells constitute a source of cytokines and growth factors such as VEGF, that may target the endothelial cells and contribute to the development of structural and functional abnormalities of the ... that is, near the superior margin of the aortic arch (level of the upper lung field), at the level of the carina (level of the middle lung field), and at the level of the orifice of the inferior ... decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor in emphysema Am J Respir Crit Care Med 2001, 163:737-44 Kanazawa H, Asai K, Hirata K, Yoshikawa...

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