inatomi t sotozono c amemiya t kanamura n kinoshita s 2004 transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders br j ophthalmol 88 1280 1284

Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx

Ngày tải lên : 09/08/2014, 01:22

... these cells in patients with severe joint involvement and rapid joint progression confirm observations that the frequency of CD4+CD28– T cells may correlate with the risk of occurrence of joint ... The association of CD4+CD28– T cells with disease status has given rise to the hypothesis that these cells directly contribute to disease manifestations Patients with nodulosis and extra-articular ... CD4+CD28– T cells in each of these disease categories is shown in Table The frequency of CD4+CD28– T cells was 4.82% in patients with limited joint manifestations, 7.05% in those with advanced joint...

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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc

Ngày tải lên : 10/08/2014, 22:21

... function BCL11Bf 5’-CACCCCCGACGAAGATGACCAC forward primer BCL11Bb 5’-CGGCCCGGGCTCCAGGTAGATG backward primer BCL11Bp 5’-6FAM-TCACCCACGAAAGGCATCTGTCCCAAGCA-TAMRA probe b2Mf 5’-CTCGCGCTACTCTCTCTTTCT ... by the BCL11B gene in transcriptional regulation, and both participated in the same protein-protein interactions, acting as apoptosis regulators along with a competitive target protein downstream ... In BCL11Bknockdown T- cell lines, when exposed to growth stimuli, T cells exhibit apoptosis in S phase with concomitant decreases in the cell-cycle inhibitor p27 and the anti-apoptotic protein...

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Báo cáo y học: "Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus" potx

Ngày tải lên : 12/08/2014, 18:20

... occurred mainly on B -cells and was not different comparing SLE patients and HC Conclusions: This study demonstrates an increased proportion of IL-21+ T- cells in SLE patients correlating with the ... (data not shown) Discussion The present study is the first demonstrating increased proportions of IL-21+ T- cells in SLE patients in comparison with HC Increased proportions of IL-21+ cells could ... experiments PCL contributed to concept and design, interpretation of data CGMK contributed to concept and design, interpretation of data and revising the article MB contributed to concept and design,...

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Báo cáo khoa học: "Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study" pot

Ngày tải lên : 12/08/2014, 22:22

... demonstrates that rhAPC resets sepsis-induced thrombin generation within the first h of infusion, without influencing parameters of fibrinolysis and inflammation Key messages • Recombinant human ... human activated protein C resets thrombin generation within the first h of infusion • The administration of recombinant activated protein C does not influence parameters of fibrinolysis and inflammation ... or suspected infection, three or more signs of systemic inflammation and a sepsis-induced dysfunction of at least one organ system that lasted no longer than 48 h In patients enrolled in the ENHANCE...

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Gray hat c A H a c k e r ’ s G u i d e t o C r e a t i n g a n d A u t o m a t i n g S e c u r i t y T o o l s

Ngày tải lên : 03/07/2017, 13:33

... AUTOMATING NESSUS REST and the Nessus API The NessusSession Class Making the HTTP Requests Logging Out and Cleaning Up Testing the NessusSession Class The NessusManager ... public string AddUser(string username, string password) { NpgsqlConnection conn = new NpgsqlConnection(_connstr); conn.Open(); string sql = "insert into users values('{0}', '{1}');"; usql = String.Format(sql, ... application! C# Crash Course Introducing Classes and Interfaces Classes and interfaces are used to create complex data structures that would be difficult to represent with just built -in structures...

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Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx

Ngày tải lên : 18/06/2014, 16:20

... Autoimmunity AST, aspartate transaminase; ALT, alanine transaminase *Assessed using the National Cancer Institute-Common Terminology Criteria for Adverse Events version 3.0 † Flu-like syndrome includes ... Transfusion Medicine Unit of the National Cancer Institute of Naples were used as controls for the evaluation of basal Treg levels following assessment of samples for infections and other diseases ... development of autoantibodies or clinical manifestations of autoimmunity were associated with statistically significant improvements in Page of 13 RFS and OS in the IFN-a 2b induction only treatment arm...

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Báo cáo y học: "Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis" ppsx

Ngày tải lên : 09/08/2014, 01:24

... cells contain higher levels of SOCS1 but contain lower levels of SOCS3 transcripts in comparison with normal CD4+ T cells These findings indicate that CD4+ T cells become resistant to the inhibitory ... activation is inhibited by SOCS3 induction in Th2 cells, whereas IL4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells SOCS1 and SOCS3 may thus have important roles as Th1-specific ... but not SOCS1 deficiency, results in sustained activation of STAT3 in response to IL-6 [8,41] The analysis of SOCS3-deficient macrophages has indicated that SOCS3 is a crucial inhibitor of the...

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Báo cáo y học: "The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus" potx

Ngày tải lên : 09/08/2014, 08:22

... cells in SLE, we investigated spontaneous T cell responses to hnRNP-A2 in patients with SLE and in healthy control subjects and characterized TCCs specific for this antigen The data obtained suggest ... proliferation andpatients and controls of heterogeneous nuclear ribonucleoprotein (hnRNP)-A2 specific T cell clones (TCCs) of systemic lupus erythematosus (SLE) patients and controls TCCs were generated ... CD4+ T cells upon incubation with supernatants from T cell clones (TCCs) CD4+ T cells of two healthy controls (HC-1, (TCCs) HC-2) and two systemic lupus erythematosus (SLE) patients (SLE-1, SLE-2)...

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Báo cáo y học: "Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis" pdf

Ngày tải lên : 09/08/2014, 08:22

... reduced catecholaminergic control on IFN-γ production in patients with RA compared with HDs mainly affects CD8-positive T cells The functional discrepancy of cytokine synthesis in patients with RA ... apoptotic or necrotic cells was observed in HDs and patients with RA (data not shown) Discussion In the present study, we determined the effects of catecholamines on cytokine production of T cells ... not otherwise indicated) The relative change of cytokine production upon co-incubation with catecholamines was determined after defining the concentration of the respective cytokine in the control...

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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt

Ngày tải lên : 09/08/2014, 14:21

... latent-cycle peptides was used, corresponding to known human leukocyte antigen (HLA) class I-restricted cytotoxic T lymphocyte epitopes Considering that the HLA status of our study patients and ... IFNγ-producing T cells In response to the full set of peptides, the number of IFNγ-producing cells was not significantly modified by immunosuppressive treatment (SpA patients receiving anti-TNF drugs ... assay analyses GC and AV contributed to interpretation of the data Competing interests The authors declare that they have no competing interests Page of (page number not for citation purposes)...

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Báo cáo y học: " Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment" ppt

Ngày tải lên : 12/08/2014, 01:21

... memory CD8 T cells, reducing its negative influence on CD8 T cells activation and function in CHB patients Most important, we demonstrate successful antiviral treatment can rescue such a functional ... memory T cells as well as on HBV-specific CD8 T cells in CHB patients It is widely accepted that CD8 T cells play an essential role in the immune response to viral infection In successful responses ... conclusion on this matter Taken together, our results suggest the mechanism linking HBV replication and abnormalities in CD8 Tcell function in patients with CHB We also demonstrate a strong negative...

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Báo cáo y học: " High Human T Cell Leukemia Virus Type-1(HTLV-1) Provirus Load in Patients with HTLV-1 Carriers Complicated with HTLV-1-unrelated disorders" docx

Ngày tải lên : 12/08/2014, 04:20

... of this pattern In contrast, the high VL samples with 10% or more displayed distinctive band patterns accompanied by dense smears with or without discrete clonal band (s) , indicating that an increase ... analyzed HTLV-1 proviral load and SBH status using the same blood samples In contrast to the maintenance of stable VL in asymptomatic carriers with no-bands or only faint discrete bands, the VL in symptomatic ... process by which the clonality of HTLV1-infected cells is established after the disappearance of dense smears It is now recognized that clonal expansion of HTLV-1infected cells is the norm in nonmalignant...

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Báo cáo y học: " Natural killer cells control a T-helper 1 response in patients with Behçet''''s disease" doc

Ngày tải lên : 12/08/2014, 12:20

... combination with an increase in the dosage of cyclosporine Activation status of natural killer cells We determined the activation status of the circulating NK cells in seven patients with aBD, 22 patients ... infliximab (n = 4), cyclosporine (n = 1), or an increased dosage of prednisolone in combination with cyclosporine (n = 2), resulting in resolution of symptoms within months Two patients with intestinal ... difficulty in classifying BD patients into those with active disease and those with inactive disease We used a strict definition to select patients with aBD: flare of characteristic BD symptoms that...

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Báo cáo y học: " Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes" pptx

Ngày tải lên : 12/08/2014, 13:22

... phenotypic markers expression of A549 versus AECII in resting conditions To compare the percentages of positive cells after cytokine stimulations versus resting conditions, the non-parametric ... Material and Methods section, we subtracted the auto-fluorescence of non-stained cells before comparing the MFI from stimulating and resting cells to take into account the observed MFI increase of the ... technique was used to assess the purity of the cell suspensions and to characterize their phenotype after cytokine stimulation Cells were first incubated for 30 minutes with FCS before staining...

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Báo cáo y học: " CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease" ppsx

Ngày tải lên : 12/08/2014, 13:22

... both control subjects and COPD patients in COPD patients, underscoring the potential importance of Th17 cytokines in this disease A potential explanation of increased expression of IL17 in COPD ... detect a difference between controls and COPD patients The discrepancy between their results and ours may reflect differences in patient selection or technique Notwithstanding these differences, ... but the results are conflicting [18,26] Nevertheless, in the context of this observation it is noteworthy that a recent study has reported that CD8+ T cells are activated in the presence of the...

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C-Reactive Protein in Patients with Pulmonary Tuberculosis ppt

Ngày tải lên : 15/03/2014, 03:20

... diabetes mellitus [9, 10], chronic infections and asthma [11, 12] The objective of the present study was to assess changes in the concentration of CRP in patients with pulmonary tuberculosis infection ... Hopstaken, K Hood and G .J Dinant, 2009 Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster ... positive [25] It is very interesting to note that sputum conversion and x-ray findings improvement is concomitant with negative C- reactive protein reaction The changes in serum CRP concentration...

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$báo cáo hóa học:" Improvement in quality of life measures in patients with refractory hepatitis C, responding to re-treatment with Pegylated interferon alpha -2b and ribavirin" docx$

báo cáo hóa học:" Improvement in quality of life measures in patients with refractory hepatitis C, responding to re-treatment with Pegylated interferon alpha -2b and ribavirin" docx

Ngày tải lên : 20/06/2014, 15:20

... frequency of injections [17-19] The side effects of interferon-based treatment include fatigue, flu like symptoms, depression, inability to concentrate and decrease in libido Discontinuation of therapy ... Erlinger S: Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy Ann Intern Med ... significant This is similar to the observation in naïve patients with HCV infection undergoing treatment [20-22,26] Hassanein et al in their study, showed a decrease in the HRQOL domain scores of...

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báo cáo hóa học: " Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer" pptx

Ngày tải lên : 20/06/2014, 15:20

... this study, assessment of QoL by FACT -C questionnaire and its responsiveness are not conclusive This result suggests the non-relevance of CCR Specific subscale of the FACT -C These questionnaires ... by a therapeutic intervention [13,14] In a clinical trial, the knowledge of instrument s responsiveness helps in the selection of measures, in setting the correct sample size and assists in prioritising ... context in which to interpret the information about change in QoL This study on responsiveness of the questionnaires provides arguments for the choice of generic to assess QoL in patients with...

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Báo cáo y học: "Serological and molecular expression of Hepatitis B infection in patients with chronic Hepatitis C from Tunisia, North Africa" pdf

Ngày tải lên : 12/08/2014, 01:21

... prevalence and the virological presentation of HBV infection in 361 Tunisian patients with chronic hepatitis C, in comparison to 361 antiHCV negative individuals considered as controls Methods Studied ... in patients with occult HBV infection as compared to HBV negatives (p = < 0.05) and to patients with resolutive infection (p = < 0.05) In contrast, the patients distribution according to gender ... significant rate that should be taken into account as part of the treatment and the follow-up of these patients A lower response to interferon therapy in patients with HCV and occult HBV infection...

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Báo cáo y học: "Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha" potx

Ngày tải lên : 12/08/2014, 02:20

... expression in patients with CHC, and that the highest increase in each miRNA was seen only in responder patients, no significant differences were found in the expression levels of IFN-induced miRNAs ... greater endogenous activation of IFN-induced pathways in patients with CHC than in healthy controls [20-23] As far as the influence of baseline expression of these miRNAs on the clinical outcome ... compared using the Wilcoxon test The same test was used to assess differences between miRNAs and MxA expression levels in patients with CHC A Spearmen rho coefficient was calculated to assess the correlation...

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