hashimoto s disease involvement of cytokine network and role of oxidative stress in the severity of hashimoto s thyroiditis

Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx

Ngày tải lên : 07/08/2014, 17:22

... analysis Data were expressed as mean ± SD For comparison of means, Student s t-test was performed using SPSS 9.0 (SPSS Inc., USA) statistical package Results Chemical-components of PMs The ratio of ... at same dose (P

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Báo cáo y học: "Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticu" docx

Ngày tải lên : 10/08/2014, 10:20

... properties, such as inhibition of KA-induced inflammatory mediators [50] Since PGE2 was synthesised in response to activation of COX-2 expressing cells, directly hyperpolarises GABA-induced neurons ... reports which show that antioxidants such as resveratrol [13] and vitamin E [53] are also protective against various animal models of SE in terms of the oxidative stress or convulsions Resveratrol ... advocated for the treatment of cancer, oxidative stress, inflammation and diabetes, but few studies have evaluated modes of action in these processes The present study demonstrates that GABA was effective...

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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Ngày tải lên : 23/03/2014, 07:20

... heterodimer and increases apoptosis The role of caspase-1 in apoptosis is not known, but in some conditions it may increase apoptosis Different symbols representing different proteins are shown in the ... transcription of caspase-1, and this warrants further studies A summary of the ﬁndings that HIPPI increases apoptosis and alters gene expression is shown in Fig Hi Pro-caspase-1 45 kDa Caspase-1 20 kDa ... box Numbers representing different processes are also shown Possible role of HIP-1 and HIPPI in the pathogenesis of HD Various cellular processes, such as apoptosis and transcriptional dysregulation,...

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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx

Ngày tải lên : 19/06/2014, 22:20

... death This study suggests that COX-2 plays an important role in the secondary activation of microglia, in the progression of the inflammatory response, and in the progressive loss of the dopaminergic ... to attenuate the progressive cell loss induced by the inflammatory response Using adjacent SNpc sections to stain and count the number of TH- and Nissl-stained neurons and Mac-1stained activated ... drugs have shown protective effects in reducing the risk of neurodegenerative disease such as Alzheimer 's disease [8,18] and PD [19] In the present study, we tested the hypothesis that excessive...

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Tài liệu A Comparison of Conventional and Organic Milk Production Systems in the U.S. potx

Ngày tải lên : 22/02/2014, 05:20

... However, the prior research is limited in terms of the scope and the depth of data supporting the analyses This study addresses these limitations, taking advantage of a unique nationwide data set of ... compute the inverse Mills ratio, which is included as an additional term in a least-squares estimation of equation (2) The second stage model is specified using the levels of production costs as the ... dairies In the models specified with operating and capital costs and with total economic costs the value of the coefficients decreased with successive size categories indicating economies of size...

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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt

Ngày tải lên : 19/06/2014, 22:20

... of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades ... of proinflammatory responses that act in concert to promote the progressive pathophysiology associated with this disease The results summarized in this review suggest that ROS and iNOS released ... neurogenesis, gliogenesis and even inflammatory processes [65,66] In the AD brain, it has been postulated that the abundance of astrocytes results in their extensive exposure to Aβ from the earliest stages...

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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx

Ngày tải lên : 09/08/2014, 06:22

... senescence and oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in ... chondrocyte senescence remains unclear Our findings, demonstrating the oxidative stress (ROS) induced telomere erosion and replicative senescence in chondrocytes, suggest the involvement of oxidative stress ... involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere erosion, and chondrocyte senescence Our findings clearly...

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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"

Ngày tải lên : 25/10/2012, 10:39

... bias in the results and is a limitation of the study Medical errors are among the leading causes of death in the United States In its highly publicised report, the Institute of Medicine estimates ... consequence of constructing their own drug prescriptions using pull down menus There were also many missed prescribers' signatures with CPOE This did not affect the patient but, in these cases, nurses ... prescribing systems, prescribing was restricted to intensive care medical staff only To compare both prescribing systems, details of all MEs identified by the ICU clinical pharmacist, in the...

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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc

Ngày tải lên : 19/02/2014, 07:20

... site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis in man and mouse are distinct, particularly in the ... (in Fabry disease) and of course, GlcCer (in Gaucher disease) By inhibiting this enzyme, the synthesis of most GSLs (and all gangliosides) is prevented The glucosyl ceramide synthase substrate mimic, ... function of MDR1, the GSLs of some other tissues are complicated by the redundancy in this function (studies in progress) and the tissue differences in MDR1 expression Thus, an effect of MDR1 inhibition...

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Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt

Ngày tải lên : 21/02/2014, 00:20

... lipofuscin pigments abundantly present in human brain tissue Results Expression of different ADH classes in tissues outside the CNS Figures and show results from speciﬁcity tests of all probes on ... immunohistochemistry also in rodents [22] Expression of ADH3 in the adult rodent and human brain Overviews of the expression patterns of the three classes of ADHs in the adult rodent brain are shown ... photomicrographs (Fig 4) show the distribution of silver grains indicating expression in three regions of the rat brain In hippocampus, ADH3 hybridization was strong within cornu amonis as well as in the...

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Tài liệu Báo cáo khoa học: Moult cycle-related changes in biological activity of moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) in the crab, Carcinus maenas From target to transcript ppt

Ngày tải lên : 21/02/2014, 00:20

... level In view of these observations, we also investigated levels of MIH and CHH peptides in the sinus gland and levels of transcripts in XO neurones during the moult cycle, to see whether signiﬁcant ... recruitment of receptors for MIH was suggested Levels of MIH and CHH in the sinus gland during the moult cycle As individual SG from single crabs always contained almost identical proﬁles and quantities ... CHH secretion is a dynamic process Taking these observations into account, and given that CHH is about 10-fold less effective than MIH in repressing ecdysteroid synthesis [4], it now seems possible...

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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafﬁcking of human acetylcholinesterase and butyrylcholinesterase potx

Ngày tải lên : 07/03/2014, 03:20

... cases (Fig 2) However, in the case of Bb, the cellular activity was decreased and secretion was increased, suggesting that the presence of this cysteine retains the enzyme intracellularly In ... C-terminal cysteine and the aromatic residues, as indicated above (not shown) Taken together, these results show that the t peptides possessing a cysteine at position 19 had a stronger effect on the ... that the secreted ⁄ cellular ratio presented a minimum with a cysteine at position 19, and was notably increased in the mutant possessing two C-terminal cysteines (S3 7C) As shown in Fig 4, the sedimentation...

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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf

Ngày tải lên : 07/03/2014, 12:20

... decreases the antioxidant capacity resulting in a net ‘steady-state’ increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the ﬂow of electrons in the respiratory chain inducing ... alterations of Na+ and K+ homeostasis in neurodegeneration, is currently unknown Nevertheless, the fact that these proteins are intensely expressed in the central nervous system [251,254,261] and their ... preparations [195] and subsequently shown to be associated with tissue damage in this and other organs, including the kidney and skeletal muscle [196,197], but not in others, i.e liver [198] Interestingly,...

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Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt

Ngày tải lên : 08/03/2014, 07:20

... behind an empty constituent in the syntax, and (2) whether the form is anaphoric in the semantics In subsequent sections, we show how the distinct mechanisms for recovering these types of missing ... felicitous in these cases This account also explains similar differences in felicity for other coordinating conjunctions as discussed in Kehler (1994), as well as why gapping is infelicitous in constructions ... representation in Figure as the source, the semantics for the missing VP may be recovered in both the target and the source clauses, and that abstracting these elements results in an "open proposition"...

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Preferences of the Central Reserve Bank of Peru and optimal monetary policy rules in the inflation targeting regime ppt

Ngày tải lên : 15/03/2014, 14:20

... for inflation and output stability and interest rate smoothing remains robust to the inclusion of exchange rate smoothing in the loss function The results found for this second case are shown in ... interest rates Nevertheless, state variables also have secondary effects on the interest rate as a result of their lagged values and of the inertial term it −1 These secondary effects can be measured ... over the interest rate predicted by the opposing weights, it** (and vice versa) The results for the encompassing test (Table 7) confirm the results presented in Figure The weights of a strict inflation...

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Processing Fluency and Aesthetic Pleasure: Is Beauty in the Perceiver''''s Processing Experience? pptx

Ngày tải lên : 16/03/2014, 18:20

... preferences for average versus exaggerated forms, and why artists and scientists have often considered truth and beauty as two sides of the same coin Processing Fluency The Concept of Processing Fluency ... of information should reveal a preference for easy-to-process stimuli Several studies bear on this issue Some of these studies explored processing ease of different forms of symmetry, such as ... cultures to begin to classify their flora and fauna, regardless of the survival needs of the tribe (see Levi-Strauss, 1962/1966) Hence, aesthetic criteria seemingly stood at the very beginnings of scientific...

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Báo cáo Y học: Functional integration of mitochondrial and hydrogenosomal ADP/ATP carriers in the Escherichia coli membrane reveals different biochemical characteristics for plants, mammals and anaerobic chytrids pdf

Ngày tải lên : 18/03/2014, 01:20

... aac3 (A.t.) aac1 (S. t.) aac1 (R.n.) aac2 (R.n.) hdgaac (N.spec.) Sense Antisense Sense Antisense Sense Antisense Sense Antisense Sense Antisense Sense Antisense Sense Antisense 5¢-TGCAGAGTTCcAtATGGTTGATCAAG-3¢ ... possesses proof reading activity Sense primers incorporating an NdeI restriction site and antisense Heterologous expression of AACs in E coli Table Oligonucleotides used for construction of the ... expression plasmids (encoding His10–AAC), the NdeI–XhoI (NdeI–BamHI or NdeI–BglII) DNA inserts of the pBSKplasmids were introduced in- frame into the corresponding restriction sites of the isopropyl...

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Blackwell Publishing Ltd Gregariousness and protandry promote reproductive insurance in the invasive gastropod Crepidula fornicata: evidence from assignment of larval paternity potx

Ngày tải lên : 22/03/2014, 12:20

... success and sex-reversal strategies? The inferred mating patterns are discussed in light of the individual features (size, position and sex at the time of sampling) of the assigned fathers and the ... Fisher test was not significant (P = 0.093) Size, position within stacks and sex of fathers Figure shows the sex of the assigned fathers at the time of sampling Surprisingly, depending on the population, ... between the effects of size and position In addition, only the offspring of females at the base of the stacks were examined, so that the male contribution to the broods of other females in the stack...

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Trends of Health Education in the Developed Countries and Recommendations for Health Education in the Kingdom Of Saudi Arabia potx

Ngày tải lên : 22/03/2014, 14:20

... problem-solving skills These instruments include the followings:1 Use of portfolios OSCE Modified essay questions Peer and self assessment reports production 263 Advances in MCQs such as R type and problem-oriented ... students unexpectedly and allowing each student to discuss his answers with the neighboring student and consequently trying to justify their answers Using the Internet and computer-assisted instructions ... through the web includes timetables, bio-sketches of students and tutors, learning topics, references, and outlines of lectures and other teaching sessions, materials for the problems, laboratory and...

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The impact of and responses to HIV/AIDS in the private security and legal services industry in South Africa potx

Ngày tải lên : 22/03/2014, 18:20

... critical assessment of HIV/AIDS in the private security and legal services industries, in terms of the prevalence rate of HIV, its impact on business and the responses of businesses to the epidemic ... security and legal services industries, in terms of the prevalence rate of HIV, its impact on business and the responses of businesses to the epidemic thus far Furthermore, the study sought to establish ... survey in the private security sector, while Chapter presents the results from the legal services sector Chapter presents the findings on the impact of HIV/AIDS and the response of businesses in the...

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