from proof of concept to confirmation of the efficacy and safety of the procedure

Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf

Ngày tải lên : 08/08/2014, 23:21

... aripiprazole and placebo (total PANSS, cognitive and hostility subscales) The therapeutic effect was evident from day On the basis of the YMRS change, the effect size Cohen d was equal to 0.30 The response ... HR = 0.31) but not to a depressive episode Unfortunately the mean time to relapse for either group was not reported At the end of the study 49% of the placebo group and 72% of the aripiprazole ... validity of psychiatric diagnosis perplexes the problem and makes the gathering of scientific data difficult, because the diagnosis of BD in particular is often made retrospectively and carries the...

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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx

Ngày tải lên : 09/08/2014, 10:23

... published Therefore, in the present double-blind and placebo-controlled clinical study, we sought to evaluate the efficacy and safety of 5-Loxin® in treatment of OA of the knee We assessed the effectiveness ... contributed to the design of the project and data analysis, and was primarily responsible for writing the manuscript KVA contributed to the design of the project, patient recruitment and management, and ... excluded from the study because they were suffering from a nonfatal viral infection during the course of study Discussion To the best of our knowledge, this is the first clinical study to evaluate the...

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Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold" doc

Ngày tải lên : 12/08/2014, 11:22

... (CPMP/ICH/135/95)5, and the principles of the Declaration of Helsinki, local drug law and standard operating procedures of the investigator, sponsor and CRO involved The study protocol and attached ... Analysis of days of onset of common cold symptoms Shown are the numbers of patients for verum, placebo and total divided into groups with days of onset of common cold symptoms at the point of inclusion ... investigator of the study and was responsible for the study and protocol design MJA performed the study on site and served as medical director RWE and CME performed the quantitative virus analysis and...

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Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx

Ngày tải lên : 12/08/2014, 15:20

... were randomly assigned to tiotropium and 195 to placebo Forty-four centres across the UK participated in the study, which lasted 12 months from October 2002 to October 2003 (Fig 1) Quality of spirometry ... tiotropium studies [11-14] and supports the clinical relevance of the sustained efficacy of tiotropium and reduction of COPD exacerbations The actual magnitude of the reduction in rescue medication ... Patients were asked not to take their morning respiratory medications (according to a pre-established washout period) prior to the morning PFT The highest value of FEV1 and FVC from three technically...

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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx

Ngày tải lên : 12/08/2014, 23:23

... compared to SMT Careful and frequent monitoring of patients with ACPE is mandatory, especially in the presence of AMI, but there is no evidence from these trials to contraindicate the use of NPPV ... probably due to the low power related to the limited number of patients in the studies analyzed To put this evidence of clinical efficacy into context, it is also important to take into account the costs ... to translate to practice and more challenging for clinicians to understand The aim of our study was to systematically review the evidence in order to answer key clinical questions about the efficacy...

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Efficacy and safety of pregabalin in the treatment of

Ngày tải lên : 21/08/2016, 18:51

... taper and follow-up phase Efficacy Analyses The primary efficacy measure was the change from baseline to endpoint in the total score of the 14-item, clinician-rated HAM-A in the pregabalin and ... visits and at LOCF endpoint on all secondary outcomes, including the HAM-A psychic and somatic factors scores, the anxiety and tension items (1 and 2) of the HAM-A, and the CGI-I, in addition to the ... treatment, so the duration of weeks is sufficient to test efficacy adequately, and the results may, therefore, generalize to short-term treatment The study was designed to investigate the efficacy of pregabalin...

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Báo cáo khoa học: "Radiosurgery for pituitary adenomas: evaluation of its efficacy and safety" ppsx

Ngày tải lên : 09/08/2014, 09:20

... confirms the adequacy of indications of the procedures and plans made More even than the concern about the pituitary function, we observe the maximum dose considered safe in the optic pathways and often ... tumoral and hormonal control and results overlapped with those of literature Proper selection of patients, the careful definition of target volume and the respect to the dose tolerance of adjacent ... in the contouring of structures and prescription of the dose required in most cases may explain the absence of hypopituitarism observed so far The absence of visual deficit induced by RS to date...

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Báo cáo y học: " Impact of race on efficacy and safety during treatment with olanzapine in schizophrenia, schizophreniform or schizoaffective disorde" pdf

Ngày tải lên : 11/08/2014, 16:22

... universally and shows similar patterns of symptoms across populations The overall prevalence of schizophrenia is estimated to be between 1% to 2% of the population, and the prevalence of major psychotic ... in all-cause time to discontinuation and PANSS Total score between white, black, and Hispanic subgroups Another study looked at the impact of race on the efficacy and safety of long-acting risperidone ... the design and coordination JLS and JG performed the statistical analysis KWP wrote the initial and subsequent drafts of the manuscript SKW coordinated the development of the initial and final...

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Báo cáo y học: " Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease" potx

Ngày tải lên : 12/08/2014, 13:22

... design of the study and the interpretation of the study data RL supervised the statistical analysis All authors contributed to the development of the manuscript, and read and approved the final ... grants from Almirall and Forest Laboratories RL and EGG are employees of Almirall CC is an employee of Forest Laboratories, and holds stock and options in the company Jones et al Respiratory Research ... was the co-ordinating study investigator and SIR, AA, PC, HM, LF, JFD, EDB and NJG were study investigators All study investigators, CC and EGG made substantial contributions to the conception and...

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Báo cáo khoa học: "Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep" pps

Ngày tải lên : 13/08/2014, 03:20

... the Ethical Committee of the University of Turin, Italy Sheep were transported to the laboratory at least two days before the experiment Anaesthesia was induced (thiopentone 10 to 15 ml/kg) and ... mechanical damage to blood components, and absence of recirculation On the other hand, it does not offer direct blood flow control, it increases left -to- right shunt, and it could lead to lower-limb ... research experience At the time of the first studies in the 1970s, the idea of 'lung rest' (that is, using low tidal volume) [8] had no scientific rationale, and the modern concepts of 'baby lung' (that...

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Báo cáo y học: "Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy" pdf

Ngày tải lên : 13/08/2014, 18:21

... factors that influence the pharmacology of drugs, a safety system in standard treatment would help to solve the black box of safety and of unknown relationship between the dosage and actions of ... enables the clinician to adjust the dosage of drugs according to the characteristics of the individual patient The interdisciplinary TDM expert group of the Society of Neuropsychopharmacology and ... psychopharmacology of the three German professional societies and initiated the network based on decisions of the commission MG (head of the TDM laboratory in Würzburg) was involved in the design of the database,...

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Báo cáo y học: "An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study" docx

Ngày tải lên : 13/08/2014, 11:23

... were found to be predictive of the total amount of fluid given to the patient on day two in the ICU The coefficients of the variables in the fitted model, their standard errors and the corresponding ... correlated with the outcome variable of interest are identified The idea is to provide the values of these predictor variables from the index patient to the model, and a predicted range of fluid requirement ... to see if we could predict the total amount of fluid administered to a patient on day two in the ICU, given the physiological data from the previous 24 hours Materials and methods The Laboratory...

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Overview of Plant Biotechnology from Its Early Roots to the Present

Ngày tải lên : 25/10/2013, 05:20

... establishing the pathways at the level of intermediates and enzymes that catalyze their formation The subsequent step is the selection of targets for further studies at the level of the genes This ... Davis, CA, and was called “FlavR Saver.” This tomato has two distinct advantages over other tomato cultivars: ﬁrst, it has a longer shelf life in storage, and second, the fruit of this tomato could ... in the postharvest storage and handling of crops; (4) the use of plant hormones to improve rooting responses of cuttings, enhancement of seed germination, breaking seed dormancy, prolongation of...

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Tài liệu Actions Against Abuse of the Global Financial System: Report from G7 Finance Ministers to the Heads of State and Government docx

Ngày tải lên : 17/02/2014, 21:20

... not be able to discover the identity of the beneficiary of the account and will be unable to meet their “know your customer” obligation The combination of market access and obscurity of ownership ... authoritative review of their financial procedures and controls and those of recipients, and to improve ways to strengthen safeguards on the use of their funds as well as governance and anti-corruption ... endorse these initiatives and urge these bodies to cooperate with each other and coordinate their actions, as appropriate, to address problematic OFCs 10 We call on OFCs to respond positively to these...

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Tài liệu An Aviator''''s Field Book Being the field reports of Oswald Bölcke, from August 1, 1914 to October 28, 1916 doc

Ngày tải lên : 18/02/2014, 09:20

... Tetschen, at the border, I was relieved of the bother of customs officials through the kindness of an Austrian officer It was the lasting grief of my companion that he had to submit to the customs in ... them from every direction They managed to get into a nearby woods by beating a hasty retreat Behind them they heard the yelling of the men and women The woods was surrounded, and they had to hide ... shells and the burning villages all about But if there was nothing to see, there certainly was plenty to hear the dull noise of the light artillery, the sharp crash of the field pieces and the crackling...

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Forest-Backed Bonds Proof of Concept Study: FINAL DRAFT - CIRCULATED TO STEERING GROUP ppt

Ngày tải lên : 06/03/2014, 08:20

... 220,000km2 of equatorial rainforests (equivalent to the size of the UK) and about 1/3rd of the island of Borneo the 3rd largest island in the world The area straddles the transboundary highlands of Indonesia ... between (a) the value of the timber, (b) the total area/geography of the concession and (c) the cost of the concession In short, equity financing applied to SFM tends to dictate the need for ... seeking to offset the impact of their carbon emissions ITTO 2005b Page 16 of 140 FINAL 06 August 2007 Forest-Backed Bonds Proof of Concept Study Forum for the Future & EnviroMarket The Forestry Sector...

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Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc

Ngày tải lên : 07/03/2014, 10:20

... C and D (to delete site II), E and F (to delete site III), G and H (to delete the perfect inverted repeat) and I and F (to delete simultaneously sites II and III) were ligated to each other The ... restriction and sequencing Cloning of genes in E coli The DNA region (from the nucleotide at position 505 to that at position 1197 of senS) encoding the cytoplasmic part (comprising the segment from the ... into the complex network of signaling processes Taking the presented and previous data into account, the TCS SenS–SenR from S reticuli is a model that is well suited to elucidate the role of other...

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From Use to Presence: On the Expressions and Aesthetics of Everyday Computational Things docx

Ngày tải lên : 07/03/2014, 17:20

... environment and the activities taking place there They were designed to be efﬁcient tools in the hands of the professional—a role we are beginning to understand as our knowledge about usability and user ... design of artifacts Evaluation then turns into aesthetics: to understand the logic of an expression on the basis of understanding the material that builds the expression We may think of an expression ... down in the chair belongs to the expression of the chair, but the users disappear as we refrain from referring to why they sit down and what they are doing sitting in the chair If we think of a...

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Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot

Ngày tải lên : 07/03/2014, 21:20

... correctly positioned to perform catalysis with the Oc ˚ atom of Ser171 at about 2.8 A from the Oc atom of ˚ Ser195 and about 2.7 A from the amino group of Lys96 4718 The analysis of the structural ... 5B) One of its amino ˚ groups is about 2.6 A from the Oc atom of Ser171 ˚ and 2.5 A from the thiol group of Cys145 4720 Even taking into account all of the limitations of molecular models of proteins ... Indeed, the sulfur atom of Cys145 is at about A ˚ from the Oc atom of Ser171 and 2.5 A from the amino group of Lys96 (Fig 4) This putative alternative triad is located in a different plane from the...

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Comparing HIV prevalence estimates from prevention of mother-to-child HIV transmission programme and the antenatal HIV surveillance in Addis Ababa docx

Ngày tải lên : 15/03/2014, 10:20

... system and it can be an asset for standardizing the PMTCT reports Even before the scaling up of the HMIS across the city, the quality of the PMTCT reports seem to be good; over 90% the reports from ... By 2005, the programme was expanded to all the ten subcities but the expansion took place at different times The programme has continued to scale up and from 2007 it has expanded into private ... standard of care Our study underscores the validity and potential of the PMTCT programme estimates for monitoring trends in HIV/AIDS prevalence and to guide prevention and control efforts and...

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