explain the role of communication and interpersonal interactions in health and social care p1
Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
Ngày tải lên :
08/03/2014, 08:20
... of GSK3 (using Li or SB-415286)
appears to be sufficient for inducing activation of GS in
muscle and fat cells, and that inhibition of the kinase
potentiates insulin action in muscle of insulin-resistant ... increases in glucose uptake and glycogen synthesis
allowing for more effective ÔchannellingÕ of glucose into
glycogen in response to insulin. However, one of the
potential difficulties in interpreting ... phosphatidylinositol
3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in
L6 muscle cells: evidence for the involvement of the mammalian
target of rapamycin (mTOR) pathway in the
L
-leucine-induced
up-regulation...
- 10
- 804
- 0
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
Ngày tải lên :
17/03/2014, 23:20
... phenylalanine was therefore
mutated to Ala, Leu, Trp or Tyr. These mutations may
in uence the shape and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme ... PAA and derivatives thereof, while maintaining
the hydrophobicity of the binding site.
To test the effect of the mutations on the specificity for
phenylacetylated substrates, the steady-state kinetic ... k
cat
represents
the rate of acylation and K
m
equals the binding constant of
the substrate to the free enzyme. The results then indicate
Ó FEBS 2002 Role of active-site phenylalanines in penicillin acylase...
- 8
- 561
- 0
báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx
Ngày tải lên :
09/08/2014, 02:20
... or
avoiding unnucessary laparotomy [17]. The guideline
also recommends PET for evaluation of therapy
response and to make the decision of continuing the
ongoing therapy or stopping and redirecting the ... chemotherapy programme again.
Lesions in the lung in 1 patient and in the proximal
jejunal segments of the intestine in another patient were
not FDG avid. So they were accepted as non malignant
and ... important limitation th at the number of patients is
small especially in the first group, the number of studies
intheliteratureinvestigatingtheroleofPETinthe
diagnosis of distant metastasis preoperatively...
- 5
- 390
- 0
The Role of Genetically Modified Organisms (GMOs) in Beverage Production
Ngày tải lên :
25/10/2013, 21:20
... create signiịcant changes in
the genetic makeup of plants and animals due to the random recombination
and sorting of thousands of genes. As a result of intervention by people, the
hybrid seed corn ... throughout the world bears little resem-
blance to teosinte, the original ancestor of corn. The newer techniques involv-
ing genetic engineering, on the other hand, allow for the transfer of a few
genes ... commercially introduced in the
U.S. in 1996 and have been rapidly adopted by farmers. It has been estimated
that 24% of the corn and almost 70% of the soybeans and cotton grown in
the U.S. in 2001...
- 6
- 498
- 0
Tài liệu Báo cáo khoa học: Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity pdf
Ngày tải lên :
19/02/2014, 02:20
... amounts of protein
from 3Y1-Ad12 cell lysates confirmed the absence of
cathepsin D in nontransfected cells, and the presence
of both the 31 kDa mature cathepsin D and the
45 kDa procathepsin D in cathepsin ... bafilomycin and the cathepsin D inhibitor pepstatin A
partially inhibited, both in vivo and in vitro, the cAMP response to cholera
toxin. This cathepsin D-dependent action of cholera toxin under the con-
trol ... decrease of 3–10-fold in the
apparent affinity of the toxin for the enzyme [6]. More-
over, both chloroquine and monensin interfered with
the ATP-dependent intraendosomal degradation of
internalized...
- 16
- 536
- 0
Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
Ngày tải lên :
07/03/2014, 03:20
... binding properties
The affinity of wild-type and mutant forms for the
cofactor was measured to evaluate the impact of the
mutations on the structure of the PLP binding site.
Because PLP binding ... interacts with the phosphate moiety of
PLP; E57Â is crucial in the binding of the l-serine
hydroxyl group [15] and in the catalysis of the hydrox-
ymethyltransferase reaction [16]; and Y65Â interacts
with ... to
explain the increase of the dissociation constant of the
monomer–dimer equilibrium determined by the muta-
tions. The results obtained in the present study also
show that the monomeric form of...
- 12
- 578
- 0
Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
Ngày tải lên :
17/03/2014, 17:20
... likely
that the increased rate of
13
C label incorporation into the C6
position of glycogen in the ADM group is indicative of
activated 6-phosphofructo-1-kinase, which can lead to
increased
13
C labeling ... concentrations. There-
fore, an understanding of the regulation of these fluxes can
provide important insights into the mechanisms and poten-
tial treatment of diabetes.
The rates of glycolysis and gluconeogenesis ... C1, the C6
and C2–C5 signals were measured simultaneously for the
first time in vivo, which provide the basis for the estimation of
direct and indirect synthesis of glycogen in the liver. The...
- 9
- 465
- 0
The role of floating-rate bank loans in institutional portfolios pdf
Ngày tải lên :
22/03/2014, 17:20
...
Russell Investments // Role of bank loans in a rising rate environment / p 7
Bank loans in rising interest rate environments
In the past 20 years (since 1992), there have been three periods of significant ...
surprise. The duration of the Credit Suisse Leveraged Loan Index is significantly lower than
durations in the traditional fixed income asset classes, reflecting the prevalence of floating
rate instruments ... price movements. The default rate is the default
rate of a bank loan portfolio (historically, 2%–3%), and the recovery rate is the amount of
principal recovered in the event of default (historically,...
- 9
- 333
- 0
Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx
Ngày tải lên :
30/03/2014, 08:20
... [16–18].
Interestingly, the sum of ATP and UTP was two-fold
higher than that of CTP and GTP, and the ratio of
dATP and dTTP to dCTP and dGTP was also 2 : 1
[16,17]. This fact is in accordance with the ... after 3 min and then
declined, while the formation of [
3
H]ATP was increased
linearly with time within the first 15 min. After 30 min,
the reaction reached equilibrium (Fig. 4A). Further
experiments ... substrate in a total
volume of 20 lL. The reaction was initiated by the addition
the enzyme (100 ngặreaction
)1
for the determination of
NTP synthesis rates and 0.51 ngặreaction
)1
for the deter-
mination...
- 8
- 349
- 0
Báo cáo khoa học: The heterogeneity of mast cell tryptase from human lung and skin Differences in size, charge and substrate affinity ppt
Ngày tải lên :
31/03/2014, 07:20
... heparin-binding site, a region of
positive surface charge extending along the left- and right-
hand sides of the ring in Fig. 10A [23]. This region is
comprised of five histidines, nine lysines, and ... were incubated with the filters for
45 min at a concentration of 5 lgặmL
)1
,andtheblots
washed and incubated with diaminobenzidine and hydrogen
peroxide. A combination of the biotinylated lectins ... lgặmL
)1
heparin.
Fig. 8. Mathematical modeling of the behavior of a mixture of isoforms
of an enzyme. (A) Hanes plot of a theoretical mixture of 5 isoforms of
an enzyme for the following cases:...
- 14
- 438
- 0
Báo cáo sinh học: " Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons" docx
Ngày tải lên :
18/06/2014, 22:20
... rhadinoviruses
belonging to the RV2 lineage of KSHV-like
rhadinoviruses. The primers and probe for this assay were
based on sequences within the 3' end of the ORF 60 cod-
ing sequence and the ORF 59/60 intergenic ... assay in this study. Dots represent residues identical to those in the RRV sequence, and highlight the similarity of
the primer sequences within the RV2 lineage of rhadinoviruses and the dissimilarity ... divergence of the Old World primate rhadinoviruses
and their hosts [26]
Identification of a novel RV2 rhadinovirus in the baboon,
Papio cynocephalus, using the RV2 QPCR assay
To further determine the...
- 12
- 509
- 0
báo cáo hóa học: " The role of cumulative physical work load in symptomatic knee osteoarthritis – a case-control study in Germany" potx
Ngày tải lên :
20/06/2014, 00:20
... between the questionnaire and observation ratings
of 0.49 for frequency of lifting, carrying, and transferring
6–15 kg. Concerning the frequency of lifting, carrying,
and transferring 6–15 kg, the ... 1.1–6.1
Kneeling/squatting and lifting/carrying combined
c
Both no kneeling/squatting and no lifting/carrying 65 22.0 137 41.9 1.0 - 1.0 -
Kneeling/squatting >0 – <870 hrs. or lifting/carrying >0 ... number of squatting and the duration
of kneeling work. D'Souza et al. [20] examine the relation-
ship between the daily amount of kneeling and knee oste-
oarthritis in the subset of participants...
- 8
- 518
- 0
báo cáo hóa học:" Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons" pot
Ngày tải lên :
20/06/2014, 04:20
... divergence of the Old World primate rhadinoviruses
and their hosts [26]
Identification of a novel RV2 rhadinovirus in the baboon,
Papio cynocephalus, using the RV2 QPCR assay
To further determine the ... assay in this study. Dots represent residues identical to those in the RRV sequence, and highlight the similarity of
the primer sequences within the RV2 lineage of rhadinoviruses and the dissimilarity ... regions of identical sequences
within both the ORF 59 and ORF 60 coding regions and
the ORF 59/60 intergenic region. As shown in Figure 2, a
region of 71 identical nucleotides in the MneRV2 and RRV
sequences...
- 12
- 471
- 0
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