effects of phl on the activities of sod cat gpx and gst in the cortex following tbi

Studies on the mechanisms of the beneficial effects of herba leonuri and leonurine on traumatic brain injury in rat

Ngày tải lên : 02/10/2015, 17:15

... 3.3.1.3 Comparison of the effects of pHL and Leo on the activities of SOD, CAT, GPx and GST in the cortex following TBI 78 3.3.2 Comparing the anti-apoptotic effects of pHL and Leo 79 ... Biochemical and molecular approaches 71 3.2.1.1 Effects of Leo on the activities of SOD, CAT, GPx and GST in the cortex following TBI 71 3.2.1.2 Effects of Leo treatment on neuronal ... and microglia gliosis following TBI 61 3.1.2 Biochemical and molecular approaches 67 viii 3.1.2.1 Effects of pHL on the activities of SOD, CAT, GPx and GST in the cortex following...

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báo cáo hóa học:" Oxford unicompartmental knee arthroplasty: medial pain and functional outcome in the medium term" pptx

Ngày tải lên : 20/06/2014, 07:20

... Osteoarthritis, of these 30 of the 48 had radiographic Grade (bone on bone) arthritis, the remaining 18 had grade OA Of the 48 patients, four had undergone revision, four had died since implantation and ... positioning of the femoral component and the Oxford score (0.38) Examples of good and poorly positioned prosthesis can be seen in Figures and Edmondson et al Journal of Orthopaedic Surgery and ... this study All contributors were fully involved with the preparation and analysis of the results of this study I would like to acknowledge the help of Matthew Hankins of the Brighton and Sussex University...

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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

Ngày tải lên : 15/02/2014, 01:20

... crystallization solutions The ligand bound was interpreted as GMP because the N2 of the base makes a hydrogen bond to a main chain carbonyl Binding of a xanthine base from XMP in the same position, would ... (Fig 1C) The 2¢OH of the ribose is hydrogen bonded to the main chain and the side chain of Asp142 (Fig 1C) Both hydroxyl groups of the ribose are involved in coordinating a putative Ca2+ ion This ... second Ca2+ ion is coordinated by the side chain of Asp201, a phosphate ion and ﬁve water molecules The phosphate involved in this interaction is bound by main chain interactions with Lys76 and...

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Tài liệu Báo cáo khoa học: Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv pdf

Ngày tải lên : 18/02/2014, 12:20

... [17], redox sensing [18] and the coordination of metal cofactors [19] The functional importance of the conserved cysteine residues in iron–sulfur cluster coordination and protein disulfide reductase ... WhiB6 and WhiB7 indicated the presence of an iron–sulfur cluster To identify and confirm the presence of the iron–sulfur cluster, the absorption spectra of the purified proteins were recorded in the ... monomer (Table 1) The sub-stoichiometric iron content of iron–sulfur proteins is generally due to the impaired incorporation of the cluster into the protein during overexpression in E coli and...

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Tài liệu Báo cáo khoa học: Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium ppt

Ngày tải lên : 18/02/2014, 14:20

... in the segment of residues 242–245, bringing the polypeptide chain back to the same subunit We analyzed the interactions of corresponding residues in SurEs to understand the reasons for domain ... form The shift in the position of the loop away from the metal ion leads to the formation of two interprotomer active sites where the Oe of E37 from one subunit coordinates with the metal ion bound ... Y238 in Aa SurE The hydroxyl group ˚ of Y238 is hydrogen bonded to D234 OD1 (2.55 A) The other interactions of D234 in Aa SurE correspond to the interactions of D230 in St SurE A different set of...

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Tài liệu Báo cáo khoa học: The Mycobacterium tuberculosis membrane protein Rv2560 ) biochemical and functional studies pdf

Ngày tải lên : 18/02/2014, 16:20

... of new therapies and ⁄ or vaccines, or the improvement of existing ones, necessary to control this disease The identification and characterization of the proteins involved in the interaction of ... by the dissociation constant and Hill coefficient The corresponding analyses for the determination of the receptor for 11024 HABPs and the identification of the critical binding residues, and the ... (in this case), their binding dissociation constants, their critical binding residues and their role in cell invasion inhibition, with the specific purpose of employing them as probable components...

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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx

Ngày tải lên : 21/02/2014, 15:20

... of this hypothesis are meager In the head-to-tail orientation, the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other ... forms of LPL reveal interesting features of LPL structure, including the conformational change in the active center, the critical sites for heparin binding, and the orientation of dimerization Investigation ... The cluster of basic residues in the C-terminal domain may constitute heparin binding-site residues that coordinate with heparin-binding residues in the N-terminal domain The cluster of hydrophobic...

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Báo cáo khoa học: Comparative biochemical and functional studies of family I soluble inorganic pyrophosphatases from photosynthetic bacteria potx

Ngày tải lên : 16/03/2014, 11:20

... (MgCl2) and mm Na4PPi (standard assay conditions) The reaction was started by the addition of enzyme, and the PPi released after 10 was determined When the efﬁciencies of other divalent metal cations ... Cloning and DNA manipulation The reaction mixture for PCR ampliﬁcation of the ppa gene from Synechocystis sp PCC 6803 (50 lL) contained 50 pmol of each of the following two pairs of oligonucleotide ... in strong ionic interactions mediated by Mg2+ [2,19] Changes in the residues involved in the interactions between subunits could explain the unusual oligomeric states found for some photosynthetic...

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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt

Ngày tải lên : 20/06/2014, 07:20

... Akt and Erk signalling pathways in mediating the effects of the gonadotropins and IGF on follicle cell function and on follicular development The stimulation of inhibin-A, activin-A, follistatin, ... actions of the Akt pathway are more pronounced than the Erk pathway in granulosa cells and vice versa in the in theca cells None the less, administration of inhibitors of these pathways in vivo inhibited ... PG: Effects of active immunization of sheep against an amino terminal peptide of the inhibin αC subunit on intrafollicular levels of activin A, inhibin A and follistatin Journal of Endocrinology...

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Báo cáo y học: "Functional outcome of nerve transfer for restoration of shoulder and elbow function in upper brachial plexus injury" potx

Ngày tải lên : 10/08/2014, 10:20

... patients and the final grading of their elbow and shoulder function are detailed in Table Table details the motor grade of the recovered muscles and the final range of movement achieved Table shows the ... supraspinatus muscle which is only an abductor attracts all the axons and reduces the potential of reinnervation of the external rotators The other explanation is, the antagonistic muscle- for instance, ... Authors' contributions HR and SRS were the main operating surgeons and designed the study, PB and SRJ performed data collection and analysis of the results, HR and PB were involved in sequence...

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Báo cáo y học: "Combination of histopathological and electromyographic patterns can help to evaluate functional outcome of critical ill patients with neuromuscular weakness syndromes" docx

Ngày tải lên : 12/08/2014, 20:20

... embedded in araldite Semithin resin transverse and longitudinal sections were stained using haematein and eosin, solochrome blue and paraphenylene diamine Ultrathin sections were double stained with ... in all of these patients to determine the cause of limb weakness and diaphragm dysfunction The medical committee of the hospital approved the study, and informed consent was obtained from the relatives ... could therefore help in the precise identification of the type and severity of neuromuscular weakness, and may lead to a better understanding of the causes and consequences of neuromuscular weakness...

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Báo cáo y học: "Retrospective agreement and consent to neurocritical care is influenced by functional outcome" ppt

Ngày tải lên : 13/08/2014, 21:21

... contributions ICK and HBH designed the study and wrote the manuscript ICK, JBK, LB, and CM obtained clinical data by reviewing institutional databases and the patient’s medical charts ICK and MK obtained ... questionnaires and telephone interviews MK, PDS, and SS co-interpreted the data and critically reviewed the manuscript All authors approved the final version of the manuscript 19 20 21 22 Competing ... ventricular drains) on admission to the neurocritical care unit (thereby explaining that withdrawal of consent would probably have correlated with rapid clinical worsening and the probability of early...

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sex determination in drosophila biochemical and functional studies of transcription factor doublesex

Ngày tải lên : 14/11/2014, 08:21

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Multi manifold diffeomorphic metric mapping for cortical registration with its applications in brain structural and functional studies

Ngày tải lên : 09/09/2015, 18:53

... clustering coeﬃcient measures the extent of inter-connectivity among the neighbors of the node It is deﬁned as the ratio of the number of existing connections among the node i’s neighbors and all their ... uniquely reconstructed based on the locations of a set of points We assume a curve embedded in R3 is a one-dimensional manifold in the sense that the local region of every point on the curve is ... important non-invasive technique for diagnosing and treating medical conditions of the brain, Magnetic resonance imaging (MRI) can help physicians evaluate both the structure and function of the brain...

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Structural and functional studies of VP9, a novel nonstructural protein from white spot syndrome virus

Ngày tải lên : 14/09/2015, 09:57

... ascertain the exact position of each atom in the asymmetric unit of the crystal Calculation of electron density is dependent on two main factors; the amplitude and the phase of the diffracted beam These ... disease The aim of this thesis is to provide structural and functional insights into one of the nonstructural viral proteins of this pathogen This study would be valuable in understanding the critical ... 1982) and irridovirus (Tidona and Darai, 1997) replicate in the cell nucleus (Kasamatsu and Nakanishi, 1998) In the first step of infection, viruses import their genomic DNA into the nuclei of infected...

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Structural and functional studies on type III and type VI secretion system proteins

Ngày tải lên : 14/09/2015, 14:13

... involved in the development of diseases such as diarrhea and hemolytic-uremic syndrome after colonizing in the large intestine, watery diarrhea after colonizing in the small intestine and urinary ... In T5SS the pre-protein consists of the following components: signal sequence, the passenger domain, linker region and β-strand The signal sequence which is present at the N-terminus guides the ... right The four functional domains of the proteins are shown: the signal sequence, the passenger domain, the linker region, and the β-domain The autotransporter polyproteins are synthesized and...

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Depression, cognitive impairment and physical functional outcome and their associated factors in stroke patients in community hospital care

Ngày tải lên : 04/10/2015, 10:24

... because of the complications they had developed during their hospitalization: (1) Diagnosis of the medical complication/s (2) Date of medical complication/s The information on the following variables ... 79 Urinary incontinence: Post stroke urinary incontinence is more commonly seen in the aged stroke patients than the younger ones.87,88 Stroke patients with urinary incontinence have more institutionalization ... al 44 in their prospective study at and 15 months on 486 patients found that worsening in cognition and worsening of depression between and 15 months follow up had an independent effect on the...

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Báo cáo y học: "Characterization of N200 and P300: Selected Studies of the Event-Related Potential Salil H. Patel 1 and Pierre N. Azzam 2"

Ngày tải lên : 02/11/2012, 11:08

... the effects of aging on the N2b component and, thus, upon selective information processing as a whole In one oddball detection study involving the effects of color deviation on N2b elicitation ... sporadically interspersed by a stimulus which deviated from the standard in the intensity of the first component and the glide direction of the second constituent The number of distinct MMN components ... effect on the latency and amplitude of the evoked MMN, the elicited N2b was found to continuously increase in latency and decrease in amplitude with increasing age These findings suggest the constancy...

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Tài liệu Physical health and functional ability of an elderly, population in Sri, Lanka doc

Ngày tải lên : 14/02/2014, 06:20

... Using this index, the proportion "feeling healthy" was 43% which is low when compared with similar observations made in other countries in the region: 56% in Myanmar, 84% in Indonesia and 62% in ... within the year preceding the survey, information on problems related to mastication and to mobility Simple clinical examinations were carried out to identify problems with vision and hearing ... as an "informant" At each interview where an informant was present, assessment of the informant of the health status of the elderly person was obtained Results The non-response rate for the study...

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Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc

Ngày tải lên : 18/02/2014, 14:20

... removed from the entire coding sequence of the MCPIP gene The coding sequence lacking the PIN domain was obtained in two steps First, the fragment of 423 bp situated in front of the PIN domain was ... degradation or its conversion into translationally active forms by the action of strong stimulants, such as endotoxin (LPS) One of the regulatory sequences involved in determining mRNA half life are the ... E185, D226, D244) in PIN domains involved in binding Mg2+ ions are conserved in all three sequences Other conserved residues are R263, V139 and N144 Determination of the MCPIP domain architecture...

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