discovery and development of maraviroc and pf 232798 ccr5 antagonists for the treatment of hiv 1 infection

Báo cáo y học: "TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4+ T cells" docx

Ngày tải lên : 12/08/2014, 23:20

... IL -1 and IL-8) and these cytokines induce the secretion of other proinflammatory cytokines or recruit other immune cells, thus possibly increasing the number of Page 11 of 16 (page number not for ... treated with the TLR2 or agonist for hours and washed twice Then, cells (5 × 10 5 in 200 ul of complete culture medium) were pulsed with HIV- 1 (12 .5 ng of p24) for 15 , 30 and 60 at 37°C The viruscell ... [17 ,18 ] Thus, by capturing HIV- 1 at sites of viral entry into the body and transferring viruses to CD4+ T cells, immature mDCs may be critical to the process of HIV- 1 transmission The impact of...

16
288
0

Báo cáo y học: "Association of chemokine receptor gene (CCR2CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians" pdf

Ngày tải lên : 13/08/2014, 01:20

... (1. 9) 17 8 (7.9) 25 (2.2) 69 (6 .1) 19 (1. 7) 10 9 (9.6) (1. 7) 42 (8.8) 11 (1. 7) 67 (10 .2) HHD 370 (16 .3 19 0 (16 .8) 18 0 (15 .9) 75 (15 .6) 10 5 (16 .1) HHE 310 (13 .7) 13 8 (12 .2) 17 2 (15 .2) 61 (12 .7) 11 1 ... 203 1. 1 0.85 -1. 46 0. 417 10 4 1. 1 0.77 -1. 56 0. 61 99 1. 2 0.75 -1. 75 0.5 31 HHD 16 7 1. 0 0.74 -1. 32 0.983 94 0.9 0.59 -1. 23 0.385 73 1. 2 0.75 -1. 92 0.442 HHE HHD/HHE 15 8 31 1 .1 1.9 0.82 -1. 51 1 .14 -3 .16 0.495 ... < 00 01 162 3.0 2.04-4. 51 < 00 01 137 4.6 2.79-7.65 < 00 01 Donor VL (per 1. 0 log10 unit) 523 1. 6 1. 32 -1. 91 < 00 01 263 1. 3 1. 03 -1. 74 0.028 260 1. 8 1. 35-2.47 < 00 01 *N represents the number of HESNs...

9
386
0

Báo cáo y học: " Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection" pptx

Ngày tải lên : 13/08/2014, 05:21

... structure of the peptides (Table 1) The antiviral properties of peptides P5, P1 and T20 were tested against infection of PBMC by X4- (HIV- 1Lai) and R5-tropic (HIV- 1JRCSF) strains of HIV- 1 As shown ... Table 1: The α-helical content of P1 & P5 alone or in the presence of N36 & LZ [θ]222 (10 -3deg cm2dmol -1) [θ]222 (10 -3deg cm2dmol -1) N36 P1 P1+N36 P5+N36 aT20 -6 -11 -17 - 21 -2 LZ P5 P1+LZ P5+LZ ... to CD4 and the co-receptor CCR5/ CXCR4, gp120 undergoes serial conformational changes that allow the insertion of the gp 41 fusion peptide into the target cell membrane and formation of the pre-hairpin...

12
304
0

design, synthesis, and biological evaluation of new anti-cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of chagas

Ngày tải lên : 14/11/2014, 11:32

... CA -1 and CA-4 analogues 11 5 4 .15 Methology suitable for the radiosynthesis of the E isomer of CA -1 1 21 4 .16 Radiosynthesis of the E isomer of CA -1 123 4 .17 Scale-up synthesis of OXi8007 12 4 4 .18 ... 20b 10 8 4 .11 Synthesis of 2,5-dinitrogen-based CA -1 analogues 11 1 4 .12 Synthesis of 2,3-dinitrogen-based CA -1 analogues 11 3 4 .13 Synthesis of CA -1 derivative 33 11 4 4 .14 Epoxidation of some nitrogen ... of analogue 13 and hydrochloride salts 11 and 14 98 4.6 Synthesis of phosphonium bromide salt 16 and dinitrobenzaldehyde 21 1 01 4.7 Proposed mechanism for the formation of benzylic chloride 15 a...

516
254
0

Báo cáo y học: " In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy" docx

Ngày tải lên : 13/08/2014, 01:20

... 10 10 80e, 1HSC+, 50f) 10 0 10 0 .1 0. 01 0.0 01 % of population 10 0 % of population 10 0 % of population Years D S4 (6x, 0.0 01 Years 0 .1 0. 01 0.0 01 11 13 11 13 0 .1 0. 01 11 13 Years Years G 0.0 01 Years ... 99f) 10 0 10 10 10 0 .1 0. 01 0.0 01 % of population 10 0 % of population % of population 10 0 0 .1 0. 01 0.0 01 11 13 0 .1 0. 01 11 13 11 13 Years E F 60e, 20HSC+, 99f) S6 (2x, S7 (2x, 80e, 20HSC+, 50f) 10 ... Page 13 of 14 10 11 12 13 14 15 Acknowledgements These studies were conducted with the support from Johnson and Johnson Research and the School of Mathematics and Statistics, University of New...

14
255
0

Báo cáo y học: "HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat" pps

Ngày tải lên : 13/08/2014, 01:21

... V370A HXB2 - 2.8 > 15 0 6.6 > 15 0 PR -1 (20R-36I-54V-63P-71I-82T) 0.6 2 .1 > 15 0 6.0 > 15 0 PR-2 (431V -10 I -13 V-36I-46I-54V-62V-63P-71T-82A-90M-93L) 2 .1 > 15 0 > 15 0 > 15 0 > 15 0 Levels of bevirimat resistance ... Update of the drug resistance mutations in HIV- 1: December 2 010 Top HIV Med 2 010 , 18 :15 6 -16 3 doi :10 .11 86 /17 42-4690-8-70 Cite this article as: Fun et al.: HIV- 1 protease inhibitor mutations affect the ... 2Gilead Sciences and IOCB Research Center, Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Prague, Czech Republic Page 11 of 12 10 11 12 Authors’...

12
239
0

Báo cáo y học: " Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonizatio" pdf

Ngày tải lên : 10/08/2014, 05:21

... μg/ml), IgG12G5 (2.5 and 12 .5 μg/ml), and IgG1B12 (1 and 10 μg/ ml) and polyclonal anti-gp160 antibodies (10 μg/ml) as positive control for HIV inhibition Complement opsonization of HIV- 1 The activation ... by HIV- 1BaL The molecules Lf, Jenabian et al AIDS Research and Therapy 2 010 , 7 :16 http://www.aidsrestherapy.com/content/7 /1/ 16 Page of Table 3: Inhibition of the production of HIV- 1BaL or HIV- 1NDK ... RPMI -16 40 were used: Lectines HHA and GNA (1, 10 and 10 0 μg/ml), Lf (200 μg/ml), PVAS (1, 10 and 10 0 μg/ ml), CADA (0.2 and μg/ml), T20 (0.5 and μg/ml), IgG2G12 (1 and 10 μg/ml), IgG2F5 (7.5 and...

8
309
0

Báo cáo y học: "Chemokine control of HIV-1 infection: Beyond a binding competition" pot

Ngày tải lên : 13/08/2014, 01:20

... Lewin SR: CCR7 ligands CCL19 and CCL 21 increase permissiveness of resting memory CD4+ T cells to HIV- 1 infection: a novel model of HIV- 1 latency Blood 2007, 11 0: 416 1- 416 4 Cameron PU, Saleh S, ... September 2 010 Accepted: 13 October 2 010 Published: 13 October 2 010 References Colin L, Van Lint C: Molecular control of HIV- 1 postintegration latency: implications for the development of new therapeutic ... cascade by the human immunodeficiency virus envelope is required for virus entry J Virol 2008, 82: 919 1-9205 doi :10 .11 86 /17 42-4690-7-86 Cite this article as: Wu: Chemokine control of HIV- 1 infection: ...

3
229
0

Báo cáo y học: "Decidual soluble factors participate in the control of HIV-1 infection at the" docx

Ngày tải lên : 13/08/2014, 01:21

... activation J Allergy Clin Immunol 19 97, 10 0:838-845 Marlin et al Retrovirology 2 011 , 8:58 http://www.retrovirology.com/content/8 /1/ 58 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Makrigiannakis ... Received: April 2 011 Accepted: 18 July 2 011 Published: 18 July 2 011 References Schroder HC, Kelve M, Muller WE: The 2-5A system and HIV infection Prog Mol Subcell Biol 19 94, 14 :17 6 -19 7 Meylan PR, ... Identification of RANTES, MIP -1 alpha, and MIP -1 beta as the major HIVsuppressive factors produced by CD8+ T cells Science 19 95, 270 :18 11- 1 815 Feng Y, Broder CC, Kennedy PE, Berger EA: HIV- 1 entry cofactor:...

13
590
0

head first iphone development a learnersguide to creating objective c applications for the iphone 3 phần 1 docx

Ngày tải lên : 14/08/2014, 20:21

... some of them, there is no right answer, and for others, part of the learning experience of the Brain Power activities is for you to decide if and when your answers are right In some of the Brain ... controller buttons for editing 211 The button should create a new view 216 The view controller defines the behavior for the view 217 A nib file contains the UI components and connections 218 You can ... two things 10 1 But when Mike’s finished typing 11 1 Customize your UITextField 11 3 Components that use the keyboard ask it to appear 11 4 Ask the textField to give up focus 11 5 Messages...

55
329
0

The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx

Ngày tải lên : 07/03/2014, 00:20

... feedback, the purpose of the conceptual model, some background of the research that lead to the development of the model, and key 11 848 Afr J Bus Manage Table Weakness characteristics of SMEs Weakness ... By these definitions, and due to the importance of the role of project management in the success of projects, the authors consider related department collaboration on product development by the ... upgrade of an existing product or a new concept (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization...

12
980
0

Báo cáo hóa học: " Research Article Development of Long-Range and High-Speed Wireless LAN for the Transmission of Telemedicine from Disaster Areas" pdf

Ngày tải lên : 22/06/2014, 06:20

... and VBR stand for constant bit rate and variable bit rate, respectively SIF stands for source input format HalfD1 stands for video size of 352 × 480 pixels for one frame FullD1 stands for 720 × ... between ﬁxed stations and 5 15 km for mobile stations And it can provide high-transmission rates of up to 70 Mbps [12 , 13 ] Of course, there is a tradeoﬀ between the distance and transmission rates ... one of the reasons why we developed IEEE802 .11 g wireless LAN units On the optical network between NPGITC and Shinshu University Hospital, a compression format of (4)-(f) is used Therefore, there...

13
318
0

Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"

Ngày tải lên : 26/10/2012, 10:04

... Conflict of interest The authors have declared that no conflict of interest exists References 10 11 12 13 14 15 16 17 18 19 20 Del Prato S, Matsuda M, Simonson DC, et al Studies on the mass action ... for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects of thioglycoside I and VII ... 2007, 13 6 ratio of 1. 32 for hSGLT2 (p

9
650
0

Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx

Ngày tải lên : 14/02/2014, 22:20

... ages of 45 and 49 years the incidence is 20 per 10 0,000 Amongst those over 75 years of age, the incidence is over 300 per 10 0,000 for men and 200 per 10 0,000 per year for women The median age of ... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... cetuximab monotherapy arm (incremental difference 12 .1% , 95% CI 4 .1 to 20.2) The rates of response in the single-arm studies were 8.8% (95% CI 2.9 to 19 .3) and 12 .0% (95% CI 8.4 to 15 .4) in the two...

34
853
0

Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx

Ngày tải lên : 18/02/2014, 02:20

... emerged in the late 19 60s and 19 70s from the work of Bagozzi (19 78), Kotler and Levy ( 19 69), Kotler and Zaltman (19 7 1) , Rothschild ( 19 79), and Shapiro ( 19 73) Carrots, Sticks, and Promises ... understanding of and accommodate the target's MOAs and the trade-off of free choice and externalities The potential for success of the three sets of tools is derived from the target's assessment of ... followed if the target cannot discern the reward in doing so Dickson (19 92) discusses the invisible hand of competition that constrains the self-interest of the firm and forces the firm to serve the...

14
780
0

Tài liệu Báo cáo khoa học: Role of hydroxyl group and R/S conﬁguration of isostere in binding properties of HIV-1 protease inhibitors docx

Ngày tải lên : 19/02/2014, 16:20

... – – 16 A28 D29 D30 V32 I47 G48 I84 I150 S1¢ S1 17 17 OE G27 G48 G49 I50 L123 P1 81 V182 RE SE – 1 5 – – – 17 16 12 S2¢ OE L23 D25 T80 P 81 V82 I84 G127 G149 I150 RE SE – 1 7 26 – 1 – 31 – – 19 from ... However, the Glu Oe1 and Oe2 in OE and RE overlap and make the same network of hydrogen bonds to the Asp29 S3¢ OE I50 A128 D129 D130 V132 I147 G148 RE SE – 14 – – 2 11 – – 31 18 23 OE R8 D129 G148 G149 ... corresponding atoms of individual residues after the least-squares alignment of Ca atoms of two subunits A and B of the complex of HIV- 1 protease with OE inhibitor 0.05 11 21 31 41 51 61 71 91 81 Residue...

11
615
0

Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

Ngày tải lên : 07/03/2014, 16:20

... 90–99, 11 4 12 1, 11 8 13 1, 12 5 13 1, 13 0 13 7 and 13 1 14 0 [23–26], which have antigenic properties Characterization of the molecular features of these antigenic sites may provide insights into their immunogenic ... Y13b/F11b (F11b points towards Y13b superimposed on DR2 and I-Au) and Y26b/Y26b form the P4 pockets; N62a/N62a, V65a/T65a and Y13b/F11b form the P6 pockets; N69a/ N69a, I72a/V72a, D57b/D57b and ... the binding and afﬁnity for I-Au because of occupation of the P1 pocket Recent thermodynamic and kinetic studies of the binding of TCRs to peptide–MHC ligands suggested that the low afﬁnity of...

15
447
0

Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Ngày tải lên : 08/03/2014, 09:20

... HIV- 1 PROTEASE Structure and function of HIV- 1 PR HIV- 1 PR catalyzes the hydrolysis of speciﬁc peptide bonds within the HIV- 1 Gag and Gag-Pol polyproteins to generate the various structural and ... likened to that of a Ôright-handÕ [35] The major subdomains of the polymerase domain of p66 are termed ﬁngers (residues 1 85, 11 8 15 5), palm (86 11 7, 15 6–237) and thumb (238– 318 ) The DNA polymerase ... 2002 information for the design of potent enhancers of RT dimerization and consequently potent inhibitors of DNA polymerization [58] HIV- 1 INTEGRASE Structure and function of HIV- 1 IN HIV- 1 IN...

9
494
0

Financial Frictions and Total Factor Productivity: Accounting for the Real Effects of Financial Crises pot

Ngày tải lên : 15/03/2014, 22:20

... Sector 12 0 11 0 11 0 10 0 10 0 90 19 94 19 95 19 96 19 97 19 98 19 99 Model 90 19 94 2000 19 95 19 96 19 97 19 98 19 99 2000 19 99 2000 19 99 2000 Data TFP in the N Sector TFP in T Sector 12 0 11 0 11 0 10 0 10 0 90 19 94 ... 19 99 19 98 19 97 19 96 19 95 19 94 19 93 19 92 19 91 1990 19 88 2000 19 99 19 98 19 97 19 96 19 95 19 94 19 93 19 92 19 91 1990 19 89 19 88 19 89 0.2 0.2 Capital Figure 3: Share of Traded Goods in Output, Labor and ... in the Non Traded Goods Sector 2000 19 99 19 98 19 97 19 96 19 95 19 94 19 93 19 92 19 91 1990 19 89 19 88 2000 19 99 7.8 19 98 9 .1 1997 7.9 19 96 9.2 19 95 19 94 9.3 19 93 8 .1 1992 9.4 19 91 8.2 19 90 9.5 19 89...

45
505
0

Báo cáo khoa học: Re-evaluation of intramolecular long-range electron transfer between tyrosine and tryptophan in lysozymes Evidence for the participation of other residues doc

Ngày tải lên : 17/03/2014, 10:20

... Tortoise (13 0) Human milk 6 5 4 6 (7.9 (9.5 (7.0 (6.3 (7.8 (4.7 (28, 62, 63, 10 8, 11 1, 12 3) (28, 62, 63, 10 8, 11 1, 12 3) (28, 62, 63, 10 8, 11 1) (3, 28, 34, 64, 10 9, 11 2) (28, 64, 10 9, 11 2, 12 4) (28, ... peptides are the same: for TrpÆ, these are 18 00 and 300 LÆmol )1 cm )1 at 510 and 410 nm, respectively; for TyrOÆ, 70 and 2600 LÆmol )1 cm )1 at, respectively, 510 and 410 nm [29,30] The estimated ... for the proteins, the value of 12 0 s )1 found for HEWL and TEWL suggests a separation distance between donor and acceptor of % 1. 4 nm [7,8 ,10 ] and thus a similar pattern of oxidation Indeed, the...

7
474
0