classification of het hepatic mitochondrial proteins based on go annotation 94

Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration

Ngày tải lên : 12/09/2015, 11:08

... Enrichment of function of proteins responsive to Sod2 haplodeficiency 90 xi Figure 23 Classification of HET hepatic mitochondrial proteins based on GO annotation 94 Figure ... Immunoblotting of thioredoxin-2 and aconitase-2 85 Figure 20 2D-DIGE observations of HET hepatic mitochondrial proteome 86 Figure 21 Global analysis HET mouse hepatic mitochondrial proteome ... impairment of mitochondrial glutathione transport may play a role in precipitating the toxic effects of troglitazone under compromised mitochondrial ROS defence This further confirms the contribution of...

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Báo cáo khoa học: Deﬁciency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice pot

Ngày tải lên : 05/03/2014, 23:20

... contents, respectively, of the different density fractions following the separation of plasma lipoproteins by density gradient ultracentrifugation Fraction corresponds to the top fraction [containing ... the circulation To determine the contribution of VLDL triglyceride secretion in apoE-mediated hepatic lipid accumulation, we compared the rate of hepatic VLDL triglyceride secretion between apoE) ... triglyceride secretion and intestinal triglyceride absorption in apoE) ⁄ ) and C57BL ⁄ mice One mechanism that could affect the hepatic triglyceride content is the secretion of hepatic triglycerides...

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Báo cáo hóa học: " Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice" ppt

Ngày tải lên : 18/06/2014, 16:20

... through deacetylation of modified lysine residues on histones and transcriptional regulators [5-7] AMPK is a heterotrimeric protein consisting of one catalytic subunit (a) and two non-catalytic subunits ... http://www.translational-medicine.com/content/8/1/120 deviation Statistical analyses were done using SPSS software version 13.0 (SPSS Inc., Chicago, IL, USA) Student’s t-test, one way-ANOVA, Kruskal-Wallis one-way ANOVA on ranks ... advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google...

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Báo cáo hóa học: " The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2" docx

Ngày tải lên : 22/06/2014, 00:20

... and liver DNA of mice was observed The accumulation of titanium is consistent with the coefﬁcients of liver and the liver injury of mice In addition, the accumulation of titanium of the organs ... induce an increase of the expression level of inﬂammatory cytokines by nano-anatase TiO2 Discussion The results of this study indicate that intraperitoneal injection of higher doses of nano-anatase ... the National Natural Science Foundation of China (grant no 20671067), the Medical Development Foundation of Soochow University (grant no EE120701) and the National Innovation Foundation of Student...

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báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx

Ngày tải lên : 11/08/2014, 00:23

... agent for acceleration of tissue regeneration following an acute insult, as well as amelioration of tissue fibrosis and dysfunction in chronic conditions [14,15] Though secretion of HGF after liver ... despite continuous injection of CCl4 after post-transplantation On the other hand, the expression of these markers was less in the control and HSC/+ HGF-CNP treated groups This observation is in good ... of activated myofibroblasts) Secretion of type I collagen by myofibroblasts that leads to fibrosis was analyzed by immunofluorescence The results of imunofluorescence study for distribution of...

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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine ﬁbrosarcoma L929 cells doc

Ngày tải lên : 18/02/2014, 13:20

... indicate that mitochondrial translocation of Bax may constitute a direct cause of cytochrome c release ROS has also been demonstrated to induce the depolarization of the mitochondrial membrane, ... after oridonin administration (Fig 5C) Addition of NAC remarkably inhibited the phosphorylation of ERK Next, the effect of p38 on oridonin-induced cell death was examined Pretreatment of cells ... function of NF-jB activation might consist of the promotion or repression of autophagy, depending on whether autophagy is a survival or death process In addition to the aforementioned signaling pathways,...

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Arsenic immobilization by calcium arsenic precipitates in lime treated soils

Ngày tải lên : 15/03/2014, 23:48

... formation of concrete-like products described as pozzolanic (LaGrega et al., 1 994) Dermatas and Meng (2003) have demonstrated that in quicklime SyS applications, the formation of pozzolanic reaction ... be there only in quantities below the detection limit of XRD As a general rule, the detection limit of the XRD analyses of crystalline phases is considered to be 5% of the total weight of the mixture ... As concentration Consequently, in the absence of any detectable pozzolanic product formation, it can be concluded that As immobilization in lime–As(III)–kaolinite slurries is precipitation controlled...

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Báo cáo khoa học: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice doc

Ngày tải lên : 16/03/2014, 04:20

... Under these conditions of storage, we could not observe any signs of precipitation or biochemical degradation, even after several months Addition of common salts containing monovalent ions (NaCl, ... high resolution FT-ion cyclotron resonance (ICR) MS, the protein displayed a notable degradation of the N-terminal part of its stalk region as shown by a clear ladder of the degradation products ... and the monodispersity of the protein in solution Gel filtration with a Superdex 200 column used for the final purification of the monodisperse proteins strongly suggested that all four proteins...

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Nonalcoholic fatty liver disease in children living in the obeseogenic society doc

Ngày tải lên : 22/03/2014, 10:20

... and decreased visualization of hepatic and portal veins secondary to compression of swollen hepatocytes on their walls Accumulation of fat may also result in abnormal hepatic vein Doppler waveform ... accuracy of ultrasound in the detection of fatty infiltration of the liver Br J Radiol 1980;53:440-442 Debongnie JC, Pauls C, Fievez M, Wibin E Prospective evaluation of the diagnostic accuracy of ... on continuing therapy as rebound increase of liver enzymes and worsening of histological features happen following cessation of therapy Other concerns include increased body weight (though nonvisceral...

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The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years pptx

Ngày tải lên : 22/03/2014, 10:20

... inclusion of these two cases among the four cases reaching the outcome of death or liver transplantation is appropriate as the comparison was done to overall mortality in the general population of ... imaging with ultrasonography, computed tomography scan, and/or magnetic resonance imaging confirming the presence of fatty infiltration of the liver The body mass index (BMI) based on body weight ... relationship between the logrank test and the Poisson distribution The p value calculated (from the one-sample log-rank test) depends on the assumption that the number of deaths follows a Poisson...

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Liver disease in children - Dr. Ahmed Al-Sarkhy, MD, MHSc, FAAP, FRCPC potx

Ngày tải lên : 28/03/2014, 09:20

... (accumulation of bile salts) Xanthomas depositions (accumulation of cholestrol) • Hepatomegaly +/- Splenomegaly • Failure to thrive (FTT)- neonates • Incidental lab finding Signs of cholestatic ... correction (Kasai portoenterostomy) : • Should be done before months (after that increase risk of fibrosis & subsequent cirrhosis) • Liver transplantation if failed Kasai or late presentation (> months) ... disease typically is self-limited and often is clinically inapparent • No chronic carrier state is identified • Diagnosis of acute infection is based on the presence of antiHAV IgM antibody in serum...

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Autoimmune Liver Disease in Children potx

Ngày tải lên : 28/03/2014, 11:20

... reminiscent of that of prolonged acute viral-like hepatitis Progression to cirrhosis was noted in of ANA/SMA-positive and of LKM1-positive patients on follow-up biopsies done between 17 to 56 months ... with attendant more severe side effects Discontinuation of treatment should be considered after year of normal liver function tests and demonstration of minimal or no inflammatory changes in liver ... grade II-IV hepatic encephalopathy from weeks to months (median, month) after onset of symptoms In the remaining children the duration of disease before diagnosis ranged from 10 days to months (median,...

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Identification of antibacterial species in plasma treated liquids

Ngày tải lên : 18/05/2014, 20:35

... inactivation of E coli compared to direct surface-DBD treatment 3000 ozone concentration (E) ozone concentration (D) ozone concentration (C) ozone concentration (B) ozone concentration (DBE) ozone concentration ... experiments, maximum E coli reduction by 3.5 log was found using a combination of NO2and H2O2 at pH One possible explanation of this result is the spontaneous reaction of nitrite with hydrogen peroxide ... effect of ozone treatment of bacteria suspensions was tested in comparison to the DBD plasma treatment in air E coli suspensions in physiological saline were treated with different concentrations of...

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báo cáo hóa học:" Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients – a pilot study" doc

Ngày tải lên : 18/06/2014, 15:20

... multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation Transplantation 1999, 68:261-266 ... characterized based on the expression of CD45RA Page of 14 (page number not for citation purposes) Journal of Translational Medicine 2009, 7:64 http://www.translational-medicine.com/content/7/1/64 ... http://www.translational-medicine.com/content/7/1/64 an up-regulation of predose IMPDH1 expression in mononuclear cells at acute rejection episodes [20] Moreover, high pretransplant IMPDH activity in mononuclear...

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Báo cáo hóa học: "The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer" docx

Ngày tải lên : 18/06/2014, 16:20

... colon carcinoma underwent palliative colon resection with or without resection of hepatic lesions None of the patients had undergone either chemotherapy or radiotherapy before the collection of ... Journal of Translational Medicine 2010, 8:13 http://www.translational-medicine.com/content/8/1/13 tumor cells [15] Therefore, TAMs might promote tumor progression by induction of chronic inflammation, ... point at tumor front Figure Representative images of macrophage phenotypes in colon cancer on consecutive sections Arrows point at tumor front Zhou et al Journal of Translational Medicine 2010,...

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Báo cáo hóa học: " Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors" docx

Ngày tải lên : 18/06/2014, 16:20

... generation was reached Mice from the N5 generations were assigned to cohorts based on age, gender, and genotype The cohorts were: Tsc2+/- months consisting of males and females, Tsc2+/+ months consisting ... Journal of Translational Medicine 2010, 8:14 http://www.translational-medicine.com/content/8/1/14 Page of 18 Table Distribution of Kidney Lesion Subtype for A/J and C57BL/6 Tsc2+/- Cohorts % of Total ... 12 mg/ mL solution of sunitinib daily (Monday-Friday) by gavage Bevacizumab treated groups received 200 μl of 0.75 mg/mL solution of bevacizumab once every two weeks by IP injection All drug doses...

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Báo cáo hóa học: " Updated survivals and prognostic factor analysis in myeloma treated by a staged approach use of bortezomib/thalidomide/dexamethasone in transplant eligible patients" pot

Ngày tải lên : 18/06/2014, 16:20

... reappearance of the paraprotein on immunofixation in CR patients, positive SPE in the nCR patients, and/or appearance of new bone lesions Oligoclonal reconstitution, defined as the appearance of a new ... methylation Chim Journal of Translational Medicine 2010, 8:124 http://www.translational-medicine.com/content/8/1/124 Page of superior EFS associated with the development of oligoclonal reconstitution ... reconstitution Figure Impact of the absence (blue line) and presence (green line) of oligoclonal reconstitution on EFS, showing a superior EFS in patients with oligoclonal reconstitution In an attempt to...

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Báo cáo sinh học: " Differential expression of papillomavirus L1 proteins encoded by authentic and codon modified L1 genes in methylcellulose-treated mouse keratinocytes" ppt

Ngày tải lên : 18/06/2014, 18:20

... differentiationdependent expression of the PV L1 proteins in KCs [8] We next examined how pre-transfection treatment of methylcellulose affected transcriptional and translational expressions of the ... differentiation In the absence of methylcellulose treatment, only weak signals of the L1 proteins were detected in KCs transfected with the two PV Nat L1 expression constructs, but the levels of L1 proteins ... 0HWK\OFHOOXORVH % 0RG / / ,QYR 7XE 1DW / / ,QYR 7XE 0HWK\OFHOOXORVH Figure Effects of post-transfection treatment of methylcellulose on expression of PV L1 genes in mouse primary KCs Effects of...

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Báo cáo hóa học: " Complexity of VTA DA neural activities in response to PFC transection in nicotine treated rats" pdf

Ngày tải lên : 19/06/2014, 08:20

... firing rate of DA neuron has reached stable condition in response to nicotine administration Figure shows an example of 20-second segment action potential recorded from PFC intact VTA DA neuron before ... dynamics of VTA DA action potentials These patterns may reflect different status of neuronal network synchronization Nonlinear dynamical analysis of neural patterns demonstrated that nicotine only ... the injection of nicotine was analyzed with LZ complexity method After firing rate of DA neuron has reached stable condition in response to nicotine, two minutes of data with the effect of nicotine...

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báo cáo hóa học: " Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice" pptx

Ngày tải lên : 19/06/2014, 22:20

... peptides (150– 200 µg of peptide/ml of antibody working solution), omission of the secondary antibody and absence of immunoreactivity in non-transgenic controls of the respective age Confocal laser scanning ... Aβ deposition, micro- and astroglial activation Comparison Comparison of Aβ deposition, micro- and astroglial activation (A) Representative detection of Aβ1–42 immunostaining, Thioflavin-S histochemistry, ... http://www.jneuroinflammation.com/content/2/1/22 Figure Characterisation of microglial inflammation Characterisation of microglial inflammation (A) Representative confocal immunohistochemistry of APP [V717I]...

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